GREMLIN Database
Q9HPM9 - Cobalamin biosynthesis
UniProt: Q9HPM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (253)
Sequences: 1465 (898)
Seq/√Len: 56.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_C279_A5.2161.00
84_V103_A4.6691.00
204_R284_E3.1411.00
128_A132_Y3.1301.00
289_T293_E3.0151.00
110_I124_I2.9481.00
267_R271_T2.8201.00
269_A292_G2.7641.00
275_I307_T2.7091.00
277_H285_E2.5821.00
82_S190_E2.5051.00
197_A245_Y2.5041.00
103_A192_V2.4651.00
82_S155_H2.4151.00
273_V294_L2.4101.00
233_H265_A2.3831.00
258_K261_E2.3571.00
149_R152_A2.2481.00
97_T195_V2.1941.00
129_E132_Y2.1801.00
289_T297_Y2.1081.00
244_I311_I2.0891.00
278_G281_R2.0491.00
100_A192_V2.0401.00
276_V279_A2.0241.00
148_D152_A1.9941.00
236_A291_L1.9791.00
289_T294_L1.9601.00
66_E72_T1.8861.00
278_G283_D1.8661.00
165_N170_A1.8560.99
231_R237_S1.8380.99
244_I247_P1.8210.99
260_C295_E1.8170.99
144_E148_D1.8020.99
232_L259_A1.7780.99
96_M100_A1.7760.99
151_L180_K1.7700.99
276_V310_V1.7430.99
128_A131_I1.6870.99
256_F294_L1.6820.99
147_V176_I1.6520.99
66_E69_V1.6360.99
290_T293_E1.6330.99
164_P168_A1.6320.99
141_S144_E1.5960.98
111_V149_R1.5890.98
82_S188_D1.5880.98
176_I180_K1.5870.98
63_D71_A1.5760.98
101_T105_A1.5700.98
67_Q70_S1.5680.98
270_D292_G1.5660.98
94_E102_A1.5350.98
110_I117_V1.5190.98
99_R103_A1.5160.98
256_F303_I1.5110.98
62_T70_S1.4970.98
204_R280_G1.4920.98
158_I173_A1.4910.98
96_M120_L1.4780.97
64_S71_A1.4580.97
64_S68_T1.4290.97
296_S300_T1.4150.97
111_V145_E1.3990.96
218_L245_Y1.3890.96
99_R192_V1.3790.96
145_E149_R1.3520.96
61_D64_S1.3470.96
202_G245_Y1.3350.95
130_E149_R1.3300.95
201_C276_V1.3230.95
229_E258_K1.3150.95
83_L177_T1.3080.95
196_P199_Q1.3020.95
67_Q71_A1.2970.95
125_T128_A1.2960.94
80_P151_L1.2950.94
102_A106_D1.2910.94
94_E99_R1.2900.94
65_N68_T1.2880.94
202_G310_V1.2880.94
84_V155_H1.2830.94
277_H304_D1.2740.94
59_S69_V1.2700.94
166_V199_Q1.2540.93
111_V146_A1.2420.93
226_P229_E1.2350.93
68_T71_A1.2160.92
107_A157_A1.2160.92
273_V295_E1.2130.92
293_E297_Y1.2080.92
244_I259_A1.2080.92
99_R190_E1.2080.92
59_S62_T1.1920.92
197_A218_L1.1690.91
168_A171_G1.1680.91
103_A190_E1.1670.91
92_R99_R1.1500.90
104_L124_I1.1490.90
62_T69_V1.1400.90
63_D67_Q1.1380.90
60_S65_N1.1350.89
260_C264_L1.1110.88
84_V157_A1.1090.88
118_D122_D1.0980.88
86_V157_A1.0870.87
277_H303_I1.0840.87
60_S64_S1.0780.87
59_S65_N1.0760.87
104_L157_A1.0700.87
59_S66_E1.0620.86
272_P286_V1.0590.86
139_E246_N1.0580.86
199_Q216_I1.0570.86
62_T66_E1.0570.86
160_G169_L1.0560.86
64_S72_T1.0560.86
86_V192_V1.0530.86
65_N73_V1.0390.85
313_N316_T1.0380.85
223_T227_E1.0370.85
231_R234_A1.0340.85
160_G246_N1.0250.84
71_A77_D1.0180.84
68_T73_V1.0150.83
139_E160_G1.0080.83
139_E169_L1.0010.83
275_I303_I0.9990.82
99_R131_I0.9900.82
147_V180_K0.9830.81
217_S240_F0.9820.81
198_A209_L0.9710.81
175_E320_D0.9710.81
80_P188_D0.9700.81
169_L246_N0.9670.80
174_L189_F0.9580.80
260_C263_L0.9570.80
172_L210_V0.9540.79
149_R154_N0.9520.79
166_V216_I0.9400.78
225_M255_N0.9360.78
109_H149_R0.9300.78
130_E154_N0.9290.78
160_G173_A0.9290.78
249_S255_N0.9270.77
71_A74_D0.9260.77
113_Y173_A0.9230.77
139_E142_R0.9220.77
277_H305_M0.9180.77
68_T72_T0.9110.76
233_H237_S0.9100.76
59_S71_A0.9090.76
113_Y246_N0.9020.76
262_I266_H0.9020.76
64_S67_Q0.9000.75
243_S310_V0.8990.75
113_Y160_G0.8980.75
119_L122_D0.8980.75
60_S63_D0.8940.75
214_V316_T0.8910.75
137_C141_S0.8870.74
62_T65_N0.8870.74
115_T139_E0.8820.74
116_Y120_L0.8690.73
137_C164_P0.8640.72
220_D224_P0.8630.72
115_T306_T0.8620.72
165_N174_L0.8610.72
113_Y139_E0.8610.72
65_N72_T0.8570.72
60_S67_Q0.8560.72
60_S69_V0.8540.71
204_R323_M0.8430.70
160_G168_A0.8410.70
66_E73_V0.8400.70
261_E264_L0.8400.70
109_H154_N0.8380.70
84_V190_E0.8370.70
72_T79_D0.8360.70
271_T313_N0.8280.69
67_Q73_V0.8230.69
150_A187_L0.8200.68
86_V104_L0.8200.68
66_E77_D0.8140.68
62_T67_Q0.8100.67
59_S296_S0.8050.67
113_Y169_L0.8010.66
111_V278_G0.7990.66
115_T160_G0.7950.66
71_A75_D0.7910.66
63_D66_E0.7900.65
212_D246_N0.7900.65
197_A202_G0.7850.65
148_D151_L0.7780.64
84_V100_A0.7750.64
267_R291_L0.7690.63
292_G296_S0.7640.63
68_T81_G0.7640.63
234_A237_S0.7640.63
177_T275_I0.7600.62
287_E303_I0.7600.62
205_L274_G0.7600.62
72_T75_D0.7550.62
150_A206_G0.7530.62
147_V151_L0.7520.62
248_W307_T0.7450.61
60_S66_E0.7450.61
61_D66_E0.7440.61
287_E302_L0.7430.61
101_T123_E0.7430.61
67_Q72_T0.7430.61
65_N74_D0.7410.60
209_L245_Y0.7410.60
100_A120_L0.7390.60
65_N69_V0.7380.60
69_V74_D0.7370.60
88_L116_Y0.7320.59
244_I275_I0.7250.59
260_C294_L0.7250.59
64_S70_S0.7220.58
217_S234_A0.7220.58
61_D65_N0.7190.58
239_E249_S0.7190.58
200_S280_G0.7180.58
114_T284_E0.7130.57
88_L120_L0.7100.57
271_T291_L0.7080.57
114_T307_T0.7080.57
115_T172_L0.7040.57
248_W303_I0.7010.56
98_D132_Y0.6980.56
257_Q261_E0.6980.56
145_E148_D0.6940.55
66_E70_S0.6930.55
180_K187_L0.6910.55
112_G247_P0.6900.55
244_I324_V0.6880.55
171_G210_V0.6850.54
217_S242_I0.6830.54
160_G212_D0.6810.54
285_E304_D0.6790.54
98_D101_T0.6780.54
161_S306_T0.6780.54
263_L304_D0.6760.54
92_R280_G0.6730.53
72_T76_F0.6720.53
59_S63_D0.6650.52
118_D121_P0.6620.52
105_A192_V0.6610.52
211_N317_Y0.6600.52
60_S292_G0.6590.52
89_G163_D0.6570.51
176_I179_S0.6560.51
171_G276_V0.6520.51
189_F278_G0.6510.51
231_R239_E0.6510.51
213_S224_P0.6510.51
207_A259_A0.6470.50
235_V240_F0.6450.50
126_D129_E0.6340.49
72_T80_P0.6310.49
134_T305_M0.6300.48
274_G323_M0.6300.48
69_V77_D0.6280.48
122_D216_I0.6270.48
263_L270_D0.6240.48
201_C244_I0.6210.48
112_G116_Y0.6210.48
135_P138_G0.6210.48
288_I304_D0.6190.47
72_T77_D0.6170.47
229_E290_T0.6160.47
215_S242_I0.6140.47
103_A106_D0.6130.47
217_S244_I0.6090.46
69_V73_V0.6080.46
285_E303_I0.6070.46
99_R186_M0.6060.46
172_L306_T0.6050.46
270_D300_T0.6040.46
139_E212_D0.6010.45
294_L308_T0.6010.45
203_A239_E0.6010.45
202_G218_L0.5990.45
114_T166_V0.5990.45
256_F309_V0.5980.45
138_G141_S0.5970.45
263_L296_S0.5970.45
229_E262_I0.5920.44
164_P306_T0.5900.44
59_S67_Q0.5890.44
63_D296_S0.5870.44
255_N275_I0.5870.44
84_V107_A0.5850.44
83_L229_E0.5850.44
188_D313_N0.5840.44
149_R170_A0.5830.43
155_H191_V0.5820.43
276_V286_V0.5780.43
201_C275_I0.5780.43
248_W275_I0.5770.43
171_G274_G0.5770.43
62_T71_A0.5750.43
294_L297_Y0.5740.42
148_D282_E0.5740.42
189_F196_P0.5720.42
62_T73_V0.5720.42
76_F79_D0.5700.42
60_S118_D0.5680.42
63_D73_V0.5680.42
196_P245_Y0.5640.41
142_R246_N0.5620.41
139_E173_A0.5620.41
147_V195_V0.5610.41
151_L186_M0.5610.41
70_S73_V0.5600.41
209_L218_L0.5600.41
172_L212_D0.5580.41
225_M228_I0.5570.41
99_R248_W0.5570.41
267_R313_N0.5560.41
158_I306_T0.5560.41
242_I263_L0.5540.40
109_H132_Y0.5540.40
173_A246_N0.5540.40
65_N70_S0.5530.40
207_A274_G0.5530.40
84_V99_R0.5530.40
61_D67_Q0.5530.40
100_A228_I0.5530.40
115_T308_T0.5520.40
131_I276_V0.5510.40
208_P274_G0.5500.40
198_A245_Y0.5490.40
69_V78_A0.5480.40
205_L286_V0.5480.40
102_A262_I0.5460.40
202_G209_L0.5450.39
142_R169_L0.5450.39
61_D68_T0.5450.39
180_K186_M0.5430.39
261_E296_S0.5420.39
178_E265_A0.5410.39
85_A169_L0.5410.39
160_G222_L0.5410.39
195_V205_L0.5400.39
171_G208_P0.5390.39
62_T72_T0.5380.39
158_I172_L0.5360.38
60_S72_T0.5360.38
123_E126_D0.5350.38
61_D296_S0.5340.38
169_L212_D0.5340.38
205_L310_V0.5320.38
69_V75_D0.5320.38
103_A315_E0.5310.38
92_R286_V0.5290.38
227_E230_S0.5290.38
95_G99_R0.5270.38
222_L249_S0.5260.37
102_A187_L0.5250.37
63_D69_V0.5210.37
170_A191_V0.5190.37
216_I244_I0.5190.37
115_T215_S0.5180.37
101_T124_I0.5160.36
82_S104_L0.5160.36
108_E257_Q0.5150.36
83_L158_I0.5140.36
235_V239_E0.5130.36
277_H287_E0.5120.36
112_G200_S0.5120.36
257_Q296_S0.5120.36
63_D70_S0.5110.36
260_C268_D0.5100.36
199_Q209_L0.5050.35
94_E119_L0.5030.35
161_S168_A0.5000.35
139_E247_P0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.9254 100 0.418 Contact Map
2yboA 2 0.7194 100 0.458 Contact Map
2zvbA 2 0.7254 100 0.46 Contact Map
1s4dA 4 0.7433 100 0.47 Contact Map
3nutA 2 0.7045 100 0.479 Contact Map
4e16A 2 0.6657 100 0.497 Contact Map
1cbfA 2 0.6955 100 0.498 Contact Map
3kwpA 2 0.6746 100 0.501 Contact Map
1ve2A 2 0.6687 100 0.504 Contact Map
3ndcA 2 0.6955 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.