Q9HPN2 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HPN2 - Cobalamin biosynthesis

UniProt:	Q9HPN2	Sequences: MPEDATPQDAIDAASQQRQRGRDARVYDHTAGDTQAGIPFIGAGPGDPGLLTVTGKELVEDADLVVHAGSLVNSELLDEYCADAETVSSVGKDLEALIPLMRDAHEDGDTVVRLHSGDPAIYGAALEQMDALEQEGVPTYIVPGVTSAFASAATLRTQLTLNGTANHVAFTRPQGKTLDAEDDHIAEFVEMGDVTTCIYLGTHAIPDVMERLLADGHDPETPVTVVYHASWPDEDVIEGTIETIGDRVEDAGYRASALAVIGDAGAGAGYERSYLYGDWANRGSDTDQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (227)
Sequences:	11254 (6950)
Seq/√Len:	461.3

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPN2 Q9HPM9 Q9HMY4 Q9HPN0 Q9HPM0 Q9HPN3
SULSO - Q97WC9 Q97W12 Q97WC5 Q97UT5 Q97WD1 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_G	57_E	3.550	1.00
56_K	60_E	3.108	1.00
104_A	109_D	2.643	1.00
219_P	242_E	2.628	1.00
73_N	114_L	2.601	1.00
239_G	243_T	2.598	1.00
39_P	58_L	2.576	1.00
227_Y	235_D	2.504	1.00
106_E	135_E	2.377	1.00
37_G	140_Y	2.372	1.00
57_E	61_D	2.264	1.00
154_T	234_E	2.202	1.00
85_E	104_A	2.197	1.00
37_G	138_P	2.175	1.00
41_I	112_V	2.082	1.00
147_S	199_Y	2.081	1.00
62_A	112_V	2.061	1.00
223_V	244_I	2.033	1.00
104_A	107_D	2.015	1.00
131_A	135_E	2.002	1.00
39_P	110_T	1.998	1.00
53_V	56_K	1.969	1.00
151_S	229_A	1.947	1.00
222_P	262_G	1.946	1.00
239_G	247_R	1.934	1.00
226_V	229_A	1.869	1.00
102_R	135_E	1.868	1.00
41_I	55_G	1.852	1.00
42_G	142_V	1.839	1.00
240_T	243_T	1.823	1.00
131_A	134_Q	1.796	1.00
228_H	233_D	1.774	1.00
37_G	110_T	1.719	1.00
211_R	214_A	1.709	1.00
103_D	107_D	1.699	1.00
64_L	104_A	1.694	1.00
63_D	110_T	1.656	1.00
185_I	188_F	1.574	1.00
239_G	244_I	1.572	1.00
74_S	78_D	1.572	1.00
63_D	109_D	1.566	1.00
57_E	60_E	1.545	1.00
65_V	80_Y	1.541	1.00
243_T	247_R	1.534	1.00
39_P	140_Y	1.529	1.00
206_P	249_E	1.520	1.00
217_H	221_T	1.511	1.00
209_M	213_L	1.502	1.00
226_V	236_V	1.480	1.00
51_L	56_K	1.479	1.00
228_H	231_W	1.477	1.00
146_T	149_F	1.469	1.00
58_L	142_V	1.465	1.00
154_T	236_V	1.458	1.00
220_E	242_E	1.451	1.00
246_D	250_D	1.449	1.00
247_R	251_A	1.436	1.00
212_L	241_I	1.435	1.00
148_A	199_Y	1.423	1.00
146_T	199_Y	1.418	1.00
47_D	54_T	1.401	1.00
38_I	105_H	1.373	1.00
67_H	86_T	1.353	1.00
102_R	106_E	1.346	1.00
100_L	104_A	1.331	1.00
100_L	103_D	1.325	1.00
120_A	125_A	1.322	1.00
49_G	54_T	1.318	1.00
209_M	245_G	1.317	1.00
198_I	261_I	1.312	1.00
61_D	110_T	1.296	1.00
42_G	118_D	1.294	1.00
105_H	137_V	1.294	1.00
98_I	131_A	1.286	1.00
54_T	140_Y	1.269	1.00
213_L	219_P	1.262	1.00
225_V	257_A	1.258	1.00
205_I	248_V	1.253	1.00
237_I	247_R	1.235	1.00
85_E	109_D	1.233	1.00
52_T	145_V	1.213	1.00
99_P	103_D	1.212	1.00
263_D	266_A	1.201	1.00
106_E	137_V	1.197	1.00
38_I	132_L	1.197	1.00
102_R	131_A	1.185	1.00
96_A	99_P	1.180	1.00
151_S	226_V	1.180	1.00
235_D	251_A	1.177	1.00
210_E	214_A	1.175	1.00
51_L	55_G	1.164	1.00
66_V	101_M	1.161	1.00
141_I	153_A	1.151	1.00
223_V	241_I	1.146	1.00
224_T	238_E	1.138	1.00
197_C	260_V	1.133	1.00
212_L	261_I	1.126	1.00
187_E	214_A	1.125	1.00
206_P	210_E	1.115	1.00
56_K	79_E	1.114	1.00
132_L	137_V	1.107	1.00
133_E	238_E	1.091	1.00
58_L	112_V	1.084	1.00
64_L	111_V	1.083	1.00
224_T	236_V	1.077	1.00
126_L	161_L	1.061	1.00
75_E	78_D	1.057	1.00
225_V	248_V	1.052	1.00
155_L	224_T	1.050	1.00
187_E	191_M	1.048	1.00
207_D	210_E	1.043	1.00
130_D	134_Q	1.038	1.00
183_D	211_R	1.036	1.00
247_R	250_D	1.029	1.00
94_L	127_E	1.028	1.00
206_P	245_G	1.022	1.00
164_T	194_V	1.019	1.00
118_D	153_A	1.009	1.00
129_M	139_T	1.009	1.00
97_L	100_L	1.003	1.00
66_V	100_L	1.003	1.00
198_I	201_G	0.989	1.00
80_Y	84_A	0.984	1.00
213_L	241_I	0.981	1.00
62_A	110_T	0.979	1.00
188_F	191_M	0.966	1.00
66_V	104_A	0.963	1.00
207_D	211_R	0.962	1.00
166_N	194_V	0.960	1.00
169_A	185_I	0.958	1.00
204_A	207_D	0.958	1.00
209_M	241_I	0.957	1.00
50_L	54_T	0.956	1.00
170_F	199_Y	0.956	1.00
141_I	236_V	0.943	1.00
169_A	193_D	0.938	1.00
66_V	87_V	0.935	1.00
162_N	166_N	0.930	1.00
212_L	217_H	0.929	1.00
93_D	96_A	0.923	1.00
227_Y	254_R	0.923	1.00
205_I	259_A	0.922	1.00
49_G	53_V	0.919	1.00
205_I	244_I	0.913	1.00
39_P	142_V	0.910	1.00
65_V	84_A	0.909	1.00
126_L	130_D	0.909	1.00
176_K	211_R	0.905	1.00
158_Q	161_L	0.900	1.00
253_Y	257_A	0.900	1.00
81_C	84_A	0.897	1.00
218_D	221_T	0.895	1.00
187_E	190_E	0.892	1.00
113_R	128_Q	0.888	1.00
51_L	76_L	0.883	1.00
169_A	186_A	0.876	1.00
170_F	185_I	0.871	1.00
99_P	131_A	0.870	1.00
169_A	194_V	0.869	1.00
187_E	211_R	0.864	1.00
66_V	111_V	0.864	1.00
64_L	109_D	0.855	1.00
39_P	62_A	0.852	1.00
210_E	245_G	0.848	1.00
76_L	79_E	0.845	1.00
197_C	258_L	0.839	1.00
55_G	142_V	0.838	1.00
245_G	249_E	0.831	1.00
120_A	141_I	0.830	1.00
213_L	242_E	0.826	1.00
121_I	159_L	0.826	1.00
94_L	98_I	0.825	1.00
157_T	224_T	0.825	1.00
42_G	150_A	0.825	1.00
141_I	154_T	0.820	1.00
167_H	194_V	0.818	1.00
133_E	139_T	0.816	1.00
119_P	123_G	0.815	1.00
121_I	149_F	0.814	1.00
126_L	158_Q	0.812	1.00
176_K	182_D	0.807	1.00
193_D	217_H	0.807	1.00
151_S	260_V	0.805	1.00
90_V	93_D	0.803	1.00
221_T	263_D	0.800	1.00
98_I	102_R	0.799	1.00
41_I	142_V	0.797	1.00
48_P	75_E	0.796	1.00
208_V	259_A	0.795	1.00
87_V	97_L	0.795	1.00
225_V	244_I	0.794	1.00
150_A	230_S	0.794	1.00
200_L	204_A	0.791	1.00
47_D	50_L	0.787	1.00
53_V	57_E	0.780	1.00
213_L	245_G	0.779	1.00
224_T	260_V	0.777	1.00
64_L	87_V	0.776	1.00
58_L	110_T	0.772	1.00
164_T	192_G	0.762	1.00
133_E	156_R	0.762	1.00
199_Y	258_L	0.759	1.00
220_E	240_T	0.756	1.00
41_I	58_L	0.753	1.00
202_T	257_A	0.749	1.00
174_Q	184_H	0.747	1.00
63_D	81_C	0.741	1.00
118_D	141_I	0.741	1.00
56_K	80_Y	0.734	1.00
58_L	140_Y	0.732	1.00
87_V	104_A	0.730	1.00
72_V	75_E	0.729	1.00
35_Q	138_P	0.729	1.00
40_F	129_M	0.724	1.00
248_V	253_Y	0.724	1.00
87_V	100_L	0.721	1.00
166_N	185_I	0.718	1.00
237_I	244_I	0.714	1.00
121_I	168_V	0.708	1.00
129_M	133_E	0.707	1.00
173_P	211_R	0.705	1.00
196_T	261_I	0.705	1.00
167_H	189_V	0.704	1.00
227_Y	257_A	0.701	1.00
59_V	65_V	0.701	1.00
40_F	125_A	0.700	1.00
188_F	193_D	0.696	1.00
237_I	253_Y	0.695	1.00
54_T	57_E	0.695	1.00
98_I	101_M	0.695	1.00
55_G	76_L	0.694	1.00
122_Y	165_A	0.693	1.00
152_A	159_L	0.692	1.00
202_T	253_Y	0.687	1.00
243_T	246_D	0.685	1.00
237_I	248_V	0.683	1.00
210_E	249_E	0.682	1.00
206_P	246_D	0.681	1.00
246_D	249_E	0.681	1.00
39_P	112_V	0.679	1.00
54_T	142_V	0.678	1.00
238_E	268_A	0.675	1.00
132_L	139_T	0.675	1.00
130_D	222_P	0.672	1.00
103_D	106_E	0.672	1.00
58_L	61_D	0.663	1.00
59_V	112_V	0.659	1.00
160_T	195_T	0.658	1.00
58_L	62_A	0.658	1.00
105_H	111_V	0.656	1.00
125_A	129_M	0.655	1.00
154_T	230_S	0.650	1.00
205_I	257_A	0.650	1.00
80_Y	86_T	0.644	1.00
60_E	79_E	0.644	1.00
248_V	252_G	0.643	1.00
91_G	94_L	0.641	1.00
183_D	187_E	0.640	1.00
37_G	105_H	0.639	1.00
196_T	212_L	0.636	0.99
205_I	209_M	0.636	0.99
74_S	77_L	0.636	0.99
262_G	265_G	0.632	0.99
70_S	255_A	0.631	0.99
222_P	240_T	0.630	0.99
223_V	245_G	0.627	0.99
185_I	191_M	0.627	0.99
187_E	216_G	0.626	0.99
120_A	153_A	0.624	0.99
148_A	197_C	0.615	0.99
70_S	88_S	0.614	0.99
186_A	208_V	0.609	0.99
152_A	260_V	0.606	0.99
188_F	192_G	0.604	0.99
126_L	160_T	0.602	0.99
73_N	77_L	0.600	0.99
192_G	196_T	0.600	0.99
169_A	192_G	0.598	0.99
102_R	132_L	0.597	0.99
66_V	90_V	0.596	0.99
150_A	229_A	0.596	0.99
209_M	244_I	0.595	0.99
151_S	258_L	0.592	0.99
47_D	230_S	0.591	0.99
208_V	211_R	0.591	0.99
185_I	189_V	0.585	0.99
73_N	76_L	0.582	0.99
95_E	99_P	0.582	0.99
98_I	127_E	0.581	0.99
237_I	251_A	0.581	0.99
149_F	159_L	0.579	0.99
95_E	131_A	0.574	0.99
53_V	79_E	0.573	0.99
48_P	79_E	0.572	0.99
168_V	197_C	0.569	0.99
88_S	97_L	0.567	0.99
51_L	80_Y	0.565	0.99
95_E	98_I	0.564	0.99
75_E	79_E	0.564	0.99
45_P	230_S	0.563	0.99
42_G	119_P	0.556	0.99
198_I	208_V	0.555	0.99
53_V	60_E	0.554	0.99
55_G	112_V	0.553	0.99
72_V	76_L	0.549	0.99
54_T	58_L	0.546	0.98
40_F	139_T	0.542	0.98
38_I	113_R	0.541	0.98
226_V	260_V	0.541	0.98
95_E	127_E	0.540	0.98
223_V	248_V	0.536	0.98
40_F	153_A	0.536	0.98
84_A	87_V	0.536	0.98
166_N	175_G	0.535	0.98
161_L	164_T	0.533	0.98
45_P	50_L	0.533	0.98
85_E	100_L	0.532	0.98
203_H	254_R	0.530	0.98
208_V	212_L	0.528	0.98
157_T	265_G	0.525	0.98
189_V	196_T	0.524	0.98
42_G	154_T	0.523	0.98
150_A	154_T	0.523	0.98
50_L	230_S	0.522	0.98
183_D	207_D	0.521	0.98
38_I	101_M	0.518	0.98
148_A	170_F	0.518	0.98
183_D	214_A	0.518	0.98
62_A	65_V	0.517	0.98
59_V	80_Y	0.517	0.98
64_L	85_E	0.515	0.98
166_N	189_V	0.515	0.98
209_M	223_V	0.513	0.98
42_G	145_V	0.512	0.98
184_H	187_E	0.510	0.98
152_A	229_A	0.504	0.97
221_T	261_I	0.502	0.97
141_I	150_A	0.501	0.97
217_H	241_I	0.501	0.97
73_N	79_E	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pjqA	2	0.934	100	0.284	Contact Map
1s4dA	4	0.9062	100	0.302	Contact Map
2yboA	2	0.8403	100	0.309	Contact Map
3kwpA	2	0.7882	100	0.326	Contact Map
4e16A	2	0.7951	100	0.327	Contact Map
3ndcA	2	0.8299	100	0.331	Contact Map
1cbfA	2	0.8299	100	0.332	Contact Map
1ve2A	2	0.7882	100	0.341	Contact Map
1va0A	2	0.7917	100	0.367	Contact Map
1wyzA	2	0.7431	100	0.368	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.