GREMLIN Database
Q9HPM1 - Precorrin isomerase
UniProt: Q9HPM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (194)
Sequences: 1630 (914)
Seq/√Len: 65.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_T37_D4.3121.00
80_G171_V3.5811.00
70_R204_V3.2321.00
95_T115_G3.1761.00
158_A161_D3.1031.00
53_R69_L3.0771.00
42_L206_R3.0741.00
119_E123_E2.6421.00
76_P171_V2.4881.00
82_R86_D2.4181.00
174_A189_L2.3961.00
40_R54_Q2.3441.00
187_T204_V2.2301.00
120_L131_A2.1201.00
95_T98_K2.0091.00
56_S212_L1.9981.00
40_R50_D1.9811.00
187_T191_E1.9621.00
64_E207_R1.9481.00
157_L181_K1.9401.00
114_I129_T1.9131.00
76_P80_G1.8871.00
84_V106_H1.8751.00
175_T216_L1.8721.00
56_S216_L1.8641.00
61_G206_R1.8251.00
30_D33_E1.7981.00
49_A71_F1.7921.00
160_A189_L1.7851.00
148_V213_A1.7791.00
163_I198_V1.7721.00
135_E138_K1.7711.00
120_L124_T1.7601.00
164_A196_Y1.7361.00
38_R180_V1.7291.00
56_S69_L1.7241.00
175_T213_A1.7030.99
75_E78_R1.6610.99
56_S65_F1.6510.99
175_T203_N1.6440.99
68_L203_N1.6410.99
64_E68_L1.6290.99
144_G170_A1.6280.99
72_N200_A1.6180.99
50_D54_Q1.5530.99
190_R204_V1.5500.99
89_P111_R1.5360.99
146_I171_V1.5120.99
133_V149_V1.4810.98
172_A189_L1.4750.98
147_A159_L1.4430.98
83_A171_V1.4330.98
60_T212_L1.4250.98
94_I97_V1.3930.98
124_T131_A1.3840.98
48_L53_R1.3630.97
126_M131_A1.3460.97
64_E67_H1.3420.97
98_K110_V1.3200.97
188_R191_E1.3140.97
70_R190_R1.2920.96
42_L63_P1.2800.96
142_Y147_A1.2650.96
56_S215_G1.2590.96
76_P201_V1.2590.96
157_L188_R1.2560.96
175_T212_L1.2530.96
135_E158_A1.2500.96
190_R200_A1.2320.95
38_R41_E1.2020.95
127_T154_T1.1960.94
34_T41_E1.1900.94
78_R82_R1.1460.93
69_L203_N1.1440.93
97_V148_V1.1440.93
172_A198_V1.1420.93
113_A141_V1.1420.93
126_M130_A1.1390.93
101_V218_N1.1120.92
81_A85_L1.1110.92
90_I217_T1.0920.91
65_F207_R1.0910.91
95_T99_A1.0850.91
119_E122_A1.0740.90
81_A223_V1.0700.90
100_G214_A1.0690.90
43_V66_Q1.0540.90
101_V110_V1.0520.90
187_T190_R1.0430.89
101_V217_T1.0380.89
133_V162_C1.0360.89
70_R200_A1.0320.89
114_I132_S1.0220.88
48_L66_Q1.0170.88
120_L135_E1.0080.87
91_V147_A0.9910.87
171_V201_V0.9870.86
190_R202_T0.9840.86
62_D207_R0.9800.86
72_N75_E0.9770.86
92_T97_V0.9710.85
91_V141_V0.9620.85
158_A162_C0.9570.85
28_A32_A0.9340.83
25_T30_D0.9340.83
80_G220_L0.9310.83
79_A82_R0.9260.83
97_V218_N0.9220.82
52_L201_V0.9190.82
160_A196_Y0.9170.82
120_L123_E0.9150.82
55_K215_G0.9140.82
163_I196_Y0.9050.81
81_A171_V0.9000.81
65_F212_L0.8980.81
212_L216_L0.8870.80
182_A202_T0.8870.80
47_T67_H0.8860.80
49_A77_V0.8810.79
68_L207_R0.8770.79
88_A145_A0.8760.79
48_L69_L0.8650.78
129_T132_S0.8600.78
89_P109_E0.8520.77
88_A144_G0.8500.77
164_A188_R0.8490.77
28_A222_H0.8450.76
115_G118_A0.8440.76
59_A215_G0.8420.76
26_E60_T0.8410.76
44_P47_T0.8400.76
160_A188_R0.8360.76
101_V148_V0.8360.76
76_P220_L0.8330.75
28_A102_T0.8230.75
173_V217_T0.8200.74
83_A146_I0.8100.73
189_L202_T0.8050.73
104_R212_L0.8050.73
58_H177_V0.7930.72
142_Y145_A0.7930.72
214_A218_N0.7890.71
53_R71_F0.7860.71
96_M100_G0.7820.71
97_V214_A0.7750.70
72_N199_P0.7740.70
149_V202_T0.7720.70
137_D162_C0.7710.70
96_M151_N0.7670.69
42_L61_G0.7660.69
163_I166_G0.7580.68
89_P143_D0.7550.68
62_D212_L0.7530.68
213_A217_T0.7520.68
43_V50_D0.7470.67
49_A76_P0.7410.67
158_A165_D0.7400.66
95_T114_I0.7390.66
80_G146_I0.7360.66
161_D166_G0.7350.66
203_N212_L0.7320.66
56_S175_T0.7320.66
30_D34_T0.7300.65
120_L138_K0.7300.65
130_A157_L0.7280.65
52_L219_E0.7270.65
71_F201_V0.7270.65
177_V180_V0.7250.65
120_L126_M0.7240.65
142_Y170_A0.7170.64
118_A122_A0.7130.64
83_A88_A0.7120.63
60_T65_F0.7100.63
65_F69_L0.7090.63
63_P207_R0.7070.63
95_T112_K0.7040.63
41_E44_P0.7040.63
188_R196_Y0.7030.62
210_S214_A0.7000.62
97_V211_G0.7000.62
145_A170_A0.6980.62
34_T38_R0.6960.62
52_L216_L0.6930.61
149_V159_L0.6900.61
58_H154_T0.6860.61
73_G76_P0.6860.61
60_T175_T0.6850.60
75_E199_P0.6760.59
153_P177_V0.6760.59
178_G186_R0.6730.59
36_M210_S0.6680.59
84_V146_I0.6660.58
151_N210_S0.6640.58
160_A182_A0.6610.58
80_G83_A0.6580.57
59_A94_I0.6580.57
65_F94_I0.6530.57
171_V220_L0.6520.57
212_L215_G0.6510.57
168_R197_G0.6500.56
173_V216_L0.6500.56
65_F203_N0.6490.56
72_N76_P0.6470.56
129_T157_L0.6440.56
109_E141_V0.6440.56
159_L163_I0.6430.56
127_T151_N0.6290.54
211_G214_A0.6290.54
89_P108_C0.6290.54
160_A164_A0.6290.54
60_T216_L0.6270.54
42_L57_V0.6220.53
57_V63_P0.6220.53
89_P145_A0.6200.53
29_L33_E0.6200.53
48_L71_F0.6200.53
128_R152_A0.6120.52
166_G197_G0.6110.52
61_G137_D0.6110.52
62_D213_A0.6060.51
128_R205_G0.6050.51
148_V217_T0.6030.51
90_I221_V0.5980.50
65_F68_L0.5980.50
144_G147_A0.5900.49
44_P67_H0.5890.49
37_D41_E0.5890.49
117_G132_S0.5850.49
53_R66_Q0.5850.49
32_A36_M0.5820.49
63_P66_Q0.5810.48
162_C167_T0.5750.48
121_A131_A0.5740.48
79_A125_G0.5710.47
84_V220_L0.5690.47
73_G82_R0.5680.47
27_K30_D0.5680.47
62_D129_T0.5670.47
56_S71_F0.5640.46
82_R139_Q0.5630.46
92_T210_S0.5600.46
31_I154_T0.5600.46
82_R85_L0.5600.46
73_G141_V0.5600.46
77_V81_A0.5600.46
33_E37_D0.5590.46
35_S96_M0.5590.46
59_A214_A0.5560.45
117_G131_A0.5560.45
100_G210_S0.5530.45
117_G128_R0.5520.45
58_H219_E0.5510.45
63_P206_R0.5510.45
159_L167_T0.5510.45
24_T157_L0.5500.45
187_T202_T0.5490.45
153_P209_G0.5450.44
151_N177_V0.5440.44
120_L136_L0.5430.44
129_T181_K0.5400.44
157_L160_A0.5380.43
113_A132_S0.5360.43
99_A112_K0.5350.43
147_A197_G0.5310.43
51_R81_A0.5300.42
75_E79_A0.5290.42
91_V222_H0.5270.42
36_M206_R0.5270.42
165_D215_G0.5270.42
35_S177_V0.5230.42
52_L71_F0.5220.42
58_H180_V0.5220.42
24_T181_K0.5200.41
27_K129_T0.5200.41
49_A75_E0.5170.41
79_A89_P0.5170.41
135_E162_C0.5150.41
159_L169_P0.5150.41
144_G169_P0.5120.40
100_G151_N0.5110.40
145_A182_A0.5090.40
117_G135_E0.5090.40
156_A189_L0.5080.40
43_V57_V0.5080.40
71_F76_P0.5050.40
97_V217_T0.5040.40
151_N180_V0.5030.39
184_E210_S0.5020.39
24_T161_D0.5010.39
35_S153_P0.5010.39
111_R141_V0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2afrA 2 0.865 100 0.181 Contact Map
1v9cA 2 0.8354 100 0.186 Contact Map
4au1A 2 0.8354 100 0.189 Contact Map
1f2vA 2 0.8481 100 0.196 Contact Map
3e7dA 2 0.827 100 0.198 Contact Map
1ou0A 4 0.7848 100 0.209 Contact Map
2fiqA 4 0.443 24.8 0.963 Contact Map
1snnA 2 0.5612 24.3 0.963 Contact Map
1tksA 2 0.5781 19.7 0.965 Contact Map
4i14A 2 0.692 18.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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