GREMLIN Database
Q9HPL0 - Histidinol-phosphate transaminase
UniProt: Q9HPL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (315)
Sequences: 43899 (30526)
Seq/√Len: 1719.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_A46_D3.2371.00
77_T83_G3.1911.00
97_T118_T3.0641.00
261_R327_D2.8021.00
62_A243_R2.7851.00
256_A260_A2.7441.00
92_V117_A2.7141.00
271_D283_D2.6431.00
153_D157_R2.6261.00
96_D136_T2.5651.00
213_A218_L2.4331.00
328_R332_A2.3611.00
85_R89_E2.2781.00
294_A298_A2.2151.00
35_P39_A2.2091.00
152_D155_A2.1931.00
128_L165_A2.1761.00
265_A330_L2.1611.00
97_T120_V2.0841.00
208_A238_G2.0341.00
263_R267_S2.0061.00
58_A239_A1.9931.00
39_A43_A1.9471.00
61_A71_R1.9301.00
157_R161_A1.8851.00
102_A121_F1.8831.00
265_A268_D1.8711.00
261_R265_A1.8321.00
171_L194_A1.8241.00
62_A65_D1.8111.00
112_V117_A1.7841.00
109_A113_E1.7501.00
328_R331_A1.7491.00
126_A130_A1.7431.00
267_S272_V1.7421.00
57_P61_A1.7281.00
175_A196_S1.7241.00
163_C170_L1.7231.00
38_R42_A1.6931.00
264_A268_D1.6931.00
43_A240_H1.6901.00
61_A65_D1.6851.00
73_T215_G1.6741.00
65_D243_R1.6691.00
265_A331_A1.6591.00
87_A192_V1.6471.00
260_A264_A1.6381.00
126_A129_D1.6331.00
97_T134_E1.6291.00
167_N190_G1.6191.00
291_A295_A1.6171.00
25_F329_L1.6141.00
231_G234_A1.5861.00
64_A71_R1.5851.00
98_V112_V1.5721.00
97_T135_H1.5531.00
80_G194_A1.5301.00
99_L135_H1.5281.00
158_A161_A1.5251.00
128_L158_A1.5241.00
69_C212_V1.5201.00
63_A210_F1.5071.00
262_M280_L1.4991.00
109_A121_F1.4971.00
211_L221_L1.4961.00
87_A171_L1.4931.00
155_A158_A1.4891.00
88_I112_V1.4831.00
62_A239_A1.4821.00
295_A298_A1.4781.00
97_T132_P1.4651.00
288_P291_A1.4651.00
102_A123_P1.4551.00
39_A42_A1.4531.00
137_L171_L1.4391.00
281_L306_A1.4371.00
303_L316_V1.4331.00
38_R46_D1.4261.00
263_R280_L1.4181.00
263_R272_V1.4161.00
249_A253_R1.4041.00
161_A165_A1.4041.00
299_E332_A1.3951.00
56_Y236_A1.3861.00
128_L132_P1.3851.00
67_V212_V1.3821.00
72_D215_G1.3731.00
163_C168_T1.3701.00
125_D158_A1.3681.00
41_Y45_L1.3661.00
197_L238_G1.3491.00
239_A243_R1.3471.00
100_V119_P1.3331.00
283_D315_H1.3191.00
164_R188_T1.3141.00
195_R210_F1.3061.00
290_D294_A1.2941.00
40_A240_H1.2891.00
94_P116_G1.2871.00
254_H257_S1.2871.00
162_R166_A1.2821.00
41_Y237_V1.2781.00
54_D222_R1.2761.00
220_T223_T1.2671.00
262_M330_L1.2661.00
154_D157_R1.2661.00
89_E115_Q1.2661.00
162_R168_T1.2581.00
283_D314_S1.2581.00
20_P300_G1.2571.00
254_H258_E1.2551.00
70_A73_T1.2501.00
88_I139_I1.2471.00
124_H158_A1.2401.00
265_A327_D1.2301.00
282_L318_V1.2251.00
219_T223_T1.2221.00
124_H128_L1.2181.00
293_M297_S1.2181.00
78_P82_A1.2131.00
259_R263_R1.2131.00
161_A164_R1.2131.00
124_H162_R1.2121.00
58_A243_R1.2101.00
99_L122_V1.2081.00
40_A43_A1.2011.00
82_A225_R1.1941.00
131_D162_R1.1881.00
54_D60_R1.1811.00
43_A47_D1.1761.00
240_H243_R1.1721.00
249_A252_R1.1691.00
154_D158_A1.1621.00
88_I92_V1.1591.00
58_A236_A1.1581.00
327_D331_A1.1581.00
83_G211_L1.1561.00
123_P126_A1.1561.00
125_D129_D1.1541.00
36_G244_Q1.1521.00
75_V218_L1.1511.00
192_V213_A1.1411.00
258_E261_R1.1371.00
60_R64_A1.1341.00
291_A294_A1.1291.00
66_H245_S1.1291.00
295_A299_E1.1281.00
253_R256_A1.1231.00
245_S249_A1.1221.00
92_V98_V1.1181.00
128_L166_A1.1141.00
257_S324_D1.1131.00
240_H244_Q1.1101.00
169_E192_V1.1091.00
259_R320_V1.1081.00
125_D128_L1.1041.00
138_A168_T1.0961.00
93_T96_D1.0941.00
189_P214_V1.0931.00
253_R257_S1.0891.00
289_V307_T1.0881.00
185_I188_T1.0801.00
192_V211_L1.0761.00
294_A297_S1.0731.00
160_A191_V1.0711.00
63_A76_Q1.0631.00
90_T224_A1.0561.00
236_A239_A1.0491.00
98_V137_L1.0361.00
250_E254_H1.0351.00
112_V119_P1.0271.00
57_P71_R1.0241.00
104_S141_C1.0231.00
67_V210_F1.0231.00
164_R189_P1.0211.00
261_R264_A1.0171.00
292_V295_A1.0141.00
58_A61_A1.0061.00
62_A66_H1.0031.00
70_A215_G1.0021.00
132_P135_H0.9991.00
36_G39_A0.9981.00
169_E190_G0.9941.00
21_D300_G0.9931.00
270_F284_V0.9931.00
264_A267_S0.9921.00
91_R137_L0.9901.00
43_A46_D0.9851.00
35_P38_R0.9831.00
128_L162_R0.9771.00
246_E250_E0.9611.00
59_F76_Q0.9561.00
64_A74_V0.9511.00
63_A74_V0.9471.00
318_V329_L0.9411.00
292_V316_V0.9411.00
73_T218_L0.9411.00
218_L222_R0.9371.00
21_D328_R0.9361.00
75_V221_L0.9331.00
164_R187_G0.9331.00
86_L225_R0.9271.00
108_Y139_I0.9261.00
164_R190_G0.9251.00
92_V137_L0.9171.00
83_G194_A0.9151.00
74_V212_V0.9141.00
91_R169_E0.9121.00
57_P60_R0.9061.00
113_E119_P0.9051.00
262_M265_A0.9031.00
258_E323_P0.9021.00
80_G175_A0.9011.00
78_P231_G0.8991.00
250_E253_R0.8981.00
157_R187_G0.8971.00
131_D168_T0.8971.00
128_L131_D0.8931.00
38_R45_L0.8931.00
169_E217_R0.8921.00
215_G219_T0.8851.00
64_A70_A0.8851.00
247_F251_T0.8831.00
80_G196_S0.8831.00
160_A188_T0.8801.00
135_H168_T0.8711.00
174_E193_V0.8701.00
66_H178_G0.8691.00
194_A211_L0.8581.00
59_F63_A0.8541.00
192_V217_R0.8511.00
247_F250_E0.8501.00
208_A230_L0.8471.00
284_V316_V0.8461.00
181_D275_S0.8441.00
324_D327_D0.8431.00
101_P122_V0.8421.00
208_A234_A0.8411.00
56_Y239_A0.8411.00
82_A227_T0.8401.00
81_L107_E0.8401.00
90_T221_L0.8341.00
246_E249_A0.8321.00
39_A46_D0.8291.00
124_H127_L0.8241.00
110_R113_E0.8241.00
40_A44_A0.8211.00
56_Y235_A0.8151.00
289_V305_D0.8141.00
122_V130_A0.8121.00
289_V293_M0.8111.00
260_A263_R0.8101.00
144_N147_T0.8071.00
132_P166_A0.8031.00
99_L130_A0.8031.00
36_G240_H0.8031.00
129_D132_P0.8001.00
303_L318_V0.8001.00
97_T136_T0.7991.00
290_D293_M0.7991.00
178_G200_L0.7981.00
257_S261_R0.7951.00
81_L105_F0.7951.00
288_P307_T0.7931.00
322_T325_E0.7931.00
160_A170_L0.7901.00
262_M320_V0.7871.00
261_R324_D0.7861.00
82_A86_L0.7741.00
176_F279_F0.7731.00
89_E224_A0.7731.00
264_A327_D0.7711.00
19_D300_G0.7691.00
32_R254_H0.7641.00
257_S260_A0.7631.00
77_T211_L0.7621.00
85_R115_Q0.7601.00
69_C73_T0.7601.00
101_P144_N0.7571.00
87_A221_L0.7571.00
150_R276_S0.7561.00
66_H201_F0.7551.00
30_T255_V0.7541.00
197_L210_F0.7461.00
285_G314_S0.7441.00
124_H155_A0.7441.00
200_L248_V0.7441.00
65_D68_D0.7431.00
79_G207_R0.7421.00
301_I333_L0.7411.00
44_A47_D0.7411.00
48_A236_A0.7371.00
66_H177_L0.7361.00
306_A309_F0.7341.00
75_V211_L0.7341.00
98_V117_A0.7331.00
99_L138_A0.7251.00
290_D307_T0.7221.00
292_V303_L0.7201.00
248_V252_R0.7201.00
222_R225_R0.7201.00
213_A221_L0.7201.00
256_A259_R0.7191.00
151_Y155_A0.7131.00
36_G247_F0.7131.00
58_A62_A0.7071.00
64_A69_C0.7071.00
86_L221_L0.7071.00
259_R274_P0.7061.00
251_T255_V0.7051.00
41_Y233_P0.7031.00
270_F282_L0.6981.00
131_D135_H0.6961.00
31_P258_E0.6951.00
108_Y112_V0.6911.00
33_T37_T0.6901.00
24_D29_T0.6871.00
42_A45_L0.6871.00
232_A236_A0.6861.00
281_L315_H0.6861.00
189_P216_D0.6861.00
142_T174_E0.6831.00
271_D285_G0.6831.00
62_A242_M0.6821.00
67_V193_V0.6811.00
282_L315_H0.6791.00
102_A312_L0.6771.00
292_V296_A0.6761.00
122_V126_A0.6761.00
163_C166_A0.6761.00
219_T222_R0.6751.00
177_L195_R0.6751.00
301_I332_A0.6741.00
323_P326_N0.6731.00
266_L282_L0.6721.00
216_D219_T0.6721.00
261_R330_L0.6651.00
140_A156_L0.6621.00
88_I137_L0.6611.00
44_A237_V0.6601.00
323_P327_D0.6581.00
120_V135_H0.6581.00
100_V112_V0.6571.00
188_T191_V0.6571.00
237_V240_H0.6561.00
151_Y156_L0.6521.00
213_A217_R0.6501.00
92_V96_D0.6491.00
153_D184_S0.6491.00
293_M305_D0.6491.00
145_N176_F0.6421.00
254_H324_D0.6401.00
100_V121_F0.6381.00
296_A333_L0.6361.00
60_R71_R0.6351.00
124_H159_F0.6351.00
172_V193_V0.6341.00
47_D240_H0.6341.00
235_A239_A0.6341.00
322_T326_N0.6341.00
306_A315_H0.6311.00
33_T38_R0.6301.00
85_R111_E0.6281.00
301_I329_L0.6281.00
273_H283_D0.6271.00
252_R256_A0.6241.00
127_L131_D0.6231.00
181_D256_A0.6231.00
139_I171_L0.6201.00
236_A240_H0.6191.00
23_L328_R0.6151.00
55_D60_R0.6151.00
38_R41_Y0.6141.00
97_T133_S0.6131.00
179_F255_V0.6121.00
75_V213_A0.6111.00
84_I111_E0.6111.00
296_A303_L0.6101.00
88_I117_A0.6091.00
60_R222_R0.6091.00
76_Q208_A0.6081.00
325_E328_R0.6071.00
201_F245_S0.6051.00
289_V314_S0.6011.00
258_E326_N0.6011.00
181_D184_S0.6011.00
143_P276_S0.5981.00
225_R230_L0.5971.00
95_G118_T0.5951.00
59_F238_G0.5921.00
75_V222_R0.5911.00
40_A237_V0.5901.00
120_V130_A0.5891.00
26_S302_R0.5881.00
142_T150_R0.5861.00
153_D185_I0.5851.00
28_N176_F0.5841.00
22_V302_R0.5841.00
127_L138_A0.5841.00
290_D305_D0.5831.00
100_V109_A0.5821.00
160_A163_C0.5801.00
131_D166_A0.5791.00
158_A162_R0.5781.00
261_R323_P0.5781.00
214_V217_R0.5771.00
150_R180_T0.5761.00
262_M326_N0.5741.00
288_P314_S0.5701.00
61_A243_R0.5701.00
135_H138_A0.5671.00
174_E177_L0.5661.00
149_D275_S0.5661.00
37_T203_L0.5661.00
268_D327_D0.5651.00
86_L224_A0.5631.00
179_F252_R0.5621.00
272_V280_L0.5621.00
262_M318_V0.5621.00
59_F62_A0.5611.00
87_A194_A0.5611.00
87_A91_R0.5601.00
78_P230_L0.5581.00
83_G209_G0.5561.00
156_L172_V0.5561.00
24_D27_A0.5541.00
88_I111_E0.5541.00
53_D57_P0.5531.00
69_C74_V0.5521.00
120_V132_P0.5521.00
37_T241_A0.5511.00
284_V287_R0.5501.00
81_L228_W0.5481.00
64_A68_D0.5471.00
19_D22_V0.5461.00
269_A285_G0.5451.00
186_A189_P0.5451.00
163_C167_N0.5431.00
36_G246_E0.5421.00
163_C190_G0.5421.00
127_L162_R0.5401.00
96_D134_E0.5371.00
251_T254_H0.5351.00
257_S323_P0.5351.00
93_T136_T0.5341.00
138_A163_C0.5311.00
197_L242_M0.5311.00
102_A311_G0.5311.00
106_S308_T0.5301.00
36_G40_A0.5281.00
102_A310_R0.5251.00
293_M303_L0.5251.00
157_R185_I0.5251.00
198_T207_R0.5241.00
56_Y232_A0.5211.00
255_V278_P0.5201.00
132_P165_A0.5201.00
297_S302_R0.5191.00
87_A137_L0.5191.00
90_T220_T0.5191.00
267_S271_D0.5171.00
41_Y44_A0.5151.00
310_R313_D0.5141.00
102_A109_A0.5141.00
99_L127_L0.5101.00
137_L169_E0.5091.00
262_M329_L0.5081.00
88_I115_Q0.5031.00
43_A244_Q0.5031.00
230_L235_A0.5021.00
61_A64_A0.5011.00
161_A188_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3piuA 2 0.994 100 0.319 Contact Map
3getA 2 0.9911 100 0.324 Contact Map
3pplA 2 0.997 100 0.33 Contact Map
3ffhA 2 0.9762 100 0.333 Contact Map
1fg7A 2 0.9732 100 0.334 Contact Map
3ly1A 2 0.9524 100 0.335 Contact Map
3ezsA 2 0.9792 100 0.338 Contact Map
3jtxA 2 0.997 100 0.338 Contact Map
3dydA 2 0.9732 100 0.341 Contact Map
4wbtA 2 0.9821 100 0.342 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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