GREMLIN Database
Q9HPN0 - Cobalamin biosynthesis
UniProt: Q9HPN0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (227)
Sequences: 12274 (7751)
Seq/√Len: 514.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_G32_D3.7881.00
31_K35_R3.3251.00
14_Y33_V2.6691.00
213_G221_G2.6381.00
87_R92_E2.5761.00
12_T126_E2.5491.00
200_D230_G2.5391.00
208_N223_T2.4961.00
227_T231_S2.4891.00
140_N222_E2.4261.00
47_Q97_V2.4231.00
12_T124_P2.2971.00
37_A95_A2.2611.00
32_D36_T2.2281.00
133_A181_Y2.1531.00
16_V95_A2.1331.00
89_R121_Y2.1051.00
28_Q31_K2.0941.00
137_G210_A2.0701.00
87_R90_D2.0241.00
14_Y93_D2.0061.00
207_I210_A2.0021.00
212_R221_G1.9881.00
228_T231_S1.9751.00
38_D93_D1.8921.00
16_V30_A1.8411.00
203_P249_G1.8351.00
39_C87_R1.8301.00
209_D221_G1.8171.00
114_M121_Y1.8091.00
85_F121_Y1.8001.00
227_T235_H1.7921.00
204_V232_V1.7791.00
17_G128_V1.7361.00
12_T93_D1.7331.00
38_D92_E1.7081.00
33_V128_V1.6811.00
32_D35_R1.6771.00
167_K170_A1.6701.00
86_E90_D1.6671.00
114_M120_A1.6541.00
169_R196_E1.5601.00
14_Y126_E1.5541.00
24_G29_R1.5471.00
48_E52_R1.5431.00
207_I224_H1.4901.00
85_F89_R1.4881.00
132_T135_L1.4841.00
89_R123_V1.4831.00
227_T232_V1.4831.00
13_L88_V1.4721.00
198_R202_V1.4631.00
201_D230_G1.4581.00
134_A181_Y1.4551.00
140_N224_H1.4251.00
26_M31_K1.4201.00
22_L29_R1.4131.00
29_R126_E1.4041.00
234_D238_E1.3921.00
83_E87_R1.3821.00
188_E237_G1.3771.00
83_E86_E1.3751.00
132_T181_Y1.3711.00
209_D212_R1.3661.00
36_T93_D1.3341.00
17_G101_D1.3301.00
141_L205_A1.3301.00
231_S235_H1.3231.00
193_V197_E1.3211.00
88_V123_V1.3101.00
180_L248_I1.3061.00
82_K86_E1.3031.00
190_A194_L1.2981.00
44_N69_V1.2811.00
137_G207_I1.2791.00
179_V247_L1.2651.00
81_A114_M1.2461.00
40_V56_L1.2441.00
127_I139_A1.2411.00
235_H239_V1.2351.00
250_T253_T1.2351.00
31_K55_T1.2311.00
103_N108_S1.2271.00
79_E82_K1.2231.00
33_V95_A1.2211.00
41_V84_A1.2111.00
191_I195_R1.2101.00
13_L115_A1.2061.00
27_T131_V1.2061.00
187_Y236_S1.1991.00
204_V229_L1.1811.00
85_F114_M1.1701.00
26_M30_A1.1541.00
39_C94_V1.1541.00
206_I244_A1.1541.00
225_T235_H1.1411.00
223_T239_V1.1241.00
186_D189_R1.1151.00
192_G195_R1.1051.00
49_F52_R1.1041.00
37_A93_D1.0911.00
199_A202_V1.0731.00
96_H111_V1.0711.00
109_D147_N1.0591.00
80_L83_E1.0541.00
68_E87_R1.0471.00
205_A224_H1.0461.00
15_V108_S1.0421.00
25_G29_R1.0421.00
77_Q110_L1.0411.00
41_V87_R1.0331.00
150_C176_F1.0311.00
206_I236_S1.0231.00
194_L198_R1.0221.00
101_D139_A1.0211.00
155_S167_K1.0121.00
116_E226_I1.0071.00
187_Y246_I1.0071.00
161_W165_E1.0041.00
235_H238_E1.0021.00
180_L183_C0.9991.00
205_A226_I0.9891.00
112_Y125_I0.9851.00
14_Y128_V0.9821.00
41_V83_E0.9821.00
73_T76_R0.9801.00
115_A123_V0.9761.00
240_G244_A0.9751.00
193_V196_E0.9691.00
187_Y232_V0.9691.00
41_V94_V0.9691.00
17_G102_P0.9591.00
208_N241_G0.9541.00
136_G211_G0.9501.00
170_A173_I0.9451.00
155_S168_L0.9381.00
152_I176_F0.9351.00
188_E233_T0.9321.00
76_R79_E0.9271.00
148_D152_I0.9261.00
30_A128_V0.9231.00
169_R173_I0.9201.00
24_G28_Q0.9161.00
127_I224_H0.8901.00
39_C92_E0.8831.00
179_V245_S0.8741.00
113_L120_A0.8741.00
156_D167_K0.8691.00
143_A205_A0.8631.00
169_R172_A0.8561.00
116_E142_G0.8551.00
137_G245_S0.8541.00
81_A85_F0.8531.00
194_L229_L0.8461.00
14_Y37_A0.8461.00
28_Q32_D0.8441.00
41_V70_V0.8391.00
159_R163_E0.8361.00
144_P147_N0.8361.00
103_N127_I0.8361.00
109_D113_L0.8341.00
16_V128_V0.8281.00
116_E125_I0.8251.00
194_L200_D0.8251.00
104_V154_L0.8171.00
86_E89_R0.8161.00
26_M50_L0.8151.00
16_V33_V0.8081.00
189_R192_G0.8071.00
104_V135_L0.8021.00
23_P49_F0.8001.00
138_A145_L0.8001.00
77_Q81_A0.7991.00
192_G196_E0.7921.00
82_K114_M0.7901.00
29_R128_V0.7871.00
101_D127_I0.7861.00
188_E234_D0.7851.00
184_W240_G0.7841.00
233_T237_G0.7831.00
33_V93_D0.7781.00
201_D228_T0.7721.00
153_S176_F0.7711.00
205_A247_L0.7711.00
236_S240_G0.7661.00
137_G247_L0.7661.00
108_S112_Y0.7651.00
134_A179_V0.7651.00
109_D144_P0.7651.00
78_I114_M0.7641.00
136_G210_A0.7641.00
29_R32_D0.7571.00
152_I167_K0.7571.00
22_L25_G0.7561.00
33_V126_E0.7551.00
206_I232_V0.7531.00
162_E165_E0.7531.00
70_V185_R0.7521.00
181_Y245_S0.7511.00
70_V80_L0.7481.00
104_V145_L0.7431.00
225_T240_G0.7401.00
127_I140_N0.7401.00
165_E193_V0.7361.00
46_Y49_F0.7351.00
190_A233_T0.7311.00
47_Q51_R0.7251.00
226_I255_V0.7251.00
33_V36_T0.7231.00
10_Y124_P0.7221.00
31_K56_L0.7201.00
64_R67_Q0.7151.00
17_G136_G0.7131.00
178_V248_I0.7131.00
225_T239_V0.7121.00
190_A198_R0.7121.00
52_R55_T0.7121.00
46_Y50_L0.7111.00
175_G198_R0.7111.00
191_I196_E0.7111.00
48_E51_R0.7101.00
208_N244_A0.7091.00
103_N139_A0.7081.00
34_V40_V0.7041.00
184_W244_A0.7031.00
234_D237_G0.7031.00
153_S171_A0.7021.00
33_V37_A0.7011.00
112_Y116_E0.6971.00
169_R197_E0.6971.00
202_V250_T0.6971.00
182_N186_D0.6951.00
88_V94_V0.6951.00
140_N211_G0.6931.00
105_Y151_T0.6931.00
191_I197_E0.6921.00
102_P106_G0.6901.00
164_I193_V0.6901.00
170_A175_G0.6871.00
170_A174_S0.6871.00
225_T232_V0.6801.00
165_E189_R0.6791.00
150_C174_S0.6771.00
42_A69_V0.6711.00
231_S234_D0.6701.00
14_Y95_A0.6701.00
225_T236_S0.6681.00
165_E169_R0.6681.00
20_P25_G0.6641.00
15_V112_Y0.6581.00
98_S106_G0.6581.00
85_F115_A0.6511.00
204_V233_T0.6481.00
163_E166_E0.6471.00
81_A84_A0.6471.00
17_G131_V0.6461.00
79_E83_E0.6421.00
165_E196_E0.6381.00
204_V236_S0.6361.00
22_L211_G0.6351.00
191_I194_L0.6351.00
203_P228_T0.6331.00
69_V72_S0.6331.00
68_E92_E0.6301.00
115_A125_I0.6301.00
44_N70_V0.6281.00
187_Y244_A0.6271.00
194_L197_E0.6251.00
39_C70_V0.6241.00
191_I233_T0.6241.00
138_A247_L0.6231.00
34_V95_A0.6201.00
29_R33_V0.6161.00
35_R55_T0.6151.00
192_G233_T0.6151.00
78_I82_K0.6131.00
72_S77_Q0.6121.00
171_A178_V0.6101.00
30_A50_L0.6091.00
146_S177_V0.6071.00
194_L248_I0.6061.00
188_E192_G0.6051.00
113_L203_P0.5980.99
207_I247_L0.5960.99
113_L147_N0.5830.99
190_A193_V0.5810.99
167_K171_A0.5800.99
75_G79_E0.5800.99
167_K173_I0.5790.99
193_V198_R0.5750.99
10_Y89_R0.5740.99
154_L179_V0.5720.99
78_I110_L0.5710.99
50_L55_T0.5700.99
172_A198_R0.5660.99
28_Q55_T0.5650.99
71_R80_L0.5640.99
37_A40_V0.5630.99
145_L179_V0.5620.99
85_F123_V0.5620.99
209_D243_G0.5590.99
75_G83_E0.5580.99
51_R56_L0.5570.99
81_A110_L0.5560.99
12_T88_V0.5550.99
173_I197_E0.5540.99
159_R162_E0.5520.99
30_A95_A0.5490.99
190_A197_E0.5470.99
64_R87_R0.5450.99
226_I253_T0.5440.99
13_L84_A0.5430.99
174_S178_V0.5420.99
78_I81_A0.5400.99
188_E191_I0.5320.99
88_V124_P0.5290.99
26_M56_L0.5280.99
25_G211_G0.5270.99
226_I252_E0.5250.99
150_C253_T0.5230.99
40_V67_Q0.5210.99
178_V198_R0.5210.99
160_G163_E0.5200.99
152_I171_A0.5200.99
128_V136_G0.5180.99
195_R233_T0.5150.98
17_G140_N0.5150.98
187_Y240_G0.5150.98
15_V139_A0.5150.98
149_F160_G0.5150.98
161_W164_I0.5130.98
136_G140_N0.5090.98
198_R229_L0.5080.98
195_R230_G0.5020.98
74_M77_Q0.5010.98
40_V51_R0.5000.98
28_Q35_R0.5000.98
158_W162_E0.5000.98
79_E86_E0.5000.98
72_S81_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yboA 2 0.8804 100 0.291 Contact Map
1pjqA 2 0.8877 100 0.307 Contact Map
2zvbA 2 0.8551 100 0.315 Contact Map
3nutA 2 0.8442 100 0.323 Contact Map
1s4dA 4 0.9348 100 0.325 Contact Map
1ve2A 2 0.8188 100 0.34 Contact Map
3kwpA 2 0.8152 100 0.354 Contact Map
4e16A 2 0.8116 100 0.359 Contact Map
3ndcA 2 0.8478 100 0.367 Contact Map
1cbfA 2 0.8297 100 0.375 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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