GREMLIN Database
Q9HPK8 - Uncharacterized protein
UniProt: Q9HPK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (354)
Sequences: 834 (685)
Seq/√Len: 36.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_H343_N7.1991.00
386_A389_D6.4001.00
349_K357_T6.1761.00
379_N382_E6.0811.00
304_S348_D5.7381.00
369_P390_M5.6961.00
298_D343_N4.4611.00
298_D346_K3.9671.00
214_E227_V3.5041.00
301_F351_P3.4121.00
304_S308_S3.1231.00
298_D354_W2.9611.00
346_K354_W2.8751.00
157_M206_M2.8131.00
172_S206_M2.6051.00
34_E46_I2.5861.00
104_F118_E2.5851.00
299_H302_P2.5821.00
352_A378_E2.5801.00
111_R221_I2.5311.00
328_L381_G2.4241.00
296_E344_R2.3921.00
43_V62_I2.3441.00
304_S307_K2.2680.99
372_N375_Y2.2250.99
104_F112_A2.2020.99
306_L380_V2.1450.99
302_P343_N2.1240.99
393_S397_N2.1120.99
147_E151_F2.0720.99
215_L227_V1.9390.98
92_K151_F1.9310.98
11_G14_S1.9150.98
206_M210_V1.8720.98
101_T104_F1.8680.98
34_E227_V1.8630.98
10_R14_S1.8580.97
169_S207_C1.8450.97
296_E340_E1.8450.97
227_V354_W1.8330.97
106_S111_R1.8080.97
343_N346_K1.7960.97
237_N393_S1.7930.97
133_T136_K1.7750.97
394_D397_N1.7670.97
297_V335_L1.7490.96
24_I72_S1.7240.96
336_Q366_H1.6940.96
22_N25_H1.6590.95
386_A390_M1.6540.95
303_K330_D1.6330.95
205_W391_I1.6270.95
360_D393_S1.5810.94
299_H346_K1.5340.93
178_Y228_R1.5310.93
149_S153_T1.5290.92
227_V351_P1.5030.92
109_V112_A1.4860.91
123_S218_G1.4840.91
302_P351_P1.4630.91
283_L338_I1.4470.90
169_S172_S1.4290.90
67_A133_T1.4260.90
389_D393_S1.4240.89
135_S139_D1.4000.89
114_M129_F1.3930.88
215_L351_P1.3890.88
349_K353_E1.3640.87
207_C211_T1.3550.87
126_L129_F1.3470.87
392_I396_L1.3450.87
371_S386_A1.3410.86
43_V83_R1.3260.86
15_K135_S1.3240.86
263_E384_L1.3160.85
40_Q70_H1.3090.85
106_S118_E1.2990.85
298_D302_P1.2980.85
44_L48_L1.2970.85
232_R347_S1.2970.85
110_L115_L1.2960.84
11_G15_K1.2950.84
66_I69_A1.2900.84
55_T61_D1.2860.84
169_S206_M1.2830.84
218_G221_I1.2820.84
101_T115_L1.2820.84
49_R89_L1.2800.84
369_P386_A1.2760.84
306_L384_L1.2550.82
46_I52_E1.2540.82
50_A214_E1.2500.82
22_N26_D1.2470.82
308_S348_D1.2350.81
26_D222_Q1.2330.81
43_V351_P1.2320.81
302_P354_W1.2300.81
63_L134_L1.2160.80
279_V391_I1.2070.80
243_E301_F1.2070.80
248_L251_Y1.2030.80
255_M399_S1.1730.78
136_K353_E1.1670.78
57_L343_N1.1590.77
353_E382_E1.1590.77
333_A384_L1.1520.77
296_E343_N1.1520.77
86_I109_V1.1510.77
61_D281_S1.1440.76
30_I38_E1.1430.76
214_E354_W1.1430.76
111_R118_E1.1420.76
112_A115_L1.1380.76
86_I276_L1.1360.76
336_Q346_K1.1350.76
382_E386_A1.1310.75
205_W257_F1.1310.75
152_R155_D1.1300.75
148_K294_S1.1270.75
168_R207_C1.1260.75
157_M176_V1.1130.74
179_Y231_L1.1120.74
299_H330_D1.1040.74
232_R338_I1.1030.73
104_F154_L1.1020.73
153_T177_I1.1020.73
154_L157_M1.0970.73
178_Y181_Y1.0910.73
261_N337_L1.0820.72
27_K346_K1.0780.72
68_T82_A1.0720.71
157_M224_I1.0670.71
305_K351_P1.0670.71
64_L82_A1.0670.71
167_I173_L1.0630.71
263_E388_K1.0620.71
221_I298_D1.0610.70
171_I220_T1.0540.70
68_T300_I1.0530.70
43_V257_F1.0530.70
306_L329_R1.0520.70
64_L68_T1.0470.69
88_A356_P1.0450.69
131_K258_D1.0430.69
12_P363_M1.0380.69
126_L130_T1.0380.69
149_S181_Y1.0360.69
212_N261_N1.0350.69
113_L118_E1.0350.69
122_L217_T1.0310.68
286_P289_A1.0300.68
28_E157_M1.0260.68
300_I342_P1.0250.68
18_N231_L1.0170.67
51_N387_R1.0160.67
372_N379_N1.0040.66
150_L177_I1.0020.66
50_A174_L0.9990.66
63_L272_S0.9990.66
306_L310_Y0.9930.65
114_M118_E0.9870.65
385_E389_D0.9860.65
90_V338_I0.9860.65
353_E386_A0.9860.65
18_N139_D0.9780.64
363_M395_L0.9770.64
246_S249_N0.9760.64
180_F332_P0.9750.64
46_I254_S0.9730.64
215_L354_W0.9730.64
283_L336_Q0.9640.63
51_N334_N0.9610.63
351_P354_W0.9560.62
219_G222_Q0.9520.62
82_A207_C0.9510.62
52_E61_D0.9510.62
65_S181_Y0.9470.62
61_D273_N0.9460.61
369_P372_N0.9430.61
106_S114_M0.9430.61
59_K134_L0.9420.61
172_S215_L0.9420.61
65_S266_F0.9380.61
300_I336_Q0.9350.61
227_V336_Q0.9330.60
65_S70_H0.9330.60
340_E344_R0.9310.60
10_R13_V0.9270.60
285_F288_V0.9270.60
101_T118_E0.9230.60
48_L57_L0.9220.59
142_M308_S0.9220.59
224_I280_L0.9100.58
396_L400_P0.9080.58
11_G18_N0.9080.58
305_K350_P0.9070.58
34_E38_E0.9070.58
153_T172_S0.9050.58
150_L210_V0.8980.57
71_W82_A0.8970.57
48_L169_S0.8960.57
88_A135_S0.8930.57
67_A206_M0.8890.57
50_A53_G0.8890.57
156_L180_F0.8870.57
233_E279_V0.8850.56
236_A241_L0.8830.56
39_S45_D0.8820.56
62_I205_W0.8790.56
334_N387_R0.8770.56
49_R266_F0.8750.55
336_Q354_W0.8720.55
102_V106_S0.8720.55
109_V118_E0.8680.55
157_M262_I0.8640.55
278_V282_L0.8630.54
53_G56_Q0.8630.54
233_E356_P0.8630.54
32_Y53_G0.8620.54
159_S199_R0.8560.54
148_K152_R0.8560.54
200_Q361_D0.8480.53
296_E347_S0.8470.53
162_F281_S0.8470.53
61_D64_L0.8460.53
339_R344_R0.8440.53
298_D336_Q0.8430.53
107_N111_R0.8430.53
46_I61_D0.8400.52
112_A116_T0.8400.52
43_V63_L0.8390.52
333_A388_K0.8360.52
85_E142_M0.8340.52
112_A118_E0.8310.52
290_N384_L0.8290.51
137_M221_I0.8290.51
59_K67_A0.8270.51
215_L336_Q0.8250.51
353_E356_P0.8240.51
245_E249_N0.8230.51
206_M278_V0.8220.51
298_D351_P0.8200.51
50_A230_A0.8180.51
48_L335_L0.8130.50
210_V278_V0.8130.50
227_V298_D0.8120.50
46_I161_G0.8110.50
175_P240_P0.8090.50
156_L203_L0.8060.49
111_R116_T0.8050.49
194_H379_N0.8030.49
13_V259_R0.7980.49
60_S64_L0.7980.49
167_I170_K0.7970.49
52_E388_K0.7970.49
58_K72_S0.7970.49
166_H281_S0.7950.48
307_K326_E0.7940.48
232_R356_P0.7940.48
52_E55_T0.7940.48
100_G106_S0.7930.48
179_Y224_I0.7920.48
40_Q66_I0.7920.48
219_G351_P0.7890.48
67_A86_I0.7880.48
343_N380_V0.7880.48
37_E46_I0.7870.48
92_K303_K0.7860.48
350_P353_E0.7860.48
137_M332_P0.7840.48
86_I171_I0.7820.47
296_E299_H0.7820.47
305_K352_A0.7780.47
55_T147_E0.7760.47
331_N384_L0.7740.47
68_T275_V0.7730.47
113_L137_M0.7720.46
384_L398_Q0.7720.46
391_I395_L0.7710.46
26_D326_E0.7710.46
333_A391_I0.7700.46
248_L252_N0.7680.46
166_H206_M0.7670.46
232_R256_G0.7660.46
255_M261_N0.7640.46
288_V295_F0.7620.46
394_D398_Q0.7620.46
209_I215_L0.7620.46
196_K338_I0.7590.45
231_L234_S0.7580.45
100_G109_V0.7570.45
242_N245_E0.7550.45
367_R390_M0.7530.45
344_R347_S0.7510.45
231_L327_K0.7510.45
110_L382_E0.7510.45
32_Y63_L0.7500.45
159_S203_L0.7460.44
48_L52_E0.7460.44
27_K30_I0.7440.44
170_K218_G0.7430.44
132_S139_D0.7430.44
112_A332_P0.7430.44
29_V95_K0.7410.44
364_Q369_P0.7400.44
379_N397_N0.7400.44
168_R171_I0.7390.44
60_S114_M0.7370.43
209_I247_T0.7370.43
148_K171_I0.7350.43
60_S129_F0.7330.43
156_L202_I0.7290.43
84_E197_E0.7290.43
111_R224_I0.7280.43
64_L71_W0.7260.43
50_A184_G0.7250.42
131_K310_Y0.7230.42
135_S389_D0.7220.42
233_E238_E0.7210.42
46_I158_K0.7180.42
149_S399_S0.7170.42
45_D127_S0.7150.42
249_N399_S0.7140.41
211_T399_S0.7100.41
104_F110_L0.7090.41
24_I161_G0.7070.41
104_F384_L0.7040.41
45_D288_V0.7040.41
12_P16_N0.7000.40
326_E329_R0.6960.40
21_Y25_H0.6960.40
49_R333_A0.6930.40
171_I215_L0.6920.40
127_S192_S0.6920.40
177_I257_F0.6910.40
43_V46_I0.6900.39
206_M300_I0.6880.39
129_F280_L0.6880.39
17_I376_E0.6880.39
52_E69_A0.6860.39
204_Y400_P0.6850.39
104_F108_F0.6830.39
156_L160_Y0.6820.39
157_M328_L0.6800.39
135_S360_D0.6770.38
218_G224_I0.6770.38
37_E341_R0.6770.38
49_R111_R0.6760.38
42_K338_I0.6760.38
11_G95_K0.6750.38
102_V115_L0.6740.38
180_F329_R0.6710.38
43_V68_T0.6680.38
196_K243_E0.6660.37
302_P346_K0.6660.37
244_I247_T0.6660.37
139_D259_R0.6650.37
49_R54_G0.6630.37
353_E359_S0.6610.37
157_M192_S0.6600.37
207_C297_V0.6590.37
26_D148_K0.6580.37
298_D306_L0.6580.37
89_L92_K0.6560.37
194_H197_E0.6550.37
267_N272_S0.6540.36
364_Q370_E0.6540.36
354_W380_V0.6510.36
52_E111_R0.6510.36
39_S174_L0.6500.36
350_P378_E0.6500.36
23_S368_I0.6490.36
300_I351_P0.6490.36
39_S131_K0.6480.36
87_Q91_D0.6470.36
68_T281_S0.6470.36
88_A391_I0.6470.36
110_L213_G0.6470.36
192_S385_E0.6460.36
303_K306_L0.6440.36
127_S211_T0.6430.36
168_R251_Y0.6430.36
84_E88_A0.6410.35
197_E353_E0.6400.35
42_K213_G0.6390.35
115_L118_E0.6390.35
64_L83_R0.6380.35
45_D89_L0.6370.35
156_L176_V0.6340.35
382_E397_N0.6330.35
197_E360_D0.6330.35
37_E236_A0.6310.35
229_K233_E0.6310.35
283_L383_F0.6310.35
129_F215_L0.6270.34
182_S332_P0.6250.34
233_E386_A0.6250.34
136_K385_E0.6230.34
160_Y163_T0.6220.34
246_S397_N0.6200.34
218_G223_T0.6200.34
65_S178_Y0.6190.34
233_E389_D0.6190.34
145_E173_L0.6180.34
31_S211_T0.6160.33
284_Y354_W0.6160.33
127_S376_E0.6160.33
232_R386_A0.6150.33
154_L195_G0.6150.33
45_D48_L0.6150.33
157_M202_I0.6140.33
213_G333_A0.6130.33
47_F51_N0.6120.33
349_K360_D0.6080.33
153_T277_R0.6070.33
102_V105_D0.6050.33
368_I375_Y0.6050.33
15_K345_K0.6040.33
46_I62_I0.6030.32
34_E380_V0.6010.32
34_E202_I0.5990.32
197_E349_K0.5990.32
129_F304_S0.5980.32
108_F173_L0.5980.32
359_S376_E0.5970.32
63_L68_T0.5970.32
363_M371_S0.5960.32
148_K238_E0.5960.32
136_K364_Q0.5930.32
237_N382_E0.5930.32
55_T218_G0.5910.32
92_K147_E0.5910.32
211_T275_V0.5910.32
301_F375_Y0.5870.31
301_F366_H0.5870.31
212_N227_V0.5870.31
15_K19_N0.5830.31
15_K29_V0.5820.31
109_V115_L0.5810.31
371_S375_Y0.5800.31
170_K280_L0.5800.31
44_L61_D0.5800.31
113_L117_G0.5790.31
120_S133_T0.5780.31
95_K308_S0.5770.31
273_N395_L0.5760.30
18_N328_L0.5730.30
139_D250_N0.5720.30
383_F387_R0.5720.30
173_L185_N0.5710.30
206_M395_L0.5710.30
109_V116_T0.5690.30
62_I282_L0.5690.30
52_E167_I0.5690.30
288_V293_Y0.5680.30
279_V283_L0.5680.30
104_F388_K0.5680.30
102_V206_M0.5680.30
108_F118_E0.5670.30
44_L354_W0.5650.30
121_S170_K0.5640.30
369_P384_L0.5630.29
205_W276_L0.5630.29
276_L335_L0.5630.29
272_S277_R0.5610.29
236_A393_S0.5610.29
19_N390_M0.5600.29
250_N365_R0.5580.29
15_K26_D0.5580.29
15_K257_F0.5570.29
279_V368_I0.5550.29
153_T380_V0.5540.29
169_S274_R0.5540.29
11_G233_E0.5520.29
40_Q130_T0.5520.29
197_E236_A0.5520.29
120_S357_T0.5510.29
27_K36_E0.5500.29
364_Q397_N0.5490.28
136_K148_K0.5490.28
111_R114_M0.5470.28
65_S207_C0.5460.28
167_I363_M0.5450.28
246_S393_S0.5450.28
84_E87_Q0.5430.28
311_L352_A0.5430.28
215_L271_K0.5410.28
356_P372_N0.5400.28
55_T275_V0.5390.28
46_I72_S0.5380.28
106_S116_T0.5380.28
159_S330_D0.5370.28
363_M366_H0.5370.28
217_T275_V0.5360.28
37_E364_Q0.5340.27
45_D49_R0.5340.27
242_N371_S0.5310.27
171_I202_I0.5310.27
50_A281_S0.5300.27
268_D275_V0.5300.27
135_S210_V0.5280.27
30_I60_S0.5260.27
89_L147_E0.5250.27
70_H225_R0.5240.27
48_L132_S0.5240.27
115_L174_L0.5220.27
141_W335_L0.5220.27
117_G136_K0.5210.27
328_L396_L0.5200.26
199_R356_P0.5200.26
13_V295_F0.5190.26
20_L39_S0.5180.26
30_I207_C0.5170.26
47_F387_R0.5160.26
195_G350_P0.5150.26
330_D343_N0.5140.26
226_G342_P0.5140.26
40_Q72_S0.5140.26
108_F141_W0.5120.26
109_V114_M0.5110.26
210_V271_K0.5110.26
110_L118_E0.5080.26
59_K82_A0.5080.26
56_Q195_G0.5070.26
310_Y353_E0.5070.26
38_E175_P0.5050.25
293_Y370_E0.5040.25
236_A239_F0.5030.25
273_N332_P0.5010.25
259_R388_K0.5010.25
48_L68_T0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h9dA 3 0.2319 71 0.952 Contact Map
2jojA 1 0.1836 13 0.969 Contact Map
2hk0A 3 0.3623 11 0.97 Contact Map
2d58A 1 0.256 10.9 0.97 Contact Map
2m97A 1 0.1643 9.3 0.971 Contact Map
1qlsA 2 0.2222 9.2 0.971 Contact Map
1j7qA 1 0.2005 8.1 0.972 Contact Map
3tvaA 1 0.3502 7.6 0.972 Contact Map
2kldA 1 0.1763 7.3 0.972 Contact Map
1tizA 1 0.1594 7.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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