Q9HPK8 - HALSA - GREMLIN Contacts

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Q9HPK8 - Uncharacterized protein

UniProt:	Q9HPK8	Sequences: MDEINEETARGPVSKNINNLYNSIHDKEVISYFEGEEESQEKVLDIFLRANEGGTQLKKSDILLSIATAHWSREDQTNSIVAREEIQALVDKLNKHESRGTVEFDSNFVLRALMLTGEVSSLSFSLSNFTKSTLSKMKDAWMSPEFEKSLFRTLDLMKSYGFTTSHIRSKISLLPVIYYFYSNGNPTISYESKHGKENRQKILYWMCSIVTNGELTTGGTIQTIRGVRKALRESPANEFPLNEIESTLNNYNKSMGFDRENIERWFNDSSKSNRVLRVVLSLLYFPNVANENYSFEVDHIFPKSKLKSDYLVDEVGMSREEASKIEKLRDNPANLQLIRERPNRKKSDKPPAEWLPTRSDDYMQRHRIPESNELYEIENVGEFLEARKDMIISDLLNQSPDRNNISMNDQEDLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	414 (354)
Sequences:	834 (685)
Seq/√Len:	36.4

HALSA - Q9HPK8 O51977

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
299_H	343_N	7.199	1.00
386_A	389_D	6.400	1.00
349_K	357_T	6.176	1.00
379_N	382_E	6.081	1.00
304_S	348_D	5.738	1.00
369_P	390_M	5.696	1.00
298_D	343_N	4.461	1.00
298_D	346_K	3.967	1.00
214_E	227_V	3.504	1.00
301_F	351_P	3.412	1.00
304_S	308_S	3.123	1.00
298_D	354_W	2.961	1.00
346_K	354_W	2.875	1.00
157_M	206_M	2.813	1.00
172_S	206_M	2.605	1.00
34_E	46_I	2.586	1.00
104_F	118_E	2.585	1.00
299_H	302_P	2.582	1.00
352_A	378_E	2.580	1.00
111_R	221_I	2.531	1.00
328_L	381_G	2.424	1.00
296_E	344_R	2.392	1.00
43_V	62_I	2.344	1.00
304_S	307_K	2.268	0.99
372_N	375_Y	2.225	0.99
104_F	112_A	2.202	0.99
306_L	380_V	2.145	0.99
302_P	343_N	2.124	0.99
393_S	397_N	2.112	0.99
147_E	151_F	2.072	0.99
215_L	227_V	1.939	0.98
92_K	151_F	1.931	0.98
11_G	14_S	1.915	0.98
206_M	210_V	1.872	0.98
101_T	104_F	1.868	0.98
34_E	227_V	1.863	0.98
10_R	14_S	1.858	0.97
169_S	207_C	1.845	0.97
296_E	340_E	1.845	0.97
227_V	354_W	1.833	0.97
106_S	111_R	1.808	0.97
343_N	346_K	1.796	0.97
237_N	393_S	1.793	0.97
133_T	136_K	1.775	0.97
394_D	397_N	1.767	0.97
297_V	335_L	1.749	0.96
24_I	72_S	1.724	0.96
336_Q	366_H	1.694	0.96
22_N	25_H	1.659	0.95
386_A	390_M	1.654	0.95
303_K	330_D	1.633	0.95
205_W	391_I	1.627	0.95
360_D	393_S	1.581	0.94
299_H	346_K	1.534	0.93
178_Y	228_R	1.531	0.93
149_S	153_T	1.529	0.92
227_V	351_P	1.503	0.92
109_V	112_A	1.486	0.91
123_S	218_G	1.484	0.91
302_P	351_P	1.463	0.91
283_L	338_I	1.447	0.90
169_S	172_S	1.429	0.90
67_A	133_T	1.426	0.90
389_D	393_S	1.424	0.89
135_S	139_D	1.400	0.89
114_M	129_F	1.393	0.88
215_L	351_P	1.389	0.88
349_K	353_E	1.364	0.87
207_C	211_T	1.355	0.87
126_L	129_F	1.347	0.87
392_I	396_L	1.345	0.87
371_S	386_A	1.341	0.86
43_V	83_R	1.326	0.86
15_K	135_S	1.324	0.86
263_E	384_L	1.316	0.85
40_Q	70_H	1.309	0.85
106_S	118_E	1.299	0.85
298_D	302_P	1.298	0.85
44_L	48_L	1.297	0.85
232_R	347_S	1.297	0.85
110_L	115_L	1.296	0.84
11_G	15_K	1.295	0.84
66_I	69_A	1.290	0.84
55_T	61_D	1.286	0.84
169_S	206_M	1.283	0.84
218_G	221_I	1.282	0.84
101_T	115_L	1.282	0.84
49_R	89_L	1.280	0.84
369_P	386_A	1.276	0.84
306_L	384_L	1.255	0.82
46_I	52_E	1.254	0.82
50_A	214_E	1.250	0.82
22_N	26_D	1.247	0.82
308_S	348_D	1.235	0.81
26_D	222_Q	1.233	0.81
43_V	351_P	1.232	0.81
302_P	354_W	1.230	0.81
63_L	134_L	1.216	0.80
279_V	391_I	1.207	0.80
243_E	301_F	1.207	0.80
248_L	251_Y	1.203	0.80
255_M	399_S	1.173	0.78
136_K	353_E	1.167	0.78
57_L	343_N	1.159	0.77
353_E	382_E	1.159	0.77
333_A	384_L	1.152	0.77
296_E	343_N	1.152	0.77
86_I	109_V	1.151	0.77
61_D	281_S	1.144	0.76
30_I	38_E	1.143	0.76
214_E	354_W	1.143	0.76
111_R	118_E	1.142	0.76
112_A	115_L	1.138	0.76
86_I	276_L	1.136	0.76
336_Q	346_K	1.135	0.76
382_E	386_A	1.131	0.75
205_W	257_F	1.131	0.75
152_R	155_D	1.130	0.75
148_K	294_S	1.127	0.75
168_R	207_C	1.126	0.75
157_M	176_V	1.113	0.74
179_Y	231_L	1.112	0.74
299_H	330_D	1.104	0.74
232_R	338_I	1.103	0.73
104_F	154_L	1.102	0.73
153_T	177_I	1.102	0.73
154_L	157_M	1.097	0.73
178_Y	181_Y	1.091	0.73
261_N	337_L	1.082	0.72
27_K	346_K	1.078	0.72
68_T	82_A	1.072	0.71
157_M	224_I	1.067	0.71
305_K	351_P	1.067	0.71
64_L	82_A	1.067	0.71
167_I	173_L	1.063	0.71
263_E	388_K	1.062	0.71
221_I	298_D	1.061	0.70
171_I	220_T	1.054	0.70
68_T	300_I	1.053	0.70
43_V	257_F	1.053	0.70
306_L	329_R	1.052	0.70
64_L	68_T	1.047	0.69
88_A	356_P	1.045	0.69
131_K	258_D	1.043	0.69
12_P	363_M	1.038	0.69
126_L	130_T	1.038	0.69
149_S	181_Y	1.036	0.69
212_N	261_N	1.035	0.69
113_L	118_E	1.035	0.69
122_L	217_T	1.031	0.68
286_P	289_A	1.030	0.68
28_E	157_M	1.026	0.68
300_I	342_P	1.025	0.68
18_N	231_L	1.017	0.67
51_N	387_R	1.016	0.67
372_N	379_N	1.004	0.66
150_L	177_I	1.002	0.66
50_A	174_L	0.999	0.66
63_L	272_S	0.999	0.66
306_L	310_Y	0.993	0.65
114_M	118_E	0.987	0.65
385_E	389_D	0.986	0.65
90_V	338_I	0.986	0.65
353_E	386_A	0.986	0.65
18_N	139_D	0.978	0.64
363_M	395_L	0.977	0.64
246_S	249_N	0.976	0.64
180_F	332_P	0.975	0.64
46_I	254_S	0.973	0.64
215_L	354_W	0.973	0.64
283_L	336_Q	0.964	0.63
51_N	334_N	0.961	0.63
351_P	354_W	0.956	0.62
219_G	222_Q	0.952	0.62
82_A	207_C	0.951	0.62
52_E	61_D	0.951	0.62
65_S	181_Y	0.947	0.62
61_D	273_N	0.946	0.61
369_P	372_N	0.943	0.61
106_S	114_M	0.943	0.61
59_K	134_L	0.942	0.61
172_S	215_L	0.942	0.61
65_S	266_F	0.938	0.61
300_I	336_Q	0.935	0.61
227_V	336_Q	0.933	0.60
65_S	70_H	0.933	0.60
340_E	344_R	0.931	0.60
10_R	13_V	0.927	0.60
285_F	288_V	0.927	0.60
101_T	118_E	0.923	0.60
48_L	57_L	0.922	0.59
142_M	308_S	0.922	0.59
224_I	280_L	0.910	0.58
396_L	400_P	0.908	0.58
11_G	18_N	0.908	0.58
305_K	350_P	0.907	0.58
34_E	38_E	0.907	0.58
153_T	172_S	0.905	0.58
150_L	210_V	0.898	0.57
71_W	82_A	0.897	0.57
48_L	169_S	0.896	0.57
88_A	135_S	0.893	0.57
67_A	206_M	0.889	0.57
50_A	53_G	0.889	0.57
156_L	180_F	0.887	0.57
233_E	279_V	0.885	0.56
236_A	241_L	0.883	0.56
39_S	45_D	0.882	0.56
62_I	205_W	0.879	0.56
334_N	387_R	0.877	0.56
49_R	266_F	0.875	0.55
336_Q	354_W	0.872	0.55
102_V	106_S	0.872	0.55
109_V	118_E	0.868	0.55
157_M	262_I	0.864	0.55
278_V	282_L	0.863	0.54
53_G	56_Q	0.863	0.54
233_E	356_P	0.863	0.54
32_Y	53_G	0.862	0.54
159_S	199_R	0.856	0.54
148_K	152_R	0.856	0.54
200_Q	361_D	0.848	0.53
296_E	347_S	0.847	0.53
162_F	281_S	0.847	0.53
61_D	64_L	0.846	0.53
339_R	344_R	0.844	0.53
298_D	336_Q	0.843	0.53
107_N	111_R	0.843	0.53
46_I	61_D	0.840	0.52
112_A	116_T	0.840	0.52
43_V	63_L	0.839	0.52
333_A	388_K	0.836	0.52
85_E	142_M	0.834	0.52
112_A	118_E	0.831	0.52
290_N	384_L	0.829	0.51
137_M	221_I	0.829	0.51
59_K	67_A	0.827	0.51
215_L	336_Q	0.825	0.51
353_E	356_P	0.824	0.51
245_E	249_N	0.823	0.51
206_M	278_V	0.822	0.51
298_D	351_P	0.820	0.51
50_A	230_A	0.818	0.51
48_L	335_L	0.813	0.50
210_V	278_V	0.813	0.50
227_V	298_D	0.812	0.50
46_I	161_G	0.811	0.50
175_P	240_P	0.809	0.50
156_L	203_L	0.806	0.49
111_R	116_T	0.805	0.49
194_H	379_N	0.803	0.49
13_V	259_R	0.798	0.49
60_S	64_L	0.798	0.49
167_I	170_K	0.797	0.49
52_E	388_K	0.797	0.49
58_K	72_S	0.797	0.49
166_H	281_S	0.795	0.48
307_K	326_E	0.794	0.48
232_R	356_P	0.794	0.48
52_E	55_T	0.794	0.48
100_G	106_S	0.793	0.48
179_Y	224_I	0.792	0.48
40_Q	66_I	0.792	0.48
219_G	351_P	0.789	0.48
67_A	86_I	0.788	0.48
343_N	380_V	0.788	0.48
37_E	46_I	0.787	0.48
92_K	303_K	0.786	0.48
350_P	353_E	0.786	0.48
137_M	332_P	0.784	0.48
86_I	171_I	0.782	0.47
296_E	299_H	0.782	0.47
305_K	352_A	0.778	0.47
55_T	147_E	0.776	0.47
331_N	384_L	0.774	0.47
68_T	275_V	0.773	0.47
113_L	137_M	0.772	0.46
384_L	398_Q	0.772	0.46
391_I	395_L	0.771	0.46
26_D	326_E	0.771	0.46
333_A	391_I	0.770	0.46
248_L	252_N	0.768	0.46
166_H	206_M	0.767	0.46
232_R	256_G	0.766	0.46
255_M	261_N	0.764	0.46
288_V	295_F	0.762	0.46
394_D	398_Q	0.762	0.46
209_I	215_L	0.762	0.46
196_K	338_I	0.759	0.45
231_L	234_S	0.758	0.45
100_G	109_V	0.757	0.45
242_N	245_E	0.755	0.45
367_R	390_M	0.753	0.45
344_R	347_S	0.751	0.45
231_L	327_K	0.751	0.45
110_L	382_E	0.751	0.45
32_Y	63_L	0.750	0.45
159_S	203_L	0.746	0.44
48_L	52_E	0.746	0.44
27_K	30_I	0.744	0.44
170_K	218_G	0.743	0.44
132_S	139_D	0.743	0.44
112_A	332_P	0.743	0.44
29_V	95_K	0.741	0.44
364_Q	369_P	0.740	0.44
379_N	397_N	0.740	0.44
168_R	171_I	0.739	0.44
60_S	114_M	0.737	0.43
209_I	247_T	0.737	0.43
148_K	171_I	0.735	0.43
60_S	129_F	0.733	0.43
156_L	202_I	0.729	0.43
84_E	197_E	0.729	0.43
111_R	224_I	0.728	0.43
64_L	71_W	0.726	0.43
50_A	184_G	0.725	0.42
131_K	310_Y	0.723	0.42
135_S	389_D	0.722	0.42
233_E	238_E	0.721	0.42
46_I	158_K	0.718	0.42
149_S	399_S	0.717	0.42
45_D	127_S	0.715	0.42
249_N	399_S	0.714	0.41
211_T	399_S	0.710	0.41
104_F	110_L	0.709	0.41
24_I	161_G	0.707	0.41
104_F	384_L	0.704	0.41
45_D	288_V	0.704	0.41
12_P	16_N	0.700	0.40
326_E	329_R	0.696	0.40
21_Y	25_H	0.696	0.40
49_R	333_A	0.693	0.40
171_I	215_L	0.692	0.40
127_S	192_S	0.692	0.40
177_I	257_F	0.691	0.40
43_V	46_I	0.690	0.39
206_M	300_I	0.688	0.39
129_F	280_L	0.688	0.39
17_I	376_E	0.688	0.39
52_E	69_A	0.686	0.39
204_Y	400_P	0.685	0.39
104_F	108_F	0.683	0.39
156_L	160_Y	0.682	0.39
157_M	328_L	0.680	0.39
135_S	360_D	0.677	0.38
218_G	224_I	0.677	0.38
37_E	341_R	0.677	0.38
49_R	111_R	0.676	0.38
42_K	338_I	0.676	0.38
11_G	95_K	0.675	0.38
102_V	115_L	0.674	0.38
180_F	329_R	0.671	0.38
43_V	68_T	0.668	0.38
196_K	243_E	0.666	0.37
302_P	346_K	0.666	0.37
244_I	247_T	0.666	0.37
139_D	259_R	0.665	0.37
49_R	54_G	0.663	0.37
353_E	359_S	0.661	0.37
157_M	192_S	0.660	0.37
207_C	297_V	0.659	0.37
26_D	148_K	0.658	0.37
298_D	306_L	0.658	0.37
89_L	92_K	0.656	0.37
194_H	197_E	0.655	0.37
267_N	272_S	0.654	0.36
364_Q	370_E	0.654	0.36
354_W	380_V	0.651	0.36
52_E	111_R	0.651	0.36
39_S	174_L	0.650	0.36
350_P	378_E	0.650	0.36
23_S	368_I	0.649	0.36
300_I	351_P	0.649	0.36
39_S	131_K	0.648	0.36
87_Q	91_D	0.647	0.36
68_T	281_S	0.647	0.36
88_A	391_I	0.647	0.36
110_L	213_G	0.647	0.36
192_S	385_E	0.646	0.36
303_K	306_L	0.644	0.36
127_S	211_T	0.643	0.36
168_R	251_Y	0.643	0.36
84_E	88_A	0.641	0.35
197_E	353_E	0.640	0.35
42_K	213_G	0.639	0.35
115_L	118_E	0.639	0.35
64_L	83_R	0.638	0.35
45_D	89_L	0.637	0.35
156_L	176_V	0.634	0.35
382_E	397_N	0.633	0.35
197_E	360_D	0.633	0.35
37_E	236_A	0.631	0.35
229_K	233_E	0.631	0.35
283_L	383_F	0.631	0.35
129_F	215_L	0.627	0.34
182_S	332_P	0.625	0.34
233_E	386_A	0.625	0.34
136_K	385_E	0.623	0.34
160_Y	163_T	0.622	0.34
246_S	397_N	0.620	0.34
218_G	223_T	0.620	0.34
65_S	178_Y	0.619	0.34
233_E	389_D	0.619	0.34
145_E	173_L	0.618	0.34
31_S	211_T	0.616	0.33
284_Y	354_W	0.616	0.33
127_S	376_E	0.616	0.33
232_R	386_A	0.615	0.33
154_L	195_G	0.615	0.33
45_D	48_L	0.615	0.33
157_M	202_I	0.614	0.33
213_G	333_A	0.613	0.33
47_F	51_N	0.612	0.33
349_K	360_D	0.608	0.33
153_T	277_R	0.607	0.33
102_V	105_D	0.605	0.33
368_I	375_Y	0.605	0.33
15_K	345_K	0.604	0.33
46_I	62_I	0.603	0.32
34_E	380_V	0.601	0.32
34_E	202_I	0.599	0.32
197_E	349_K	0.599	0.32
129_F	304_S	0.598	0.32
108_F	173_L	0.598	0.32
359_S	376_E	0.597	0.32
63_L	68_T	0.597	0.32
363_M	371_S	0.596	0.32
148_K	238_E	0.596	0.32
136_K	364_Q	0.593	0.32
237_N	382_E	0.593	0.32
55_T	218_G	0.591	0.32
92_K	147_E	0.591	0.32
211_T	275_V	0.591	0.32
301_F	375_Y	0.587	0.31
301_F	366_H	0.587	0.31
212_N	227_V	0.587	0.31
15_K	19_N	0.583	0.31
15_K	29_V	0.582	0.31
109_V	115_L	0.581	0.31
371_S	375_Y	0.580	0.31
170_K	280_L	0.580	0.31
44_L	61_D	0.580	0.31
113_L	117_G	0.579	0.31
120_S	133_T	0.578	0.31
95_K	308_S	0.577	0.31
273_N	395_L	0.576	0.30
18_N	328_L	0.573	0.30
139_D	250_N	0.572	0.30
383_F	387_R	0.572	0.30
173_L	185_N	0.571	0.30
206_M	395_L	0.571	0.30
109_V	116_T	0.569	0.30
62_I	282_L	0.569	0.30
52_E	167_I	0.569	0.30
288_V	293_Y	0.568	0.30
279_V	283_L	0.568	0.30
104_F	388_K	0.568	0.30
102_V	206_M	0.568	0.30
108_F	118_E	0.567	0.30
44_L	354_W	0.565	0.30
121_S	170_K	0.564	0.30
369_P	384_L	0.563	0.29
205_W	276_L	0.563	0.29
276_L	335_L	0.563	0.29
272_S	277_R	0.561	0.29
236_A	393_S	0.561	0.29
19_N	390_M	0.560	0.29
250_N	365_R	0.558	0.29
15_K	26_D	0.558	0.29
15_K	257_F	0.557	0.29
279_V	368_I	0.555	0.29
153_T	380_V	0.554	0.29
169_S	274_R	0.554	0.29
11_G	233_E	0.552	0.29
40_Q	130_T	0.552	0.29
197_E	236_A	0.552	0.29
120_S	357_T	0.551	0.29
27_K	36_E	0.550	0.29
364_Q	397_N	0.549	0.28
136_K	148_K	0.549	0.28
111_R	114_M	0.547	0.28
65_S	207_C	0.546	0.28
167_I	363_M	0.545	0.28
246_S	393_S	0.545	0.28
84_E	87_Q	0.543	0.28
311_L	352_A	0.543	0.28
215_L	271_K	0.541	0.28
356_P	372_N	0.540	0.28
55_T	275_V	0.539	0.28
46_I	72_S	0.538	0.28
106_S	116_T	0.538	0.28
159_S	330_D	0.537	0.28
363_M	366_H	0.537	0.28
217_T	275_V	0.536	0.28
37_E	364_Q	0.534	0.27
45_D	49_R	0.534	0.27
242_N	371_S	0.531	0.27
171_I	202_I	0.531	0.27
50_A	281_S	0.530	0.27
268_D	275_V	0.530	0.27
135_S	210_V	0.528	0.27
30_I	60_S	0.526	0.27
89_L	147_E	0.525	0.27
70_H	225_R	0.524	0.27
48_L	132_S	0.524	0.27
115_L	174_L	0.522	0.27
141_W	335_L	0.522	0.27
117_G	136_K	0.521	0.27
328_L	396_L	0.520	0.26
199_R	356_P	0.520	0.26
13_V	295_F	0.519	0.26
20_L	39_S	0.518	0.26
30_I	207_C	0.517	0.26
47_F	387_R	0.516	0.26
195_G	350_P	0.515	0.26
330_D	343_N	0.514	0.26
226_G	342_P	0.514	0.26
40_Q	72_S	0.514	0.26
108_F	141_W	0.512	0.26
109_V	114_M	0.511	0.26
210_V	271_K	0.511	0.26
110_L	118_E	0.508	0.26
59_K	82_A	0.508	0.26
56_Q	195_G	0.507	0.26
310_Y	353_E	0.507	0.26
38_E	175_P	0.505	0.25
293_Y	370_E	0.504	0.25
236_A	239_F	0.503	0.25
273_N	332_P	0.501	0.25
259_R	388_K	0.501	0.25
48_L	68_T	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4h9dA	3	0.2319	71	0.952	Contact Map
2jojA	1	0.1836	13	0.969	Contact Map
2hk0A	3	0.3623	11	0.97	Contact Map
2d58A	1	0.256	10.9	0.97	Contact Map
2m97A	1	0.1643	9.3	0.971	Contact Map
1qlsA	2	0.2222	9.2	0.971	Contact Map
1j7qA	1	0.2005	8.1	0.972	Contact Map
3tvaA	1	0.3502	7.6	0.972	Contact Map
2kldA	1	0.1763	7.3	0.972	Contact Map
1tizA	1	0.1594	7.2	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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