Q9HPL9 - HALSA - GREMLIN Contacts

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Q9HPL9 - Uncharacterized protein

UniProt:	Q9HPL9	Sequences: MTRDALLLLGRDTPHARETLATHAQRLRGRAVADAVHARHYDHEPRRDLRGRLTAIDADRVFAVPMTTAHTRETTVGVPAALQALTDATVQYCEPIGRSGAVTDVIHDRATDAAADAPSAIGLVTLGASSLPYHRQVAEYHAARLRERGTYDDVATSHLVQNPAVECLRYNLSTDDAVVVPVFVAAGAATDRDIPDRLDLARGGIAYADPLGAHPRLTDAVEATLAQQRVLADRDTTAATTLTATAPAFATDGDGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	256 (197)
Sequences:	783 (519)
Seq/√Len:	37.0

BACSU - SIRB
HALSA - Q9HPL9 CBIX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_R	89_T	3.660	1.00
75_T	131_L	3.560	1.00
60_R	91_Q	3.265	1.00
108_D	216_R	3.239	1.00
50_R	90_V	3.175	1.00
118_P	175_D	3.032	1.00
37_H	49_L	2.949	1.00
94_E	227_Q	2.755	1.00
108_D	214_H	2.743	1.00
157_S	168_L	2.740	1.00
35_A	52_R	2.704	1.00
73_E	77_G	2.484	1.00
71_T	189_A	2.411	1.00
62_F	228_Q	2.369	1.00
63_A	82_L	2.226	0.99
73_E	189_A	2.207	0.99
45_P	48_D	2.130	0.99
73_E	79_P	2.118	0.99
126_L	189_A	1.954	0.98
62_F	229_R	1.921	0.98
157_S	172_L	1.885	0.98
226_A	230_V	1.863	0.98
101_A	219_D	1.821	0.97
51_G	88_A	1.800	0.97
35_A	56_I	1.765	0.97
68_T	182_V	1.764	0.97
183_F	190_T	1.676	0.96
190_T	210_P	1.670	0.95
142_A	156_T	1.658	0.95
104_D	216_R	1.643	0.95
110_A	180_V	1.641	0.95
106_I	123_L	1.630	0.95
124_V	157_S	1.615	0.95
40_H	73_E	1.614	0.95
105_V	214_H	1.562	0.94
126_L	185_A	1.557	0.93
178_V	208_A	1.545	0.93
87_D	111_T	1.545	0.93
72_R	126_L	1.534	0.93
109_R	112_D	1.521	0.93
119_S	178_V	1.495	0.92
119_S	176_D	1.474	0.91
195_P	199_D	1.457	0.91
46_R	78_V	1.439	0.90
101_A	223_A	1.430	0.90
134_H	161_Q	1.405	0.89
160_V	183_F	1.402	0.89
183_F	211_L	1.386	0.89
72_R	160_V	1.371	0.88
64_V	164_A	1.339	0.87
75_T	126_L	1.339	0.87
39_R	71_T	1.332	0.86
220_A	223_A	1.329	0.86
136_Q	140_Y	1.323	0.86
67_T	71_T	1.308	0.85
78_V	105_V	1.303	0.85
123_L	142_A	1.295	0.85
143_A	147_E	1.271	0.84
96_I	224_T	1.239	0.82
184_V	217_L	1.233	0.82
186_A	191_D	1.228	0.82
122_G	157_S	1.220	0.81
53_L	58_A	1.196	0.80
40_H	126_L	1.195	0.80
158_H	163_P	1.176	0.79
142_A	154_V	1.175	0.79
134_H	189_A	1.166	0.78
120_A	177_A	1.162	0.78
70_H	121_I	1.144	0.77
36_V	82_L	1.142	0.77
163_P	182_V	1.134	0.76
140_Y	147_E	1.128	0.76
67_T	77_G	1.119	0.75
143_A	161_Q	1.115	0.75
67_T	189_A	1.113	0.75
107_H	148_R	1.110	0.75
104_D	148_R	1.105	0.74
67_T	74_T	1.104	0.74
58_A	69_A	1.102	0.74
194_I	198_L	1.093	0.73
126_L	160_V	1.093	0.73
61_V	89_T	1.087	0.73
215_P	222_E	1.086	0.73
102_V	106_I	1.077	0.72
70_H	137_V	1.075	0.72
49_L	54_T	1.073	0.72
217_L	220_A	1.060	0.71
81_A	95_P	1.056	0.71
68_T	184_V	1.055	0.71
135_R	158_H	1.049	0.70
51_G	55_A	1.030	0.69
122_G	168_L	1.028	0.69
75_T	184_V	1.020	0.68
124_V	168_L	1.016	0.68
93_C	155_A	1.015	0.68
70_H	75_T	1.012	0.67
62_F	93_C	1.012	0.67
117_A	152_D	1.012	0.67
68_T	73_E	1.006	0.67
95_P	106_I	1.005	0.67
113_A	178_V	1.002	0.67
126_L	131_L	1.000	0.66
169_R	204_G	0.999	0.66
61_V	167_C	0.997	0.66
84_A	87_D	0.996	0.66
41_Y	122_G	0.988	0.66
176_D	206_A	0.984	0.65
50_R	85_L	0.984	0.65
194_I	220_A	0.981	0.65
63_A	157_S	0.981	0.65
40_H	185_A	0.977	0.65
41_Y	126_L	0.976	0.65
72_R	124_V	0.971	0.64
38_A	164_A	0.969	0.64
69_A	159_L	0.964	0.64
99_S	223_A	0.962	0.63
98_R	126_L	0.957	0.63
38_A	173_S	0.955	0.63
129_S	163_P	0.949	0.62
106_I	180_V	0.931	0.61
59_D	111_T	0.928	0.61
61_V	90_V	0.922	0.60
63_A	90_V	0.919	0.60
56_I	209_D	0.917	0.60
104_D	108_D	0.914	0.59
75_T	133_Y	0.903	0.58
41_Y	128_A	0.902	0.58
121_I	151_Y	0.895	0.58
42_D	123_L	0.895	0.58
62_F	225_L	0.885	0.57
121_I	154_V	0.880	0.56
96_I	102_V	0.873	0.56
53_L	96_I	0.873	0.56
69_A	185_A	0.870	0.56
182_V	185_A	0.865	0.55
135_R	161_Q	0.864	0.55
209_D	230_V	0.860	0.55
99_S	220_A	0.853	0.54
105_V	217_L	0.851	0.54
195_P	207_Y	0.845	0.53
122_G	172_L	0.843	0.53
66_M	221_V	0.837	0.53
198_L	205_I	0.835	0.53
178_V	206_A	0.830	0.52
222_E	225_L	0.825	0.52
180_V	208_A	0.824	0.52
67_T	186_A	0.822	0.51
135_R	147_E	0.816	0.51
39_R	187_G	0.815	0.51
106_I	145_L	0.814	0.51
67_T	73_E	0.813	0.51
146_R	179_V	0.811	0.50
41_Y	189_A	0.804	0.50
170_Y	202_R	0.789	0.49
145_L	149_G	0.789	0.49
66_M	220_A	0.788	0.48
35_A	49_L	0.785	0.48
67_T	211_L	0.783	0.48
224_T	227_Q	0.780	0.48
39_R	183_F	0.769	0.47
78_V	92_Y	0.766	0.46
40_H	186_A	0.766	0.46
51_G	152_D	0.765	0.46
121_I	138_A	0.755	0.46
140_Y	143_A	0.753	0.45
129_S	184_V	0.746	0.45
79_P	189_A	0.743	0.44
43_H	48_D	0.743	0.44
126_L	183_F	0.740	0.44
77_G	169_R	0.739	0.44
126_L	129_S	0.739	0.44
64_V	192_R	0.738	0.44
65_P	127_G	0.737	0.44
177_A	191_D	0.737	0.44
107_H	196_D	0.735	0.44
181_P	190_T	0.735	0.44
155_A	171_N	0.734	0.44
112_D	209_D	0.733	0.44
96_I	108_D	0.731	0.43
92_Y	95_P	0.728	0.43
204_G	226_A	0.727	0.43
53_L	213_A	0.724	0.43
72_R	185_A	0.718	0.42
178_V	181_P	0.715	0.42
120_A	172_L	0.714	0.42
223_A	226_A	0.710	0.42
128_A	163_P	0.710	0.42
66_M	121_I	0.708	0.41
103_T	145_L	0.703	0.41
179_V	209_D	0.699	0.41
73_E	126_L	0.696	0.40
75_T	129_S	0.693	0.40
185_A	189_A	0.691	0.40
98_R	141_H	0.688	0.40
166_E	197_R	0.685	0.40
159_L	183_F	0.683	0.39
139_E	211_L	0.680	0.39
132_P	188_A	0.680	0.39
160_V	190_T	0.678	0.39
154_V	163_P	0.677	0.39
134_H	220_A	0.676	0.39
191_D	195_P	0.675	0.39
114_A	178_V	0.673	0.38
110_A	151_Y	0.671	0.38
56_I	118_P	0.670	0.38
47_R	51_G	0.669	0.38
143_A	146_R	0.668	0.38
102_V	114_A	0.664	0.38
44_E	126_L	0.661	0.37
133_Y	140_Y	0.660	0.37
99_S	182_V	0.659	0.37
83_Q	151_Y	0.656	0.37
74_T	134_H	0.655	0.37
202_R	205_I	0.652	0.37
200_L	219_D	0.652	0.37
133_Y	137_V	0.647	0.36
38_A	227_Q	0.646	0.36
198_L	207_Y	0.641	0.36
98_R	225_L	0.641	0.36
82_L	214_H	0.635	0.35
51_G	221_V	0.631	0.35
141_H	167_C	0.626	0.35
126_L	188_A	0.621	0.34
126_L	182_V	0.619	0.34
168_L	172_L	0.618	0.34
64_V	225_L	0.618	0.34
114_A	151_Y	0.617	0.34
98_R	137_V	0.617	0.34
91_Q	220_A	0.613	0.34
123_L	154_V	0.610	0.33
55_A	230_V	0.609	0.33
70_H	94_E	0.609	0.33
125_T	185_A	0.608	0.33
135_R	143_A	0.606	0.33
91_Q	229_R	0.602	0.33
140_Y	188_A	0.601	0.33
97_G	128_A	0.600	0.33
66_M	124_V	0.599	0.33
61_V	126_L	0.594	0.32
112_D	196_D	0.594	0.32
224_T	228_Q	0.591	0.32
140_Y	201_A	0.591	0.32
121_I	170_Y	0.591	0.32
86_T	90_V	0.586	0.32
40_H	124_V	0.586	0.32
97_G	129_S	0.585	0.31
163_P	185_A	0.583	0.31
99_S	164_A	0.582	0.31
129_S	141_H	0.581	0.31
112_D	205_I	0.580	0.31
102_V	219_D	0.580	0.31
217_L	226_A	0.577	0.31
48_D	215_P	0.575	0.31
82_L	92_Y	0.567	0.30
131_L	177_A	0.561	0.30
177_A	205_I	0.559	0.30
52_R	87_D	0.557	0.29
199_D	206_A	0.556	0.29
81_A	84_A	0.556	0.29
134_H	212_G	0.556	0.29
129_S	158_H	0.553	0.29
134_H	158_H	0.552	0.29
194_I	207_Y	0.550	0.29
115_A	219_D	0.550	0.29
78_V	185_A	0.550	0.29
198_L	225_L	0.547	0.29
77_G	172_L	0.545	0.28
128_A	187_G	0.543	0.28
110_A	145_L	0.542	0.28
104_D	175_D	0.541	0.28
43_H	80_A	0.536	0.28
75_T	194_I	0.536	0.28
74_T	184_V	0.535	0.28
53_L	184_V	0.535	0.28
44_E	163_P	0.535	0.28
104_D	228_Q	0.528	0.27
68_T	185_A	0.527	0.27
41_Y	44_E	0.526	0.27
124_V	165_V	0.526	0.27
111_T	117_A	0.526	0.27
54_T	58_A	0.523	0.27
188_A	221_V	0.520	0.27
159_L	165_V	0.518	0.27
68_T	75_T	0.517	0.27
107_H	199_D	0.515	0.26
99_S	105_V	0.514	0.26
40_H	72_R	0.513	0.26
154_V	212_G	0.511	0.26
173_S	205_I	0.509	0.26
186_A	210_P	0.508	0.26
166_E	170_Y	0.508	0.26
38_A	184_V	0.507	0.26
181_P	189_A	0.507	0.26
77_G	102_V	0.502	0.26
44_E	75_T	0.501	0.25
70_H	126_L	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ccsA	1	0.8438	100	0.456	Contact Map
2jh3A	2	0.9531	100	0.462	Contact Map
2xvyA	3	0.8906	100	0.489	Contact Map
2xwpA	5	0.8828	100	0.526	Contact Map
1lbqA	2	0.9844	100	0.589	Contact Map
3hcnA	2	0.9844	100	0.611	Contact Map
2h1vA	1	0.8945	100	0.615	Contact Map
1tjnA	4	0.4297	99.9	0.704	Contact Map
2xwsA	2	0.4336	99.9	0.706	Contact Map
3lyhA	2	0.457	99.9	0.706	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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