GREMLIN Database
Q9HPN3 - Cobalamin biosynthesis
UniProt: Q9HPN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (208)
Sequences: 9180 (5502)
Seq/√Len: 381.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K25_E3.8081.00
14_D22_R3.4921.00
129_A190_G3.1941.00
4_Y23_T3.0361.00
183_R192_T2.6761.00
27_A85_A2.6691.00
196_R200_E2.6121.00
126_F185_L2.5621.00
182_G185_L2.4821.00
49_R78_R2.4371.00
4_Y83_D2.3761.00
196_R204_R2.3561.00
184_R189_Q2.3241.00
6_V85_A2.1851.00
78_R81_D2.1061.00
14_D19_R2.1001.00
197_D200_E2.0801.00
76_A110_P2.0251.00
19_R115_Q1.9661.00
28_D83_D1.8981.00
130_L180_T1.8741.00
23_T117_V1.8401.00
4_Y115_Q1.8191.00
169_H173_V1.8081.00
104_T110_P1.8021.00
22_R25_E1.8011.00
12_E19_R1.7961.00
18_L21_K1.7931.00
122_A160_F1.7781.00
34_G60_D1.7431.00
22_R26_A1.7211.00
26_A83_D1.6901.00
93_N98_F1.6541.00
169_H202_A1.6441.00
141_A154_P1.6321.00
214_R217_L1.6211.00
73_A77_P1.6151.00
164_D167_A1.5951.00
29_V78_R1.5811.00
196_R201_I1.5701.00
30_V44_H1.5611.00
6_V20_G1.5151.00
141_A155_D1.5101.00
121_S124_S1.5041.00
184_R187_M1.5041.00
77_P81_D1.4661.00
200_E204_R1.4511.00
76_A104_T1.4431.00
7_G92_P1.4411.00
74_E77_P1.4221.00
70_D73_A1.4091.00
32_S50_I1.4081.00
167_A170_E1.4021.00
5_G98_F1.3901.00
126_F182_G1.3701.00
74_E78_R1.3571.00
171_G174_D1.3221.00
165_A201_I1.3191.00
16_L20_G1.3171.00
17_T120_V1.3021.00
183_R205_D1.3011.00
23_T85_A1.2801.00
139_G155_D1.2731.00
93_N116_T1.2731.00
159_L162_V1.2711.00
170_E174_D1.2631.00
51_G74_E1.2571.00
3_V105_L1.2481.00
31_Y78_R1.2371.00
21_K43_H1.2271.00
41_A44_H1.2091.00
147_Q151_P1.2081.00
4_Y117_V1.2011.00
125_A186_Y1.1921.00
158_I211_Y1.1921.00
142_L160_F1.1841.00
80_R110_P1.1731.00
104_T107_A1.1721.00
102_R114_V1.1661.00
123_V160_F1.1641.00
20_G117_V1.1621.00
38_R42_T1.1601.00
159_L212_A1.1591.00
76_A80_R1.1401.00
129_A186_Y1.1351.00
106_D131_G1.1261.00
166_P170_E1.1241.00
181_Y208_T1.1191.00
166_P203_D1.1181.00
169_H198_P1.1131.00
45_V48_S1.1131.00
23_T115_Q1.1001.00
31_Y74_E1.0991.00
34_G52_D1.0971.00
179_V201_I1.0941.00
10_P15_L1.0931.00
167_A171_G1.0921.00
19_R117_V1.0761.00
94_V140_L1.0761.00
15_L19_R1.0701.00
67_A70_D1.0691.00
19_R22_R1.0641.00
190_G193_T1.0631.00
51_G78_R1.0611.00
127_T211_Y1.0531.00
66_A70_D1.0511.00
165_A210_A1.0401.00
121_S160_F1.0391.00
171_G175_A1.0291.00
94_V124_S1.0181.00
99_G136_A1.0131.00
127_T134_V1.0101.00
79_A112_I1.0001.00
6_V117_V0.9921.00
194_V204_R0.9881.00
31_Y75_V0.9791.00
86_F101_L0.9771.00
132_V180_T0.9671.00
182_G193_T0.9621.00
123_V142_L0.9501.00
39_T42_T0.9441.00
31_Y84_V0.9431.00
106_D114_V0.9411.00
61_P163_T0.9381.00
28_D45_V0.9321.00
116_T128_T0.9311.00
166_P202_A0.9281.00
3_V79_A0.9271.00
172_L212_A0.9241.00
148_G151_P0.9221.00
80_R112_I0.9161.00
13_P39_T0.9151.00
88_T96_S0.9071.00
92_P96_S0.9021.00
31_Y51_G0.8921.00
120_V125_A0.8821.00
19_R23_T0.8721.00
126_F209_L0.8681.00
66_A74_E0.8611.00
129_A193_T0.8611.00
181_Y201_I0.8571.00
180_T195_T0.8561.00
183_R208_T0.8521.00
14_D18_L0.8521.00
98_F102_R0.8511.00
23_T83_D0.8501.00
25_E43_H0.8471.00
37_S40_V0.8411.00
158_I209_L0.8401.00
94_V134_V0.8371.00
12_E186_Y0.8361.00
195_T216_T0.8341.00
4_Y27_A0.8291.00
41_A45_V0.8271.00
16_L40_V0.8241.00
169_H201_I0.8201.00
154_P157_M0.8201.00
72_A75_V0.8181.00
20_G40_V0.8181.00
23_T26_A0.8141.00
103_R136_A0.8111.00
72_A104_T0.8061.00
24_L85_A0.8001.00
24_L30_V0.7991.00
92_P116_T0.7981.00
44_H50_I0.7981.00
125_A185_L0.7971.00
116_T131_G0.7941.00
158_I172_L0.7941.00
173_V199_A0.7911.00
183_R194_V0.7901.00
30_V48_S0.7851.00
159_L168_T0.7781.00
16_L21_K0.7781.00
12_E15_L0.7721.00
63_K66_A0.7711.00
69_R104_T0.7711.00
69_R73_A0.7661.00
60_D63_K0.7621.00
79_A84_V0.7611.00
178_D214_R0.7611.00
29_V51_G0.7601.00
36_L39_T0.7591.00
4_Y85_A0.7581.00
31_Y57_M0.7491.00
52_D65_R0.7491.00
37_S41_A0.7431.00
157_M172_L0.7411.00
40_V43_H0.7321.00
156_R161_K0.7321.00
126_F211_Y0.7311.00
32_S52_D0.7281.00
34_G61_P0.7231.00
130_L193_T0.7201.00
72_A76_A0.7191.00
27_A83_D0.7171.00
61_P64_L0.7131.00
23_T27_A0.7121.00
165_A169_H0.7071.00
139_G144_E0.7071.00
20_G85_A0.7061.00
201_I204_R0.7051.00
195_T217_L0.7021.00
3_V75_V0.7000.99
107_A110_P0.6990.99
40_V44_H0.6970.99
130_L182_G0.6960.99
18_L43_H0.6930.99
76_A112_I0.6920.99
132_V216_T0.6900.99
6_V23_T0.6840.99
18_L22_R0.6840.99
199_A202_A0.6830.99
70_D77_P0.6810.99
122_A127_T0.6800.99
36_L40_V0.6730.99
135_D140_L0.6720.99
13_P43_H0.6700.99
98_F116_T0.6700.99
139_G143_R0.6690.99
179_V202_A0.6690.99
37_S44_H0.6680.99
177_Y214_R0.6670.99
49_R74_E0.6660.99
103_R107_A0.6620.99
77_P80_R0.6610.99
145_A168_T0.6610.99
79_A113_D0.6550.99
62_E66_A0.6540.99
27_A30_V0.6530.99
138_A148_G0.6520.99
93_N102_R0.6520.99
102_R106_D0.6440.99
124_S134_V0.6430.99
172_L176_G0.6400.99
44_H48_S0.6370.99
88_T97_T0.6350.99
170_E202_A0.6330.99
10_P186_Y0.6290.99
154_P177_Y0.6230.99
125_A209_L0.6210.99
24_L44_H0.6190.99
8_L36_L0.6190.99
15_L186_Y0.6190.99
184_R207_Y0.6130.99
178_D199_A0.6120.99
160_F209_L0.6050.99
102_R116_T0.5980.98
172_L177_Y0.5970.98
144_E147_Q0.5940.98
184_R205_D0.5920.98
156_R160_F0.5850.98
37_S43_H0.5840.98
63_K67_A0.5820.98
169_H179_V0.5810.98
89_L207_Y0.5780.98
41_A87_A0.5750.98
173_V202_A0.5750.98
141_A153_G0.5750.98
140_L143_R0.5740.98
127_T185_L0.5730.98
6_V24_L0.5730.98
173_V177_Y0.5730.98
70_D74_E0.5710.98
140_L144_E0.5700.98
134_V158_I0.5660.98
179_V198_P0.5660.98
5_G101_L0.5640.98
64_L68_W0.5590.98
46_P49_R0.5590.98
75_V79_A0.5570.97
181_Y194_V0.5560.97
105_L114_V0.5560.97
68_W71_A0.5540.97
42_T45_V0.5520.97
182_G211_Y0.5500.97
100_H137_G0.5470.97
173_V176_G0.5440.97
93_N128_T0.5440.97
7_G120_V0.5430.97
140_L145_A0.5430.97
22_R43_H0.5430.97
147_Q150_S0.5420.97
165_A181_Y0.5400.97
156_R215_D0.5390.97
180_T211_Y0.5370.97
102_R131_G0.5350.97
12_E129_A0.5290.97
181_Y196_R0.5240.96
38_R50_I0.5230.96
183_R206_Y0.5230.96
61_P206_Y0.5210.96
157_M212_A0.5200.96
48_S51_G0.5190.96
63_K70_D0.5180.96
114_V131_G0.5170.96
75_V84_V0.5160.96
143_R159_L0.5150.96
211_Y215_D0.5140.96
99_G103_R0.5120.96
71_A75_V0.5120.96
200_E203_D0.5120.96
3_V112_I0.5110.96
139_G145_A0.5090.96
64_L67_A0.5080.96
57_M66_A0.5070.96
149_A152_T0.5050.96
78_R84_V0.5040.96
99_G135_D0.5030.95
79_A82_G0.5020.95
181_Y210_A0.5020.95
69_R72_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.9359 100 0.3 Contact Map
1ve2A 2 0.906 100 0.305 Contact Map
2yboA 2 0.9017 100 0.306 Contact Map
1s4dA 4 0.9701 100 0.318 Contact Map
2e0nA 2 0.9359 100 0.321 Contact Map
2qbuA 2 0.8889 100 0.342 Contact Map
2zvbA 2 0.8675 100 0.359 Contact Map
4e16A 2 0.8632 100 0.361 Contact Map
1cbfA 2 0.8761 100 0.362 Contact Map
3ndcA 2 0.8932 100 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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