GREMLIN Database
CBIA - Cobyrinate a,c-diamide synthase
UniProt: Q9HPL7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (420)
Sequences: 2249 (1673)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_V106_T4.7031.00
313_A319_V4.2711.00
135_L139_A4.1821.00
245_A283_C4.1571.00
129_S137_F4.1361.00
243_T268_D3.8951.00
312_R317_L3.6861.00
37_D210_D3.5721.00
92_V115_L3.3311.00
388_S424_Y3.2281.00
182_P215_H3.0531.00
255_A289_P3.0201.00
122_D157_R3.0191.00
286_V309_L2.9731.00
38_A213_A2.9431.00
332_S350_D2.7801.00
250_A276_A2.7391.00
82_Y113_L2.6851.00
164_A168_R2.6471.00
313_A420_T2.5891.00
111_S141_A2.5871.00
212_A216_V2.5851.00
17_G22_V2.5521.00
44_P61_V2.5461.00
28_T32_A2.5071.00
12_G115_L2.4911.00
331_E348_P2.4741.00
260_R269_V2.4171.00
38_A219_K2.3731.00
141_A147_D2.3581.00
332_S340_T2.3251.00
111_S147_D2.2161.00
30_A212_A2.2161.00
37_D213_A2.1941.00
32_A61_V2.1821.00
298_D302_D2.1431.00
246_V271_T2.1381.00
178_F224_V2.1061.00
375_G378_A2.0691.00
121_V134_A2.0661.00
164_A180_R2.0631.00
331_E350_D2.0571.00
280_L308_T2.0181.00
313_A346_V1.9731.00
155_A171_L1.9641.00
118_V221_I1.9311.00
279_D308_T1.9231.00
364_E379_T1.9151.00
244_V267_A1.9011.00
47_A109_V1.8981.00
309_L344_A1.8971.00
32_A44_P1.8951.00
37_D206_D1.8781.00
370_D375_G1.8781.00
243_T270_V1.8071.00
27_A181_V1.7831.00
248_D271_T1.7751.00
57_H65_S1.7731.00
15_L120_V1.7711.00
176_T220_R1.7691.00
134_A175_L1.7681.00
74_G77_G1.7471.00
364_E381_R1.7431.00
247_A272_F1.7431.00
134_A171_L1.7371.00
307_D311_A1.7101.00
84_Q265_E1.6761.00
43_Q63_T1.6751.00
33_R206_D1.6621.00
32_A57_H1.6571.00
33_R37_D1.6551.00
257_P264_R1.6491.00
71_W381_R1.6461.00
35_L89_V1.6401.00
131_A170_A1.6381.00
334_T340_T1.6381.00
370_D376_S1.6311.00
37_D209_V1.6251.00
264_R271_T1.6131.00
365_L425_A1.6131.00
155_A177_Y1.6111.00
367_A374_A1.6081.00
327_M351_V1.6011.00
296_H299_A1.6001.00
286_V317_L1.5991.00
301_A342_E1.5961.00
257_P261_E1.5901.00
330_A349_A1.5891.00
280_L283_C1.5891.00
126_G133_T1.5831.00
330_A351_V1.5771.00
347_L420_T1.5771.00
366_R379_T1.5641.00
18_T22_V1.5631.00
310_G314_A1.5591.00
14_V115_L1.5501.00
305_A308_T1.5300.99
161_G182_P1.5240.99
34_A218_A1.5230.99
118_V154_L1.5180.99
261_E264_R1.5130.99
314_A418_Y1.5000.99
209_V213_A1.4940.99
246_V269_V1.4920.99
277_G306_L1.4870.99
27_A154_L1.4800.99
114_D149_D1.4670.99
198_M253_C1.4600.99
75_T108_R1.4450.99
366_R401_A1.4400.99
353_M424_Y1.4380.99
220_R223_D1.4380.99
303_A306_L1.4370.99
89_V222_A1.4340.99
47_A95_M1.4340.99
297_T341_A1.4200.99
13_V91_V1.4050.99
216_V221_I1.4030.99
40_H88_D1.3990.99
353_M388_S1.3970.99
319_V420_T1.3890.99
13_V225_A1.3880.99
118_V178_F1.3830.99
32_A91_V1.3570.99
12_G228_P1.3440.99
246_V260_R1.3410.99
124_S157_R1.3410.99
66_R261_E1.3110.98
244_V285_G1.2990.98
303_A328_A1.2850.98
327_M388_S1.2850.98
32_A65_S1.2820.98
354_Q389_A1.2800.98
308_T312_R1.2680.98
123_A167_I1.2670.98
184_R211_A1.2650.98
340_T350_D1.2640.98
40_H222_A1.2560.98
245_A286_V1.2500.98
247_A274_P1.2490.98
41_D88_D1.2410.98
27_A120_V1.2340.98
117_V148_V1.2260.97
297_T333_L1.2250.97
288_L309_L1.2230.97
70_P112_E1.2200.97
121_V130_V1.2190.97
13_V118_V1.2150.97
70_P109_V1.2090.97
141_A148_V1.2050.97
16_G117_V1.2050.97
95_M106_T1.2010.97
33_R209_V1.1990.97
82_Y115_L1.1970.97
135_L140_Y1.1880.97
185_D188_D1.1820.97
327_M333_L1.1780.97
264_R268_D1.1690.97
180_R215_H1.1650.97
198_M292_Y1.1630.97
138_Q150_V1.1490.96
335_T339_D1.1480.96
12_G82_Y1.1440.96
243_T283_C1.1390.96
306_L309_L1.1380.96
210_D214_A1.1370.96
58_E66_R1.1330.96
334_T350_D1.1320.96
98_L148_V1.1320.96
225_A228_P1.1300.96
300_L328_A1.1290.96
249_D273_S1.1290.96
335_T341_A1.1250.96
334_T352_R1.1100.95
329_L420_T1.0990.95
89_V225_A1.0990.95
321_G422_G1.0970.95
365_L402_V1.0950.95
161_G165_D1.0930.95
159_H183_P1.0860.95
12_G114_D1.0860.95
103_V108_R1.0840.95
35_L222_A1.0840.95
242_Q267_A1.0830.95
270_V283_C1.0810.95
80_R84_Q1.0810.95
44_P65_S1.0750.95
306_L328_A1.0740.95
292_Y295_L1.0700.94
77_G81_T1.0670.94
41_D86_D1.0580.94
151_A224_V1.0480.94
280_L306_L1.0480.94
142_A147_D1.0430.94
79_R112_E1.0360.93
123_A158_A1.0360.93
78_M109_V1.0330.93
111_S148_V1.0330.93
277_G303_A1.0310.93
41_D63_T1.0310.93
63_T87_G1.0270.93
128_Q140_Y1.0220.93
178_F220_R1.0150.93
186_D207_D1.0130.93
352_R389_A1.0090.92
11_D228_P1.0090.92
349_A390_A1.0080.92
119_L129_S0.9980.92
259_T429_P0.9970.92
319_V346_V0.9910.92
211_A215_H0.9890.92
400_F421_L0.9800.91
187_L211_A0.9780.91
350_D391_T0.9750.91
10_M90_C0.9720.91
330_A390_A0.9710.91
286_V319_V0.9710.91
374_A378_A0.9690.91
15_L118_V0.9660.91
287_Y320_L0.9630.91
165_D169_D0.9600.91
126_G130_V0.9580.90
75_T112_E0.9570.90
123_A155_A0.9560.90
181_V211_A0.9530.90
107_A148_V0.9520.90
104_A109_V0.9460.90
404_R408_I0.9390.90
178_F221_I0.9380.89
258_A261_E0.9370.89
368_T401_A0.9370.89
102_S128_Q0.9340.89
158_A167_I0.9320.89
371_T374_A0.9240.89
18_T137_F0.9180.88
55_S198_M0.9160.88
34_A38_A0.9150.88
277_G328_A0.9100.88
35_L40_H0.9090.88
312_R319_V0.9090.88
330_A347_L0.9080.88
331_E349_A0.9060.88
17_G137_F0.9060.88
19_A22_V0.9030.88
43_Q87_G0.9010.88
56_H205_D0.8980.87
19_A122_D0.8920.87
133_T137_F0.8920.87
70_P78_M0.8890.87
12_G92_V0.8870.87
45_A90_C0.8870.87
363_V404_R0.8850.87
43_Q58_E0.8850.87
327_M343_M0.8850.87
241_G268_D0.8840.86
78_M112_E0.8800.86
285_G318_P0.8800.86
106_T115_L0.8750.86
278_D303_A0.8750.86
27_A212_A0.8740.86
33_R60_V0.8710.86
286_V312_R0.8700.86
206_D209_V0.8650.85
58_E64_P0.8630.85
63_T86_D0.8620.85
191_D387_Y0.8610.85
110_A117_V0.8590.85
217_A220_R0.8570.85
98_L117_V0.8550.85
142_A148_V0.8520.84
38_A222_A0.8510.84
31_V212_A0.8480.84
162_R165_D0.8420.84
96_M127_M0.8410.84
184_R187_L0.8400.84
155_A180_R0.8400.84
26_V57_H0.8390.83
259_T263_L0.8370.83
301_A341_A0.8360.83
304_P307_D0.8340.83
311_A315_D0.8320.83
320_L421_L0.8300.83
243_T284_D0.8300.83
307_D310_G0.8250.82
312_R315_D0.8250.82
352_R391_T0.8170.82
210_D213_A0.8150.82
157_R183_P0.8100.81
331_E345_G0.8070.81
102_S111_S0.8040.81
59_P205_D0.8000.80
98_L141_A0.7980.80
119_L137_F0.7960.80
114_D229_P0.7950.80
335_T338_G0.7930.80
168_R172_P0.7920.80
70_P108_R0.7910.80
57_H61_V0.7860.79
378_A434_F0.7830.79
171_L177_Y0.7810.79
71_W272_F0.7810.79
313_A344_A0.7810.79
99_Y148_V0.7800.79
92_V113_L0.7770.79
224_V228_P0.7770.79
278_D306_L0.7760.78
278_D305_A0.7760.78
135_L138_Q0.7730.78
52_I193_H0.7730.78
76_D298_D0.7720.78
242_Q245_A0.7710.78
228_P231_P0.7680.78
298_D339_D0.7640.77
55_S199_G0.7600.77
413_D425_A0.7600.77
346_V420_T0.7570.77
280_L303_A0.7550.77
47_A106_T0.7550.77
176_T179_G0.7540.76
330_A333_L0.7520.76
310_G344_A0.7480.76
198_M201_E0.7460.76
131_A140_Y0.7440.75
259_T287_Y0.7440.75
108_R112_E0.7440.75
96_M100_D0.7420.75
52_I56_H0.7410.75
359_A389_A0.7380.75
40_H89_V0.7370.75
250_A299_A0.7320.74
367_A378_A0.7320.74
239_D242_Q0.7320.74
94_G106_T0.7320.74
96_M191_D0.7310.74
198_M295_L0.7290.74
283_C317_L0.7280.74
73_S81_T0.7280.74
299_A310_G0.7270.74
430_E433_A0.7270.74
11_D225_A0.7260.74
81_T109_V0.7240.73
51_F253_C0.7240.73
31_V35_L0.7240.73
231_P235_D0.7230.73
207_D210_D0.7220.73
18_T129_S0.7210.73
334_T338_G0.7210.73
368_T412_H0.7210.73
168_R217_A0.7190.73
280_L312_R0.7190.73
115_L228_P0.7160.73
200_S248_D0.7140.72
19_A126_G0.7130.72
164_A182_P0.7130.72
211_A214_A0.7130.72
309_L328_A0.7080.72
35_L91_V0.7060.72
367_A371_T0.7050.71
33_R36_A0.7040.71
73_S78_M0.7010.71
36_A60_V0.7000.71
12_G229_P0.6990.71
71_W104_A0.6980.71
11_D227_T0.6980.71
323_C426_H0.6980.71
98_L107_A0.6950.70
123_A177_Y0.6950.70
32_A42_V0.6920.70
100_D361_D0.6920.70
219_K222_A0.6900.70
129_S133_T0.6890.70
13_V221_I0.6870.70
297_T301_A0.6870.70
360_L411_D0.6870.70
121_V137_F0.6840.69
16_G95_M0.6840.69
194_L383_H0.6810.69
367_A370_D0.6800.69
15_L221_I0.6790.69
25_T196_L0.6790.69
360_L363_V0.6750.68
311_A314_A0.6740.68
354_Q358_Q0.6740.68
127_M166_G0.6720.68
255_A269_V0.6710.68
402_V425_A0.6680.67
253_C292_Y0.6670.67
82_Y90_C0.6670.67
160_G183_P0.6660.67
66_R258_A0.6660.67
366_R403_E0.6650.67
14_V92_V0.6650.67
208_A213_A0.6630.67
332_S342_E0.6620.67
243_T271_T0.6610.67
155_A167_I0.6600.66
71_W364_E0.6580.66
404_R409_D0.6560.66
247_A273_S0.6550.66
56_H202_A0.6530.66
415_L422_G0.6510.65
272_F306_L0.6510.65
369_G397_R0.6500.65
405_G408_I0.6500.65
130_V155_A0.6450.65
189_V208_A0.6420.64
283_C286_V0.6410.64
107_A141_A0.6400.64
282_A337_D0.6380.64
220_R224_V0.6380.64
58_E61_V0.6370.64
160_G163_H0.6360.64
72_L259_T0.6360.64
326_L390_A0.6340.63
35_L218_A0.6340.63
15_L27_A0.6330.63
193_H323_C0.6310.63
209_V216_V0.6280.63
314_A417_E0.6280.63
182_P211_A0.6270.62
320_L427_V0.6270.62
334_T391_T0.6260.62
15_L131_A0.6260.62
326_L422_G0.6260.62
34_A213_A0.6250.62
34_A209_V0.6240.62
326_L423_T0.6240.62
279_D306_L0.6230.62
159_H163_H0.6220.62
74_G78_M0.6210.62
51_F327_M0.6200.62
76_D79_R0.6190.62
55_S253_C0.6190.62
313_A347_L0.6190.62
36_A61_V0.6180.61
224_V227_T0.6160.61
295_L387_Y0.6160.61
404_R411_D0.6130.61
172_P216_V0.6110.61
150_V175_L0.6110.61
189_V202_A0.6110.61
64_P257_P0.6100.60
194_L323_C0.6100.60
152_G178_F0.6080.60
102_S141_A0.6070.60
76_D223_D0.6070.60
367_A377_G0.6070.60
75_T79_R0.6050.60
164_A177_Y0.6050.60
363_V384_E0.6050.60
167_I171_L0.6040.60
391_T395_D0.6030.60
44_P424_Y0.6010.59
72_L382_G0.6000.59
382_G425_A0.5980.59
373_T377_G0.5970.59
50_D53_D0.5970.59
370_D373_T0.5970.59
212_A215_H0.5960.59
402_V405_G0.5960.59
400_F404_R0.5940.58
394_S417_E0.5940.58
333_L343_M0.5940.58
364_E403_E0.5930.58
159_H359_A0.5920.58
429_P432_T0.5920.58
111_S149_D0.5910.58
358_Q389_A0.5890.58
327_M330_A0.5880.58
192_R254_F0.5870.57
67_S362_H0.5860.57
238_P299_A0.5860.57
11_D226_R0.5850.57
70_P74_G0.5850.57
208_A216_V0.5850.57
298_D341_A0.5850.57
367_A416_T0.5840.57
26_V353_M0.5830.57
270_V285_G0.5820.57
316_G419_R0.5820.57
30_A209_V0.5810.57
61_V65_S0.5800.57
96_M166_G0.5800.57
168_R177_Y0.5780.56
279_D282_A0.5780.56
70_P104_A0.5770.56
310_G319_V0.5750.56
72_L428_H0.5740.56
130_V167_I0.5740.56
275_V361_D0.5730.56
159_H360_L0.5730.56
276_A306_L0.5730.56
36_A89_V0.5710.55
153_V171_L0.5700.55
273_S306_L0.5700.55
313_A316_G0.5690.55
416_T419_R0.5680.55
99_Y162_R0.5670.55
30_A34_A0.5670.55
288_L324_G0.5670.55
31_V218_A0.5670.55
277_G305_A0.5660.55
29_L60_V0.5660.55
66_R428_H0.5650.55
30_A181_V0.5640.54
14_V109_V0.5630.54
398_F408_I0.5620.54
189_V197_H0.5620.54
184_R207_D0.5610.54
96_M361_D0.5600.54
401_A412_H0.5590.54
261_E265_E0.5590.54
150_V154_L0.5590.54
245_A270_V0.5590.54
96_M194_L0.5580.54
255_A287_Y0.5580.54
20_S96_M0.5570.54
355_D389_A0.5570.54
277_G308_T0.5550.53
31_V221_I0.5550.53
347_L415_L0.5550.53
260_R271_T0.5540.53
245_A288_L0.5530.53
178_F218_A0.5520.53
324_G327_M0.5520.53
49_P100_D0.5510.53
254_F323_C0.5510.53
155_A164_A0.5510.53
404_R407_G0.5510.53
160_G360_L0.5480.52
177_Y180_R0.5470.52
66_R85_G0.5470.52
279_D305_A0.5460.52
124_S183_P0.5450.52
33_R212_A0.5440.52
79_R378_A0.5440.52
128_Q289_P0.5430.52
68_L78_M0.5430.52
254_F385_F0.5430.52
402_V413_D0.5420.52
37_D214_A0.5410.51
191_D327_M0.5390.51
192_R293_P0.5390.51
275_V299_A0.5380.51
194_L385_F0.5380.51
20_S95_M0.5370.51
20_S24_K0.5370.51
276_A299_A0.5370.51
233_A369_G0.5370.51
73_S77_G0.5370.51
163_H360_L0.5370.51
151_A178_F0.5370.51
36_A63_T0.5360.51
16_G98_L0.5360.51
43_Q66_R0.5350.51
31_V91_V0.5330.50
158_A164_A0.5330.50
13_V89_V0.5320.50
98_L110_A0.5320.50
399_A404_R0.5310.50
95_M357_Y0.5310.50
108_R111_S0.5300.50
222_A226_R0.5290.50
12_G225_A0.5290.50
40_H219_K0.5290.50
351_V390_A0.5290.50
109_V112_E0.5280.50
172_P177_Y0.5280.50
254_F383_H0.5270.50
121_V129_S0.5270.50
326_L387_Y0.5270.50
208_A212_A0.5250.49
398_F413_D0.5240.49
274_P288_L0.5230.49
288_L317_L0.5230.49
363_V402_V0.5220.49
326_L394_S0.5220.49
12_G227_T0.5220.49
197_H201_E0.5210.49
220_R235_D0.5200.49
229_P232_P0.5200.49
193_H385_F0.5190.49
320_L414_G0.5190.49
42_V88_D0.5190.49
198_M202_A0.5180.48
12_G90_C0.5180.48
370_D377_G0.5180.48
51_F319_V0.5170.48
77_G428_H0.5160.48
245_A272_F0.5160.48
405_G413_D0.5160.48
110_A148_V0.5150.48
193_H254_F0.5150.48
242_Q268_D0.5150.48
159_H164_A0.5150.48
326_L413_D0.5150.48
125_A374_A0.5140.48
104_A129_S0.5140.48
252_F277_G0.5130.48
358_Q363_V0.5130.48
357_Y360_L0.5120.48
22_V26_V0.5120.48
313_A418_Y0.5110.48
363_V425_A0.5110.48
33_R63_T0.5100.47
195_G254_F0.5100.47
231_P236_P0.5100.47
28_T57_H0.5090.47
48_G53_D0.5090.47
31_V216_V0.5090.47
287_Y347_L0.5070.47
20_S360_L0.5070.47
51_F383_H0.5070.47
183_P360_L0.5070.47
29_L56_H0.5060.47
193_H295_L0.5060.47
96_M357_Y0.5040.47
323_C385_F0.5040.47
151_A176_T0.5040.47
230_R307_D0.5030.47
29_L65_S0.5020.46
181_V208_A0.5020.46
153_V179_G0.5020.46
190_P209_V0.5020.46
99_Y104_A0.5010.46
42_V89_V0.5010.46
309_L346_V0.5010.46
323_C383_H0.5010.46
238_P241_G0.5000.46
126_G137_F0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s1mA 4 0.9342 100 0.678 Contact Map
1vcoA 4 0.9093 100 0.698 Contact Map
3nvaA 2 0.9342 100 0.706 Contact Map
4zdjA 4 0.9138 100 0.708 Contact Map
4a0gA 2 0.6825 100 0.828 Contact Map
3fijA 4 0.4263 99.9 0.859 Contact Map
1ka9H 1 0.424 99.9 0.862 Contact Map
3fgnA 2 0.4535 99.9 0.863 Contact Map
3ug7A 4 0.4399 99.9 0.865 Contact Map
2issD 1 0.4082 99.9 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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