Q9HPN0 - HALSA - GREMLIN Contacts

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Q9HPN0 - Cobalamin biosynthesis

UniProt:	Q9HPN0	Sequences: MSDANEAADYGTLYVVGIGPGLPGGMTQRAKDVVRTADCVVASNLYQEFLRRDGTLPPADAGERPDQEVVRSTMGRQIELAKEAFERVRDGEDVAHVSGGDPNVYGKSDLVYLMAEEEAAYDVPIEIVPGVTAALGGAANLGAPLSNDFCTISLSDKWRGWEEIEEKLRAAAISGFVVVLYNCWRDYERAIGVLREERADDVPVAIINDAGRGDAGRNTDGETHTITTLGSVTDHSGEVGGMGASILIGTDETAVWENDHRKHLVTPRGGRDVEDF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (227)
Sequences:	12274 (7751)
Seq/√Len:	514.5

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPN0 Q9HPM9 Q9HPN2 Q9HMY4 Q9HPM0 Q9HPN3
SULSO - Q97WC5 Q97W12 Q97UT5 Q97WC9 Q97WC8 Q97WD1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_G	32_D	3.788	1.00
31_K	35_R	3.325	1.00
14_Y	33_V	2.669	1.00
213_G	221_G	2.638	1.00
87_R	92_E	2.576	1.00
12_T	126_E	2.549	1.00
200_D	230_G	2.539	1.00
208_N	223_T	2.496	1.00
227_T	231_S	2.489	1.00
140_N	222_E	2.426	1.00
47_Q	97_V	2.423	1.00
12_T	124_P	2.297	1.00
37_A	95_A	2.261	1.00
32_D	36_T	2.228	1.00
133_A	181_Y	2.153	1.00
16_V	95_A	2.133	1.00
89_R	121_Y	2.105	1.00
28_Q	31_K	2.094	1.00
137_G	210_A	2.070	1.00
87_R	90_D	2.024	1.00
14_Y	93_D	2.006	1.00
207_I	210_A	2.002	1.00
212_R	221_G	1.988	1.00
228_T	231_S	1.975	1.00
38_D	93_D	1.892	1.00
16_V	30_A	1.841	1.00
203_P	249_G	1.835	1.00
39_C	87_R	1.830	1.00
209_D	221_G	1.817	1.00
114_M	121_Y	1.809	1.00
85_F	121_Y	1.800	1.00
227_T	235_H	1.792	1.00
204_V	232_V	1.779	1.00
17_G	128_V	1.736	1.00
12_T	93_D	1.733	1.00
38_D	92_E	1.708	1.00
33_V	128_V	1.681	1.00
32_D	35_R	1.677	1.00
167_K	170_A	1.670	1.00
86_E	90_D	1.667	1.00
114_M	120_A	1.654	1.00
169_R	196_E	1.560	1.00
14_Y	126_E	1.554	1.00
24_G	29_R	1.547	1.00
48_E	52_R	1.543	1.00
207_I	224_H	1.490	1.00
85_F	89_R	1.488	1.00
132_T	135_L	1.484	1.00
89_R	123_V	1.483	1.00
227_T	232_V	1.483	1.00
13_L	88_V	1.472	1.00
198_R	202_V	1.463	1.00
201_D	230_G	1.458	1.00
134_A	181_Y	1.455	1.00
140_N	224_H	1.425	1.00
26_M	31_K	1.420	1.00
22_L	29_R	1.413	1.00
29_R	126_E	1.404	1.00
234_D	238_E	1.392	1.00
83_E	87_R	1.382	1.00
188_E	237_G	1.377	1.00
83_E	86_E	1.375	1.00
132_T	181_Y	1.371	1.00
209_D	212_R	1.366	1.00
36_T	93_D	1.334	1.00
17_G	101_D	1.330	1.00
141_L	205_A	1.330	1.00
231_S	235_H	1.323	1.00
193_V	197_E	1.321	1.00
88_V	123_V	1.310	1.00
180_L	248_I	1.306	1.00
82_K	86_E	1.303	1.00
190_A	194_L	1.298	1.00
44_N	69_V	1.281	1.00
137_G	207_I	1.279	1.00
179_V	247_L	1.265	1.00
81_A	114_M	1.246	1.00
40_V	56_L	1.244	1.00
127_I	139_A	1.241	1.00
235_H	239_V	1.235	1.00
250_T	253_T	1.235	1.00
31_K	55_T	1.231	1.00
103_N	108_S	1.227	1.00
79_E	82_K	1.223	1.00
33_V	95_A	1.221	1.00
41_V	84_A	1.211	1.00
191_I	195_R	1.210	1.00
13_L	115_A	1.206	1.00
27_T	131_V	1.206	1.00
187_Y	236_S	1.199	1.00
204_V	229_L	1.181	1.00
85_F	114_M	1.170	1.00
26_M	30_A	1.154	1.00
39_C	94_V	1.154	1.00
206_I	244_A	1.154	1.00
225_T	235_H	1.141	1.00
223_T	239_V	1.124	1.00
186_D	189_R	1.115	1.00
192_G	195_R	1.105	1.00
49_F	52_R	1.104	1.00
37_A	93_D	1.091	1.00
199_A	202_V	1.073	1.00
96_H	111_V	1.071	1.00
109_D	147_N	1.059	1.00
80_L	83_E	1.054	1.00
68_E	87_R	1.047	1.00
205_A	224_H	1.046	1.00
15_V	108_S	1.042	1.00
25_G	29_R	1.042	1.00
77_Q	110_L	1.041	1.00
41_V	87_R	1.033	1.00
150_C	176_F	1.031	1.00
206_I	236_S	1.023	1.00
194_L	198_R	1.022	1.00
101_D	139_A	1.021	1.00
155_S	167_K	1.012	1.00
116_E	226_I	1.007	1.00
187_Y	246_I	1.007	1.00
161_W	165_E	1.004	1.00
235_H	238_E	1.002	1.00
180_L	183_C	0.999	1.00
205_A	226_I	0.989	1.00
112_Y	125_I	0.985	1.00
14_Y	128_V	0.982	1.00
41_V	83_E	0.982	1.00
73_T	76_R	0.980	1.00
115_A	123_V	0.976	1.00
240_G	244_A	0.975	1.00
193_V	196_E	0.969	1.00
187_Y	232_V	0.969	1.00
41_V	94_V	0.969	1.00
17_G	102_P	0.959	1.00
208_N	241_G	0.954	1.00
136_G	211_G	0.950	1.00
170_A	173_I	0.945	1.00
155_S	168_L	0.938	1.00
152_I	176_F	0.935	1.00
188_E	233_T	0.932	1.00
76_R	79_E	0.927	1.00
148_D	152_I	0.926	1.00
30_A	128_V	0.923	1.00
169_R	173_I	0.920	1.00
24_G	28_Q	0.916	1.00
127_I	224_H	0.890	1.00
39_C	92_E	0.883	1.00
179_V	245_S	0.874	1.00
113_L	120_A	0.874	1.00
156_D	167_K	0.869	1.00
143_A	205_A	0.863	1.00
169_R	172_A	0.856	1.00
116_E	142_G	0.855	1.00
137_G	245_S	0.854	1.00
81_A	85_F	0.853	1.00
194_L	229_L	0.846	1.00
14_Y	37_A	0.846	1.00
28_Q	32_D	0.844	1.00
41_V	70_V	0.839	1.00
159_R	163_E	0.836	1.00
144_P	147_N	0.836	1.00
103_N	127_I	0.836	1.00
109_D	113_L	0.834	1.00
16_V	128_V	0.828	1.00
116_E	125_I	0.825	1.00
194_L	200_D	0.825	1.00
104_V	154_L	0.817	1.00
86_E	89_R	0.816	1.00
26_M	50_L	0.815	1.00
16_V	33_V	0.808	1.00
189_R	192_G	0.807	1.00
104_V	135_L	0.802	1.00
23_P	49_F	0.800	1.00
138_A	145_L	0.800	1.00
77_Q	81_A	0.799	1.00
192_G	196_E	0.792	1.00
82_K	114_M	0.790	1.00
29_R	128_V	0.787	1.00
101_D	127_I	0.786	1.00
188_E	234_D	0.785	1.00
184_W	240_G	0.784	1.00
233_T	237_G	0.783	1.00
33_V	93_D	0.778	1.00
201_D	228_T	0.772	1.00
153_S	176_F	0.771	1.00
205_A	247_L	0.771	1.00
236_S	240_G	0.766	1.00
137_G	247_L	0.766	1.00
108_S	112_Y	0.765	1.00
134_A	179_V	0.765	1.00
109_D	144_P	0.765	1.00
78_I	114_M	0.764	1.00
136_G	210_A	0.764	1.00
29_R	32_D	0.757	1.00
152_I	167_K	0.757	1.00
22_L	25_G	0.756	1.00
33_V	126_E	0.755	1.00
206_I	232_V	0.753	1.00
162_E	165_E	0.753	1.00
70_V	185_R	0.752	1.00
181_Y	245_S	0.751	1.00
70_V	80_L	0.748	1.00
104_V	145_L	0.743	1.00
225_T	240_G	0.740	1.00
127_I	140_N	0.740	1.00
165_E	193_V	0.736	1.00
46_Y	49_F	0.735	1.00
190_A	233_T	0.731	1.00
47_Q	51_R	0.725	1.00
226_I	255_V	0.725	1.00
33_V	36_T	0.723	1.00
10_Y	124_P	0.722	1.00
31_K	56_L	0.720	1.00
64_R	67_Q	0.715	1.00
17_G	136_G	0.713	1.00
178_V	248_I	0.713	1.00
225_T	239_V	0.712	1.00
190_A	198_R	0.712	1.00
52_R	55_T	0.712	1.00
46_Y	50_L	0.711	1.00
175_G	198_R	0.711	1.00
191_I	196_E	0.711	1.00
48_E	51_R	0.710	1.00
208_N	244_A	0.709	1.00
103_N	139_A	0.708	1.00
34_V	40_V	0.704	1.00
184_W	244_A	0.703	1.00
234_D	237_G	0.703	1.00
153_S	171_A	0.702	1.00
33_V	37_A	0.701	1.00
112_Y	116_E	0.697	1.00
169_R	197_E	0.697	1.00
202_V	250_T	0.697	1.00
182_N	186_D	0.695	1.00
88_V	94_V	0.695	1.00
140_N	211_G	0.693	1.00
105_Y	151_T	0.693	1.00
191_I	197_E	0.692	1.00
102_P	106_G	0.690	1.00
164_I	193_V	0.690	1.00
170_A	175_G	0.687	1.00
170_A	174_S	0.687	1.00
225_T	232_V	0.680	1.00
165_E	189_R	0.679	1.00
150_C	174_S	0.677	1.00
42_A	69_V	0.671	1.00
231_S	234_D	0.670	1.00
14_Y	95_A	0.670	1.00
225_T	236_S	0.668	1.00
165_E	169_R	0.668	1.00
20_P	25_G	0.664	1.00
15_V	112_Y	0.658	1.00
98_S	106_G	0.658	1.00
85_F	115_A	0.651	1.00
204_V	233_T	0.648	1.00
163_E	166_E	0.647	1.00
81_A	84_A	0.647	1.00
17_G	131_V	0.646	1.00
79_E	83_E	0.642	1.00
165_E	196_E	0.638	1.00
204_V	236_S	0.636	1.00
22_L	211_G	0.635	1.00
191_I	194_L	0.635	1.00
203_P	228_T	0.633	1.00
69_V	72_S	0.633	1.00
68_E	92_E	0.630	1.00
115_A	125_I	0.630	1.00
44_N	70_V	0.628	1.00
187_Y	244_A	0.627	1.00
194_L	197_E	0.625	1.00
39_C	70_V	0.624	1.00
191_I	233_T	0.624	1.00
138_A	247_L	0.623	1.00
34_V	95_A	0.620	1.00
29_R	33_V	0.616	1.00
35_R	55_T	0.615	1.00
192_G	233_T	0.615	1.00
78_I	82_K	0.613	1.00
72_S	77_Q	0.612	1.00
171_A	178_V	0.610	1.00
30_A	50_L	0.609	1.00
146_S	177_V	0.607	1.00
194_L	248_I	0.606	1.00
188_E	192_G	0.605	1.00
113_L	203_P	0.598	0.99
207_I	247_L	0.596	0.99
113_L	147_N	0.583	0.99
190_A	193_V	0.581	0.99
167_K	171_A	0.580	0.99
75_G	79_E	0.580	0.99
167_K	173_I	0.579	0.99
193_V	198_R	0.575	0.99
10_Y	89_R	0.574	0.99
154_L	179_V	0.572	0.99
78_I	110_L	0.571	0.99
50_L	55_T	0.570	0.99
172_A	198_R	0.566	0.99
28_Q	55_T	0.565	0.99
71_R	80_L	0.564	0.99
37_A	40_V	0.563	0.99
145_L	179_V	0.562	0.99
85_F	123_V	0.562	0.99
209_D	243_G	0.559	0.99
75_G	83_E	0.558	0.99
51_R	56_L	0.557	0.99
81_A	110_L	0.556	0.99
12_T	88_V	0.555	0.99
173_I	197_E	0.554	0.99
159_R	162_E	0.552	0.99
30_A	95_A	0.549	0.99
190_A	197_E	0.547	0.99
64_R	87_R	0.545	0.99
226_I	253_T	0.544	0.99
13_L	84_A	0.543	0.99
174_S	178_V	0.542	0.99
78_I	81_A	0.540	0.99
188_E	191_I	0.532	0.99
88_V	124_P	0.529	0.99
26_M	56_L	0.528	0.99
25_G	211_G	0.527	0.99
226_I	252_E	0.525	0.99
150_C	253_T	0.523	0.99
40_V	67_Q	0.521	0.99
178_V	198_R	0.521	0.99
160_G	163_E	0.520	0.99
152_I	171_A	0.520	0.99
128_V	136_G	0.518	0.99
195_R	233_T	0.515	0.98
17_G	140_N	0.515	0.98
187_Y	240_G	0.515	0.98
15_V	139_A	0.515	0.98
149_F	160_G	0.515	0.98
161_W	164_I	0.513	0.98
136_G	140_N	0.509	0.98
198_R	229_L	0.508	0.98
195_R	230_G	0.502	0.98
74_M	77_Q	0.501	0.98
40_V	51_R	0.500	0.98
28_Q	35_R	0.500	0.98
158_W	162_E	0.500	0.98
79_E	86_E	0.500	0.98
72_S	81_A	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yboA	2	0.8804	100	0.291	Contact Map
1pjqA	2	0.8877	100	0.307	Contact Map
2zvbA	2	0.8551	100	0.315	Contact Map
3nutA	2	0.8442	100	0.323	Contact Map
1s4dA	4	0.9348	100	0.325	Contact Map
1ve2A	2	0.8188	100	0.34	Contact Map
3kwpA	2	0.8152	100	0.354	Contact Map
4e16A	2	0.8116	100	0.359	Contact Map
3ndcA	2	0.8478	100	0.367	Contact Map
1cbfA	2	0.8297	100	0.375	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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