GREMLIN Database
Q9HPN2 - Cobalamin biosynthesis
UniProt: Q9HPN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (227)
Sequences: 11254 (6950)
Seq/√Len: 461.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_G57_E3.5501.00
56_K60_E3.1081.00
104_A109_D2.6431.00
219_P242_E2.6281.00
73_N114_L2.6011.00
239_G243_T2.5981.00
39_P58_L2.5761.00
227_Y235_D2.5041.00
106_E135_E2.3771.00
37_G140_Y2.3721.00
57_E61_D2.2641.00
154_T234_E2.2021.00
85_E104_A2.1971.00
37_G138_P2.1751.00
41_I112_V2.0821.00
147_S199_Y2.0811.00
62_A112_V2.0611.00
223_V244_I2.0331.00
104_A107_D2.0151.00
131_A135_E2.0021.00
39_P110_T1.9981.00
53_V56_K1.9691.00
151_S229_A1.9471.00
222_P262_G1.9461.00
239_G247_R1.9341.00
226_V229_A1.8691.00
102_R135_E1.8681.00
41_I55_G1.8521.00
42_G142_V1.8391.00
240_T243_T1.8231.00
131_A134_Q1.7961.00
228_H233_D1.7741.00
37_G110_T1.7191.00
211_R214_A1.7091.00
103_D107_D1.6991.00
64_L104_A1.6941.00
63_D110_T1.6561.00
185_I188_F1.5741.00
239_G244_I1.5721.00
74_S78_D1.5721.00
63_D109_D1.5661.00
57_E60_E1.5451.00
65_V80_Y1.5411.00
243_T247_R1.5341.00
39_P140_Y1.5291.00
206_P249_E1.5201.00
217_H221_T1.5111.00
209_M213_L1.5021.00
226_V236_V1.4801.00
51_L56_K1.4791.00
228_H231_W1.4771.00
146_T149_F1.4691.00
58_L142_V1.4651.00
154_T236_V1.4581.00
220_E242_E1.4511.00
246_D250_D1.4491.00
247_R251_A1.4361.00
212_L241_I1.4351.00
148_A199_Y1.4231.00
146_T199_Y1.4181.00
47_D54_T1.4011.00
38_I105_H1.3731.00
67_H86_T1.3531.00
102_R106_E1.3461.00
100_L104_A1.3311.00
100_L103_D1.3251.00
120_A125_A1.3221.00
49_G54_T1.3181.00
209_M245_G1.3171.00
198_I261_I1.3121.00
61_D110_T1.2961.00
42_G118_D1.2941.00
105_H137_V1.2941.00
98_I131_A1.2861.00
54_T140_Y1.2691.00
213_L219_P1.2621.00
225_V257_A1.2581.00
205_I248_V1.2531.00
237_I247_R1.2351.00
85_E109_D1.2331.00
52_T145_V1.2131.00
99_P103_D1.2121.00
263_D266_A1.2011.00
106_E137_V1.1971.00
38_I132_L1.1971.00
102_R131_A1.1851.00
96_A99_P1.1801.00
151_S226_V1.1801.00
235_D251_A1.1771.00
210_E214_A1.1751.00
51_L55_G1.1641.00
66_V101_M1.1611.00
141_I153_A1.1511.00
223_V241_I1.1461.00
224_T238_E1.1381.00
197_C260_V1.1331.00
212_L261_I1.1261.00
187_E214_A1.1251.00
206_P210_E1.1151.00
56_K79_E1.1141.00
132_L137_V1.1071.00
133_E238_E1.0911.00
58_L112_V1.0841.00
64_L111_V1.0831.00
224_T236_V1.0771.00
126_L161_L1.0611.00
75_E78_D1.0571.00
225_V248_V1.0521.00
155_L224_T1.0501.00
187_E191_M1.0481.00
207_D210_E1.0431.00
130_D134_Q1.0381.00
183_D211_R1.0361.00
247_R250_D1.0291.00
94_L127_E1.0281.00
206_P245_G1.0221.00
164_T194_V1.0191.00
118_D153_A1.0091.00
129_M139_T1.0091.00
97_L100_L1.0031.00
66_V100_L1.0031.00
198_I201_G0.9891.00
80_Y84_A0.9841.00
213_L241_I0.9811.00
62_A110_T0.9791.00
188_F191_M0.9661.00
66_V104_A0.9631.00
207_D211_R0.9621.00
166_N194_V0.9601.00
169_A185_I0.9581.00
204_A207_D0.9581.00
209_M241_I0.9571.00
50_L54_T0.9561.00
170_F199_Y0.9561.00
141_I236_V0.9431.00
169_A193_D0.9381.00
66_V87_V0.9351.00
162_N166_N0.9301.00
212_L217_H0.9291.00
93_D96_A0.9231.00
227_Y254_R0.9231.00
205_I259_A0.9221.00
49_G53_V0.9191.00
205_I244_I0.9131.00
39_P142_V0.9101.00
65_V84_A0.9091.00
126_L130_D0.9091.00
176_K211_R0.9051.00
158_Q161_L0.9001.00
253_Y257_A0.9001.00
81_C84_A0.8971.00
218_D221_T0.8951.00
187_E190_E0.8921.00
113_R128_Q0.8881.00
51_L76_L0.8831.00
169_A186_A0.8761.00
170_F185_I0.8711.00
99_P131_A0.8701.00
169_A194_V0.8691.00
187_E211_R0.8641.00
66_V111_V0.8641.00
64_L109_D0.8551.00
39_P62_A0.8521.00
210_E245_G0.8481.00
76_L79_E0.8451.00
197_C258_L0.8391.00
55_G142_V0.8381.00
245_G249_E0.8311.00
120_A141_I0.8301.00
213_L242_E0.8261.00
121_I159_L0.8261.00
94_L98_I0.8251.00
157_T224_T0.8251.00
42_G150_A0.8251.00
141_I154_T0.8201.00
167_H194_V0.8181.00
133_E139_T0.8161.00
119_P123_G0.8151.00
121_I149_F0.8141.00
126_L158_Q0.8121.00
176_K182_D0.8071.00
193_D217_H0.8071.00
151_S260_V0.8051.00
90_V93_D0.8031.00
221_T263_D0.8001.00
98_I102_R0.7991.00
41_I142_V0.7971.00
48_P75_E0.7961.00
208_V259_A0.7951.00
87_V97_L0.7951.00
225_V244_I0.7941.00
150_A230_S0.7941.00
200_L204_A0.7911.00
47_D50_L0.7871.00
53_V57_E0.7801.00
213_L245_G0.7791.00
224_T260_V0.7771.00
64_L87_V0.7761.00
58_L110_T0.7721.00
164_T192_G0.7621.00
133_E156_R0.7621.00
199_Y258_L0.7591.00
220_E240_T0.7561.00
41_I58_L0.7531.00
202_T257_A0.7491.00
174_Q184_H0.7471.00
63_D81_C0.7411.00
118_D141_I0.7411.00
56_K80_Y0.7341.00
58_L140_Y0.7321.00
87_V104_A0.7301.00
72_V75_E0.7291.00
35_Q138_P0.7291.00
40_F129_M0.7241.00
248_V253_Y0.7241.00
87_V100_L0.7211.00
166_N185_I0.7181.00
237_I244_I0.7141.00
121_I168_V0.7081.00
129_M133_E0.7071.00
173_P211_R0.7051.00
196_T261_I0.7051.00
167_H189_V0.7041.00
227_Y257_A0.7011.00
59_V65_V0.7011.00
40_F125_A0.7001.00
188_F193_D0.6961.00
237_I253_Y0.6951.00
54_T57_E0.6951.00
98_I101_M0.6951.00
55_G76_L0.6941.00
122_Y165_A0.6931.00
152_A159_L0.6921.00
202_T253_Y0.6871.00
243_T246_D0.6851.00
237_I248_V0.6831.00
210_E249_E0.6821.00
206_P246_D0.6811.00
246_D249_E0.6811.00
39_P112_V0.6791.00
54_T142_V0.6781.00
238_E268_A0.6751.00
132_L139_T0.6751.00
130_D222_P0.6721.00
103_D106_E0.6721.00
58_L61_D0.6631.00
59_V112_V0.6591.00
160_T195_T0.6581.00
58_L62_A0.6581.00
105_H111_V0.6561.00
125_A129_M0.6551.00
154_T230_S0.6501.00
205_I257_A0.6501.00
80_Y86_T0.6441.00
60_E79_E0.6441.00
248_V252_G0.6431.00
91_G94_L0.6411.00
183_D187_E0.6401.00
37_G105_H0.6391.00
196_T212_L0.6360.99
205_I209_M0.6360.99
74_S77_L0.6360.99
262_G265_G0.6320.99
70_S255_A0.6310.99
222_P240_T0.6300.99
223_V245_G0.6270.99
185_I191_M0.6270.99
187_E216_G0.6260.99
120_A153_A0.6240.99
148_A197_C0.6150.99
70_S88_S0.6140.99
186_A208_V0.6090.99
152_A260_V0.6060.99
188_F192_G0.6040.99
126_L160_T0.6020.99
73_N77_L0.6000.99
192_G196_T0.6000.99
169_A192_G0.5980.99
102_R132_L0.5970.99
66_V90_V0.5960.99
150_A229_A0.5960.99
209_M244_I0.5950.99
151_S258_L0.5920.99
47_D230_S0.5910.99
208_V211_R0.5910.99
185_I189_V0.5850.99
73_N76_L0.5820.99
95_E99_P0.5820.99
98_I127_E0.5810.99
237_I251_A0.5810.99
149_F159_L0.5790.99
95_E131_A0.5740.99
53_V79_E0.5730.99
48_P79_E0.5720.99
168_V197_C0.5690.99
88_S97_L0.5670.99
51_L80_Y0.5650.99
95_E98_I0.5640.99
75_E79_E0.5640.99
45_P230_S0.5630.99
42_G119_P0.5560.99
198_I208_V0.5550.99
53_V60_E0.5540.99
55_G112_V0.5530.99
72_V76_L0.5490.99
54_T58_L0.5460.98
40_F139_T0.5420.98
38_I113_R0.5410.98
226_V260_V0.5410.98
95_E127_E0.5400.98
223_V248_V0.5360.98
40_F153_A0.5360.98
84_A87_V0.5360.98
166_N175_G0.5350.98
161_L164_T0.5330.98
45_P50_L0.5330.98
85_E100_L0.5320.98
203_H254_R0.5300.98
208_V212_L0.5280.98
157_T265_G0.5250.98
189_V196_T0.5240.98
42_G154_T0.5230.98
150_A154_T0.5230.98
50_L230_S0.5220.98
183_D207_D0.5210.98
38_I101_M0.5180.98
148_A170_F0.5180.98
183_D214_A0.5180.98
62_A65_V0.5170.98
59_V80_Y0.5170.98
64_L85_E0.5150.98
166_N189_V0.5150.98
209_M223_V0.5130.98
42_G145_V0.5120.98
184_H187_E0.5100.98
152_A229_A0.5040.97
221_T261_I0.5020.97
141_I150_A0.5010.97
217_H241_I0.5010.97
73_N79_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.934 100 0.284 Contact Map
1s4dA 4 0.9062 100 0.302 Contact Map
2yboA 2 0.8403 100 0.309 Contact Map
3kwpA 2 0.7882 100 0.326 Contact Map
4e16A 2 0.7951 100 0.327 Contact Map
3ndcA 2 0.8299 100 0.331 Contact Map
1cbfA 2 0.8299 100 0.332 Contact Map
1ve2A 2 0.7882 100 0.341 Contact Map
1va0A 2 0.7917 100 0.367 Contact Map
1wyzA 2 0.7431 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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