GREMLIN Database
COBQ - Probable cobyric acid synthase
UniProt: Q9HPL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 512 (467)
Sequences: 2235 (1463)
Seq/√Len: 67.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_D137_R4.3791.00
27_G495_V4.3571.00
222_D226_T3.9341.00
34_D493_A3.6191.00
173_D205_R3.6001.00
35_R496_D3.5851.00
57_A84_A3.3171.00
32_L144_V3.1731.00
362_R387_E2.9561.00
361_D385_P2.9451.00
34_D496_D2.9071.00
362_R377_A2.8621.00
327_V378_V2.7591.00
34_D82_R2.7181.00
240_I495_V2.6781.00
359_L446_V2.6631.00
16_A19_V2.6461.00
283_L320_L2.6181.00
210_V499_V2.6171.00
35_R505_G2.6021.00
70_I75_Y2.5621.00
170_R201_D2.5401.00
170_R205_R2.4841.00
364_T377_A2.4831.00
277_T304_A2.4381.00
219_S222_D2.4261.00
180_V187_A2.3721.00
334_R339_G2.3551.00
156_L227_E2.3101.00
33_A82_R2.2601.00
277_T302_R2.2561.00
317_A464_F2.2521.00
107_D134_A2.2481.00
298_T461_R2.2261.00
196_A231_R2.1521.00
24_V240_I2.1501.00
192_H231_R2.1441.00
385_P429_P2.1201.00
364_T387_E2.1161.00
386_V426_T2.0691.00
159_H199_P2.0511.00
170_R202_I2.0431.00
318_V342_L2.0191.00
12_V179_V2.0181.00
159_H202_I2.0141.00
76_V247_L1.9731.00
117_G219_S1.9621.00
200_D204_D1.9371.00
294_P456_G1.9341.00
84_A398_A1.9311.00
76_V488_S1.9241.00
38_S142_N1.9011.00
226_T230_A1.8961.00
284_P332_A1.8941.00
13_A176_I1.8921.00
279_A306_Q1.8891.00
13_A166_L1.8601.00
130_A133_A1.8581.00
364_T389_A1.8561.00
277_T315_A1.8481.00
135_H139_A1.8421.00
399_V451_L1.8261.00
333_A342_L1.8201.00
52_R75_Y1.8191.00
227_E231_R1.8171.00
279_A315_A1.8011.00
350_V455_F1.7911.00
180_V191_L1.7611.00
28_L32_L1.7601.00
191_L209_A1.7481.00
416_V451_L1.6850.99
192_H196_A1.6800.99
177_L237_L1.6790.99
168_T172_A1.6750.99
350_V447_L1.6460.99
339_G381_V1.6400.99
147_A168_T1.6400.99
31_L495_V1.6370.99
10_I146_V1.6200.99
53_A396_V1.6080.99
29_C146_V1.6030.99
503_P506_V1.5950.99
282_H307_P1.5800.99
94_L104_L1.5700.99
79_R488_S1.5680.99
280_V303_V1.5570.99
318_V345_F1.5560.99
26_A488_S1.5560.99
27_G31_L1.5510.99
336_A339_G1.5230.99
367_A392_P1.5230.99
458_D461_R1.5200.99
221_L225_I1.5190.99
136_A139_A1.5150.99
240_I498_H1.5140.99
58_D86_S1.5100.99
68_G87_T1.5100.99
227_E230_A1.5000.99
37_L144_V1.4980.99
114_Y123_H1.4960.99
333_A336_A1.4710.99
292_L305_Y1.4700.99
370_S376_G1.4670.99
88_D141_D1.4610.98
361_D429_P1.4580.98
76_V248_P1.4520.98
500_D503_P1.4510.98
226_T229_E1.4500.98
391_Q425_R1.4440.98
426_T450_Y1.4390.98
12_V28_L1.4390.98
107_D133_A1.4350.98
356_Y448_G1.4340.98
195_L234_V1.4320.98
496_D505_G1.4310.98
331_R335_E1.4270.98
187_A211_I1.4270.98
86_S137_R1.4250.98
400_T417_T1.4210.98
132_A171_F1.4160.98
331_R378_V1.4130.98
479_P482_T1.4130.98
34_D489_D1.4050.98
200_D203_R1.4030.98
31_L501_L1.4030.98
9_T135_H1.4030.98
350_V454_L1.3930.98
12_V25_A1.3910.98
384_L446_V1.3910.98
31_L496_D1.3880.98
40_A142_N1.3870.98
447_L464_F1.3790.98
83_T142_N1.3720.98
360_G388_T1.3680.98
458_D479_P1.3640.98
58_D68_G1.3640.98
441_A445_R1.3600.98
395_R425_R1.3560.98
177_L210_V1.3550.98
304_A315_A1.3530.98
195_L206_V1.3510.97
280_V305_Y1.3370.97
400_T415_A1.3370.97
220_L223_P1.3370.97
12_V210_V1.3330.97
86_S141_D1.3300.97
437_G440_S1.3210.97
361_D387_E1.3150.97
356_Y386_V1.3140.97
123_H127_A1.3130.97
246_G483_P1.3070.97
107_D130_A1.3020.97
26_A76_V1.2990.97
28_L499_V1.2970.97
428_V431_G1.2960.97
79_R484_D1.2950.97
402_E415_A1.2900.97
254_S257_D1.2810.97
170_R199_P1.2800.97
31_L35_R1.2790.96
88_D107_D1.2790.96
166_L176_I1.2720.96
123_H126_D1.2720.96
312_L341_A1.2680.96
109_R393_D1.2670.96
51_A287_S1.2630.96
139_A145_V1.2600.96
97_R325_N1.2540.96
483_P487_P1.2450.96
225_I236_V1.2420.96
131_A163_L1.2360.96
204_D234_V1.2290.96
438_P441_A1.2200.95
449_T454_L1.2160.95
218_R222_D1.2150.95
342_L349_I1.2150.95
106_V130_A1.2110.95
466_D469_F1.2050.95
225_I239_V1.2020.95
487_P490_A1.1980.95
115_S118_S1.1980.95
332_A336_A1.1960.95
363_I390_F1.1950.95
317_A468_V1.1950.95
38_S143_D1.1940.95
9_T172_A1.1930.95
317_A348_P1.1870.95
156_L221_L1.1850.95
229_E236_V1.1840.95
237_L503_P1.1770.94
16_A190_S1.1690.94
207_A507_P1.1660.94
199_P202_I1.1490.94
301_V465_R1.1460.94
97_R113_H1.1430.93
195_L203_R1.1430.93
104_L111_V1.1350.93
460_A464_F1.1340.93
107_D137_R1.1280.93
349_I383_V1.1260.93
401_R416_V1.1250.93
327_V376_G1.1230.93
387_E427_T1.1220.93
248_P484_D1.1200.93
363_I378_V1.1170.93
320_L358_M1.1140.93
469_F474_V1.1090.92
402_E413_T1.1070.92
416_V460_A1.1050.92
388_T450_Y1.1050.92
88_D134_A1.1030.92
329_D358_M1.1010.92
330_L334_R1.0920.92
334_R378_V1.0860.92
280_V292_L1.0850.92
327_V363_I1.0850.92
12_V19_V1.0840.92
98_G101_E1.0810.91
196_A203_R1.0780.91
128_R171_F1.0750.91
350_V464_F1.0740.91
281_P338_L1.0720.91
97_R101_E1.0650.91
79_R481_D1.0610.91
396_V421_I1.0610.91
203_R234_V1.0580.91
373_D376_G1.0510.90
283_L333_A1.0470.90
195_L209_A1.0450.90
277_T314_A1.0440.90
100_A115_S1.0420.90
118_S121_E1.0400.90
99_D285_H1.0380.90
495_V499_V1.0340.90
191_L228_I1.0330.89
292_L352_L1.0330.89
156_L231_R1.0290.89
111_V123_H1.0290.89
325_N328_D1.0280.89
501_L505_G1.0270.89
87_T107_D1.0250.89
281_P320_L1.0230.89
40_A83_T1.0200.89
370_S373_D1.0150.89
24_V495_V1.0140.89
106_V127_A1.0120.88
44_A92_V1.0110.88
330_L363_I1.0080.88
330_L378_V1.0060.88
13_A153_I1.0020.88
277_T313_A1.0020.88
128_R167_E0.9990.88
330_L358_M0.9970.88
403_L460_A0.9930.88
209_A236_V0.9910.87
281_P306_Q0.9880.87
309_D341_A0.9870.87
181_D184_R0.9830.87
156_L197_L0.9780.87
414_G459_A0.9770.87
275_S300_G0.9730.86
385_P431_G0.9660.86
311_P341_A0.9620.86
103_Q324_K0.9600.86
132_A136_A0.9590.86
318_V347_G0.9550.85
177_L504_L0.9540.85
136_A171_F0.9540.85
308_L311_P0.9540.85
385_P439_A0.9530.85
178_L206_V0.9520.85
292_L303_V0.9480.85
128_R132_A0.9480.85
428_V433_P0.9470.85
235_P503_P0.9470.85
398_A417_T0.9430.85
188_F224_G0.9380.84
92_V163_L0.9330.84
110_A423_M0.9280.84
114_Y119_Y0.9260.84
385_P428_V0.9250.84
306_Q313_A0.9190.83
237_L507_P0.9180.83
308_L332_A0.9170.83
275_S302_R0.9160.83
417_T481_D0.9160.83
18_H254_S0.9140.83
359_L384_L0.9140.83
458_D480_A0.9130.83
362_R379_D0.9130.83
82_R485_Q0.9120.83
23_T26_A0.9100.83
326_T363_I0.9080.82
222_D239_V0.8960.82
316_D472_A0.8950.81
120_Y124_W0.8950.81
343_R383_V0.8870.81
130_A134_A0.8850.81
503_P507_P0.8840.81
135_H147_A0.8810.80
438_P443_R0.8780.80
317_A350_V0.8770.80
469_F473_G0.8760.80
278_V319_V0.8710.80
285_H325_N0.8680.79
124_W161_R0.8650.79
11_L166_L0.8560.78
482_T486_S0.8550.78
135_H168_T0.8550.78
469_F472_A0.8540.78
366_A389_A0.8540.78
24_V179_V0.8520.78
180_V209_A0.8510.78
208_G237_L0.8490.78
401_R451_L0.8490.78
101_E124_W0.8480.78
37_L143_D0.8450.78
240_I499_V0.8440.78
391_Q395_R0.8440.78
188_F197_L0.8410.77
32_L37_L0.8410.77
25_A28_L0.8400.77
389_A427_T0.8380.77
306_Q315_A0.8380.77
422_H450_Y0.8350.77
438_P442_A0.8310.76
494_L498_H0.8310.76
159_H167_E0.8300.76
334_R379_D0.8260.76
342_L381_V0.8260.76
192_H195_L0.8250.76
279_A304_A0.8240.76
367_A389_A0.8210.76
283_L323_T0.8210.76
210_V240_I0.8210.76
40_A138_L0.8200.75
12_V177_L0.8150.75
348_P445_R0.8120.75
25_A146_V0.8110.75
371_T390_F0.8100.75
187_A191_L0.8060.74
153_I166_L0.8050.74
172_A205_R0.8040.74
132_A172_A0.8030.74
129_D133_A0.8020.74
87_T137_R0.7990.74
323_T390_F0.7990.74
51_A290_T0.7980.73
372_A375_L0.7960.73
388_T426_T0.7920.73
315_A342_L0.7920.73
481_D485_Q0.7880.73
156_L188_F0.7840.72
127_A163_L0.7810.72
31_L240_I0.7800.72
70_I86_S0.7790.72
126_D129_D0.7750.71
360_G386_V0.7740.71
79_R485_Q0.7740.71
248_P488_S0.7720.71
209_A234_V0.7710.71
119_Y252_S0.7700.71
484_D488_S0.7700.71
211_I228_I0.7690.71
136_A140_A0.7680.71
300_G469_F0.7660.70
218_R225_I0.7650.70
494_L497_A0.7650.70
370_S375_L0.7650.70
223_P226_T0.7640.70
175_T207_A0.7630.70
44_A168_T0.7600.70
18_H249_A0.7600.70
428_V432_V0.7590.70
274_A302_R0.7590.70
32_L505_G0.7570.69
51_A248_P0.7560.69
493_A497_A0.7560.69
485_Q489_D0.7530.69
16_A228_I0.7530.69
134_A137_R0.7520.69
353_C394_K0.7500.69
97_R100_A0.7490.69
192_H232_T0.7490.69
367_A391_Q0.7480.69
12_V190_S0.7480.69
38_S141_D0.7480.69
327_V331_R0.7470.68
178_L191_L0.7450.68
24_V210_V0.7410.68
434_Q437_G0.7360.67
153_I194_T0.7350.67
138_L145_V0.7340.67
154_A221_L0.7340.67
39_V143_D0.7320.67
243_D494_L0.7300.67
338_L342_L0.7280.66
22_S71_G0.7260.66
501_L504_L0.7230.66
56_V59_G0.7230.66
135_H145_V0.7220.66
44_A131_A0.7220.66
298_T458_D0.7210.66
35_R502_D0.7160.65
343_R379_D0.7160.65
296_A305_Y0.7140.65
198_L206_V0.7130.65
304_A313_A0.7110.65
197_L206_V0.7100.65
68_G109_R0.7080.64
375_L378_V0.7070.64
13_A44_A0.7050.64
455_F464_F0.7040.64
124_W167_E0.7040.64
121_E126_D0.7030.64
246_G487_P0.7020.64
48_S223_P0.6990.63
248_P480_A0.6980.63
437_G441_A0.6960.63
49_N105_V0.6950.63
192_H228_I0.6940.63
86_S142_N0.6910.62
57_A398_A0.6900.62
29_C33_A0.6890.62
98_G285_H0.6880.62
360_G450_Y0.6860.62
33_A83_T0.6850.62
35_R504_L0.6850.62
309_D338_L0.6840.62
403_L412_A0.6840.62
417_T457_N0.6830.62
284_P323_T0.6830.62
240_I494_L0.6800.61
154_A198_L0.6770.61
124_W163_L0.6760.61
197_L223_P0.6750.61
382_G385_P0.6730.60
345_F349_I0.6730.60
191_L211_I0.6720.60
128_R131_A0.6710.60
276_V465_R0.6700.60
298_T460_A0.6690.60
28_L504_L0.6690.60
281_P312_L0.6650.59
44_A164_A0.6630.59
75_Y79_R0.6600.59
75_Y85_A0.6590.59
255_L289_F0.6590.59
133_A137_R0.6590.59
339_G343_R0.6580.59
211_I225_I0.6570.59
132_A163_L0.6570.59
292_L319_V0.6570.59
127_A131_A0.6550.58
156_L187_A0.6550.58
98_G124_W0.6550.58
218_R239_V0.6540.58
29_C81_A0.6540.58
348_P467_A0.6520.58
97_R110_A0.6500.58
386_V446_V0.6480.57
34_D505_G0.6450.57
327_V375_L0.6450.57
326_T390_F0.6440.57
207_A210_V0.6440.57
10_I252_S0.6440.57
319_V352_L0.6430.57
309_D332_A0.6430.57
334_R363_I0.6420.57
341_A344_A0.6420.57
166_L202_I0.6410.57
209_A232_T0.6400.57
126_D130_A0.6390.56
248_P293_A0.6380.56
340_R343_R0.6360.56
222_D225_I0.6360.56
188_F225_I0.6350.56
211_I221_L0.6340.56
495_V498_H0.6340.56
191_L237_L0.6340.56
73_S147_A0.6330.56
367_A371_T0.6330.56
170_R173_D0.6330.56
312_L338_L0.6310.55
430_D433_P0.6300.55
429_P432_V0.6300.55
377_A387_E0.6300.55
15_T190_S0.6290.55
52_R70_I0.6280.55
201_D204_D0.6280.55
229_E235_P0.6250.55
183_E215_R0.6230.55
466_D474_V0.6230.55
385_P441_A0.6220.54
79_R248_P0.6220.54
98_G325_N0.6220.54
70_I85_A0.6190.54
386_V448_G0.6170.54
137_R140_A0.6160.54
35_R501_L0.6140.53
137_R141_D0.6140.53
187_A224_G0.6130.53
125_A129_D0.6130.53
192_H197_L0.6120.53
167_E175_T0.6110.53
111_V130_A0.6100.53
357_Q388_T0.6090.53
340_R344_A0.6080.53
304_A310_A0.6070.53
31_L505_G0.6070.53
132_A168_T0.6060.53
51_A449_T0.6060.53
72_V248_P0.6060.53
331_R375_L0.6050.52
248_P290_T0.6050.52
124_W127_A0.6050.52
105_V202_I0.6030.52
116_A119_Y0.6030.52
241_P498_H0.6030.52
298_T465_R0.6020.52
466_D472_A0.6020.52
462_R469_F0.6010.52
9_T174_A0.6000.52
298_T462_R0.6000.52
154_A189_A0.6000.52
497_A501_L0.5980.52
101_E115_S0.5970.51
104_L114_Y0.5960.51
278_V392_P0.5940.51
92_V442_A0.5940.51
48_S123_H0.5940.51
100_A218_R0.5930.51
279_A313_A0.5920.51
342_L345_F0.5910.51
97_R290_T0.5910.51
51_A97_R0.5900.51
128_R163_L0.5890.51
47_M150_A0.5890.51
147_A174_A0.5880.50
195_L236_V0.5850.50
478_A504_L0.5840.50
225_I232_T0.5840.50
324_K450_Y0.5830.50
281_P342_L0.5820.50
97_R318_V0.5810.50
34_D485_Q0.5810.50
156_L223_P0.5810.50
468_V471_A0.5800.49
192_H206_V0.5800.49
156_L224_G0.5800.49
34_D492_A0.5790.49
99_D187_A0.5780.49
249_A289_F0.5780.49
221_L227_E0.5770.49
147_A172_A0.5760.49
188_F227_E0.5750.49
12_V253_V0.5750.49
334_R343_R0.5750.49
104_L119_Y0.5750.49
101_E113_H0.5750.49
332_A341_A0.5750.49
107_D135_H0.5740.49
228_I236_V0.5740.49
40_A141_D0.5740.49
286_I305_Y0.5730.49
280_V319_V0.5720.48
271_P274_A0.5710.48
334_R381_V0.5690.48
279_A341_A0.5690.48
84_A417_T0.5680.48
351_G360_G0.5680.48
313_A341_A0.5680.48
166_L198_L0.5670.48
237_L504_L0.5670.48
10_I396_V0.5650.48
484_D487_P0.5640.48
478_A483_P0.5630.47
12_V23_T0.5630.47
182_I211_I0.5630.47
294_P461_R0.5620.47
58_D87_T0.5600.47
31_L492_A0.5600.47
451_L457_N0.5600.47
176_I206_V0.5590.47
284_P390_F0.5590.47
273_A361_D0.5580.47
449_T457_N0.5570.47
10_I449_T0.5570.47
109_R133_A0.5560.47
248_P487_P0.5560.47
103_Q423_M0.5540.46
18_H257_D0.5540.46
279_A309_D0.5540.46
393_D425_R0.5540.46
23_T245_P0.5530.46
32_L507_P0.5530.46
94_L119_Y0.5520.46
175_T507_P0.5510.46
12_V176_I0.5510.46
98_G102_S0.5510.46
371_T392_P0.5500.46
140_A415_A0.5490.46
207_A237_L0.5490.46
351_G446_V0.5490.46
40_A134_A0.5490.46
16_A184_R0.5490.46
281_P309_D0.5480.46
195_L232_T0.5470.46
285_H328_D0.5470.46
171_F205_R0.5460.45
13_A147_A0.5440.45
106_V396_V0.5440.45
306_Q345_F0.5420.45
343_R381_V0.5420.45
127_A192_H0.5420.45
284_P363_I0.5410.45
468_V472_A0.5400.45
88_D138_L0.5390.45
309_D313_A0.5380.44
286_I289_F0.5380.44
94_L102_S0.5370.44
18_H253_V0.5360.44
325_N373_D0.5360.44
31_L498_H0.5360.44
103_Q110_A0.5360.44
184_R252_S0.5350.44
349_I446_V0.5350.44
68_G164_A0.5340.44
207_A234_V0.5340.44
84_A140_A0.5330.44
486_S490_A0.5330.44
23_T164_A0.5320.44
470_A473_G0.5320.44
327_V373_D0.5320.44
293_A296_A0.5310.44
356_Y371_T0.5300.44
324_K388_T0.5300.44
12_V154_A0.5290.43
76_V484_D0.5290.43
201_D205_R0.5290.43
356_Y439_A0.5280.43
51_A72_V0.5280.43
111_V114_Y0.5270.43
135_H174_A0.5270.43
15_T280_V0.5270.43
159_H170_R0.5260.43
312_L318_V0.5260.43
102_S116_A0.5240.43
221_L316_D0.5240.43
363_I380_G0.5230.43
428_V439_A0.5230.43
211_I239_V0.5220.43
328_D373_D0.5220.43
28_L210_V0.5210.42
131_A134_A0.5210.42
49_N290_T0.5200.42
154_A285_H0.5200.42
252_S282_H0.5190.42
48_S221_L0.5190.42
33_A485_Q0.5180.42
386_V389_A0.5180.42
156_L192_H0.5180.42
183_E401_R0.5180.42
82_R145_V0.5170.42
357_Q450_Y0.5170.42
25_A76_V0.5160.42
332_A335_E0.5150.42
461_R465_R0.5140.42
279_A303_V0.5140.42
307_P311_P0.5140.42
183_E211_I0.5130.42
230_A501_L0.5130.42
208_G323_T0.5120.41
138_L224_G0.5110.41
100_A124_W0.5110.41
48_S79_R0.5100.41
159_H166_L0.5100.41
277_T306_Q0.5090.41
456_G480_A0.5090.41
178_L209_A0.5080.41
146_V505_G0.5080.41
502_D505_G0.5080.41
297_R480_A0.5060.41
83_T89_H0.5060.41
276_V301_V0.5060.41
113_H120_Y0.5050.41
72_V176_I0.5050.41
290_T294_P0.5040.40
195_L228_I0.5040.40
79_R83_T0.5040.40
19_V153_I0.5040.40
204_D273_A0.5040.40
119_Y123_H0.5030.40
295_L350_V0.5030.40
236_V239_V0.5030.40
11_L153_I0.5020.40
221_L226_T0.5020.40
204_D335_E0.5020.40
157_N182_I0.5010.40
32_L146_V0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s1mA 4 0.832 100 0.778 Contact Map
4zdjA 4 0.8184 100 0.78 Contact Map
3nvaA 2 0.8164 100 0.79 Contact Map
1vcoA 4 0.832 100 0.8 Contact Map
4a0gA 2 0.6914 100 0.862 Contact Map
3zq6A 2 0.4492 99.9 0.893 Contact Map
3ug7A 4 0.4727 99.9 0.894 Contact Map
3fgnA 2 0.4453 99.9 0.895 Contact Map
2issD 1 0.3379 99.9 0.896 Contact Map
2ywjA 1 0.3418 99.9 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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