GREMLIN Database
Y1572 - UPF0284 protein VNG_1572C
UniProt: Q9HPL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (316)
Sequences: 311 (231)
Seq/√Len: 13.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_G266_A5.3681.00
154_A198_A5.0131.00
214_A239_V4.1711.00
116_A200_R3.6150.99
12_A210_V3.5530.99
280_P309_L3.4070.99
22_E31_P3.3810.98
181_L202_M3.1240.97
13_A140_T3.0110.97
9_F304_G3.0000.97
108_R176_V2.8580.95
124_Y215_A2.7580.94
153_A174_E2.6740.93
323_R327_I2.6240.93
254_S258_G2.6040.92
29_A40_A2.4510.90
257_A265_D2.4170.89
233_A268_A2.3730.88
56_V59_S2.3500.88
70_T316_G2.3100.87
322_V326_I2.2880.86
58_V61_S2.2830.86
137_I307_G2.2470.85
150_G180_A2.2450.85
255_F280_P2.2040.84
25_S143_G2.1720.83
131_H274_A2.1680.83
69_I305_M2.1320.82
85_D98_T2.1130.81
227_A307_G2.1130.81
251_A310_A2.0750.80
151_V198_A2.0700.80
255_F295_L2.0600.80
264_I268_A2.0060.78
86_A99_T1.9770.77
232_L235_A1.9770.77
18_T107_I1.9570.76
214_A248_M1.9290.75
64_P330_Y1.9240.75
14_G206_V1.8960.74
74_R79_F1.8920.74
104_G205_P1.8780.73
112_P207_L1.8700.73
207_L235_A1.8430.71
11_L42_A1.8140.70
123_A213_L1.8030.70
59_S62_G1.7930.69
112_P203_G1.7740.68
104_G168_N1.7480.67
225_T251_A1.7470.67
98_T101_I1.7410.67
162_S168_N1.7320.67
325_A328_S1.7280.66
64_P290_A1.7130.66
56_V61_S1.6930.65
45_L150_G1.6910.65
269_A307_G1.6740.64
70_T308_A1.6670.63
177_V181_L1.6580.63
59_S64_P1.6300.62
58_V64_P1.5970.60
143_G209_V1.5900.60
13_A88_L1.5770.59
206_V210_V1.5330.57
82_L126_F1.5040.55
38_P108_R1.4730.54
123_A314_E1.4470.52
141_I206_V1.4360.52
112_P195_P1.4290.51
135_L212_G1.3900.49
149_M159_R1.3890.49
99_T250_L1.3680.48
142_P169_P1.3650.48
65_T141_I1.3640.48
194_E197_A1.3550.47
120_Y196_V1.3310.46
18_T164_S1.3170.45
45_L303_V1.3120.45
63_C243_G1.3070.45
18_T202_M1.2970.44
259_D300_K1.2940.44
240_R272_D1.2800.44
135_L217_A1.2680.43
223_D277_V1.2640.43
196_V272_D1.2410.42
130_L237_A1.2410.42
269_A331_D1.2320.41
256_V264_I1.2290.41
136_V271_Q1.2220.41
56_V62_G1.2190.40
64_P142_P1.2180.40
82_L97_V1.2060.40
162_S264_I1.2020.40
10_A128_H1.2010.40
73_V257_A1.1920.39
150_G177_V1.1910.39
150_G214_A1.1880.39
291_M316_G1.1870.39
155_L237_A1.1870.39
32_A308_A1.1860.39
29_A184_S1.1820.39
307_G316_G1.1710.38
103_P248_M1.1700.38
30_D34_M1.1640.38
69_I309_L1.1550.37
174_E178_D1.1540.37
102_S105_A1.1520.37
251_A276_T1.1480.37
33_L308_A1.1360.36
149_M153_A1.1360.36
64_P138_A1.1330.36
121_S316_G1.1310.36
254_S295_L1.1300.36
227_A314_E1.1290.36
236_G248_M1.1170.35
179_D269_A1.1140.35
131_H308_A1.1130.35
14_G84_I1.1110.35
17_R266_A1.1090.35
233_A267_L1.1080.35
166_P257_A1.1080.35
65_T309_L1.1080.35
13_A305_M1.1050.35
131_H311_L1.1050.35
86_A123_A1.0990.35
154_A257_A1.0890.34
151_V203_G1.0890.34
33_L119_A1.0870.34
265_D275_V1.0730.33
199_V268_A1.0700.33
163_S259_D1.0640.33
162_S230_T1.0580.33
59_S65_T1.0550.33
195_P280_P1.0550.33
104_G250_L1.0530.32
150_G154_A1.0500.32
287_S327_I1.0470.32
71_R163_S1.0460.32
162_S262_A1.0410.32
121_S214_A1.0390.32
24_I180_A1.0320.32
29_A33_L1.0320.32
193_G197_A1.0290.31
242_D318_G1.0280.31
7_T11_L1.0280.31
120_Y212_G1.0250.31
146_T327_I1.0240.31
266_A270_D1.0240.31
38_P59_S1.0210.31
158_P182_A1.0200.31
175_R179_D1.0130.31
61_S64_P1.0100.31
115_D118_A0.9970.30
141_I256_V0.9970.30
46_T114_P0.9950.30
95_P290_A0.9900.30
126_F169_P0.9890.30
48_G267_L0.9870.30
134_E326_I0.9820.29
107_I150_G0.9800.29
16_T27_A0.9760.29
86_A209_V0.9740.29
230_T326_I0.9730.29
100_G103_P0.9690.29
34_M38_P0.9690.29
287_S331_D0.9640.29
225_T264_I0.9550.28
149_M177_V0.9550.28
78_G113_V0.9550.28
234_T305_M0.9510.28
164_S238_L0.9430.28
205_P234_T0.9400.28
142_P162_S0.9400.28
76_L121_S0.9380.27
263_G309_L0.9350.27
280_P295_L0.9290.27
65_T104_G0.9270.27
239_V248_M0.9270.27
11_L80_E0.9240.27
61_S106_D0.9230.27
13_A94_A0.9160.27
82_L208_A0.9150.26
58_V142_P0.9150.26
18_T217_A0.9140.26
26_A164_S0.9140.26
19_A26_A0.9140.26
129_G248_M0.9020.26
84_I194_E0.8950.26
113_V123_A0.8940.26
22_E254_S0.8940.26
85_D92_T0.8940.26
69_I326_I0.8930.26
38_P106_D0.8920.26
152_L256_V0.8900.25
40_A224_V0.8900.25
85_D90_E0.8900.25
63_C255_F0.8830.25
28_G41_D0.8820.25
291_M327_I0.8810.25
24_I135_L0.8810.25
206_V256_V0.8800.25
166_P210_V0.8740.25
47_Y51_V0.8720.25
14_G163_S0.8710.25
34_M59_S0.8640.24
150_G256_V0.8600.24
137_I217_A0.8580.24
25_S61_S0.8570.24
102_S137_I0.8520.24
119_A198_A0.8520.24
56_V64_P0.8510.24
38_P207_L0.8490.24
40_A180_A0.8480.24
71_R75_E0.8450.24
162_S169_P0.8420.24
210_V235_A0.8380.23
107_I180_A0.8380.23
132_T137_I0.8380.23
7_T24_I0.8370.23
99_T209_V0.8350.23
109_D298_E0.8330.23
236_G268_A0.8330.23
17_R20_A0.8320.23
58_V62_G0.8310.23
184_S273_L0.8280.23
18_T177_V0.8270.23
86_A135_L0.8230.23
127_G138_A0.8160.23
240_R271_Q0.8070.22
33_L298_E0.8070.22
116_A322_V0.8060.22
32_A35_A0.8040.22
113_V116_A0.8040.22
97_V249_T0.8040.22
86_A130_L0.8040.22
179_D321_S0.8040.22
10_A14_G0.8020.22
17_R105_A0.8010.22
45_L83_V0.7980.22
83_V94_A0.7980.22
18_T180_A0.7950.22
198_A203_G0.7950.22
161_V211_A0.7920.22
278_T317_I0.7910.22
65_T169_P0.7890.22
17_R89_A0.7870.22
246_E281_A0.7780.21
117_E318_G0.7760.21
87_G148_A0.7710.21
260_D324_N0.7700.21
137_I179_D0.7690.21
151_V312_A0.7670.21
142_P223_D0.7650.21
150_G255_F0.7650.21
104_G141_I0.7650.21
8_L82_L0.7620.21
17_R35_A0.7620.21
207_L250_L0.7600.21
90_E114_P0.7580.21
7_T326_I0.7540.20
170_V256_V0.7540.20
110_E239_V0.7530.20
128_H318_G0.7500.20
98_T210_V0.7470.20
308_A329_V0.7440.20
68_V157_E0.7420.20
225_T248_M0.7390.20
106_D168_N0.7390.20
55_V176_V0.7390.20
133_D272_D0.7390.20
153_A210_V0.7340.20
92_T147_T0.7310.20
107_I177_V0.7290.20
111_T202_M0.7270.20
32_A237_A0.7240.19
276_T310_A0.7240.19
17_R114_P0.7240.19
224_V275_V0.7210.19
35_A70_T0.7210.19
172_L264_I0.7200.19
22_E274_A0.7180.19
125_E175_R0.7170.19
94_A314_E0.7160.19
287_S325_A0.7130.19
249_T274_A0.7130.19
92_T206_V0.7110.19
320_D324_N0.7090.19
77_V194_E0.7090.19
289_P293_A0.7080.19
43_E306_G0.7080.19
250_L331_D0.7060.19
196_V260_D0.7050.19
233_A264_I0.7030.19
11_L29_A0.7030.19
286_E327_I0.7020.19
119_A141_I0.7020.19
67_A126_F0.7010.19
19_A88_L0.7000.19
33_L326_I0.6910.18
75_E135_L0.6900.18
57_P152_L0.6890.18
180_A202_M0.6870.18
255_F281_A0.6860.18
7_T25_S0.6850.18
227_A256_V0.6840.18
120_Y238_L0.6840.18
118_A122_A0.6820.18
149_M161_V0.6820.18
220_A281_A0.6780.18
128_H220_A0.6760.18
231_Q300_K0.6760.18
110_E119_A0.6760.18
90_E210_V0.6740.18
24_I114_P0.6740.18
206_V305_M0.6740.18
286_E295_L0.6730.18
38_P43_E0.6720.18
169_P216_G0.6700.18
319_M323_R0.6680.18
133_D222_I0.6670.18
121_S124_Y0.6650.18
213_L216_G0.6610.17
137_I175_R0.6610.17
52_R90_E0.6560.17
32_A192_A0.6550.17
18_T120_Y0.6530.17
158_P171_A0.6520.17
94_A206_V0.6510.17
63_C293_A0.6490.17
113_V298_E0.6460.17
72_A281_A0.6440.17
99_T119_A0.6410.17
19_A34_M0.6400.17
27_A41_D0.6390.17
268_A329_V0.6370.17
195_P278_T0.6370.17
85_D101_I0.6350.17
67_A142_P0.6350.17
119_A201_Q0.6350.17
17_R100_G0.6320.17
29_A263_G0.6310.17
255_F283_E0.6310.17
60_P150_G0.6300.17
50_T62_G0.6280.17
28_G37_T0.6280.17
37_T41_D0.6280.17
222_I277_V0.6270.16
262_A282_F0.6260.16
84_I162_S0.6250.16
75_E325_A0.6220.16
21_I286_E0.6220.16
84_I126_F0.6210.16
59_S63_C0.6200.16
153_A177_V0.6160.16
26_A44_L0.6160.16
161_V205_P0.6130.16
283_E295_L0.6130.16
167_N287_S0.6120.16
186_L196_V0.6110.16
18_T150_G0.6110.16
40_A147_T0.6100.16
151_V208_A0.6090.16
77_V317_I0.6070.16
289_P292_A0.6060.16
35_A79_F0.6040.16
137_I186_L0.6020.16
65_T225_T0.6010.16
24_I115_D0.6000.16
29_A166_P0.6000.16
146_T173_K0.5990.16
86_A181_L0.5970.16
14_G278_T0.5970.16
250_L273_L0.5970.16
163_S330_Y0.5970.16
30_D299_A0.5960.16
37_T43_E0.5960.16
69_I280_P0.5950.16
288_H331_D0.5930.16
86_A159_R0.5930.16
266_A309_L0.5920.16
156_G173_K0.5910.15
274_A293_A0.5910.15
134_E314_E0.5910.15
131_H135_L0.5900.15
38_P65_T0.5890.15
131_H303_V0.5880.15
271_Q274_A0.5870.15
178_D199_V0.5870.15
7_T134_E0.5860.15
166_P230_T0.5860.15
40_A300_K0.5850.15
121_S320_D0.5840.15
9_F262_A0.5830.15
44_L150_G0.5820.15
138_A210_V0.5820.15
166_P251_A0.5820.15
194_E320_D0.5810.15
159_R267_L0.5780.15
121_S171_A0.5780.15
261_S268_A0.5770.15
12_A129_G0.5750.15
92_T232_L0.5750.15
71_R146_T0.5750.15
84_I97_V0.5740.15
203_G208_A0.5710.15
160_I239_V0.5710.15
68_V137_I0.5700.15
100_G318_G0.5660.15
9_F256_V0.5650.15
214_A326_I0.5630.15
76_L247_P0.5610.15
34_M106_D0.5600.15
105_A263_G0.5590.15
55_V62_G0.5570.15
47_Y263_G0.5550.15
108_R113_V0.5550.15
15_A106_D0.5550.15
13_A114_P0.5550.15
199_V238_L0.5540.14
255_F282_F0.5530.14
271_Q318_G0.5510.14
106_D119_A0.5510.14
18_T224_V0.5500.14
134_E176_V0.5490.14
154_A309_L0.5480.14
39_S152_L0.5460.14
7_T325_A0.5460.14
254_S281_A0.5440.14
141_I282_F0.5410.14
7_T88_L0.5410.14
14_G122_A0.5410.14
178_D192_A0.5410.14
268_A325_A0.5410.14
133_D318_G0.5400.14
75_E237_A0.5350.14
48_G141_I0.5350.14
165_L172_L0.5350.14
45_L99_T0.5350.14
50_T76_L0.5330.14
33_L59_S0.5330.14
158_P324_N0.5330.14
96_T278_T0.5320.14
77_V308_A0.5310.14
159_R237_A0.5280.14
75_E91_P0.5280.14
214_A234_T0.5280.14
104_G262_A0.5260.14
22_E312_A0.5240.14
14_G236_G0.5240.14
257_A277_V0.5240.14
94_A256_V0.5240.14
71_R116_A0.5240.14
149_M235_A0.5220.14
183_A248_M0.5180.14
249_T312_A0.5180.14
136_V206_V0.5170.14
13_A241_H0.5170.14
73_V227_A0.5150.14
248_M292_A0.5140.13
83_V307_G0.5130.13
123_A140_T0.5130.13
69_I325_A0.5120.13
100_G120_Y0.5110.13
240_R273_L0.5100.13
11_L15_A0.5060.13
34_M108_R0.5050.13
40_A251_A0.5050.13
99_T177_V0.5050.13
147_T231_Q0.5040.13
285_R320_D0.5030.13
116_A250_L0.5020.13
121_S137_I0.5010.13
45_L295_L0.5010.13
102_S114_P0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u4gA 2 0.958 100 0.314 Contact Map
3l0zA 2 0.979 100 0.359 Contact Map
1wx1A 2 0.7928 100 0.748 Contact Map
4hdrA 1 0.8018 100 0.751 Contact Map
4kqiA 2 0.8078 100 0.753 Contact Map
4hdrB 1 0.8018 100 0.764 Contact Map
2o8vA 2 0.4715 25.7 0.975 Contact Map
4mg4A 4 0.4054 17.7 0.977 Contact Map
2an7A 2 0.1171 15.2 0.978 Contact Map
3wg6A 1 0.2643 13.6 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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