GREMLIN Database
CBIZ - Adenosylcobinamide amidohydrolase
UniProt: Q9HPK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (191)
Sequences: 553 (410)
Seq/√Len: 29.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_A197_A4.2971.00
162_T183_A3.8371.00
154_A195_R3.6851.00
94_A201_S3.5251.00
124_L198_V3.5141.00
19_R134_D3.3991.00
140_L190_T3.0261.00
92_A198_V2.9781.00
96_L202_L2.6751.00
151_T198_V2.5240.99
126_A190_T2.4200.99
99_P163_S2.3720.99
145_A149_A2.3290.99
92_A124_L2.3070.99
21_L138_S2.2690.99
21_L29_D2.2320.99
85_C196_E2.2210.98
39_T75_V2.1340.98
38_I56_R2.0470.97
144_A166_V1.9850.97
94_A202_L1.8960.96
141_V166_V1.8530.95
82_I89_A1.8330.95
44_W52_Y1.8050.94
38_I52_Y1.7850.94
79_H205_R1.7830.94
85_C192_A1.7500.94
131_A171_D1.7500.94
90_V126_A1.7360.93
122_V152_L1.7290.93
200_A204_S1.7150.93
177_A186_V1.6940.92
138_S141_V1.6540.91
125_V167_V1.6120.90
71_L167_V1.6070.90
96_L161_T1.6070.90
92_A201_S1.5760.89
142_A145_A1.5720.89
98_N162_T1.5340.88
10_V13_L1.5300.88
99_P162_T1.4950.87
94_A163_S1.4870.86
81_R200_A1.4720.86
90_V193_C1.4560.85
49_T72_L1.4500.85
100_A162_T1.4480.85
80_A91_A1.4170.83
35_A125_V1.4160.83
35_A169_A1.4120.83
96_L122_V1.4120.83
40_V72_L1.3990.83
25_W53_V1.3920.82
128_T190_T1.3900.82
155_T202_L1.3260.79
139_N183_A1.3060.78
49_T179_Y1.2890.77
99_P158_F1.2830.77
149_A159_P1.2780.76
18_A171_D1.2640.76
51_E54_T1.2640.76
52_Y183_A1.2630.76
83_A200_A1.2540.75
37_S148_K1.2420.74
98_N184_T1.2340.74
10_V14_A1.2160.73
83_A196_E1.2000.72
40_V179_Y1.1870.71
51_E207_A1.1570.69
89_A127_A1.1570.69
100_A150_A1.1550.69
32_A69_P1.1420.68
159_P191_R1.1380.68
139_N165_A1.1360.67
27_G182_S1.1270.67
75_V179_Y1.1220.66
151_T195_R1.1210.66
84_R89_A1.1190.66
72_L165_A1.0960.65
98_N103_P1.0910.64
124_L166_V1.0910.64
52_Y56_R1.0880.64
155_T158_F1.0850.64
123_N181_G1.0840.64
40_V165_A1.0810.64
148_K165_A1.0790.63
133_D136_A1.0780.63
102_L143_V1.0770.63
37_S163_S1.0550.62
98_N179_Y1.0550.62
75_V202_L1.0500.61
144_A190_T1.0480.61
29_D137_L1.0460.61
129_T189_A1.0430.61
128_T186_V1.0360.60
46_P52_Y1.0350.60
186_V189_A1.0340.60
86_G115_K1.0310.60
126_A155_T1.0100.58
31_R201_S1.0060.58
90_V197_A1.0050.58
162_T182_S0.9990.57
41_P74_G0.9970.57
143_V182_S0.9940.57
23_T148_K0.9900.57
183_A188_A0.9850.56
31_R137_L0.9720.55
48_S51_E0.9690.55
158_F191_R0.9650.55
100_A183_A0.9560.54
50_H54_T0.9460.53
98_N161_T0.9150.51
51_E178_P0.9080.50
23_T139_N0.9050.50
51_E63_A0.9000.50
81_R201_S0.8990.49
24_G69_P0.8920.49
188_A192_A0.8840.48
101_A156_A0.8770.48
82_I168_V0.8740.48
74_G138_S0.8730.47
24_G75_V0.8580.46
144_A194_V0.8560.46
61_G67_D0.8550.46
98_N101_A0.8530.46
155_T199_R0.8520.46
21_L137_L0.8330.44
82_I91_A0.8320.44
68_A129_T0.8260.44
20_W69_P0.8220.43
23_T37_S0.8200.43
95_G161_T0.8130.43
20_W169_A0.8100.43
44_W139_N0.8080.42
103_P191_R0.8070.42
33_D67_D0.7990.42
126_A144_A0.7990.42
155_T203_D0.7940.41
49_T70_V0.7890.41
162_T188_A0.7870.41
137_L170_C0.7860.41
154_A199_R0.7830.40
35_A50_H0.7830.40
13_L16_P0.7770.40
136_A145_A0.7720.40
19_R31_R0.7720.40
93_T121_T0.7640.39
143_V148_K0.7640.39
102_L182_S0.7600.39
158_F163_S0.7580.39
20_W35_A0.7570.38
23_T191_R0.7540.38
59_A200_A0.7510.38
31_R172_P0.7480.38
42_D202_L0.7430.37
19_R170_C0.7350.37
163_S202_L0.7300.36
75_V205_R0.7260.36
40_V184_T0.7240.36
39_T79_H0.7220.36
111_L114_A0.7200.36
44_W143_V0.7190.36
99_P102_L0.7160.35
112_P149_A0.7060.35
153_L158_F0.7050.35
100_A161_T0.7020.34
122_V159_P0.7010.34
130_R143_V0.6970.34
49_T165_A0.6940.34
131_A173_G0.6920.34
47_D52_Y0.6900.34
95_G160_G0.6890.34
124_L144_A0.6810.33
114_A178_P0.6810.33
100_A163_S0.6790.33
132_L136_A0.6780.33
51_E124_L0.6750.33
37_S71_L0.6750.33
141_V145_A0.6720.32
162_T189_A0.6710.32
93_T164_D0.6690.32
90_V124_L0.6660.32
149_A157_G0.6660.32
56_R60_A0.6660.32
19_R169_A0.6660.32
122_V166_V0.6630.32
75_V148_K0.6620.32
121_T160_G0.6550.31
87_P129_T0.6550.31
33_D126_A0.6510.31
44_W102_L0.6510.31
35_A72_L0.6430.30
42_D74_G0.6430.30
141_V144_A0.6400.30
144_A147_A0.6390.30
90_V167_V0.6380.30
71_L150_A0.6280.29
113_D116_R0.6230.29
100_A159_P0.6220.29
122_V158_F0.6210.29
36_Y57_L0.6200.29
77_Q102_L0.6170.29
88_V129_T0.6150.29
26_N77_Q0.6140.28
128_T180_S0.6130.28
78_E124_L0.6100.28
147_A201_S0.6090.28
130_R195_R0.6090.28
101_A154_A0.6090.28
51_E61_G0.6060.28
91_A169_A0.6050.28
133_D170_C0.6040.28
24_G182_S0.6030.28
198_V201_S0.6030.28
33_D54_T0.6020.28
57_L70_V0.6010.28
79_H204_S0.6000.28
185_P188_A0.5900.27
41_P149_A0.5840.27
13_L51_E0.5840.27
62_F87_P0.5820.26
71_L125_V0.5800.26
126_A166_V0.5770.26
150_A183_A0.5770.26
58_A62_F0.5770.26
168_V185_P0.5750.26
35_A172_P0.5740.26
149_A153_L0.5730.26
21_L140_L0.5720.26
27_G102_L0.5720.26
69_P167_V0.5700.26
42_D72_L0.5670.26
59_A157_G0.5650.25
146_E190_T0.5650.25
121_T164_D0.5640.25
80_A97_S0.5610.25
126_A175_E0.5600.25
55_D133_D0.5600.25
53_V70_V0.5500.25
41_P76_A0.5480.24
26_N70_V0.5470.24
123_N187_G0.5460.24
143_V183_A0.5450.24
128_T174_G0.5450.24
38_I139_N0.5440.24
33_D116_R0.5430.24
123_N160_G0.5430.24
103_P184_T0.5420.24
124_L128_T0.5400.24
95_G164_D0.5390.24
152_L167_V0.5380.24
105_D145_A0.5370.24
81_R204_S0.5370.24
31_R128_T0.5350.24
50_H178_P0.5300.23
139_N162_T0.5300.23
53_V72_L0.5290.23
137_L168_V0.5290.23
44_W74_G0.5290.23
121_T161_T0.5270.23
34_R63_A0.5270.23
26_N44_W0.5250.23
40_V123_N0.5220.23
18_A127_A0.5220.23
146_E158_F0.5210.23
72_L179_Y0.5200.23
96_L152_L0.5170.23
23_T102_L0.5170.23
100_A191_R0.5160.23
150_A162_T0.5160.23
147_A194_V0.5160.23
156_A174_G0.5150.23
57_L184_T0.5150.23
21_L182_S0.5110.22
75_V184_T0.5100.22
160_G164_D0.5090.22
40_V181_G0.5090.22
91_A132_L0.5060.22
133_D137_L0.5060.22
50_H90_V0.5060.22
16_P70_V0.5030.22
80_A83_A0.5030.22
54_T185_P0.5020.22
35_A39_T0.5020.22
63_A112_P0.5010.22
88_V173_G0.5000.22
125_V165_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b65A 4 0.9134 28.3 0.956 Contact Map
3n2wA 4 0.9134 9.4 0.965 Contact Map
1qd1A 2 0.3853 8.4 0.966 Contact Map
2lr1B 1 0.0909 7.7 0.966 Contact Map
4rsxA 1 0.2771 6.8 0.967 Contact Map
3zpnA 2 0.2468 5.5 0.968 Contact Map
2eo2A 1 0.3074 5.2 0.969 Contact Map
4mcjA 3 0.316 5 0.969 Contact Map
4rswA 2 0.2771 4.7 0.969 Contact Map
2drhA 4 0.9048 4.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.