Q9HPN1 - HALSA - GREMLIN Contacts

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Q9HPN1 - Cobalamin biosynthesis

UniProt:	Q9HPN1	Sequences: MSTDNDTETDDSGGHCSTPDSDGEVAEDIAIVAFERKRDTAAEIVAGIGDRYDSIDILDYHGDVFAEHWGEYDCFVGLMASGIAMRKTAGLLDDKWEDPAVVVVDEALTWAIPLTGGHHGANQVADDLASMGAVPAMTTASEAAGKQGVEERAKALDTHVVNGDSTVATNLAVLDENLGPVARLDGPQAVVVGDDVTVLKRNSDDGVVLGTGSVSGADEQQFRDAWAASLAATDYDIDDVEFVATGTRKADEEGLLAAAEALGLGVVAFEKETLEAHEGPTPSRSKELIGWPGIAEASAIAGGRDNELLAEKERYDEAVTVAVGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (292)
Sequences:	1092 (889)
Seq/√Len:	52.0

HALSA - Q9HPN1
SULSO - Q97WD0 Q980Y9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
110_W	134_V	4.491	1.00
245_T	266_V	4.480	1.00
102_V	111_A	3.677	1.00
270_E	273_T	3.420	1.00
215_S	251_D	3.305	1.00
246_G	289_I	3.237	1.00
207_V	235_Y	3.092	1.00
293_G	297_A	3.075	1.00
81_S	114_L	2.968	1.00
74_C	124_V	2.897	1.00
248_R	289_I	2.778	1.00
222_F	258_A	2.631	1.00
245_T	268_A	2.607	1.00
222_F	254_G	2.596	1.00
113_P	125_A	2.575	1.00
223_R	261_A	2.551	1.00
225_A	319_V	2.443	1.00
299_A	324_G	2.342	1.00
96_W	163_G	2.273	1.00
230_L	240_V	2.260	1.00
244_A	302_G	2.240	1.00
274_L	298_S	2.231	1.00
226_W	258_A	2.190	1.00
209_L	240_V	2.142	1.00
209_L	226_W	2.124	1.00
92_L	115_T	2.079	1.00
281_T	311_E	2.023	1.00
79_M	84_A	1.967	1.00
214_V	318_A	1.873	0.99
229_S	321_V	1.871	0.99
32_V	75_F	1.825	0.99
110_W	136_A	1.811	0.99
223_R	262_L	1.810	0.99
246_G	271_K	1.809	0.99
169_T	179_G	1.800	0.99
303_G	306_N	1.788	0.99
282_P	292_P	1.787	0.99
243_V	259_A	1.745	0.99
94_D	163_G	1.726	0.99
229_S	310_A	1.724	0.99
141_S	170_N	1.724	0.99
102_V	124_V	1.719	0.99
286_K	292_P	1.703	0.99
225_A	315_Y	1.693	0.99
128_L	131_M	1.690	0.99
77_G	84_A	1.685	0.99
96_W	119_H	1.678	0.99
285_S	288_L	1.670	0.98
253_E	257_A	1.665	0.98
83_I	87_K	1.654	0.98
310_A	323_V	1.649	0.98
122_N	139_T	1.588	0.98
30_A	72_Y	1.582	0.98
225_A	321_V	1.579	0.98
104_V	111_A	1.565	0.98
219_E	254_G	1.565	0.98
207_V	323_V	1.530	0.97
277_H	301_A	1.510	0.97
221_Q	318_A	1.500	0.97
250_A	268_A	1.493	0.97
104_V	131_M	1.489	0.97
66_A	91_L	1.477	0.97
229_S	233_T	1.475	0.97
44_I	128_L	1.472	0.97
242_F	267_V	1.465	0.96
219_E	261_A	1.458	0.96
94_D	97_E	1.454	0.96
208_V	242_F	1.442	0.96
226_W	321_V	1.413	0.96
76_V	102_V	1.401	0.95
216_G	254_G	1.397	0.95
300_I	308_L	1.390	0.95
219_E	257_A	1.388	0.95
209_L	243_V	1.366	0.95
227_A	262_L	1.366	0.95
33_A	38_R	1.363	0.95
116_G	119_H	1.362	0.95
113_P	128_L	1.361	0.95
228_A	232_A	1.357	0.95
40_T	78_L	1.349	0.94
65_F	77_G	1.345	0.94
211_T	255_L	1.341	0.94
258_A	262_L	1.333	0.94
139_T	142_E	1.318	0.94
223_R	258_A	1.316	0.94
223_R	227_A	1.315	0.94
113_P	135_P	1.312	0.94
213_S	252_E	1.304	0.93
74_C	102_V	1.301	0.93
149_V	170_N	1.298	0.93
64_V	68_H	1.298	0.93
40_T	108_L	1.295	0.93
271_K	289_I	1.294	0.93
273_T	301_A	1.293	0.93
233_T	310_A	1.290	0.93
93_D	97_E	1.287	0.93
29_I	74_C	1.271	0.92
227_A	237_I	1.268	0.92
235_Y	323_V	1.261	0.92
103_V	112_I	1.261	0.92
275_E	291_W	1.260	0.92
232_A	313_E	1.251	0.92
111_A	128_L	1.251	0.92
107_A	143_A	1.249	0.92
214_V	217_A	1.247	0.92
222_F	319_V	1.244	0.92
257_A	260_E	1.218	0.91
275_E	292_P	1.216	0.91
219_E	258_A	1.214	0.91
236_D	239_D	1.214	0.91
159_H	205_D	1.206	0.90
269_F	274_L	1.196	0.90
256_L	268_A	1.181	0.89
243_V	264_L	1.180	0.89
172_A	177_N	1.172	0.89
76_V	104_V	1.170	0.89
275_E	286_K	1.163	0.89
213_S	255_L	1.152	0.88
123_Q	155_A	1.145	0.88
230_L	237_I	1.145	0.88
214_V	285_S	1.140	0.88
122_N	142_E	1.140	0.88
296_E	312_K	1.136	0.87
194_D	206_G	1.135	0.87
247_T	271_K	1.132	0.87
28_D	73_D	1.130	0.87
111_A	133_A	1.129	0.87
300_I	324_G	1.125	0.87
245_T	259_A	1.119	0.87
292_P	297_A	1.116	0.86
65_F	91_L	1.109	0.86
249_K	252_E	1.108	0.86
161_V	238_D	1.097	0.86
163_G	166_T	1.097	0.86
217_A	222_F	1.095	0.85
65_F	88_T	1.093	0.85
74_C	100_A	1.085	0.85
173_V	179_G	1.076	0.84
269_F	302_G	1.064	0.84
162_N	166_T	1.057	0.83
33_A	41_A	1.057	0.83
285_S	318_A	1.052	0.83
254_G	258_A	1.052	0.83
213_S	217_A	1.051	0.83
247_T	270_E	1.047	0.83
48_I	127_D	1.046	0.83
34_F	79_M	1.038	0.82
60_Y	63_D	1.036	0.82
215_S	252_E	1.030	0.82
161_V	236_D	1.027	0.81
295_A	322_A	1.026	0.81
100_A	121_A	1.023	0.81
211_T	226_W	1.021	0.81
125_A	135_P	1.010	0.80
279_G	297_A	1.003	0.80
259_A	264_L	1.002	0.80
228_A	315_Y	0.986	0.79
274_L	297_A	0.984	0.79
222_F	226_W	0.981	0.78
244_A	269_F	0.975	0.78
292_P	295_A	0.966	0.77
206_G	239_D	0.965	0.77
255_L	266_V	0.964	0.77
291_W	297_A	0.963	0.77
208_V	244_A	0.955	0.77
209_L	230_L	0.953	0.76
67_E	71_E	0.949	0.76
38_R	42_A	0.948	0.76
248_R	288_L	0.944	0.76
271_K	274_L	0.944	0.76
217_A	254_G	0.938	0.75
78_L	104_V	0.936	0.75
68_H	75_F	0.930	0.75
211_T	321_V	0.929	0.75
221_Q	225_A	0.927	0.74
32_V	68_H	0.925	0.74
149_V	173_V	0.924	0.74
308_L	324_G	0.922	0.74
240_V	264_L	0.920	0.74
109_T	134_V	0.919	0.74
258_A	264_L	0.918	0.74
259_A	266_V	0.917	0.74
209_L	323_V	0.911	0.73
186_G	190_V	0.905	0.73
209_L	321_V	0.900	0.72
226_W	240_V	0.892	0.71
105_D	109_T	0.884	0.71
76_V	275_E	0.870	0.70
83_I	153_A	0.857	0.68
151_E	155_A	0.851	0.68
254_G	259_A	0.850	0.68
37_K	144_A	0.849	0.68
108_L	133_A	0.848	0.68
296_E	322_A	0.844	0.67
88_T	92_L	0.841	0.67
274_L	293_G	0.841	0.67
227_A	231_A	0.840	0.67
36_R	175_D	0.839	0.67
103_V	136_A	0.837	0.67
166_T	170_N	0.833	0.66
103_V	138_T	0.832	0.66
79_M	83_I	0.832	0.66
146_K	173_V	0.830	0.66
279_G	293_G	0.829	0.66
119_H	163_G	0.828	0.66
167_V	171_L	0.824	0.65
31_I	44_I	0.817	0.65
30_A	68_H	0.815	0.64
69_W	122_N	0.812	0.64
221_Q	315_Y	0.810	0.64
204_D	239_D	0.807	0.64
229_S	323_V	0.806	0.64
217_A	221_Q	0.806	0.64
103_V	113_P	0.796	0.63
310_A	313_E	0.796	0.63
225_A	229_S	0.787	0.62
230_L	323_V	0.787	0.62
153_A	158_T	0.785	0.62
149_V	166_T	0.783	0.61
242_F	302_G	0.782	0.61
190_V	193_G	0.779	0.61
142_E	150_E	0.779	0.61
84_A	147_Q	0.778	0.61
256_L	266_V	0.778	0.61
84_A	103_V	0.775	0.61
213_S	222_F	0.773	0.60
141_S	167_V	0.770	0.60
281_T	292_P	0.768	0.60
79_M	147_Q	0.766	0.60
300_I	322_A	0.764	0.59
31_I	41_A	0.757	0.59
285_S	291_W	0.752	0.58
104_V	128_L	0.751	0.58
247_T	250_A	0.749	0.58
297_A	318_A	0.740	0.57
87_K	91_L	0.739	0.57
141_S	153_A	0.739	0.57
211_T	243_V	0.739	0.57
211_T	222_F	0.738	0.57
280_P	297_A	0.735	0.56
152_R	156_L	0.735	0.56
285_S	295_A	0.735	0.56
99_P	239_D	0.734	0.56
34_F	84_A	0.733	0.56
162_N	165_S	0.730	0.56
147_Q	297_A	0.728	0.56
34_F	297_A	0.724	0.55
95_K	118_H	0.724	0.55
31_I	78_L	0.722	0.55
142_E	148_G	0.722	0.55
174_L	297_A	0.717	0.55
181_V	186_G	0.714	0.54
277_H	293_G	0.713	0.54
267_V	323_V	0.713	0.54
113_P	136_A	0.712	0.54
106_E	143_A	0.709	0.54
32_V	128_L	0.707	0.54
216_G	219_E	0.706	0.53
81_S	84_A	0.705	0.53
271_K	298_S	0.703	0.53
186_G	189_A	0.697	0.53
106_E	144_A	0.694	0.52
42_A	46_A	0.694	0.52
220_Q	257_A	0.694	0.52
243_V	258_A	0.693	0.52
110_W	143_A	0.691	0.52
111_A	131_M	0.690	0.52
65_F	87_K	0.690	0.52
192_V	195_D	0.689	0.52
44_I	111_A	0.689	0.52
211_T	258_A	0.689	0.52
220_Q	232_A	0.689	0.52
47_G	272_E	0.688	0.52
299_A	306_N	0.688	0.52
39_D	43_E	0.684	0.51
165_S	168_A	0.684	0.51
83_I	214_V	0.683	0.51
40_T	104_V	0.680	0.51
106_E	140_A	0.678	0.51
214_V	288_L	0.677	0.50
112_I	138_T	0.676	0.50
161_V	166_T	0.675	0.50
282_P	285_S	0.674	0.50
68_H	72_Y	0.672	0.50
280_P	292_P	0.670	0.50
191_V	195_D	0.670	0.50
111_A	129_A	0.669	0.50
162_N	169_T	0.669	0.50
233_T	321_V	0.663	0.49
300_I	306_N	0.662	0.49
108_L	204_D	0.660	0.49
241_E	265_G	0.660	0.49
147_Q	152_R	0.657	0.48
122_N	137_M	0.656	0.48
274_L	291_W	0.654	0.48
123_Q	126_D	0.650	0.48
102_V	128_L	0.646	0.47
58_L	64_V	0.645	0.47
220_Q	261_A	0.642	0.47
38_R	41_A	0.641	0.47
212_G	249_K	0.639	0.46
282_P	293_G	0.635	0.46
80_A	139_T	0.635	0.46
113_P	137_M	0.633	0.46
288_L	291_W	0.633	0.46
237_I	262_L	0.632	0.46
61_H	64_V	0.632	0.46
65_F	83_I	0.632	0.46
216_G	253_E	0.627	0.45
253_E	309_L	0.627	0.45
149_V	293_G	0.626	0.45
167_V	170_N	0.626	0.45
51_R	55_I	0.626	0.45
231_A	273_T	0.623	0.45
296_E	308_L	0.622	0.45
183_R	186_G	0.620	0.45
43_E	47_G	0.620	0.45
129_A	133_A	0.620	0.45
100_A	299_A	0.612	0.44
78_L	244_A	0.611	0.44
149_V	295_A	0.611	0.44
50_D	239_D	0.608	0.43
44_I	131_M	0.607	0.43
153_A	167_V	0.607	0.43
170_N	173_V	0.607	0.43
92_L	165_S	0.604	0.43
85_M	103_V	0.604	0.43
35_E	211_T	0.603	0.43
44_I	104_V	0.603	0.43
125_A	133_A	0.603	0.43
74_C	128_L	0.602	0.43
37_K	107_A	0.600	0.42
299_A	303_G	0.600	0.42
163_G	171_L	0.600	0.42
302_G	322_A	0.598	0.42
308_L	322_A	0.597	0.42
148_G	213_S	0.594	0.42
158_T	295_A	0.592	0.42
160_V	174_L	0.591	0.42
116_G	295_A	0.591	0.42
175_D	293_G	0.591	0.42
160_V	166_T	0.591	0.42
152_R	297_A	0.590	0.41
229_S	313_E	0.589	0.41
54_S	58_L	0.587	0.41
280_P	291_W	0.586	0.41
70_G	93_D	0.586	0.41
207_V	310_A	0.586	0.41
167_V	174_L	0.585	0.41
143_A	295_A	0.584	0.41
282_P	297_A	0.583	0.41
80_A	83_I	0.583	0.41
167_V	179_G	0.583	0.41
79_M	152_R	0.582	0.41
203_S	309_L	0.580	0.40
69_W	179_G	0.579	0.40
282_P	288_L	0.579	0.40
105_D	110_W	0.578	0.40
215_S	249_K	0.576	0.40
63_D	66_A	0.575	0.40
107_A	144_A	0.573	0.40
221_Q	316_D	0.572	0.40
141_S	174_L	0.570	0.39
168_A	190_V	0.568	0.39
169_T	289_I	0.567	0.39
78_L	83_I	0.567	0.39
234_D	237_I	0.565	0.39
37_K	272_E	0.564	0.39
226_W	229_S	0.564	0.39
216_G	252_E	0.563	0.39
281_T	296_E	0.563	0.39
37_K	106_E	0.561	0.39
118_H	212_G	0.560	0.38
227_A	261_A	0.559	0.38
141_S	158_T	0.559	0.38
177_N	187_P	0.552	0.38
114_L	171_L	0.552	0.38
240_V	323_V	0.551	0.38
98_D	105_D	0.549	0.37
183_R	192_V	0.549	0.37
183_R	190_V	0.548	0.37
80_A	115_T	0.542	0.37
241_E	302_G	0.542	0.37
166_T	174_L	0.540	0.36
279_G	292_P	0.539	0.36
286_K	291_W	0.538	0.36
79_M	106_E	0.537	0.36
181_V	190_V	0.534	0.36
68_H	101_V	0.532	0.36
122_N	135_P	0.531	0.36
176_E	179_G	0.531	0.36
100_A	119_H	0.531	0.36
61_H	87_K	0.530	0.36
230_L	235_Y	0.529	0.35
244_A	266_V	0.526	0.35
46_A	234_D	0.525	0.35
217_A	319_V	0.524	0.35
123_Q	151_E	0.524	0.35
209_L	250_A	0.523	0.35
66_A	70_G	0.522	0.35
188_Q	191_V	0.521	0.35
44_I	165_S	0.521	0.35
171_L	175_D	0.520	0.35
140_A	173_V	0.520	0.35
166_T	171_L	0.520	0.35
85_M	133_A	0.519	0.34
102_V	145_G	0.518	0.34
214_V	291_W	0.518	0.34
193_G	269_F	0.517	0.34
153_A	295_A	0.516	0.34
112_I	273_T	0.516	0.34
150_E	252_E	0.515	0.34
110_W	137_M	0.514	0.34
44_I	265_G	0.514	0.34
235_Y	310_A	0.514	0.34
162_N	207_V	0.514	0.34
139_T	174_L	0.512	0.34
306_N	309_L	0.512	0.34
273_T	276_A	0.511	0.34
190_V	195_D	0.511	0.34
118_H	150_E	0.510	0.34
281_T	297_A	0.509	0.34
226_W	230_L	0.508	0.33
106_E	142_E	0.508	0.33
113_P	119_H	0.507	0.33
34_F	318_A	0.507	0.33
172_A	313_E	0.507	0.33
28_D	269_F	0.506	0.33
148_G	303_G	0.505	0.33
69_W	75_F	0.503	0.33
43_E	240_V	0.503	0.33
141_S	163_G	0.502	0.33
31_I	238_D	0.502	0.33
88_T	101_V	0.502	0.33
80_A	126_D	0.502	0.33
41_A	205_D	0.502	0.33
127_D	178_L	0.501	0.33
203_S	211_T	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3eeqA	2	0.88	100	0.209	Contact Map
2w6kA	1	0.3969	100	0.671	Contact Map
3by5A	2	0.3569	100	0.683	Contact Map
2wc1A	1	0.4462	85.1	0.955	Contact Map
3f6rA	1	0.3908	84.1	0.956	Contact Map
1ag9A	2	0.4369	82.5	0.956	Contact Map
2arkA	4	0.4831	81.9	0.957	Contact Map
1yobA	1	0.4431	81.8	0.957	Contact Map
1ykgA	1	0.4	81.2	0.957	Contact Map
4heqA	2	0.3877	80.2	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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