GREMLIN Database
Q9HPL6 - Cobalamin adenosyltransferase
UniProt: Q9HPL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (177)
Sequences: 1885 (985)
Seq/√Len: 74.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_V186_L3.9471.00
208_K214_E3.5481.00
194_T198_E3.2581.00
53_A153_V2.9961.00
202_L212_P2.9531.00
176_D199_R2.8741.00
64_H128_I2.7841.00
119_N170_D2.5921.00
46_T50_L2.4981.00
175_I184_V2.4911.00
49_A153_V2.3931.00
183_E220_R2.2941.00
126_Q170_D2.2001.00
52_M185_V2.1971.00
168_P195_F2.1581.00
54_M85_A2.1061.00
37_V196_V2.0831.00
95_E124_R2.0811.00
173_A177_T1.9781.00
39_W192_E1.9741.00
35_V186_L1.9431.00
157_V171_V1.9101.00
50_L54_M1.9051.00
59_H81_G1.8811.00
34_L212_P1.8791.00
168_P193_P1.8331.00
124_R127_E1.8231.00
35_V178_K1.7801.00
56_A61_F1.7611.00
205_E209_Q1.7001.00
168_P172_V1.6651.00
93_T149_V1.6321.00
161_A193_P1.6281.00
36_Q202_L1.6150.99
36_Q183_E1.6140.99
53_A65_V1.6060.99
57_A92_I1.6040.99
35_V175_I1.6000.99
38_W48_A1.5840.99
197_T203_V1.5740.99
86_I92_I1.5680.99
53_A63_T1.5160.99
54_M86_I1.5000.99
112_D116_A1.4920.99
174_L184_V1.4700.99
41_D208_K1.4560.99
65_V153_V1.4540.99
83_Y87_D1.4530.99
169_E195_F1.4170.99
65_V92_I1.4120.99
152_L182_L1.3950.98
119_N123_A1.3800.98
172_V199_R1.3780.98
93_T128_I1.3410.98
116_A120_G1.3220.98
50_L65_V1.3090.98
203_V210_R1.3080.98
158_L192_E1.2940.98
53_A92_I1.2820.97
129_V174_L1.2740.97
49_A187_T1.2740.97
34_L217_Q1.2640.97
36_Q220_R1.2120.96
161_A166_V1.2070.96
99_H113_E1.1960.96
162_N190_H1.1910.96
172_V176_D1.1880.96
125_A154_L1.1690.95
36_Q212_P1.1610.95
64_H149_V1.1570.95
123_A126_Q1.1200.94
62_R148_G1.1180.94
129_V182_L1.1130.94
57_A85_A1.1050.94
126_Q174_L1.1000.94
61_F150_H1.0820.93
97_A121_G1.0800.93
88_A91_G1.0690.93
146_T149_V1.0660.93
128_I149_V1.0480.92
192_E196_V1.0380.92
39_W189_G1.0290.91
101_G110_S1.0260.91
56_A150_H1.0240.91
192_E197_T1.0230.91
149_V152_L1.0050.90
85_A89_V1.0000.90
120_G123_A0.9980.90
66_V125_A0.9920.90
161_A171_V0.9900.90
47_T67_Q0.9850.89
68_L125_A0.9840.89
167_D170_D0.9650.88
161_A168_P0.9640.88
69_M159_Y0.9600.88
123_A127_E0.9590.88
201_D215_N0.9560.88
212_P217_Q0.9470.87
101_G104_G0.9440.87
115_A119_N0.9390.87
179_P182_L0.9320.87
178_K184_V0.9310.87
103_H165_L0.9300.87
119_N167_D0.9220.86
52_M224_E0.9200.86
66_V124_R0.9150.86
151_L185_V0.9050.85
38_W206_V0.9030.85
47_T52_M0.9000.85
38_W47_T0.8960.84
150_H181_D0.8910.84
197_T209_Q0.8850.84
41_D207_R0.8820.83
66_V97_A0.8800.83
178_K182_L0.8800.83
33_G178_K0.8790.83
98_G121_G0.8630.82
110_S113_E0.8630.82
169_E173_A0.8610.82
64_H95_E0.8580.82
38_W52_M0.8480.81
35_V199_R0.8470.81
93_T127_E0.8360.80
147_E182_L0.8280.79
126_Q173_A0.8230.79
31_E218_G0.8210.79
173_A176_D0.8100.78
110_S114_H0.8050.77
164_G193_P0.8030.77
66_V95_E0.8020.77
35_V157_V0.7970.77
98_G118_A0.7920.76
66_V121_G0.7820.75
166_V171_V0.7750.75
84_A87_D0.7740.75
37_V158_L0.7660.74
59_H224_E0.7660.74
74_G84_A0.7490.72
114_H118_A0.7480.72
129_V184_V0.7480.72
25_T28_A0.7460.72
57_A89_V0.7460.72
99_H114_H0.7450.72
99_H117_R0.7440.72
147_E181_D0.7430.72
126_Q177_T0.7390.71
41_D190_H0.7390.71
26_P29_P0.7360.71
52_M223_T0.7340.71
159_Y163_R0.7340.71
69_M117_R0.7280.70
183_E202_L0.7160.69
52_M151_L0.7110.68
108_G111_D0.7090.68
41_D194_T0.7030.67
126_Q130_D0.7030.67
62_R150_H0.7020.67
81_G85_A0.6870.66
38_W212_P0.6860.65
160_A166_V0.6850.65
62_R91_G0.6840.65
97_A124_R0.6820.65
69_M103_H0.6780.65
130_D177_T0.6760.64
83_Y94_Y0.6740.64
71_G96_N0.6730.64
122_L129_V0.6690.64
85_A88_A0.6680.63
114_H117_R0.6670.63
200_A203_V0.6660.63
129_V152_L0.6650.63
89_V92_I0.6530.62
83_Y96_N0.6520.62
103_H111_D0.6520.62
69_M101_G0.6510.61
113_E165_L0.6440.61
38_W220_R0.6440.61
125_A128_I0.6410.60
32_F217_Q0.6410.60
38_W202_L0.6340.59
59_H221_K0.6320.59
38_W208_K0.6310.59
124_R128_I0.6300.59
104_G122_L0.6260.58
27_T30_A0.6260.58
110_S118_A0.6230.58
197_T210_R0.6220.58
122_L126_Q0.6180.57
158_L224_E0.6180.57
56_A151_L0.6160.57
50_L83_Y0.6160.57
62_R93_T0.6150.57
183_E224_E0.6150.57
107_D117_R0.6110.57
61_F221_K0.6100.56
65_V94_Y0.6050.56
98_G114_H0.6020.56
159_Y162_N0.5950.55
177_T215_N0.5950.55
103_H108_G0.5920.54
48_A52_M0.5910.54
118_A121_G0.5890.54
104_G108_G0.5890.54
83_Y224_E0.5880.54
104_G110_S0.5870.54
170_D174_L0.5870.54
111_D115_A0.5860.54
114_H159_Y0.5860.54
97_A117_R0.5820.53
115_A165_L0.5800.53
61_F183_E0.5740.52
122_L165_L0.5730.52
121_G125_A0.5670.51
127_E146_T0.5640.51
125_A152_L0.5630.51
104_G165_L0.5610.50
48_A206_V0.5600.50
122_L174_L0.5580.50
149_V182_L0.5560.50
51_G82_E0.5550.50
174_L178_K0.5550.50
152_L215_N0.5540.50
130_D146_T0.5520.49
71_G83_Y0.5510.49
94_Y221_K0.5490.49
146_T152_L0.5440.48
71_G114_H0.5430.48
185_V223_T0.5420.48
221_K225_Y0.5380.48
53_A151_L0.5380.48
39_W203_V0.5360.47
34_L202_L0.5360.47
208_K224_E0.5340.47
83_Y190_H0.5340.47
101_G114_H0.5330.47
46_T83_Y0.5310.47
65_V86_I0.5310.47
203_V209_Q0.5300.47
72_G80_R0.5300.47
113_E116_A0.5290.46
42_G45_K0.5280.46
40_G51_G0.5240.46
186_L196_V0.5230.46
123_A169_E0.5230.46
168_P197_T0.5220.46
38_W183_E0.5200.45
169_E176_D0.5200.45
55_R204_T0.5180.45
157_V161_A0.5180.45
73_T84_A0.5180.45
48_A204_T0.5170.45
212_P220_R0.5170.45
62_R149_V0.5130.44
102_W111_D0.5110.44
123_A130_D0.5110.44
127_E130_D0.5090.44
50_L94_Y0.5090.44
74_G80_R0.5090.44
55_R58_G0.5060.44
81_G84_A0.5060.44
36_Q223_T0.5040.43
164_G167_D0.5040.43
108_G115_A0.5040.43
73_T87_D0.5020.43
61_F181_D0.5010.43
69_M165_L0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g5tA 2 0.6978 100 0.479 Contact Map
2orvA 3 0.5689 100 0.654 Contact Map
2j9rA 3 0.6 99.8 0.747 Contact Map
1w4rA 3 0.6222 99.7 0.765 Contact Map
3e2iA 3 0.5911 99.7 0.775 Contact Map
1xx6A 4 0.6267 99.6 0.779 Contact Map
2b8tA 3 0.6533 99.4 0.808 Contact Map
4uxhA 3 0.6089 98.8 0.853 Contact Map
2orwA 3 0.6089 98.7 0.86 Contact Map
4a4zA 1 0.8667 96.6 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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