GREMLIN Database
COBS - Adenosylcobinamide-GDP ribazoletransferase
UniProt: Q9HPL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (186)
Sequences: 2776 (2217)
Seq/√Len: 162.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_D49_T4.9731.00
47_R169_L3.7761.00
35_G63_A3.5281.00
25_I62_A3.2231.00
166_L177_V3.2211.00
101_M182_N3.1141.00
40_V50_V2.9271.00
31_V67_V2.8391.00
93_T189_G2.8051.00
158_A188_V2.7281.00
16_L72_V2.6771.00
32_A64_V2.5721.00
97_A182_N2.5351.00
56_T61_I2.2851.00
67_V187_V2.2421.00
20_F66_V2.2371.00
32_A60_A2.1321.00
13_F69_A2.1231.00
38_A170_L2.0661.00
17_A66_V1.9971.00
42_G46_D1.9951.00
71_L183_E1.9891.00
154_G192_A1.9481.00
9_G72_V1.9321.00
13_F70_G1.9251.00
34_A177_V1.9101.00
104_V181_V1.8931.00
89_V193_G1.8811.00
48_R174_N1.8171.00
162_T166_L1.7061.00
11_V15_Y1.6281.00
7_P77_G1.6141.00
37_A51_L1.5841.00
69_A72_V1.5651.00
58_V62_A1.4991.00
71_L186_R1.4801.00
105_A178_F1.4721.00
48_R111_P1.4561.00
173_A178_F1.4461.00
9_G73_T1.4451.00
32_A56_T1.4211.00
31_V63_A1.4201.00
163_R167_T1.4131.00
102_A131_V1.4051.00
111_P174_N1.3751.00
28_L183_E1.3651.00
107_L163_R1.3561.00
65_V68_V1.3511.00
151_A189_G1.3421.00
65_V69_A1.3251.00
107_L167_T1.3001.00
145_S148_A1.2891.00
10_T74_G1.2801.00
74_G191_H1.2731.00
38_A47_R1.2651.00
31_V35_G1.2611.00
117_S121_G1.2551.00
162_T181_V1.2491.00
94_E183_E1.2481.00
44_P48_R1.2471.00
93_T190_L1.2401.00
13_F73_T1.2211.00
9_G76_L1.2041.00
34_A38_A1.2031.00
94_E186_R1.2031.00
110_A174_N1.2021.00
99_T132_A1.1991.00
70_G187_V1.1981.00
19_V94_E1.1931.00
14_A70_G1.1741.00
44_P47_R1.1691.00
100_S159_G1.1681.00
67_V183_E1.1661.00
108_A167_T1.1531.00
164_R168_G1.1491.00
28_L64_V1.1461.00
13_F72_V1.1441.00
47_R170_L1.1151.00
62_A68_V1.1111.00
43_D46_D1.1091.00
105_A120_T1.1061.00
56_T64_V1.0951.00
20_F28_L1.0851.00
111_P114_G1.0830.99
39_V59_G1.0700.99
31_V184_V1.0580.99
107_L178_F1.0460.99
124_T127_A1.0320.99
12_A76_L1.0310.99
32_A58_V1.0310.99
56_T60_A1.0270.99
155_A185_S1.0270.99
52_K111_P1.0230.99
67_V71_L1.0200.99
158_A184_V1.0190.99
55_T58_V1.0090.99
103_A132_A0.9960.99
10_T73_T0.9950.99
131_V135_A0.9940.99
161_L165_W0.9860.99
100_S185_S0.9800.99
40_V47_R0.9770.99
48_R51_L0.9750.99
71_L187_V0.9720.99
51_L174_N0.9710.99
164_R167_T0.9700.99
91_V95_V0.9680.99
34_A166_L0.9370.99
155_A189_G0.9110.98
20_F62_A0.9100.98
6_V195_V0.9090.98
40_V43_D0.9000.98
20_F68_V0.8820.98
74_G187_V0.8760.98
97_A186_R0.8710.98
98_K182_N0.8700.98
158_A162_T0.8620.97
104_V163_R0.8620.97
90_V94_E0.8590.97
181_V185_S0.8460.97
37_A41_H0.8450.97
40_V59_G0.8410.97
19_V186_R0.8300.97
42_G47_R0.8280.97
91_V94_E0.8210.97
135_A138_V0.8170.97
25_I59_G0.8120.96
43_D49_T0.8110.96
44_P171_G0.8110.96
20_F25_I0.8090.96
95_V135_A0.8080.96
18_V22_V0.8070.96
38_A177_V0.8060.96
165_W169_L0.7990.96
185_S189_G0.7890.96
12_A16_L0.7890.96
178_F181_V0.7880.96
96_G189_G0.7740.95
103_A159_G0.7670.95
128_L131_V0.7610.95
85_T88_G0.7560.95
112_H117_S0.7530.95
24_G105_A0.7390.94
97_A100_S0.7380.94
74_G194_V0.7370.94
19_V178_F0.7240.93
134_V138_V0.7190.93
38_A166_L0.7130.93
139_A142_S0.7120.93
58_V61_I0.7100.93
6_V191_H0.7100.93
32_A61_I0.7070.92
109_H113_D0.7050.92
7_P10_T0.7040.92
19_V71_L0.7010.92
52_K113_D0.7000.92
45_A49_T0.6980.92
173_A177_V0.6980.92
15_Y19_V0.6970.92
159_G163_R0.6960.92
8_H12_A0.6930.92
49_T53_D0.6920.92
60_A63_A0.6900.92
182_N185_S0.6890.91
6_V10_T0.6840.91
105_A115_L0.6800.91
101_M178_F0.6780.91
93_T97_A0.6730.91
109_H116_G0.6720.90
115_L119_F0.6650.90
96_G135_A0.6650.90
92_A135_A0.6610.90
105_A116_G0.6610.90
149_A153_A0.6600.90
70_G73_T0.6580.90
135_A139_A0.6550.89
61_I64_V0.6510.89
47_R59_G0.6500.89
96_G155_A0.6490.89
37_A54_T0.6490.89
16_L75_S0.6450.89
99_T103_A0.6450.89
53_D58_V0.6410.88
99_T135_A0.6380.88
14_A74_G0.6330.88
15_Y90_V0.6320.88
7_P11_V0.6320.88
146_P149_A0.6310.88
126_G129_P0.6300.87
175_G179_G0.6280.87
37_A180_A0.6260.87
88_G91_V0.6250.87
61_I65_V0.6230.87
77_G194_V0.6220.87
50_V59_G0.6210.87
104_V173_A0.6190.87
178_F182_N0.6160.86
119_F173_A0.6130.86
53_D186_R0.6130.86
126_G130_A0.6090.86
104_V178_F0.6060.85
35_G180_A0.6050.85
42_G50_V0.6040.85
14_A146_P0.6040.85
160_A164_R0.6040.85
138_V141_A0.6030.85
151_A192_A0.6000.85
148_A151_A0.5990.85
5_G12_A0.5960.84
70_G191_H0.5950.84
130_A150_G0.5950.84
16_L19_V0.5940.84
15_Y75_S0.5890.84
12_A72_V0.5880.84
28_L40_V0.5870.84
165_W168_G0.5830.83
41_H170_L0.5800.83
139_A145_S0.5770.82
26_N120_T0.5760.82
60_A185_S0.5760.82
129_P132_A0.5750.82
17_A21_A0.5740.82
13_F62_A0.5740.82
138_V142_S0.5730.82
130_A140_L0.5710.82
85_T133_G0.5700.82
24_G53_D0.5690.82
142_S145_S0.5680.81
105_A173_A0.5620.81
191_H194_V0.5610.81
41_H46_D0.5610.81
32_A178_F0.5600.81
100_S181_V0.5600.81
89_V93_T0.5560.80
162_T184_V0.5560.80
111_P173_A0.5530.80
9_G16_L0.5510.80
71_L98_K0.5500.79
188_V194_V0.5490.79
59_G63_A0.5480.79
28_L71_L0.5470.79
74_G190_L0.5430.79
110_A172_G0.5430.79
133_G137_P0.5430.79
157_G161_L0.5420.78
86_A102_A0.5420.78
99_T131_V0.5410.78
166_L173_A0.5410.78
26_N118_Q0.5400.78
34_A174_N0.5400.78
151_A155_A0.5390.78
137_P141_A0.5370.78
46_D50_V0.5360.78
72_V76_L0.5360.78
9_G77_G0.5320.77
49_T55_T0.5310.77
96_G152_L0.5280.77
116_G119_F0.5260.76
15_Y94_E0.5260.76
47_R177_V0.5240.76
79_A87_V0.5230.76
127_A131_V0.5220.76
54_T58_V0.5180.75
132_A135_A0.5180.75
159_G181_V0.5160.75
116_G183_E0.5150.75
26_N42_G0.5140.75
94_E182_N0.5120.74
134_V137_P0.5110.74
95_V101_M0.5090.74
126_G160_A0.5080.74
77_G153_A0.5080.74
180_A184_V0.5060.74
161_L164_R0.5030.73
170_L177_V0.5020.73
19_V183_E0.5020.73
41_H54_T0.5010.73
25_I58_V0.5010.73
5_G9_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6mA 2 0.7739 5.8 0.954 Contact Map
3tx3A 2 0.804 2.8 0.961 Contact Map
3j45G 1 0.3015 1.7 0.965 Contact Map
2wjnL 1 0.598 1.6 0.965 Contact Map
2jttC 1 0.1407 1.6 0.966 Contact Map
4mndA 2 0.7739 1.3 0.968 Contact Map
2akhX 1 0.3869 1.2 0.968 Contact Map
3dinE 1 0.2864 1.1 0.969 Contact Map
4yl6B 1 0.0854 1.1 0.969 Contact Map
1rzhL 1 0.598 1.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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