Q9HPL0 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HPL0 - Histidinol-phosphate transaminase

UniProt:	Q9HPL0	Sequences: MHPDAVRDAGRVAHGGSDDPDVLDFSANTTPRTPPGTRAAYAAALDDAARYPDDDYPAFRAAAADHVDCARDTVVQTPGGLAGIRLAIETRVTPGDTVLVPAPSFSEYAREVELQGATPVFVPHDALLDADPSEHTLAIACTPNNPTGDRYDDDALRAFAARCRAANTELLVDEAFLGFTDAPSIAGTPGVVVARSLTKLFGLPGLRAGFLVAVGDRLTTLRTARRTWNLGAPAAAVGAHAMRQSEFVAETRRHVASERARMRAALSDAFDVHPSSAPFLLLDVGPRPVDAVMAAASAEGIRLRDATTFRGLDSHVRVAVRTPDENDRLLAALADV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (315)
Sequences:	43899 (30526)
Seq/√Len:	1719.9

ECOLI - YBDL ALAC MALY ALAA YDCR HIS8 AVTA YJIR
BACSU - HIS8 AAT3 PATA MTNE AAT1 YDEF AAT2 YDFD YUGH YDEL YCXD YISV CBL YHDI GABR
HALSA - Q9HPL0 HIS8 Q9HQW2 Q9HQK2 Q9HRX4 Q9HRM6
SULSO - AAT Y104 Q97YX5 HIS8 Q97TY7 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_A	46_D	3.237	1.00
77_T	83_G	3.191	1.00
97_T	118_T	3.064	1.00
261_R	327_D	2.802	1.00
62_A	243_R	2.785	1.00
256_A	260_A	2.744	1.00
92_V	117_A	2.714	1.00
271_D	283_D	2.643	1.00
153_D	157_R	2.626	1.00
96_D	136_T	2.565	1.00
213_A	218_L	2.433	1.00
328_R	332_A	2.361	1.00
85_R	89_E	2.278	1.00
294_A	298_A	2.215	1.00
35_P	39_A	2.209	1.00
152_D	155_A	2.193	1.00
128_L	165_A	2.176	1.00
265_A	330_L	2.161	1.00
97_T	120_V	2.084	1.00
208_A	238_G	2.034	1.00
263_R	267_S	2.006	1.00
58_A	239_A	1.993	1.00
39_A	43_A	1.947	1.00
61_A	71_R	1.930	1.00
157_R	161_A	1.885	1.00
102_A	121_F	1.883	1.00
265_A	268_D	1.871	1.00
261_R	265_A	1.832	1.00
171_L	194_A	1.824	1.00
62_A	65_D	1.811	1.00
112_V	117_A	1.784	1.00
109_A	113_E	1.750	1.00
328_R	331_A	1.749	1.00
126_A	130_A	1.743	1.00
267_S	272_V	1.742	1.00
57_P	61_A	1.728	1.00
175_A	196_S	1.724	1.00
163_C	170_L	1.723	1.00
38_R	42_A	1.693	1.00
264_A	268_D	1.693	1.00
43_A	240_H	1.690	1.00
61_A	65_D	1.685	1.00
73_T	215_G	1.674	1.00
65_D	243_R	1.669	1.00
265_A	331_A	1.659	1.00
87_A	192_V	1.647	1.00
260_A	264_A	1.638	1.00
126_A	129_D	1.633	1.00
97_T	134_E	1.629	1.00
167_N	190_G	1.619	1.00
291_A	295_A	1.617	1.00
25_F	329_L	1.614	1.00
231_G	234_A	1.586	1.00
64_A	71_R	1.585	1.00
98_V	112_V	1.572	1.00
97_T	135_H	1.553	1.00
80_G	194_A	1.530	1.00
99_L	135_H	1.528	1.00
158_A	161_A	1.525	1.00
128_L	158_A	1.524	1.00
69_C	212_V	1.520	1.00
63_A	210_F	1.507	1.00
262_M	280_L	1.499	1.00
109_A	121_F	1.497	1.00
211_L	221_L	1.496	1.00
87_A	171_L	1.493	1.00
155_A	158_A	1.489	1.00
88_I	112_V	1.483	1.00
62_A	239_A	1.482	1.00
295_A	298_A	1.478	1.00
97_T	132_P	1.465	1.00
288_P	291_A	1.465	1.00
102_A	123_P	1.455	1.00
39_A	42_A	1.453	1.00
137_L	171_L	1.439	1.00
281_L	306_A	1.437	1.00
303_L	316_V	1.433	1.00
38_R	46_D	1.426	1.00
263_R	280_L	1.418	1.00
263_R	272_V	1.416	1.00
249_A	253_R	1.404	1.00
161_A	165_A	1.404	1.00
299_E	332_A	1.395	1.00
56_Y	236_A	1.386	1.00
128_L	132_P	1.385	1.00
67_V	212_V	1.382	1.00
72_D	215_G	1.373	1.00
163_C	168_T	1.370	1.00
125_D	158_A	1.368	1.00
41_Y	45_L	1.366	1.00
197_L	238_G	1.349	1.00
239_A	243_R	1.347	1.00
100_V	119_P	1.333	1.00
283_D	315_H	1.319	1.00
164_R	188_T	1.314	1.00
195_R	210_F	1.306	1.00
290_D	294_A	1.294	1.00
40_A	240_H	1.289	1.00
94_P	116_G	1.287	1.00
254_H	257_S	1.287	1.00
162_R	166_A	1.282	1.00
41_Y	237_V	1.278	1.00
54_D	222_R	1.276	1.00
220_T	223_T	1.267	1.00
262_M	330_L	1.266	1.00
154_D	157_R	1.266	1.00
89_E	115_Q	1.266	1.00
162_R	168_T	1.258	1.00
283_D	314_S	1.258	1.00
20_P	300_G	1.257	1.00
254_H	258_E	1.255	1.00
70_A	73_T	1.250	1.00
88_I	139_I	1.247	1.00
124_H	158_A	1.240	1.00
265_A	327_D	1.230	1.00
282_L	318_V	1.225	1.00
219_T	223_T	1.222	1.00
124_H	128_L	1.218	1.00
293_M	297_S	1.218	1.00
78_P	82_A	1.213	1.00
259_R	263_R	1.213	1.00
161_A	164_R	1.213	1.00
124_H	162_R	1.212	1.00
58_A	243_R	1.210	1.00
99_L	122_V	1.208	1.00
40_A	43_A	1.201	1.00
82_A	225_R	1.194	1.00
131_D	162_R	1.188	1.00
54_D	60_R	1.181	1.00
43_A	47_D	1.176	1.00
240_H	243_R	1.172	1.00
249_A	252_R	1.169	1.00
154_D	158_A	1.162	1.00
88_I	92_V	1.159	1.00
58_A	236_A	1.158	1.00
327_D	331_A	1.158	1.00
83_G	211_L	1.156	1.00
123_P	126_A	1.156	1.00
125_D	129_D	1.154	1.00
36_G	244_Q	1.152	1.00
75_V	218_L	1.151	1.00
192_V	213_A	1.141	1.00
258_E	261_R	1.137	1.00
60_R	64_A	1.134	1.00
291_A	294_A	1.129	1.00
66_H	245_S	1.129	1.00
295_A	299_E	1.128	1.00
253_R	256_A	1.123	1.00
245_S	249_A	1.122	1.00
92_V	98_V	1.118	1.00
128_L	166_A	1.114	1.00
257_S	324_D	1.113	1.00
240_H	244_Q	1.110	1.00
169_E	192_V	1.109	1.00
259_R	320_V	1.108	1.00
125_D	128_L	1.104	1.00
138_A	168_T	1.096	1.00
93_T	96_D	1.094	1.00
189_P	214_V	1.093	1.00
253_R	257_S	1.089	1.00
289_V	307_T	1.088	1.00
185_I	188_T	1.080	1.00
192_V	211_L	1.076	1.00
294_A	297_S	1.073	1.00
160_A	191_V	1.071	1.00
63_A	76_Q	1.063	1.00
90_T	224_A	1.056	1.00
236_A	239_A	1.049	1.00
98_V	137_L	1.036	1.00
250_E	254_H	1.035	1.00
112_V	119_P	1.027	1.00
57_P	71_R	1.024	1.00
104_S	141_C	1.023	1.00
67_V	210_F	1.023	1.00
164_R	189_P	1.021	1.00
261_R	264_A	1.017	1.00
292_V	295_A	1.014	1.00
58_A	61_A	1.006	1.00
62_A	66_H	1.003	1.00
70_A	215_G	1.002	1.00
132_P	135_H	0.999	1.00
36_G	39_A	0.998	1.00
169_E	190_G	0.994	1.00
21_D	300_G	0.993	1.00
270_F	284_V	0.993	1.00
264_A	267_S	0.992	1.00
91_R	137_L	0.990	1.00
43_A	46_D	0.985	1.00
35_P	38_R	0.983	1.00
128_L	162_R	0.977	1.00
246_E	250_E	0.961	1.00
59_F	76_Q	0.956	1.00
64_A	74_V	0.951	1.00
63_A	74_V	0.947	1.00
318_V	329_L	0.941	1.00
292_V	316_V	0.941	1.00
73_T	218_L	0.941	1.00
218_L	222_R	0.937	1.00
21_D	328_R	0.936	1.00
75_V	221_L	0.933	1.00
164_R	187_G	0.933	1.00
86_L	225_R	0.927	1.00
108_Y	139_I	0.926	1.00
164_R	190_G	0.925	1.00
92_V	137_L	0.917	1.00
83_G	194_A	0.915	1.00
74_V	212_V	0.914	1.00
91_R	169_E	0.912	1.00
57_P	60_R	0.906	1.00
113_E	119_P	0.905	1.00
262_M	265_A	0.903	1.00
258_E	323_P	0.902	1.00
80_G	175_A	0.901	1.00
78_P	231_G	0.899	1.00
250_E	253_R	0.898	1.00
157_R	187_G	0.897	1.00
131_D	168_T	0.897	1.00
128_L	131_D	0.893	1.00
38_R	45_L	0.893	1.00
169_E	217_R	0.892	1.00
215_G	219_T	0.885	1.00
64_A	70_A	0.885	1.00
247_F	251_T	0.883	1.00
80_G	196_S	0.883	1.00
160_A	188_T	0.880	1.00
135_H	168_T	0.871	1.00
174_E	193_V	0.870	1.00
66_H	178_G	0.869	1.00
194_A	211_L	0.858	1.00
59_F	63_A	0.854	1.00
192_V	217_R	0.851	1.00
247_F	250_E	0.850	1.00
208_A	230_L	0.847	1.00
284_V	316_V	0.846	1.00
181_D	275_S	0.844	1.00
324_D	327_D	0.843	1.00
101_P	122_V	0.842	1.00
208_A	234_A	0.841	1.00
56_Y	239_A	0.841	1.00
82_A	227_T	0.840	1.00
81_L	107_E	0.840	1.00
90_T	221_L	0.834	1.00
246_E	249_A	0.832	1.00
39_A	46_D	0.829	1.00
124_H	127_L	0.824	1.00
110_R	113_E	0.824	1.00
40_A	44_A	0.821	1.00
56_Y	235_A	0.815	1.00
289_V	305_D	0.814	1.00
122_V	130_A	0.812	1.00
289_V	293_M	0.811	1.00
260_A	263_R	0.810	1.00
144_N	147_T	0.807	1.00
132_P	166_A	0.803	1.00
99_L	130_A	0.803	1.00
36_G	240_H	0.803	1.00
129_D	132_P	0.800	1.00
303_L	318_V	0.800	1.00
97_T	136_T	0.799	1.00
290_D	293_M	0.799	1.00
178_G	200_L	0.798	1.00
257_S	261_R	0.795	1.00
81_L	105_F	0.795	1.00
288_P	307_T	0.793	1.00
322_T	325_E	0.793	1.00
160_A	170_L	0.790	1.00
262_M	320_V	0.787	1.00
261_R	324_D	0.786	1.00
82_A	86_L	0.774	1.00
176_F	279_F	0.773	1.00
89_E	224_A	0.773	1.00
264_A	327_D	0.771	1.00
19_D	300_G	0.769	1.00
32_R	254_H	0.764	1.00
257_S	260_A	0.763	1.00
77_T	211_L	0.762	1.00
85_R	115_Q	0.760	1.00
69_C	73_T	0.760	1.00
101_P	144_N	0.757	1.00
87_A	221_L	0.757	1.00
150_R	276_S	0.756	1.00
66_H	201_F	0.755	1.00
30_T	255_V	0.754	1.00
197_L	210_F	0.746	1.00
285_G	314_S	0.744	1.00
124_H	155_A	0.744	1.00
200_L	248_V	0.744	1.00
65_D	68_D	0.743	1.00
79_G	207_R	0.742	1.00
301_I	333_L	0.741	1.00
44_A	47_D	0.741	1.00
48_A	236_A	0.737	1.00
66_H	177_L	0.736	1.00
306_A	309_F	0.734	1.00
75_V	211_L	0.734	1.00
98_V	117_A	0.733	1.00
99_L	138_A	0.725	1.00
290_D	307_T	0.722	1.00
292_V	303_L	0.720	1.00
248_V	252_R	0.720	1.00
222_R	225_R	0.720	1.00
213_A	221_L	0.720	1.00
256_A	259_R	0.719	1.00
151_Y	155_A	0.713	1.00
36_G	247_F	0.713	1.00
58_A	62_A	0.707	1.00
64_A	69_C	0.707	1.00
86_L	221_L	0.707	1.00
259_R	274_P	0.706	1.00
251_T	255_V	0.705	1.00
41_Y	233_P	0.703	1.00
270_F	282_L	0.698	1.00
131_D	135_H	0.696	1.00
31_P	258_E	0.695	1.00
108_Y	112_V	0.691	1.00
33_T	37_T	0.690	1.00
24_D	29_T	0.687	1.00
42_A	45_L	0.687	1.00
232_A	236_A	0.686	1.00
281_L	315_H	0.686	1.00
189_P	216_D	0.686	1.00
142_T	174_E	0.683	1.00
271_D	285_G	0.683	1.00
62_A	242_M	0.682	1.00
67_V	193_V	0.681	1.00
282_L	315_H	0.679	1.00
102_A	312_L	0.677	1.00
292_V	296_A	0.676	1.00
122_V	126_A	0.676	1.00
163_C	166_A	0.676	1.00
219_T	222_R	0.675	1.00
177_L	195_R	0.675	1.00
301_I	332_A	0.674	1.00
323_P	326_N	0.673	1.00
266_L	282_L	0.672	1.00
216_D	219_T	0.672	1.00
261_R	330_L	0.665	1.00
140_A	156_L	0.662	1.00
88_I	137_L	0.661	1.00
44_A	237_V	0.660	1.00
323_P	327_D	0.658	1.00
120_V	135_H	0.658	1.00
100_V	112_V	0.657	1.00
188_T	191_V	0.657	1.00
237_V	240_H	0.656	1.00
151_Y	156_L	0.652	1.00
213_A	217_R	0.650	1.00
92_V	96_D	0.649	1.00
153_D	184_S	0.649	1.00
293_M	305_D	0.649	1.00
145_N	176_F	0.642	1.00
254_H	324_D	0.640	1.00
100_V	121_F	0.638	1.00
296_A	333_L	0.636	1.00
60_R	71_R	0.635	1.00
124_H	159_F	0.635	1.00
172_V	193_V	0.634	1.00
47_D	240_H	0.634	1.00
235_A	239_A	0.634	1.00
322_T	326_N	0.634	1.00
306_A	315_H	0.631	1.00
33_T	38_R	0.630	1.00
85_R	111_E	0.628	1.00
301_I	329_L	0.628	1.00
273_H	283_D	0.627	1.00
252_R	256_A	0.624	1.00
127_L	131_D	0.623	1.00
181_D	256_A	0.623	1.00
139_I	171_L	0.620	1.00
236_A	240_H	0.619	1.00
23_L	328_R	0.615	1.00
55_D	60_R	0.615	1.00
38_R	41_Y	0.614	1.00
97_T	133_S	0.613	1.00
179_F	255_V	0.612	1.00
75_V	213_A	0.611	1.00
84_I	111_E	0.611	1.00
296_A	303_L	0.610	1.00
88_I	117_A	0.609	1.00
60_R	222_R	0.609	1.00
76_Q	208_A	0.608	1.00
325_E	328_R	0.607	1.00
201_F	245_S	0.605	1.00
289_V	314_S	0.601	1.00
258_E	326_N	0.601	1.00
181_D	184_S	0.601	1.00
143_P	276_S	0.598	1.00
225_R	230_L	0.597	1.00
95_G	118_T	0.595	1.00
59_F	238_G	0.592	1.00
75_V	222_R	0.591	1.00
40_A	237_V	0.590	1.00
120_V	130_A	0.589	1.00
26_S	302_R	0.588	1.00
142_T	150_R	0.586	1.00
153_D	185_I	0.585	1.00
28_N	176_F	0.584	1.00
22_V	302_R	0.584	1.00
127_L	138_A	0.584	1.00
290_D	305_D	0.583	1.00
100_V	109_A	0.582	1.00
160_A	163_C	0.580	1.00
131_D	166_A	0.579	1.00
158_A	162_R	0.578	1.00
261_R	323_P	0.578	1.00
214_V	217_R	0.577	1.00
150_R	180_T	0.576	1.00
262_M	326_N	0.574	1.00
288_P	314_S	0.570	1.00
61_A	243_R	0.570	1.00
135_H	138_A	0.567	1.00
174_E	177_L	0.566	1.00
149_D	275_S	0.566	1.00
37_T	203_L	0.566	1.00
268_D	327_D	0.565	1.00
86_L	224_A	0.563	1.00
179_F	252_R	0.562	1.00
272_V	280_L	0.562	1.00
262_M	318_V	0.562	1.00
59_F	62_A	0.561	1.00
87_A	194_A	0.561	1.00
87_A	91_R	0.560	1.00
78_P	230_L	0.558	1.00
83_G	209_G	0.556	1.00
156_L	172_V	0.556	1.00
24_D	27_A	0.554	1.00
88_I	111_E	0.554	1.00
53_D	57_P	0.553	1.00
69_C	74_V	0.552	1.00
120_V	132_P	0.552	1.00
37_T	241_A	0.551	1.00
284_V	287_R	0.550	1.00
81_L	228_W	0.548	1.00
64_A	68_D	0.547	1.00
19_D	22_V	0.546	1.00
269_A	285_G	0.545	1.00
186_A	189_P	0.545	1.00
163_C	167_N	0.543	1.00
36_G	246_E	0.542	1.00
163_C	190_G	0.542	1.00
127_L	162_R	0.540	1.00
96_D	134_E	0.537	1.00
251_T	254_H	0.535	1.00
257_S	323_P	0.535	1.00
93_T	136_T	0.534	1.00
138_A	163_C	0.531	1.00
197_L	242_M	0.531	1.00
102_A	311_G	0.531	1.00
106_S	308_T	0.530	1.00
36_G	40_A	0.528	1.00
102_A	310_R	0.525	1.00
293_M	303_L	0.525	1.00
157_R	185_I	0.525	1.00
198_T	207_R	0.524	1.00
56_Y	232_A	0.521	1.00
255_V	278_P	0.520	1.00
132_P	165_A	0.520	1.00
297_S	302_R	0.519	1.00
87_A	137_L	0.519	1.00
90_T	220_T	0.519	1.00
267_S	271_D	0.517	1.00
41_Y	44_A	0.515	1.00
310_R	313_D	0.514	1.00
102_A	109_A	0.514	1.00
99_L	127_L	0.510	1.00
137_L	169_E	0.509	1.00
262_M	329_L	0.508	1.00
88_I	115_Q	0.503	1.00
43_A	244_Q	0.503	1.00
230_L	235_A	0.502	1.00
61_A	64_A	0.501	1.00
161_A	188_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3piuA	2	0.994	100	0.319	Contact Map
3getA	2	0.9911	100	0.324	Contact Map
3pplA	2	0.997	100	0.33	Contact Map
3ffhA	2	0.9762	100	0.333	Contact Map
1fg7A	2	0.9732	100	0.334	Contact Map
3ly1A	2	0.9524	100	0.335	Contact Map
3ezsA	2	0.9792	100	0.338	Contact Map
3jtxA	2	0.997	100	0.338	Contact Map
3dydA	2	0.9732	100	0.341	Contact Map
4wbtA	2	0.9821	100	0.342	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.