GREMLIN Database
Q9HPL1 - Uncharacterized protein
UniProt: Q9HPL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (176)
Sequences: 180 (144)
Seq/√Len: 10.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A68_T4.9321.00
69_P79_A4.0280.99
3_C45_A3.3290.97
5_G9_R3.1650.96
4_G9_R3.1650.96
140_P144_N3.1590.96
55_A67_E3.0320.94
72_G75_A2.6290.89
28_D57_H2.4870.86
77_L81_L2.3610.83
17_P93_A2.2350.79
69_P143_V2.1760.77
2_M5_G2.1020.74
3_C9_R2.0870.74
19_F92_A2.0410.72
15_E54_T1.9760.70
15_E52_P1.8320.63
91_V98_L1.7940.62
4_G7_G1.7520.60
12_A47_V1.7420.59
66_I131_T1.7210.58
40_I169_R1.7060.58
2_M9_R1.7050.58
10_L140_P1.6730.56
62_P109_A1.6580.55
34_L43_T1.6490.55
89_L102_V1.6460.55
19_F172_A1.6100.53
25_A96_P1.5750.51
114_T117_A1.5110.48
92_A95_L1.5060.48
29_H103_V1.4900.47
20_E44_H1.4590.46
63_L143_V1.4590.46
3_C103_V1.4360.45
27_V145_V1.4330.45
5_G16_K1.4110.44
4_G16_K1.4110.44
7_G17_P1.4070.43
66_I95_L1.3980.43
44_H47_V1.3740.42
27_V166_V1.3520.41
31_R85_G1.3340.40
22_G156_R1.3210.39
24_R179_L1.3030.39
30_V167_N1.2900.38
44_H68_T1.2820.38
12_A19_F1.2800.38
101_A137_A1.2720.37
92_A144_N1.2700.37
144_N150_D1.2630.37
51_A93_A1.2540.36
11_D172_A1.2530.36
114_T150_D1.2330.36
80_A84_V1.2220.35
7_G171_D1.2200.35
33_A148_G1.2190.35
46_A91_V1.2150.35
31_R166_V1.2120.35
26_M96_P1.2090.35
109_A126_E1.1970.34
84_V88_V1.1970.34
31_R63_L1.1860.34
50_H81_L1.1850.33
129_V168_H1.1850.33
10_L28_D1.1650.33
31_R89_L1.1610.32
2_M7_G1.1590.32
31_R146_V1.1570.32
9_R16_K1.1510.32
89_L103_V1.1360.31
43_T169_R1.1320.31
63_L164_V1.1090.30
27_V131_T1.0910.30
97_L128_G1.0840.29
54_T152_E1.0830.29
77_L175_A1.0760.29
21_V26_M1.0670.29
10_L50_H1.0650.29
146_V161_R1.0570.28
87_P129_V1.0480.28
100_P171_D1.0460.28
95_L140_P1.0150.27
106_V151_T0.9970.26
138_W152_E0.9960.26
120_P144_N0.9950.26
48_S54_T0.9740.25
106_V176_A0.9730.25
22_G179_L0.9720.25
15_E48_S0.9640.25
74_V140_P0.9580.25
43_T66_I0.9580.25
2_M6_R0.9570.25
99_A103_V0.9570.25
73_Y120_P0.9560.25
89_L169_R0.9550.25
7_G141_T0.9520.24
30_V162_L0.9520.24
31_R122_A0.9500.24
90_T130_S0.9460.24
137_A149_G0.9340.24
43_T156_R0.9290.24
98_L103_V0.9200.23
92_A146_V0.9200.23
143_V151_T0.9140.23
65_L138_W0.9130.23
72_G121_R0.9060.23
93_A120_P0.9050.23
68_T167_N0.9040.23
34_L58_L0.9010.23
48_S66_I0.8970.23
72_G91_V0.8940.22
48_S163_A0.8900.22
70_G76_D0.8770.22
70_G94_D0.8770.22
76_D94_D0.8770.22
54_T144_N0.8750.22
22_G103_V0.8750.22
46_A84_V0.8740.22
34_L97_L0.8730.22
15_E51_A0.8720.22
7_G10_L0.8700.22
48_S77_L0.8690.22
5_G10_L0.8580.21
4_G10_L0.8580.21
110_A179_L0.8560.21
75_A133_A0.8490.21
80_A135_A0.8480.21
67_E111_D0.8420.21
99_A115_T0.8400.21
160_A166_V0.8400.21
33_A96_P0.8360.21
89_L107_V0.8300.20
118_C138_W0.8290.20
143_V157_S0.8230.20
74_V144_N0.8190.20
145_V166_V0.8110.20
117_A164_V0.8060.20
110_A144_N0.8040.20
46_A167_N0.8040.20
51_A114_T0.8030.20
23_G166_V0.8020.20
81_L156_R0.7990.19
99_A102_V0.7900.19
101_A152_E0.7860.19
49_P88_V0.7850.19
146_V150_D0.7790.19
27_V179_L0.7760.19
118_C168_H0.7760.19
33_A98_L0.7690.19
26_M166_V0.7650.18
6_R64_S0.7650.18
6_R59_A0.7620.18
24_R101_A0.7610.18
120_P162_L0.7570.18
27_V45_A0.7540.18
129_V174_V0.7540.18
34_L95_L0.7520.18
66_I107_V0.7510.18
38_G98_L0.7460.18
36_A104_D0.7440.18
69_P132_D0.7420.18
45_A88_V0.7400.18
30_V96_P0.7390.18
48_S162_L0.7350.18
78_T81_L0.7330.18
74_V120_P0.7260.17
10_L84_V0.7240.17
21_V175_A0.7230.17
28_D38_G0.7230.17
112_G158_F0.7170.17
21_V25_A0.7130.17
87_P171_D0.7010.17
93_A131_T0.6990.17
40_I120_P0.6980.17
47_V136_D0.6950.16
81_L99_A0.6950.16
63_L135_A0.6930.16
3_C58_L0.6910.16
53_D178_L0.6910.16
48_S58_L0.6900.16
21_V164_V0.6830.16
43_T177_R0.6830.16
14_A80_A0.6820.16
53_D60_A0.6800.16
140_P145_V0.6790.16
39_R47_V0.6770.16
34_L128_G0.6770.16
96_P159_D0.6710.16
147_G173_A0.6600.16
84_V148_G0.6600.16
97_L159_D0.6590.16
10_L87_P0.6580.16
31_R173_A0.6570.16
3_C10_L0.6550.15
49_P97_L0.6550.15
93_A127_L0.6550.15
149_G160_A0.6460.15
14_A51_A0.6440.15
125_H164_V0.6430.15
73_Y87_P0.6420.15
59_A82_D0.6380.15
23_G145_V0.6320.15
46_A80_A0.6290.15
127_L132_D0.6250.15
94_D142_G0.6240.15
76_D142_G0.6240.15
70_G142_G0.6240.15
38_G168_H0.6240.15
12_A21_V0.6180.15
97_L117_A0.6180.15
20_E169_R0.6170.15
45_A155_H0.6160.15
95_L144_N0.6010.14
43_T99_A0.5980.14
19_F138_W0.5940.14
35_E106_V0.5910.14
6_R12_A0.5900.14
29_H110_A0.5850.14
164_V174_V0.5790.14
143_V154_T0.5790.14
130_S175_A0.5780.14
82_D177_R0.5720.14
150_D155_H0.5720.14
152_E178_L0.5670.13
62_P132_D0.5650.13
66_I71_D0.5640.13
113_A151_T0.5620.13
40_I47_V0.5600.13
38_G87_P0.5580.13
62_P71_D0.5570.13
124_K166_V0.5550.13
24_R64_S0.5530.13
24_R39_R0.5530.13
14_A19_F0.5500.13
31_R36_A0.5460.13
21_V50_H0.5440.13
21_V85_G0.5420.13
77_L90_T0.5410.13
62_P67_E0.5390.13
65_L107_V0.5340.13
73_Y77_L0.5320.13
54_T162_L0.5280.13
53_D56_A0.5270.13
2_M16_K0.5260.13
18_L72_G0.5260.13
55_A59_A0.5250.12
77_L92_A0.5220.12
93_A100_P0.5210.12
19_F174_V0.5190.12
55_A80_A0.5170.12
90_T154_T0.5150.12
84_V155_H0.5110.12
27_V58_L0.5090.12
89_L98_L0.5090.12
60_A85_G0.5070.12
16_K70_G0.5060.12
16_K76_D0.5060.12
16_K94_D0.5060.12
2_M95_L0.5030.12
108_A115_T0.5020.12
22_G29_H0.5010.12
17_P140_P0.5000.12
60_A69_P0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rsbA 1 0.873 99.9 0.627 Contact Map
1vpaA 2 0.9577 99.9 0.674 Contact Map
2weeA 1 0.9153 99.9 0.679 Contact Map
2wawA 1 0.9365 99.9 0.679 Contact Map
3ngwA 2 0.8942 99.9 0.687 Contact Map
3q80A 2 0.9418 99.9 0.688 Contact Map
1i52A 2 0.9471 99.9 0.69 Contact Map
4fceA 3 0.9683 99.9 0.692 Contact Map
4zdqA 2 0.9524 99.9 0.692 Contact Map
2xwlA 2 0.963 99.9 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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