GREMLIN Database
Q9HPL3 - Probable cobalamin biosynthesis protein CobD
UniProt: Q9HPL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (285)
Sequences: 2622 (2066)
Seq/√Len: 122.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_V207_V5.2211.00
47_L198_T4.6911.00
54_A203_L3.7331.00
101_A145_T3.4551.00
65_V177_A3.3001.00
216_A232_A3.2251.00
133_S136_E3.1591.00
189_L200_S3.0021.00
32_F57_L2.9911.00
53_A189_L2.9461.00
51_A198_T2.9021.00
113_S116_A2.8491.00
54_A58_P2.7431.00
114_L137_L2.6381.00
91_T176_A2.6051.00
38_V42_P2.4801.00
88_V160_F2.4791.00
62_A178_W2.4221.00
113_S117_A2.3141.00
51_A199_A2.2951.00
95_R99_A2.2331.00
11_V85_G2.1511.00
223_A254_V2.0801.00
132_L136_E2.0731.00
120_R123_A2.0521.00
281_R287_S2.0381.00
262_P272_A2.0381.00
101_A141_A2.0021.00
258_R275_G1.9581.00
149_L215_A1.9421.00
121_L140_A1.9381.00
264_V270_A1.9181.00
154_V215_A1.9181.00
224_R227_A1.9081.00
206_A209_W1.8861.00
58_P178_W1.8731.00
156_P179_V1.8481.00
40_D195_R1.8211.00
35_A57_L1.8051.00
228_A253_A1.7881.00
155_A179_V1.7671.00
262_P270_A1.7321.00
54_A200_S1.7301.00
160_F176_A1.7071.00
178_W207_V1.6681.00
232_A246_W1.6601.00
43_W196_V1.6451.00
198_T202_R1.6321.00
158_A214_L1.6211.00
54_A185_L1.6191.00
236_A246_W1.6081.00
91_T177_A1.6051.00
179_V208_M1.5951.00
203_L207_V1.5611.00
152_G187_S1.5541.00
61_A65_V1.5371.00
227_A230_S1.5341.00
12_G85_G1.5291.00
121_L137_L1.5291.00
220_A229_V1.5211.00
150_A155_A1.5211.00
107_A116_A1.5111.00
219_I251_L1.5071.00
88_V176_A1.5061.00
182_V203_L1.4921.00
46_P49_V1.4911.00
16_D21_E1.4881.00
287_S290_G1.4851.00
34_R38_V1.4741.00
185_L200_S1.4511.00
180_K187_S1.4361.00
231_R234_A1.4291.00
154_V218_L1.4171.00
126_G191_Y1.4151.00
162_V175_A1.4141.00
54_A199_A1.4091.00
44_T49_V1.4071.00
236_A245_G1.4011.00
58_P203_L1.3881.00
116_A119_R1.3781.00
149_L219_I1.3691.00
8_A12_G1.3581.00
72_A83_V1.3441.00
17_A94_R1.3391.00
142_V259_L1.3341.00
21_E30_A1.3221.00
116_A120_R1.3141.00
266_E269_E1.3111.00
273_L276_L1.2981.00
39_V53_A1.2721.00
231_R235_D1.2681.00
232_A236_A1.2671.00
104_V137_L1.2641.00
231_R253_A1.2621.00
32_F181_A1.2591.00
146_A251_L1.2430.99
8_A85_G1.2430.99
272_A275_G1.2320.99
12_G88_V1.2310.99
98_L102_S1.2270.99
228_A254_V1.2180.99
105_I110_T1.2110.99
30_A34_R1.2090.99
25_G31_W1.2070.99
13_V299_A1.2060.99
149_L154_V1.2030.99
179_V183_N1.1760.99
36_V189_L1.1660.99
57_L60_A1.1600.99
100_E103_G1.1550.99
15_L89_F1.1520.99
43_W53_A1.1480.99
9_V160_F1.1430.99
219_I298_A1.1380.99
13_V94_R1.1350.99
80_G84_A1.1270.99
128_D267_L1.1220.99
39_V56_A1.1180.99
152_G180_K1.1170.99
220_A225_A1.1160.99
35_A60_A1.1040.99
44_T196_V1.0990.99
81_A85_G1.0950.99
47_L199_A1.0920.99
240_P271_A1.0900.99
239_P248_M1.0870.99
103_G120_R1.0800.99
36_V185_L1.0780.98
139_S263_G1.0770.98
54_A182_V1.0730.98
33_G188_M1.0690.98
276_L279_S1.0660.98
108_T138_R1.0590.98
159_A175_A1.0580.98
199_A203_L1.0400.98
271_A276_L1.0350.98
100_E120_R1.0350.98
220_A228_A1.0310.98
271_A279_S1.0260.98
251_L291_G1.0080.98
11_V81_A1.0040.98
126_G248_M0.9990.98
150_A247_P0.9980.97
19_I89_F0.9970.97
104_V107_A0.9820.97
108_T134_A0.9810.97
56_A60_A0.9810.97
125_A129_P0.9800.97
126_G187_S0.9790.97
126_G140_A0.9700.97
251_L294_Y0.9700.97
220_A254_V0.9570.97
100_E144_S0.9550.97
119_R123_A0.9540.97
192_R198_T0.9520.97
216_A246_W0.9500.97
48_A52_L0.9450.97
229_V233_A0.9380.96
261_K267_L0.9310.96
47_L51_A0.9270.96
122_R129_P0.9250.96
40_D44_T0.9230.96
186_D201_A0.9210.96
9_V157_L0.9200.96
102_S105_I0.9200.96
43_W52_L0.9180.96
69_V84_A0.9170.96
275_G278_E0.9110.96
43_W49_V0.9090.96
257_C283_V0.8970.95
129_P132_L0.8900.95
284_R287_S0.8850.95
98_L292_L0.8800.95
235_D253_A0.8800.95
72_A80_G0.8760.95
226_P230_S0.8740.95
235_D238_A0.8730.95
134_A138_R0.8670.94
14_A18_A0.8630.94
147_E183_N0.8600.94
273_L277_A0.8590.94
69_V72_A0.8580.94
115_D130_D0.8560.94
183_N187_S0.8510.94
223_A228_A0.8450.94
100_E123_A0.8440.94
87_V169_L0.8440.94
240_P263_G0.8410.93
61_A181_A0.8390.93
150_A208_M0.8350.93
76_S80_G0.8350.93
219_I250_T0.8310.93
216_A220_A0.8300.93
107_A120_R0.8280.93
112_N117_A0.8250.93
178_W182_V0.8170.92
36_V53_A0.8100.92
27_H33_G0.8090.92
69_V169_L0.8090.92
86_L90_V0.8060.92
136_E263_G0.8020.92
69_V80_G0.8020.92
227_A256_D0.8010.92
57_L181_A0.7990.92
132_L140_A0.7900.91
121_L136_E0.7840.91
138_R142_V0.7800.91
215_A247_P0.7800.91
256_D280_R0.7740.90
33_G148_N0.7730.90
236_A249_A0.7720.90
203_L206_A0.7660.90
60_A63_A0.7620.90
8_A84_A0.7600.89
108_T117_A0.7590.89
190_G197_G0.7570.89
150_A179_V0.7550.89
71_V75_G0.7530.89
262_P275_G0.7490.89
67_A71_V0.7490.89
279_S285_V0.7450.88
231_R278_E0.7390.88
232_A249_A0.7360.88
285_V288_T0.7310.88
227_A231_R0.7310.88
216_A250_T0.7280.87
183_N208_M0.7270.87
151_D186_D0.7260.87
193_S266_E0.7240.87
38_V41_R0.7220.87
60_A64_T0.7220.87
158_A162_V0.7220.87
192_R240_P0.7210.87
105_I289_A0.7210.87
284_R288_T0.7200.87
283_V287_S0.7200.87
288_T291_G0.7190.87
154_V302_Y0.7190.87
147_E151_D0.7190.87
102_S106_A0.7180.87
279_S282_G0.7170.87
151_D204_D0.7150.86
97_L148_N0.7140.86
240_P244_S0.7140.86
66_W70_T0.7140.86
126_G205_D0.7100.86
13_V17_A0.7100.86
148_N188_M0.7090.86
147_E186_D0.7080.86
64_T67_A0.7080.86
69_V83_V0.7050.86
214_L218_L0.7020.85
13_V303_A0.6940.85
178_W181_A0.6940.85
228_A232_A0.6910.84
170_P175_A0.6870.84
186_D190_G0.6840.84
45_R49_V0.6830.84
33_G147_E0.6810.84
136_E139_S0.6810.84
12_G176_A0.6800.83
9_V161_A0.6800.83
142_V251_L0.6790.83
95_R98_L0.6770.83
131_A264_V0.6770.83
127_R265_Y0.6770.83
62_A66_W0.6760.83
112_N134_A0.6750.83
186_D205_D0.6720.83
118_R132_L0.6720.83
147_E204_D0.6670.82
142_V291_G0.6670.82
20_A95_R0.6650.82
186_D241_S0.6630.82
6_V10_A0.6620.82
278_E281_R0.6600.82
146_A239_P0.6590.82
147_E184_T0.6580.81
98_L296_L0.6580.81
30_A89_F0.6570.81
139_S261_K0.6570.81
103_G107_A0.6560.81
48_A51_A0.6500.81
218_L302_Y0.6500.81
33_G184_T0.6490.81
90_V177_A0.6490.81
260_V263_G0.6480.80
199_A206_A0.6460.80
142_V257_C0.6460.80
27_H184_T0.6420.80
39_V57_L0.6410.80
75_G79_A0.6410.80
148_N205_D0.6410.80
23_P30_A0.6400.80
145_T295_A0.6380.79
112_N116_A0.6370.79
292_L295_A0.6370.79
100_E107_A0.6360.79
65_V87_V0.6360.79
55_I59_L0.6340.79
131_A136_E0.6320.79
110_T286_V0.6310.79
54_A207_V0.6280.78
106_A111_E0.6280.78
146_A248_M0.6250.78
51_A55_I0.6230.78
63_A66_W0.6210.78
230_S233_A0.6210.78
148_N191_Y0.6190.77
196_V200_S0.6170.77
272_A279_S0.6160.77
98_L283_V0.6140.77
37_G40_D0.6130.77
224_R228_A0.6130.77
148_N151_D0.6130.77
220_A232_A0.6120.77
197_G201_A0.6110.76
153_L295_A0.6110.76
83_V87_V0.6100.76
299_A302_Y0.6100.76
222_T301_V0.6090.76
62_A175_A0.6090.76
218_L289_A0.6080.76
119_R122_R0.6060.76
186_D204_D0.6040.76
96_M100_E0.6040.76
233_A237_G0.6030.76
150_A215_A0.6030.76
33_G191_Y0.6020.75
201_A205_D0.6000.75
30_A33_G0.5990.75
35_A38_V0.5980.75
246_W253_A0.5970.75
33_G151_D0.5930.74
100_E121_L0.5900.74
263_G267_L0.5890.74
231_R236_A0.5880.74
110_T289_A0.5850.73
157_L161_A0.5840.73
97_L147_E0.5820.73
31_W35_A0.5820.73
184_T188_M0.5790.73
58_P185_L0.5770.72
21_E248_M0.5770.72
287_S291_G0.5710.72
291_G295_A0.5700.71
115_D119_R0.5670.71
128_D264_V0.5670.71
254_V294_Y0.5650.71
135_G282_G0.5640.71
250_T254_V0.5630.70
192_R202_R0.5630.70
147_E201_A0.5630.70
190_G205_D0.5620.70
258_R279_S0.5620.70
205_D241_S0.5620.70
102_S289_A0.5610.70
282_G285_V0.5600.70
104_V125_A0.5590.70
224_R256_D0.5580.70
127_R143_E0.5570.70
138_R196_V0.5540.69
32_F177_A0.5540.69
93_S152_G0.5540.69
205_D242_P0.5530.69
136_E140_A0.5530.69
190_G201_A0.5520.69
39_V43_W0.5510.69
91_T160_F0.5510.69
27_H125_A0.5470.68
94_R299_A0.5470.68
151_D205_D0.5460.68
284_R290_G0.5450.68
204_D241_S0.5440.68
183_N204_D0.5430.68
79_A111_E0.5410.67
147_E205_D0.5410.67
184_T191_Y0.5400.67
184_T187_S0.5390.67
84_A169_L0.5390.67
193_S196_V0.5390.67
277_A280_R0.5380.67
201_A204_D0.5360.67
100_E124_L0.5350.67
128_D131_A0.5340.66
239_P261_K0.5320.66
65_V69_V0.5320.66
224_R253_A0.5320.66
117_A137_L0.5300.66
78_L82_V0.5300.66
33_G205_D0.5280.66
10_A298_A0.5280.66
154_V247_P0.5260.65
221_A225_A0.5250.65
39_V44_T0.5220.65
53_A196_V0.5220.65
94_R153_L0.5220.65
276_L288_T0.5210.65
210_V214_L0.5210.65
58_P182_V0.5190.64
92_T180_K0.5190.64
201_A241_S0.5170.64
63_A67_A0.5170.64
151_D184_T0.5160.64
22_P28_P0.5150.64
151_D190_G0.5140.64
222_T297_T0.5140.64
15_L19_I0.5140.64
107_A117_A0.5130.63
155_A159_A0.5130.63
272_A278_E0.5130.63
217_V229_V0.5120.63
58_P181_A0.5120.63
180_K183_N0.5110.63
219_I254_V0.5110.63
111_E115_D0.5100.63
143_E260_V0.5090.63
183_N186_D0.5080.63
72_A76_S0.5060.62
286_V289_A0.5050.62
149_L298_A0.5040.62
101_A107_A0.5030.62
33_G187_S0.5030.62
151_D183_N0.5010.62
212_A247_P0.5010.62
150_A216_A0.5000.61
104_V121_L0.5000.61
155_A208_M0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksdA 1 0.2175 3.2 0.974 Contact Map
4h33A 3 0.2208 2.4 0.976 Contact Map
3j00Z 1 0.3019 2.3 0.976 Contact Map
3j01B 1 0.3766 2.3 0.976 Contact Map
2ls2A 1 0.0617 1.9 0.977 Contact Map
4av3A 2 0.211 1.8 0.977 Contact Map
4pl0A 2 0.7857 1.7 0.978 Contact Map
2qdqA 2 0.1039 1.5 0.978 Contact Map
3rvyA 3 0.2597 1.3 0.979 Contact Map
2kncA 1 0.0909 1.2 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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