GREMLIN Database
Q9HPM0 - Precorrin-3 methylase
UniProt: Q9HPM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (216)
Sequences: 13066 (8213)
Seq/√Len: 558.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_A49_R3.8991.00
48_E52_R3.4401.00
31_H50_A2.6561.00
93_R98_A2.6401.00
142_R218_E2.6341.00
211_E219_S2.5791.00
29_A128_R2.5581.00
223_T227_E2.5431.00
54_A101_T2.5341.00
203_P226_G2.4751.00
29_A126_P2.3901.00
49_R53_D2.2991.00
74_D93_R2.2771.00
64_V103_V2.2321.00
33_V101_T2.2171.00
45_A48_E2.1101.00
139_A213_L2.1041.00
31_H99_R2.0611.00
135_S181_P2.0571.00
206_D247_R2.0531.00
224_T227_E2.0461.00
55_E99_R2.0241.00
210_L213_L2.0231.00
33_V47_G2.0001.00
95_A123_V1.9611.00
212_R217_D1.9481.00
223_T231_H1.9071.00
55_E98_A1.8121.00
93_R96_D1.7781.00
34_G130_V1.7551.00
167_R170_D1.7551.00
29_A99_R1.7371.00
91_G123_V1.7101.00
207_A228_L1.7051.00
50_A130_V1.6651.00
56_V93_R1.6581.00
41_A46_R1.6321.00
49_R52_R1.6101.00
31_H128_R1.5831.00
65_E69_D1.5821.00
210_L220_I1.5741.00
92_E96_D1.5061.00
227_E231_H1.4961.00
192_A196_L1.4871.00
223_T228_L1.4721.00
46_R128_R1.4371.00
169_R197_E1.4311.00
201_A205_L1.4311.00
142_R220_I1.4181.00
39_N46_R1.4171.00
194_D197_E1.4131.00
89_A93_R1.4081.00
134_S137_Q1.4071.00
143_A208_L1.4051.00
164_G194_D1.3891.00
139_A210_L1.3831.00
43_L48_E1.3741.00
136_L181_P1.3671.00
53_D99_R1.3641.00
95_A125_E1.3511.00
212_R215_H1.3421.00
204_D226_G1.3341.00
88_S92_E1.3271.00
89_A92_E1.3161.00
59_G75_L1.3091.00
151_T176_H1.3071.00
134_S181_P1.3061.00
192_A229_A1.2951.00
231_H236_T1.2921.00
74_D98_A1.2831.00
34_G107_D1.2821.00
169_R198_A1.2701.00
91_G95_A1.2691.00
57_I71_T1.2361.00
109_N114_Q1.2281.00
180_L246_V1.2241.00
61_E81_R1.2221.00
94_V125_E1.2191.00
208_L222_R1.2071.00
129_V141_S1.2051.00
30_V94_V1.1961.00
79_G82_D1.1721.00
231_H235_E1.1701.00
221_T231_H1.1631.00
207_A225_L1.1611.00
48_E70_L1.1571.00
187_M190_D1.1401.00
230_A235_E1.1321.00
179_V245_A1.1311.00
63_V66_F1.1281.00
50_A101_T1.1261.00
209_V242_S1.1221.00
195_L225_L1.1211.00
189_G193_A1.1041.00
58_V90_F1.1041.00
58_V100_G1.1031.00
196_L203_P1.0971.00
196_L226_G1.0951.00
188_P232_A1.0931.00
85_A88_S1.0841.00
43_L47_G1.0811.00
44_T133_I1.0681.00
58_V76_L1.0411.00
193_A197_E1.0311.00
47_G130_V1.0301.00
56_V100_G1.0261.00
86_A89_A1.0261.00
169_R194_D1.0151.00
189_G234_E1.0121.00
165_V194_D1.0101.00
194_D198_A1.0091.00
152_F157_K1.0031.00
208_L220_I1.0021.00
107_D141_S1.0011.00
195_L246_V0.9921.00
34_G108_P0.9921.00
169_R173_G0.9911.00
42_F46_R0.9901.00
156_H167_R0.9761.00
190_D193_A0.9731.00
209_V232_A0.9701.00
31_H54_A0.9671.00
138_V214_T0.9621.00
238_F242_S0.9581.00
211_E239_S0.9561.00
66_F69_D0.9561.00
58_V93_R0.9551.00
54_A99_R0.9541.00
87_L121_R0.9491.00
188_P244_L0.9481.00
152_F156_H0.9421.00
162_S166_A0.9291.00
56_V98_A0.9291.00
31_H130_V0.9271.00
155_L181_P0.9261.00
41_A45_A0.9131.00
189_G229_A0.9101.00
58_V89_A0.9041.00
190_D194_D0.9011.00
180_L183_P0.8941.00
114_Q117_G0.8931.00
109_N129_V0.8921.00
156_H168_L0.8751.00
193_A229_A0.8751.00
170_D173_G0.8731.00
64_V68_A0.8731.00
45_A49_R0.8721.00
33_V50_A0.8711.00
129_V220_I0.8611.00
219_S236_T0.8611.00
67_V70_L0.8611.00
196_L229_A0.8581.00
62_T67_V0.8571.00
188_P228_L0.8421.00
170_D174_D0.8401.00
153_V176_H0.8381.00
145_T208_L0.8361.00
56_V76_L0.8361.00
33_V130_V0.8341.00
68_A71_T0.8331.00
64_V71_T0.8291.00
196_L225_L0.8271.00
179_V243_V0.8251.00
192_A225_L0.8211.00
110_H137_Q0.8161.00
150_T155_L0.8121.00
169_R172_V0.8111.00
52_R70_L0.8091.00
50_A53_D0.8081.00
140_A147_M0.8041.00
154_T175_R0.7991.00
83_E87_L0.7931.00
37_P42_F0.7891.00
195_L201_A0.7891.00
50_A128_R0.7851.00
57_I73_A0.7851.00
108_P112_G0.7811.00
76_L89_A0.7741.00
109_N115_F0.7711.00
204_D224_T0.7691.00
152_F155_L0.7681.00
65_E68_A0.7661.00
157_K167_R0.7661.00
46_R130_V0.7641.00
202_A205_L0.7621.00
46_R49_R0.7541.00
91_G121_R0.7531.00
87_L91_G0.7521.00
61_E77_T0.7511.00
27_D126_P0.7431.00
83_E117_G0.7431.00
154_T176_H0.7351.00
40_P66_F0.7281.00
79_G83_E0.7281.00
66_F70_L0.7271.00
155_L158_S0.7181.00
139_A245_A0.7161.00
153_V167_R0.7161.00
154_T157_K0.7161.00
138_V213_L0.7151.00
50_A99_R0.7141.00
206_D224_T0.7141.00
149_D153_V0.7121.00
181_P243_V0.7121.00
232_A238_F0.7121.00
139_A243_V0.7081.00
165_V190_D0.7071.00
119_V127_V0.7041.00
104_L112_G0.7011.00
117_G120_E0.6991.00
107_D129_V0.6971.00
161_V165_V0.6971.00
189_G230_A0.6961.00
43_L67_V0.6931.00
39_N42_F0.6931.00
136_L179_V0.6931.00
118_K121_R0.6901.00
82_D85_A0.6871.00
142_R214_T0.6851.00
211_E242_S0.6821.00
129_V142_R0.6801.00
208_L245_A0.6791.00
82_D186_L0.6761.00
31_H101_T0.6741.00
168_L191_I0.6701.00
61_E82_D0.6701.00
92_E95_A0.6661.00
76_L86_A0.6651.00
150_T156_H0.6641.00
50_A54_A0.6641.00
75_L78_C0.6621.00
209_V228_L0.6601.00
88_S121_R0.6601.00
175_R201_A0.6561.00
51_I101_T0.6551.00
34_G138_V0.6541.00
51_I57_I0.6501.00
165_V197_E0.6501.00
56_V74_D0.6491.00
110_H147_M0.6471.00
221_T236_T0.6461.00
94_V100_G0.6461.00
109_N141_S0.6391.00
39_N214_T0.6361.00
184_F238_F0.6351.00
62_T65_E0.6291.00
115_F118_K0.6281.00
80_Y83_E0.6261.00
151_T174_D0.6241.00
78_C83_E0.6221.00
221_T238_F0.6221.00
183_P186_L0.6181.00
188_P242_S0.6161.00
182_R187_M0.6121.00
198_A201_A0.6121.00
62_T71_T0.6111.00
34_G133_I0.6101.00
191_I244_L0.6091.00
165_V169_R0.6071.00
64_V67_V0.6071.00
178_L201_A0.6061.00
150_T157_K0.6061.00
221_T232_A0.6051.00
54_A57_I0.6021.00
74_D89_A0.5991.00
221_T228_L0.5981.00
84_Q88_S0.5961.00
47_G67_V0.5941.00
46_R50_A0.5941.00
173_G198_A0.5931.00
47_G101_T0.5891.00
180_L191_I0.5871.00
76_L93_R0.5861.00
115_F149_D0.5861.00
178_L246_V0.5861.00
170_D175_R0.5861.00
65_E75_L0.5831.00
115_F120_E0.5750.99
230_A234_E0.5720.99
115_F146_P0.5700.99
184_F242_S0.5690.99
172_V198_A0.5660.99
104_L113_Y0.5610.99
159_G163_D0.5610.99
192_A228_L0.5560.99
227_E230_A0.5560.99
206_D222_R0.5550.99
152_F158_S0.5480.99
160_D163_D0.5480.99
58_V78_C0.5480.99
166_A169_R0.5420.99
84_Q87_L0.5410.99
167_R171_A0.5390.99
85_A89_A0.5390.99
178_L195_L0.5360.99
51_I71_T0.5360.99
210_L245_A0.5340.99
67_V71_T0.5340.99
138_V142_R0.5290.99
188_P238_F0.5260.99
77_T86_A0.5250.99
48_E71_T0.5240.99
211_E221_T0.5230.99
162_S165_V0.5210.99
188_P192_A0.5210.99
147_M179_V0.5200.99
63_V71_T0.5190.99
111_S152_F0.5160.99
159_G162_S0.5160.99
232_A237_P0.5150.99
32_A115_F0.5150.99
87_L90_F0.5140.99
43_L71_T0.5110.99
64_V70_L0.5110.99
140_A245_A0.5110.99
40_P70_L0.5080.99
147_M177_L0.5060.99
151_T154_T0.5060.99
152_F176_H0.5060.99
91_G125_E0.5010.99
45_A52_R0.5010.99
78_C87_L0.5010.99
30_V90_F0.5010.99
234_E237_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yboA 2 0.892 100 0.227 Contact Map
1pjqA 2 0.948 100 0.229 Contact Map
3kwpA 2 0.876 100 0.234 Contact Map
1s4dA 4 0.92 100 0.235 Contact Map
1cbfA 2 0.904 100 0.246 Contact Map
3ndcA 2 0.88 100 0.255 Contact Map
3nutA 2 0.868 100 0.255 Contact Map
4e16A 2 0.864 100 0.256 Contact Map
1wyzA 2 0.836 100 0.26 Contact Map
2zvbA 2 0.86 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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