Y1572 - HALSA - GREMLIN Contacts

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Y1572 - UPF0284 protein VNG_1572C

UniProt:	Q9HPL8	Sequences: MSGTPDTLFALAAGATRTAAIEGISAAGADPALMAHTPSADAELLTYGHTVRAPVVPVSPSGCPTPAVITRAVRELVGFESLVIDAGLAEPTGAPTVTTGISPGADIRDETPVPDAEAAYSAAYEFGHGLHTDELVIAETIPGGTTTAMGVLAALGEPRIVSSSLPNNPVALKERVVDDALAASGLEQGDLAGEPVAAVRQMGDPVLAVVAGLAAGALDAGIDVTLAGGTQLATAGALVRHDGVTEPMTLATTSFVAGDDSAGIDALAADQDLAVTVTDPAFEARESHPAMAAYLDGEAKEGVGMGGALALAAEAGIGMDSVRNAIISVYDRV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (316)
Sequences:	311 (231)
Seq/√Len:	13.0

HALSA - Y1572
SULSO - Y2213

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
263_G	266_A	5.368	1.00
154_A	198_A	5.013	1.00
214_A	239_V	4.171	1.00
116_A	200_R	3.615	0.99
12_A	210_V	3.553	0.99
280_P	309_L	3.407	0.99
22_E	31_P	3.381	0.98
181_L	202_M	3.124	0.97
13_A	140_T	3.011	0.97
9_F	304_G	3.000	0.97
108_R	176_V	2.858	0.95
124_Y	215_A	2.758	0.94
153_A	174_E	2.674	0.93
323_R	327_I	2.624	0.93
254_S	258_G	2.604	0.92
29_A	40_A	2.451	0.90
257_A	265_D	2.417	0.89
233_A	268_A	2.373	0.88
56_V	59_S	2.350	0.88
70_T	316_G	2.310	0.87
322_V	326_I	2.288	0.86
58_V	61_S	2.283	0.86
137_I	307_G	2.247	0.85
150_G	180_A	2.245	0.85
255_F	280_P	2.204	0.84
25_S	143_G	2.172	0.83
131_H	274_A	2.168	0.83
69_I	305_M	2.132	0.82
85_D	98_T	2.113	0.81
227_A	307_G	2.113	0.81
251_A	310_A	2.075	0.80
151_V	198_A	2.070	0.80
255_F	295_L	2.060	0.80
264_I	268_A	2.006	0.78
86_A	99_T	1.977	0.77
232_L	235_A	1.977	0.77
18_T	107_I	1.957	0.76
214_A	248_M	1.929	0.75
64_P	330_Y	1.924	0.75
14_G	206_V	1.896	0.74
74_R	79_F	1.892	0.74
104_G	205_P	1.878	0.73
112_P	207_L	1.870	0.73
207_L	235_A	1.843	0.71
11_L	42_A	1.814	0.70
123_A	213_L	1.803	0.70
59_S	62_G	1.793	0.69
112_P	203_G	1.774	0.68
104_G	168_N	1.748	0.67
225_T	251_A	1.747	0.67
98_T	101_I	1.741	0.67
162_S	168_N	1.732	0.67
325_A	328_S	1.728	0.66
64_P	290_A	1.713	0.66
56_V	61_S	1.693	0.65
45_L	150_G	1.691	0.65
269_A	307_G	1.674	0.64
70_T	308_A	1.667	0.63
177_V	181_L	1.658	0.63
59_S	64_P	1.630	0.62
58_V	64_P	1.597	0.60
143_G	209_V	1.590	0.60
13_A	88_L	1.577	0.59
206_V	210_V	1.533	0.57
82_L	126_F	1.504	0.55
38_P	108_R	1.473	0.54
123_A	314_E	1.447	0.52
141_I	206_V	1.436	0.52
112_P	195_P	1.429	0.51
135_L	212_G	1.390	0.49
149_M	159_R	1.389	0.49
99_T	250_L	1.368	0.48
142_P	169_P	1.365	0.48
65_T	141_I	1.364	0.48
194_E	197_A	1.355	0.47
120_Y	196_V	1.331	0.46
18_T	164_S	1.317	0.45
45_L	303_V	1.312	0.45
63_C	243_G	1.307	0.45
18_T	202_M	1.297	0.44
259_D	300_K	1.294	0.44
240_R	272_D	1.280	0.44
135_L	217_A	1.268	0.43
223_D	277_V	1.264	0.43
196_V	272_D	1.241	0.42
130_L	237_A	1.241	0.42
269_A	331_D	1.232	0.41
256_V	264_I	1.229	0.41
136_V	271_Q	1.222	0.41
56_V	62_G	1.219	0.40
64_P	142_P	1.218	0.40
82_L	97_V	1.206	0.40
162_S	264_I	1.202	0.40
10_A	128_H	1.201	0.40
73_V	257_A	1.192	0.39
150_G	177_V	1.191	0.39
150_G	214_A	1.188	0.39
291_M	316_G	1.187	0.39
155_L	237_A	1.187	0.39
32_A	308_A	1.186	0.39
29_A	184_S	1.182	0.39
307_G	316_G	1.171	0.38
103_P	248_M	1.170	0.38
30_D	34_M	1.164	0.38
69_I	309_L	1.155	0.37
174_E	178_D	1.154	0.37
102_S	105_A	1.152	0.37
251_A	276_T	1.148	0.37
33_L	308_A	1.136	0.36
149_M	153_A	1.136	0.36
64_P	138_A	1.133	0.36
121_S	316_G	1.131	0.36
254_S	295_L	1.130	0.36
227_A	314_E	1.129	0.36
236_G	248_M	1.117	0.35
179_D	269_A	1.114	0.35
131_H	308_A	1.113	0.35
14_G	84_I	1.111	0.35
17_R	266_A	1.109	0.35
233_A	267_L	1.108	0.35
166_P	257_A	1.108	0.35
65_T	309_L	1.108	0.35
13_A	305_M	1.105	0.35
131_H	311_L	1.105	0.35
86_A	123_A	1.099	0.35
154_A	257_A	1.089	0.34
151_V	203_G	1.089	0.34
33_L	119_A	1.087	0.34
265_D	275_V	1.073	0.33
199_V	268_A	1.070	0.33
163_S	259_D	1.064	0.33
162_S	230_T	1.058	0.33
59_S	65_T	1.055	0.33
195_P	280_P	1.055	0.33
104_G	250_L	1.053	0.32
150_G	154_A	1.050	0.32
287_S	327_I	1.047	0.32
71_R	163_S	1.046	0.32
162_S	262_A	1.041	0.32
121_S	214_A	1.039	0.32
24_I	180_A	1.032	0.32
29_A	33_L	1.032	0.32
193_G	197_A	1.029	0.31
242_D	318_G	1.028	0.31
7_T	11_L	1.028	0.31
120_Y	212_G	1.025	0.31
146_T	327_I	1.024	0.31
266_A	270_D	1.024	0.31
38_P	59_S	1.021	0.31
158_P	182_A	1.020	0.31
175_R	179_D	1.013	0.31
61_S	64_P	1.010	0.31
115_D	118_A	0.997	0.30
141_I	256_V	0.997	0.30
46_T	114_P	0.995	0.30
95_P	290_A	0.990	0.30
126_F	169_P	0.989	0.30
48_G	267_L	0.987	0.30
134_E	326_I	0.982	0.29
107_I	150_G	0.980	0.29
16_T	27_A	0.976	0.29
86_A	209_V	0.974	0.29
230_T	326_I	0.973	0.29
100_G	103_P	0.969	0.29
34_M	38_P	0.969	0.29
287_S	331_D	0.964	0.29
225_T	264_I	0.955	0.28
149_M	177_V	0.955	0.28
78_G	113_V	0.955	0.28
234_T	305_M	0.951	0.28
164_S	238_L	0.943	0.28
205_P	234_T	0.940	0.28
142_P	162_S	0.940	0.28
76_L	121_S	0.938	0.27
263_G	309_L	0.935	0.27
280_P	295_L	0.929	0.27
65_T	104_G	0.927	0.27
239_V	248_M	0.927	0.27
11_L	80_E	0.924	0.27
61_S	106_D	0.923	0.27
13_A	94_A	0.916	0.27
82_L	208_A	0.915	0.26
58_V	142_P	0.915	0.26
18_T	217_A	0.914	0.26
26_A	164_S	0.914	0.26
19_A	26_A	0.914	0.26
129_G	248_M	0.902	0.26
84_I	194_E	0.895	0.26
113_V	123_A	0.894	0.26
22_E	254_S	0.894	0.26
85_D	92_T	0.894	0.26
69_I	326_I	0.893	0.26
38_P	106_D	0.892	0.26
152_L	256_V	0.890	0.25
40_A	224_V	0.890	0.25
85_D	90_E	0.890	0.25
63_C	255_F	0.883	0.25
28_G	41_D	0.882	0.25
291_M	327_I	0.881	0.25
24_I	135_L	0.881	0.25
206_V	256_V	0.880	0.25
166_P	210_V	0.874	0.25
47_Y	51_V	0.872	0.25
14_G	163_S	0.871	0.25
34_M	59_S	0.864	0.24
150_G	256_V	0.860	0.24
137_I	217_A	0.858	0.24
25_S	61_S	0.857	0.24
102_S	137_I	0.852	0.24
119_A	198_A	0.852	0.24
56_V	64_P	0.851	0.24
38_P	207_L	0.849	0.24
40_A	180_A	0.848	0.24
71_R	75_E	0.845	0.24
162_S	169_P	0.842	0.24
210_V	235_A	0.838	0.23
107_I	180_A	0.838	0.23
132_T	137_I	0.838	0.23
7_T	24_I	0.837	0.23
99_T	209_V	0.835	0.23
109_D	298_E	0.833	0.23
236_G	268_A	0.833	0.23
17_R	20_A	0.832	0.23
58_V	62_G	0.831	0.23
184_S	273_L	0.828	0.23
18_T	177_V	0.827	0.23
86_A	135_L	0.823	0.23
127_G	138_A	0.816	0.23
240_R	271_Q	0.807	0.22
33_L	298_E	0.807	0.22
116_A	322_V	0.806	0.22
32_A	35_A	0.804	0.22
113_V	116_A	0.804	0.22
97_V	249_T	0.804	0.22
86_A	130_L	0.804	0.22
179_D	321_S	0.804	0.22
10_A	14_G	0.802	0.22
17_R	105_A	0.801	0.22
45_L	83_V	0.798	0.22
83_V	94_A	0.798	0.22
18_T	180_A	0.795	0.22
198_A	203_G	0.795	0.22
161_V	211_A	0.792	0.22
278_T	317_I	0.791	0.22
65_T	169_P	0.789	0.22
17_R	89_A	0.787	0.22
246_E	281_A	0.778	0.21
117_E	318_G	0.776	0.21
87_G	148_A	0.771	0.21
260_D	324_N	0.770	0.21
137_I	179_D	0.769	0.21
151_V	312_A	0.767	0.21
142_P	223_D	0.765	0.21
150_G	255_F	0.765	0.21
104_G	141_I	0.765	0.21
8_L	82_L	0.762	0.21
17_R	35_A	0.762	0.21
207_L	250_L	0.760	0.21
90_E	114_P	0.758	0.21
7_T	326_I	0.754	0.20
170_V	256_V	0.754	0.20
110_E	239_V	0.753	0.20
128_H	318_G	0.750	0.20
98_T	210_V	0.747	0.20
308_A	329_V	0.744	0.20
68_V	157_E	0.742	0.20
225_T	248_M	0.739	0.20
106_D	168_N	0.739	0.20
55_V	176_V	0.739	0.20
133_D	272_D	0.739	0.20
153_A	210_V	0.734	0.20
92_T	147_T	0.731	0.20
107_I	177_V	0.729	0.20
111_T	202_M	0.727	0.20
32_A	237_A	0.724	0.19
276_T	310_A	0.724	0.19
17_R	114_P	0.724	0.19
224_V	275_V	0.721	0.19
35_A	70_T	0.721	0.19
172_L	264_I	0.720	0.19
22_E	274_A	0.718	0.19
125_E	175_R	0.717	0.19
94_A	314_E	0.716	0.19
287_S	325_A	0.713	0.19
249_T	274_A	0.713	0.19
92_T	206_V	0.711	0.19
320_D	324_N	0.709	0.19
77_V	194_E	0.709	0.19
289_P	293_A	0.708	0.19
43_E	306_G	0.708	0.19
250_L	331_D	0.706	0.19
196_V	260_D	0.705	0.19
233_A	264_I	0.703	0.19
11_L	29_A	0.703	0.19
286_E	327_I	0.702	0.19
119_A	141_I	0.702	0.19
67_A	126_F	0.701	0.19
19_A	88_L	0.700	0.19
33_L	326_I	0.691	0.18
75_E	135_L	0.690	0.18
57_P	152_L	0.689	0.18
180_A	202_M	0.687	0.18
255_F	281_A	0.686	0.18
7_T	25_S	0.685	0.18
227_A	256_V	0.684	0.18
120_Y	238_L	0.684	0.18
118_A	122_A	0.682	0.18
149_M	161_V	0.682	0.18
220_A	281_A	0.678	0.18
128_H	220_A	0.676	0.18
231_Q	300_K	0.676	0.18
110_E	119_A	0.676	0.18
90_E	210_V	0.674	0.18
24_I	114_P	0.674	0.18
206_V	305_M	0.674	0.18
286_E	295_L	0.673	0.18
38_P	43_E	0.672	0.18
169_P	216_G	0.670	0.18
319_M	323_R	0.668	0.18
133_D	222_I	0.667	0.18
121_S	124_Y	0.665	0.18
213_L	216_G	0.661	0.17
137_I	175_R	0.661	0.17
52_R	90_E	0.656	0.17
32_A	192_A	0.655	0.17
18_T	120_Y	0.653	0.17
158_P	171_A	0.652	0.17
94_A	206_V	0.651	0.17
63_C	293_A	0.649	0.17
113_V	298_E	0.646	0.17
72_A	281_A	0.644	0.17
99_T	119_A	0.641	0.17
19_A	34_M	0.640	0.17
27_A	41_D	0.639	0.17
268_A	329_V	0.637	0.17
195_P	278_T	0.637	0.17
85_D	101_I	0.635	0.17
67_A	142_P	0.635	0.17
119_A	201_Q	0.635	0.17
17_R	100_G	0.632	0.17
29_A	263_G	0.631	0.17
255_F	283_E	0.631	0.17
60_P	150_G	0.630	0.17
50_T	62_G	0.628	0.17
28_G	37_T	0.628	0.17
37_T	41_D	0.628	0.17
222_I	277_V	0.627	0.16
262_A	282_F	0.626	0.16
84_I	162_S	0.625	0.16
75_E	325_A	0.622	0.16
21_I	286_E	0.622	0.16
84_I	126_F	0.621	0.16
59_S	63_C	0.620	0.16
153_A	177_V	0.616	0.16
26_A	44_L	0.616	0.16
161_V	205_P	0.613	0.16
283_E	295_L	0.613	0.16
167_N	287_S	0.612	0.16
186_L	196_V	0.611	0.16
18_T	150_G	0.611	0.16
40_A	147_T	0.610	0.16
151_V	208_A	0.609	0.16
77_V	317_I	0.607	0.16
289_P	292_A	0.606	0.16
35_A	79_F	0.604	0.16
137_I	186_L	0.602	0.16
65_T	225_T	0.601	0.16
24_I	115_D	0.600	0.16
29_A	166_P	0.600	0.16
146_T	173_K	0.599	0.16
86_A	181_L	0.597	0.16
14_G	278_T	0.597	0.16
250_L	273_L	0.597	0.16
163_S	330_Y	0.597	0.16
30_D	299_A	0.596	0.16
37_T	43_E	0.596	0.16
69_I	280_P	0.595	0.16
288_H	331_D	0.593	0.16
86_A	159_R	0.593	0.16
266_A	309_L	0.592	0.16
156_G	173_K	0.591	0.15
274_A	293_A	0.591	0.15
134_E	314_E	0.591	0.15
131_H	135_L	0.590	0.15
38_P	65_T	0.589	0.15
131_H	303_V	0.588	0.15
271_Q	274_A	0.587	0.15
178_D	199_V	0.587	0.15
7_T	134_E	0.586	0.15
166_P	230_T	0.586	0.15
40_A	300_K	0.585	0.15
121_S	320_D	0.584	0.15
9_F	262_A	0.583	0.15
44_L	150_G	0.582	0.15
138_A	210_V	0.582	0.15
166_P	251_A	0.582	0.15
194_E	320_D	0.581	0.15
159_R	267_L	0.578	0.15
121_S	171_A	0.578	0.15
261_S	268_A	0.577	0.15
12_A	129_G	0.575	0.15
92_T	232_L	0.575	0.15
71_R	146_T	0.575	0.15
84_I	97_V	0.574	0.15
203_G	208_A	0.571	0.15
160_I	239_V	0.571	0.15
68_V	137_I	0.570	0.15
100_G	318_G	0.566	0.15
9_F	256_V	0.565	0.15
214_A	326_I	0.563	0.15
76_L	247_P	0.561	0.15
34_M	106_D	0.560	0.15
105_A	263_G	0.559	0.15
55_V	62_G	0.557	0.15
47_Y	263_G	0.555	0.15
108_R	113_V	0.555	0.15
15_A	106_D	0.555	0.15
13_A	114_P	0.555	0.15
199_V	238_L	0.554	0.14
255_F	282_F	0.553	0.14
271_Q	318_G	0.551	0.14
106_D	119_A	0.551	0.14
18_T	224_V	0.550	0.14
134_E	176_V	0.549	0.14
154_A	309_L	0.548	0.14
39_S	152_L	0.546	0.14
7_T	325_A	0.546	0.14
254_S	281_A	0.544	0.14
141_I	282_F	0.541	0.14
7_T	88_L	0.541	0.14
14_G	122_A	0.541	0.14
178_D	192_A	0.541	0.14
268_A	325_A	0.541	0.14
133_D	318_G	0.540	0.14
75_E	237_A	0.535	0.14
48_G	141_I	0.535	0.14
165_L	172_L	0.535	0.14
45_L	99_T	0.535	0.14
50_T	76_L	0.533	0.14
33_L	59_S	0.533	0.14
158_P	324_N	0.533	0.14
96_T	278_T	0.532	0.14
77_V	308_A	0.531	0.14
159_R	237_A	0.528	0.14
75_E	91_P	0.528	0.14
214_A	234_T	0.528	0.14
104_G	262_A	0.526	0.14
22_E	312_A	0.524	0.14
14_G	236_G	0.524	0.14
257_A	277_V	0.524	0.14
94_A	256_V	0.524	0.14
71_R	116_A	0.524	0.14
149_M	235_A	0.522	0.14
183_A	248_M	0.518	0.14
249_T	312_A	0.518	0.14
136_V	206_V	0.517	0.14
13_A	241_H	0.517	0.14
73_V	227_A	0.515	0.14
248_M	292_A	0.514	0.13
83_V	307_G	0.513	0.13
123_A	140_T	0.513	0.13
69_I	325_A	0.512	0.13
100_G	120_Y	0.511	0.13
240_R	273_L	0.510	0.13
11_L	15_A	0.506	0.13
34_M	108_R	0.505	0.13
40_A	251_A	0.505	0.13
99_T	177_V	0.505	0.13
147_T	231_Q	0.504	0.13
285_R	320_D	0.503	0.13
116_A	250_L	0.502	0.13
121_S	137_I	0.501	0.13
45_L	295_L	0.501	0.13
102_S	114_P	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3u4gA	2	0.958	100	0.314	Contact Map
3l0zA	2	0.979	100	0.359	Contact Map
1wx1A	2	0.7928	100	0.748	Contact Map
4hdrA	1	0.8018	100	0.751	Contact Map
4kqiA	2	0.8078	100	0.753	Contact Map
4hdrB	1	0.8018	100	0.764	Contact Map
2o8vA	2	0.4715	25.7	0.975	Contact Map
4mg4A	4	0.4054	17.7	0.977	Contact Map
2an7A	2	0.1171	15.2	0.978	Contact Map
3wg6A	1	0.2643	13.6	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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