GREMLIN Database
Q9HPL9 - Uncharacterized protein
UniProt: Q9HPL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (197)
Sequences: 783 (519)
Seq/√Len: 37.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_R89_T3.6601.00
75_T131_L3.5601.00
60_R91_Q3.2651.00
108_D216_R3.2391.00
50_R90_V3.1751.00
118_P175_D3.0321.00
37_H49_L2.9491.00
94_E227_Q2.7551.00
108_D214_H2.7431.00
157_S168_L2.7401.00
35_A52_R2.7041.00
73_E77_G2.4841.00
71_T189_A2.4111.00
62_F228_Q2.3691.00
63_A82_L2.2260.99
73_E189_A2.2070.99
45_P48_D2.1300.99
73_E79_P2.1180.99
126_L189_A1.9540.98
62_F229_R1.9210.98
157_S172_L1.8850.98
226_A230_V1.8630.98
101_A219_D1.8210.97
51_G88_A1.8000.97
35_A56_I1.7650.97
68_T182_V1.7640.97
183_F190_T1.6760.96
190_T210_P1.6700.95
142_A156_T1.6580.95
104_D216_R1.6430.95
110_A180_V1.6410.95
106_I123_L1.6300.95
124_V157_S1.6150.95
40_H73_E1.6140.95
105_V214_H1.5620.94
126_L185_A1.5570.93
178_V208_A1.5450.93
87_D111_T1.5450.93
72_R126_L1.5340.93
109_R112_D1.5210.93
119_S178_V1.4950.92
119_S176_D1.4740.91
195_P199_D1.4570.91
46_R78_V1.4390.90
101_A223_A1.4300.90
134_H161_Q1.4050.89
160_V183_F1.4020.89
183_F211_L1.3860.89
72_R160_V1.3710.88
64_V164_A1.3390.87
75_T126_L1.3390.87
39_R71_T1.3320.86
220_A223_A1.3290.86
136_Q140_Y1.3230.86
67_T71_T1.3080.85
78_V105_V1.3030.85
123_L142_A1.2950.85
143_A147_E1.2710.84
96_I224_T1.2390.82
184_V217_L1.2330.82
186_A191_D1.2280.82
122_G157_S1.2200.81
53_L58_A1.1960.80
40_H126_L1.1950.80
158_H163_P1.1760.79
142_A154_V1.1750.79
134_H189_A1.1660.78
120_A177_A1.1620.78
70_H121_I1.1440.77
36_V82_L1.1420.77
163_P182_V1.1340.76
140_Y147_E1.1280.76
67_T77_G1.1190.75
143_A161_Q1.1150.75
67_T189_A1.1130.75
107_H148_R1.1100.75
104_D148_R1.1050.74
67_T74_T1.1040.74
58_A69_A1.1020.74
194_I198_L1.0930.73
126_L160_V1.0930.73
61_V89_T1.0870.73
215_P222_E1.0860.73
102_V106_I1.0770.72
70_H137_V1.0750.72
49_L54_T1.0730.72
217_L220_A1.0600.71
81_A95_P1.0560.71
68_T184_V1.0550.71
135_R158_H1.0490.70
51_G55_A1.0300.69
122_G168_L1.0280.69
75_T184_V1.0200.68
124_V168_L1.0160.68
93_C155_A1.0150.68
70_H75_T1.0120.67
62_F93_C1.0120.67
117_A152_D1.0120.67
68_T73_E1.0060.67
95_P106_I1.0050.67
113_A178_V1.0020.67
126_L131_L1.0000.66
169_R204_G0.9990.66
61_V167_C0.9970.66
84_A87_D0.9960.66
41_Y122_G0.9880.66
176_D206_A0.9840.65
50_R85_L0.9840.65
194_I220_A0.9810.65
63_A157_S0.9810.65
40_H185_A0.9770.65
41_Y126_L0.9760.65
72_R124_V0.9710.64
38_A164_A0.9690.64
69_A159_L0.9640.64
99_S223_A0.9620.63
98_R126_L0.9570.63
38_A173_S0.9550.63
129_S163_P0.9490.62
106_I180_V0.9310.61
59_D111_T0.9280.61
61_V90_V0.9220.60
63_A90_V0.9190.60
56_I209_D0.9170.60
104_D108_D0.9140.59
75_T133_Y0.9030.58
41_Y128_A0.9020.58
121_I151_Y0.8950.58
42_D123_L0.8950.58
62_F225_L0.8850.57
121_I154_V0.8800.56
96_I102_V0.8730.56
53_L96_I0.8730.56
69_A185_A0.8700.56
182_V185_A0.8650.55
135_R161_Q0.8640.55
209_D230_V0.8600.55
99_S220_A0.8530.54
105_V217_L0.8510.54
195_P207_Y0.8450.53
122_G172_L0.8430.53
66_M221_V0.8370.53
198_L205_I0.8350.53
178_V206_A0.8300.52
222_E225_L0.8250.52
180_V208_A0.8240.52
67_T186_A0.8220.51
135_R147_E0.8160.51
39_R187_G0.8150.51
106_I145_L0.8140.51
67_T73_E0.8130.51
146_R179_V0.8110.50
41_Y189_A0.8040.50
170_Y202_R0.7890.49
145_L149_G0.7890.49
66_M220_A0.7880.48
35_A49_L0.7850.48
67_T211_L0.7830.48
224_T227_Q0.7800.48
39_R183_F0.7690.47
78_V92_Y0.7660.46
40_H186_A0.7660.46
51_G152_D0.7650.46
121_I138_A0.7550.46
140_Y143_A0.7530.45
129_S184_V0.7460.45
79_P189_A0.7430.44
43_H48_D0.7430.44
126_L183_F0.7400.44
77_G169_R0.7390.44
126_L129_S0.7390.44
64_V192_R0.7380.44
65_P127_G0.7370.44
177_A191_D0.7370.44
107_H196_D0.7350.44
181_P190_T0.7350.44
155_A171_N0.7340.44
112_D209_D0.7330.44
96_I108_D0.7310.43
92_Y95_P0.7280.43
204_G226_A0.7270.43
53_L213_A0.7240.43
72_R185_A0.7180.42
178_V181_P0.7150.42
120_A172_L0.7140.42
223_A226_A0.7100.42
128_A163_P0.7100.42
66_M121_I0.7080.41
103_T145_L0.7030.41
179_V209_D0.6990.41
73_E126_L0.6960.40
75_T129_S0.6930.40
185_A189_A0.6910.40
98_R141_H0.6880.40
166_E197_R0.6850.40
159_L183_F0.6830.39
139_E211_L0.6800.39
132_P188_A0.6800.39
160_V190_T0.6780.39
154_V163_P0.6770.39
134_H220_A0.6760.39
191_D195_P0.6750.39
114_A178_V0.6730.38
110_A151_Y0.6710.38
56_I118_P0.6700.38
47_R51_G0.6690.38
143_A146_R0.6680.38
102_V114_A0.6640.38
44_E126_L0.6610.37
133_Y140_Y0.6600.37
99_S182_V0.6590.37
83_Q151_Y0.6560.37
74_T134_H0.6550.37
202_R205_I0.6520.37
200_L219_D0.6520.37
133_Y137_V0.6470.36
38_A227_Q0.6460.36
198_L207_Y0.6410.36
98_R225_L0.6410.36
82_L214_H0.6350.35
51_G221_V0.6310.35
141_H167_C0.6260.35
126_L188_A0.6210.34
126_L182_V0.6190.34
168_L172_L0.6180.34
64_V225_L0.6180.34
114_A151_Y0.6170.34
98_R137_V0.6170.34
91_Q220_A0.6130.34
123_L154_V0.6100.33
55_A230_V0.6090.33
70_H94_E0.6090.33
125_T185_A0.6080.33
135_R143_A0.6060.33
91_Q229_R0.6020.33
140_Y188_A0.6010.33
97_G128_A0.6000.33
66_M124_V0.5990.33
61_V126_L0.5940.32
112_D196_D0.5940.32
224_T228_Q0.5910.32
140_Y201_A0.5910.32
121_I170_Y0.5910.32
86_T90_V0.5860.32
40_H124_V0.5860.32
97_G129_S0.5850.31
163_P185_A0.5830.31
99_S164_A0.5820.31
129_S141_H0.5810.31
112_D205_I0.5800.31
102_V219_D0.5800.31
217_L226_A0.5770.31
48_D215_P0.5750.31
82_L92_Y0.5670.30
131_L177_A0.5610.30
177_A205_I0.5590.30
52_R87_D0.5570.29
199_D206_A0.5560.29
81_A84_A0.5560.29
134_H212_G0.5560.29
129_S158_H0.5530.29
134_H158_H0.5520.29
194_I207_Y0.5500.29
115_A219_D0.5500.29
78_V185_A0.5500.29
198_L225_L0.5470.29
77_G172_L0.5450.28
128_A187_G0.5430.28
110_A145_L0.5420.28
104_D175_D0.5410.28
43_H80_A0.5360.28
75_T194_I0.5360.28
74_T184_V0.5350.28
53_L184_V0.5350.28
44_E163_P0.5350.28
104_D228_Q0.5280.27
68_T185_A0.5270.27
41_Y44_E0.5260.27
124_V165_V0.5260.27
111_T117_A0.5260.27
54_T58_A0.5230.27
188_A221_V0.5200.27
159_L165_V0.5180.27
68_T75_T0.5170.27
107_H199_D0.5150.26
99_S105_V0.5140.26
40_H72_R0.5130.26
154_V212_G0.5110.26
173_S205_I0.5090.26
186_A210_P0.5080.26
166_E170_Y0.5080.26
38_A184_V0.5070.26
181_P189_A0.5070.26
77_G102_V0.5020.26
44_E75_T0.5010.25
70_H126_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ccsA 1 0.8438 100 0.456 Contact Map
2jh3A 2 0.9531 100 0.462 Contact Map
2xvyA 3 0.8906 100 0.489 Contact Map
2xwpA 5 0.8828 100 0.526 Contact Map
1lbqA 2 0.9844 100 0.589 Contact Map
3hcnA 2 0.9844 100 0.611 Contact Map
2h1vA 1 0.8945 100 0.615 Contact Map
1tjnA 4 0.4297 99.9 0.704 Contact Map
2xwsA 2 0.4336 99.9 0.706 Contact Map
3lyhA 2 0.457 99.9 0.706 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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