GREMLIN Database
Q9HPN1 - Cobalamin biosynthesis
UniProt: Q9HPN1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (292)
Sequences: 1092 (889)
Seq/√Len: 52.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_W134_V4.4911.00
245_T266_V4.4801.00
102_V111_A3.6771.00
270_E273_T3.4201.00
215_S251_D3.3051.00
246_G289_I3.2371.00
207_V235_Y3.0921.00
293_G297_A3.0751.00
81_S114_L2.9681.00
74_C124_V2.8971.00
248_R289_I2.7781.00
222_F258_A2.6311.00
245_T268_A2.6071.00
222_F254_G2.5961.00
113_P125_A2.5751.00
223_R261_A2.5511.00
225_A319_V2.4431.00
299_A324_G2.3421.00
96_W163_G2.2731.00
230_L240_V2.2601.00
244_A302_G2.2401.00
274_L298_S2.2311.00
226_W258_A2.1901.00
209_L240_V2.1421.00
209_L226_W2.1241.00
92_L115_T2.0791.00
281_T311_E2.0231.00
79_M84_A1.9671.00
214_V318_A1.8730.99
229_S321_V1.8710.99
32_V75_F1.8250.99
110_W136_A1.8110.99
223_R262_L1.8100.99
246_G271_K1.8090.99
169_T179_G1.8000.99
303_G306_N1.7880.99
282_P292_P1.7870.99
243_V259_A1.7450.99
94_D163_G1.7260.99
229_S310_A1.7240.99
141_S170_N1.7240.99
102_V124_V1.7190.99
286_K292_P1.7030.99
225_A315_Y1.6930.99
128_L131_M1.6900.99
77_G84_A1.6850.99
96_W119_H1.6780.99
285_S288_L1.6700.98
253_E257_A1.6650.98
83_I87_K1.6540.98
310_A323_V1.6490.98
122_N139_T1.5880.98
30_A72_Y1.5820.98
225_A321_V1.5790.98
104_V111_A1.5650.98
219_E254_G1.5650.98
207_V323_V1.5300.97
277_H301_A1.5100.97
221_Q318_A1.5000.97
250_A268_A1.4930.97
104_V131_M1.4890.97
66_A91_L1.4770.97
229_S233_T1.4750.97
44_I128_L1.4720.97
242_F267_V1.4650.96
219_E261_A1.4580.96
94_D97_E1.4540.96
208_V242_F1.4420.96
226_W321_V1.4130.96
76_V102_V1.4010.95
216_G254_G1.3970.95
300_I308_L1.3900.95
219_E257_A1.3880.95
209_L243_V1.3660.95
227_A262_L1.3660.95
33_A38_R1.3630.95
116_G119_H1.3620.95
113_P128_L1.3610.95
228_A232_A1.3570.95
40_T78_L1.3490.94
65_F77_G1.3450.94
211_T255_L1.3410.94
258_A262_L1.3330.94
139_T142_E1.3180.94
223_R258_A1.3160.94
223_R227_A1.3150.94
113_P135_P1.3120.94
213_S252_E1.3040.93
74_C102_V1.3010.93
149_V170_N1.2980.93
64_V68_H1.2980.93
40_T108_L1.2950.93
271_K289_I1.2940.93
273_T301_A1.2930.93
233_T310_A1.2900.93
93_D97_E1.2870.93
29_I74_C1.2710.92
227_A237_I1.2680.92
235_Y323_V1.2610.92
103_V112_I1.2610.92
275_E291_W1.2600.92
232_A313_E1.2510.92
111_A128_L1.2510.92
107_A143_A1.2490.92
214_V217_A1.2470.92
222_F319_V1.2440.92
257_A260_E1.2180.91
275_E292_P1.2160.91
219_E258_A1.2140.91
236_D239_D1.2140.91
159_H205_D1.2060.90
269_F274_L1.1960.90
256_L268_A1.1810.89
243_V264_L1.1800.89
172_A177_N1.1720.89
76_V104_V1.1700.89
275_E286_K1.1630.89
213_S255_L1.1520.88
123_Q155_A1.1450.88
230_L237_I1.1450.88
214_V285_S1.1400.88
122_N142_E1.1400.88
296_E312_K1.1360.87
194_D206_G1.1350.87
247_T271_K1.1320.87
28_D73_D1.1300.87
111_A133_A1.1290.87
300_I324_G1.1250.87
245_T259_A1.1190.87
292_P297_A1.1160.86
65_F91_L1.1090.86
249_K252_E1.1080.86
161_V238_D1.0970.86
163_G166_T1.0970.86
217_A222_F1.0950.85
65_F88_T1.0930.85
74_C100_A1.0850.85
173_V179_G1.0760.84
269_F302_G1.0640.84
162_N166_T1.0570.83
33_A41_A1.0570.83
285_S318_A1.0520.83
254_G258_A1.0520.83
213_S217_A1.0510.83
247_T270_E1.0470.83
48_I127_D1.0460.83
34_F79_M1.0380.82
60_Y63_D1.0360.82
215_S252_E1.0300.82
161_V236_D1.0270.81
295_A322_A1.0260.81
100_A121_A1.0230.81
211_T226_W1.0210.81
125_A135_P1.0100.80
279_G297_A1.0030.80
259_A264_L1.0020.80
228_A315_Y0.9860.79
274_L297_A0.9840.79
222_F226_W0.9810.78
244_A269_F0.9750.78
292_P295_A0.9660.77
206_G239_D0.9650.77
255_L266_V0.9640.77
291_W297_A0.9630.77
208_V244_A0.9550.77
209_L230_L0.9530.76
67_E71_E0.9490.76
38_R42_A0.9480.76
248_R288_L0.9440.76
271_K274_L0.9440.76
217_A254_G0.9380.75
78_L104_V0.9360.75
68_H75_F0.9300.75
211_T321_V0.9290.75
221_Q225_A0.9270.74
32_V68_H0.9250.74
149_V173_V0.9240.74
308_L324_G0.9220.74
240_V264_L0.9200.74
109_T134_V0.9190.74
258_A264_L0.9180.74
259_A266_V0.9170.74
209_L323_V0.9110.73
186_G190_V0.9050.73
209_L321_V0.9000.72
226_W240_V0.8920.71
105_D109_T0.8840.71
76_V275_E0.8700.70
83_I153_A0.8570.68
151_E155_A0.8510.68
254_G259_A0.8500.68
37_K144_A0.8490.68
108_L133_A0.8480.68
296_E322_A0.8440.67
88_T92_L0.8410.67
274_L293_G0.8410.67
227_A231_A0.8400.67
36_R175_D0.8390.67
103_V136_A0.8370.67
166_T170_N0.8330.66
103_V138_T0.8320.66
79_M83_I0.8320.66
146_K173_V0.8300.66
279_G293_G0.8290.66
119_H163_G0.8280.66
167_V171_L0.8240.65
31_I44_I0.8170.65
30_A68_H0.8150.64
69_W122_N0.8120.64
221_Q315_Y0.8100.64
204_D239_D0.8070.64
229_S323_V0.8060.64
217_A221_Q0.8060.64
103_V113_P0.7960.63
310_A313_E0.7960.63
225_A229_S0.7870.62
230_L323_V0.7870.62
153_A158_T0.7850.62
149_V166_T0.7830.61
242_F302_G0.7820.61
190_V193_G0.7790.61
142_E150_E0.7790.61
84_A147_Q0.7780.61
256_L266_V0.7780.61
84_A103_V0.7750.61
213_S222_F0.7730.60
141_S167_V0.7700.60
281_T292_P0.7680.60
79_M147_Q0.7660.60
300_I322_A0.7640.59
31_I41_A0.7570.59
285_S291_W0.7520.58
104_V128_L0.7510.58
247_T250_A0.7490.58
297_A318_A0.7400.57
87_K91_L0.7390.57
141_S153_A0.7390.57
211_T243_V0.7390.57
211_T222_F0.7380.57
280_P297_A0.7350.56
152_R156_L0.7350.56
285_S295_A0.7350.56
99_P239_D0.7340.56
34_F84_A0.7330.56
162_N165_S0.7300.56
147_Q297_A0.7280.56
34_F297_A0.7240.55
95_K118_H0.7240.55
31_I78_L0.7220.55
142_E148_G0.7220.55
174_L297_A0.7170.55
181_V186_G0.7140.54
277_H293_G0.7130.54
267_V323_V0.7130.54
113_P136_A0.7120.54
106_E143_A0.7090.54
32_V128_L0.7070.54
216_G219_E0.7060.53
81_S84_A0.7050.53
271_K298_S0.7030.53
186_G189_A0.6970.53
106_E144_A0.6940.52
42_A46_A0.6940.52
220_Q257_A0.6940.52
243_V258_A0.6930.52
110_W143_A0.6910.52
111_A131_M0.6900.52
65_F87_K0.6900.52
192_V195_D0.6890.52
44_I111_A0.6890.52
211_T258_A0.6890.52
220_Q232_A0.6890.52
47_G272_E0.6880.52
299_A306_N0.6880.52
39_D43_E0.6840.51
165_S168_A0.6840.51
83_I214_V0.6830.51
40_T104_V0.6800.51
106_E140_A0.6780.51
214_V288_L0.6770.50
112_I138_T0.6760.50
161_V166_T0.6750.50
282_P285_S0.6740.50
68_H72_Y0.6720.50
280_P292_P0.6700.50
191_V195_D0.6700.50
111_A129_A0.6690.50
162_N169_T0.6690.50
233_T321_V0.6630.49
300_I306_N0.6620.49
108_L204_D0.6600.49
241_E265_G0.6600.49
147_Q152_R0.6570.48
122_N137_M0.6560.48
274_L291_W0.6540.48
123_Q126_D0.6500.48
102_V128_L0.6460.47
58_L64_V0.6450.47
220_Q261_A0.6420.47
38_R41_A0.6410.47
212_G249_K0.6390.46
282_P293_G0.6350.46
80_A139_T0.6350.46
113_P137_M0.6330.46
288_L291_W0.6330.46
237_I262_L0.6320.46
61_H64_V0.6320.46
65_F83_I0.6320.46
216_G253_E0.6270.45
253_E309_L0.6270.45
149_V293_G0.6260.45
167_V170_N0.6260.45
51_R55_I0.6260.45
231_A273_T0.6230.45
296_E308_L0.6220.45
183_R186_G0.6200.45
43_E47_G0.6200.45
129_A133_A0.6200.45
100_A299_A0.6120.44
78_L244_A0.6110.44
149_V295_A0.6110.44
50_D239_D0.6080.43
44_I131_M0.6070.43
153_A167_V0.6070.43
170_N173_V0.6070.43
92_L165_S0.6040.43
85_M103_V0.6040.43
35_E211_T0.6030.43
44_I104_V0.6030.43
125_A133_A0.6030.43
74_C128_L0.6020.43
37_K107_A0.6000.42
299_A303_G0.6000.42
163_G171_L0.6000.42
302_G322_A0.5980.42
308_L322_A0.5970.42
148_G213_S0.5940.42
158_T295_A0.5920.42
160_V174_L0.5910.42
116_G295_A0.5910.42
175_D293_G0.5910.42
160_V166_T0.5910.42
152_R297_A0.5900.41
229_S313_E0.5890.41
54_S58_L0.5870.41
280_P291_W0.5860.41
70_G93_D0.5860.41
207_V310_A0.5860.41
167_V174_L0.5850.41
143_A295_A0.5840.41
282_P297_A0.5830.41
80_A83_I0.5830.41
167_V179_G0.5830.41
79_M152_R0.5820.41
203_S309_L0.5800.40
69_W179_G0.5790.40
282_P288_L0.5790.40
105_D110_W0.5780.40
215_S249_K0.5760.40
63_D66_A0.5750.40
107_A144_A0.5730.40
221_Q316_D0.5720.40
141_S174_L0.5700.39
168_A190_V0.5680.39
169_T289_I0.5670.39
78_L83_I0.5670.39
234_D237_I0.5650.39
37_K272_E0.5640.39
226_W229_S0.5640.39
216_G252_E0.5630.39
281_T296_E0.5630.39
37_K106_E0.5610.39
118_H212_G0.5600.38
227_A261_A0.5590.38
141_S158_T0.5590.38
177_N187_P0.5520.38
114_L171_L0.5520.38
240_V323_V0.5510.38
98_D105_D0.5490.37
183_R192_V0.5490.37
183_R190_V0.5480.37
80_A115_T0.5420.37
241_E302_G0.5420.37
166_T174_L0.5400.36
279_G292_P0.5390.36
286_K291_W0.5380.36
79_M106_E0.5370.36
181_V190_V0.5340.36
68_H101_V0.5320.36
122_N135_P0.5310.36
176_E179_G0.5310.36
100_A119_H0.5310.36
61_H87_K0.5300.36
230_L235_Y0.5290.35
244_A266_V0.5260.35
46_A234_D0.5250.35
217_A319_V0.5240.35
123_Q151_E0.5240.35
209_L250_A0.5230.35
66_A70_G0.5220.35
188_Q191_V0.5210.35
44_I165_S0.5210.35
171_L175_D0.5200.35
140_A173_V0.5200.35
166_T171_L0.5200.35
85_M133_A0.5190.34
102_V145_G0.5180.34
214_V291_W0.5180.34
193_G269_F0.5170.34
153_A295_A0.5160.34
112_I273_T0.5160.34
150_E252_E0.5150.34
110_W137_M0.5140.34
44_I265_G0.5140.34
235_Y310_A0.5140.34
162_N207_V0.5140.34
139_T174_L0.5120.34
306_N309_L0.5120.34
273_T276_A0.5110.34
190_V195_D0.5110.34
118_H150_E0.5100.34
281_T297_A0.5090.34
226_W230_L0.5080.33
106_E142_E0.5080.33
113_P119_H0.5070.33
34_F318_A0.5070.33
172_A313_E0.5070.33
28_D269_F0.5060.33
148_G303_G0.5050.33
69_W75_F0.5030.33
43_E240_V0.5030.33
141_S163_G0.5020.33
31_I238_D0.5020.33
88_T101_V0.5020.33
80_A126_D0.5020.33
41_A205_D0.5020.33
127_D178_L0.5010.33
203_S211_T0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eeqA 2 0.88 100 0.209 Contact Map
2w6kA 1 0.3969 100 0.671 Contact Map
3by5A 2 0.3569 100 0.683 Contact Map
2wc1A 1 0.4462 85.1 0.955 Contact Map
3f6rA 1 0.3908 84.1 0.956 Contact Map
1ag9A 2 0.4369 82.5 0.956 Contact Map
2arkA 4 0.4831 81.9 0.957 Contact Map
1yobA 1 0.4431 81.8 0.957 Contact Map
1ykgA 1 0.4 81.2 0.957 Contact Map
4heqA 2 0.3877 80.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.