GREMLIN Database
Q9HPK7 - Uncharacterized protein
UniProt: Q9HPK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (283)
Sequences: 2078 (1548)
Seq/√Len: 92.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_V230_A8.1411.00
78_E82_T3.8981.00
73_R96_R3.6181.00
177_A303_F3.1801.00
165_T180_T3.0291.00
60_G79_L2.9651.00
167_V275_V2.7531.00
176_A196_D2.7181.00
230_A233_N2.6521.00
174_P306_L2.5931.00
262_Q265_L2.5591.00
221_L226_V2.5121.00
219_D223_A2.4971.00
64_C75_V2.4911.00
21_T24_L2.3531.00
227_V233_N2.3491.00
55_P59_R2.2471.00
38_F112_K2.2351.00
79_L88_C2.2321.00
230_A236_N2.2271.00
177_A306_L2.1851.00
165_T212_Y2.0831.00
136_T283_K2.0311.00
36_E53_E2.0301.00
236_N239_D2.0281.00
147_A150_C1.9861.00
294_G297_H1.9861.00
130_T205_W1.8991.00
195_R224_A1.8921.00
164_C302_V1.8881.00
56_E90_F1.8691.00
190_A217_W1.8581.00
121_A314_I1.8381.00
239_D242_D1.7981.00
97_D101_R1.7911.00
174_P310_L1.7811.00
166_I279_N1.7791.00
292_A297_H1.7701.00
116_H119_E1.7691.00
135_S163_G1.7521.00
227_V236_N1.7511.00
119_E123_L1.7421.00
131_Y175_I1.6971.00
34_F116_H1.6801.00
198_L224_A1.6721.00
60_G99_V1.6711.00
191_M220_H1.6201.00
27_F89_G1.6031.00
180_T189_T1.5741.00
76_E96_R1.5621.00
36_E55_P1.5381.00
227_V232_Y1.5331.00
178_E299_R1.5321.00
221_L230_A1.5181.00
114_F306_L1.4931.00
129_L204_I1.4901.00
63_H84_V1.4771.00
175_I197_A1.4761.00
57_L102_F1.4761.00
65_Y301_Q1.4491.00
205_W229_V1.4380.99
287_L305_A1.4330.99
290_T298_A1.4150.99
59_R88_C1.4130.99
33_E36_E1.4070.99
43_P105_D1.3990.99
97_D100_D1.3820.99
173_I313_A1.3780.99
190_A194_T1.3760.99
302_V306_L1.3730.99
179_F299_R1.3690.99
166_I278_T1.3660.99
20_E24_L1.3600.99
217_W220_H1.3590.99
282_V305_A1.3520.99
139_R289_R1.3390.99
74_P78_E1.3310.99
189_T193_V1.3300.99
205_W268_T1.3240.99
152_D182_S1.3170.99
22_E27_F1.3010.99
155_D158_Y1.2950.99
147_A151_Y1.2910.99
38_F41_F1.2890.99
236_N242_D1.2880.99
168_S171_Q1.2850.99
78_E84_V1.2830.99
173_I314_I1.2710.99
148_S151_Y1.2670.99
290_T301_Q1.2670.99
229_V232_Y1.2650.99
111_N115_D1.2600.99
235_R239_D1.2590.99
31_S34_F1.2590.99
237_T240_P1.2350.98
148_S154_T1.2330.98
20_E27_F1.2310.98
136_T279_N1.2300.98
135_S186_P1.2290.98
85_W93_P1.2220.98
273_T277_R1.2210.98
214_T217_W1.2190.98
133_I190_A1.1920.98
235_R238_D1.1810.98
236_N241_K1.1800.98
146_D149_K1.1770.98
57_L98_A1.1730.98
176_A193_V1.1660.98
184_Q189_T1.1590.98
282_V309_R1.1490.97
285_C309_R1.1440.97
196_D203_P1.1370.97
185_A188_E1.1320.97
32_F35_L1.1230.97
237_T242_D1.1140.97
152_D163_G1.1130.97
178_E189_T1.1040.97
76_E95_S1.1010.97
228_P233_N1.1010.97
52_H56_E1.0960.97
76_E93_P1.0910.96
71_G103_L1.0900.96
265_L268_T1.0820.96
236_N240_P1.0820.96
60_G94_P1.0790.96
132_C274_G1.0780.96
67_K84_V1.0740.96
167_V278_T1.0690.96
63_H67_K1.0640.96
128_D170_G1.0620.96
154_T161_G1.0530.96
22_E26_L1.0530.96
299_R303_F1.0530.96
275_V278_T1.0520.96
139_R159_Y1.0470.96
52_H102_F1.0450.95
205_W227_V1.0430.95
271_R274_G1.0420.95
234_A237_T1.0370.95
292_A301_Q1.0320.95
135_S165_T1.0230.95
191_M195_R1.0220.95
60_G75_V1.0180.95
235_R242_D1.0170.95
133_I208_G1.0160.95
76_E99_V1.0100.95
189_T192_R1.0050.94
165_T193_V1.0040.94
110_V303_F1.0030.94
136_T164_C0.9980.94
281_S309_R0.9940.94
117_L307_C0.9930.94
313_A316_N0.9870.94
69_I98_A0.9840.94
76_E80_R0.9690.93
229_V233_N0.9650.93
90_F93_P0.9610.93
283_K287_L0.9600.93
38_F116_H0.9570.93
121_A173_I0.9560.93
278_T309_R0.9540.93
164_C179_F0.9390.92
228_P231_P0.9370.92
198_L202_K0.9350.92
130_T268_T0.9350.92
25_A29_H0.9290.92
236_N260_L0.9250.92
187_E214_T0.9240.91
62_L66_Y0.9230.91
21_T25_A0.9180.91
280_E284_D0.9120.91
230_A237_T0.9110.91
313_A317_Y0.9080.91
151_Y160_H0.9080.91
234_A239_D0.9050.91
111_N196_D0.9040.91
96_R100_D0.9030.91
229_V268_T0.9010.90
179_F302_V0.8980.90
165_T186_P0.8970.90
310_L313_A0.8930.90
281_S312_V0.8920.90
202_K225_G0.8870.90
69_I78_E0.8850.90
113_V307_C0.8830.90
150_C181_E0.8820.89
60_G88_C0.8790.89
231_P234_A0.8770.89
35_L39_D0.8740.89
234_A241_K0.8730.89
67_K81_N0.8730.89
165_T189_T0.8680.89
59_R87_S0.8650.89
237_T241_K0.8650.89
259_Q262_Q0.8620.88
285_C290_T0.8610.88
308_L312_V0.8590.88
101_R104_T0.8580.88
146_D162_Y0.8570.88
178_E193_V0.8530.88
87_S160_H0.8510.88
220_H224_A0.8500.88
192_R195_R0.8480.88
235_R240_P0.8460.87
178_E192_R0.8460.87
192_R225_G0.8460.87
208_G230_A0.8390.87
274_G277_R0.8340.87
272_R276_E0.8340.87
137_D186_P0.8320.87
149_K152_D0.8310.87
234_A238_D0.8250.86
208_G211_A0.8230.86
141_M293_R0.8220.86
292_A298_A0.8140.85
147_A152_D0.8130.85
42_A45_E0.8090.85
149_K162_Y0.8050.85
21_T27_F0.8010.84
54_P142_P0.8010.84
190_A208_G0.7980.84
188_E217_W0.7970.84
164_C306_L0.7970.84
111_N299_R0.7900.84
36_E39_D0.7850.83
210_S265_L0.7850.83
166_I174_P0.7800.83
295_R299_R0.7780.83
130_T207_V0.7750.82
172_K313_A0.7750.82
135_S212_Y0.7730.82
154_T159_Y0.7680.82
104_T297_H0.7660.82
172_K309_R0.7630.81
260_L265_L0.7590.81
285_C312_V0.7560.81
76_E79_L0.7550.81
24_L27_F0.7530.81
170_G267_E0.7490.80
120_Q124_R0.7430.80
193_V196_D0.7430.80
203_P226_V0.7420.80
291_H301_Q0.7420.80
281_S284_D0.7380.79
76_E100_D0.7370.79
231_P236_N0.7360.79
221_L224_A0.7360.79
138_V164_C0.7310.79
176_A197_A0.7300.79
54_P57_L0.7220.78
80_R200_V0.7220.78
52_H60_G0.7210.78
174_P177_A0.7180.77
162_Y295_R0.7170.77
261_K265_L0.7150.77
70_Y161_G0.7110.77
142_P160_H0.7090.76
75_V99_V0.7070.76
282_V287_L0.7070.76
209_D276_E0.7000.76
166_I275_V0.7000.76
223_A226_V0.6990.75
22_E25_A0.6970.75
281_S285_C0.6930.75
172_K281_S0.6870.74
126_L173_I0.6860.74
144_D160_H0.6850.74
185_A211_A0.6830.74
79_L93_P0.6810.74
110_V300_A0.6800.73
208_G217_W0.6800.73
157_E166_I0.6760.73
150_C154_T0.6760.73
168_S275_V0.6750.73
174_P313_A0.6740.73
180_T193_V0.6720.73
33_E45_E0.6710.72
190_A206_M0.6700.72
137_D152_D0.6680.72
165_T184_Q0.6680.72
135_S152_D0.6660.72
129_L170_G0.6630.72
265_L269_Y0.6580.71
185_A283_K0.6550.71
129_L199_A0.6550.71
45_E50_R0.6470.70
235_R241_K0.6460.70
298_A307_C0.6420.69
71_G207_V0.6410.69
56_E92_R0.6400.69
153_P159_Y0.6390.69
30_L38_F0.6390.69
131_Y203_P0.6370.69
290_T302_V0.6360.68
76_E94_P0.6310.68
21_T86_L0.6300.68
185_A214_T0.6300.68
187_E211_A0.6300.68
309_R313_A0.6290.68
207_V229_V0.6290.68
300_A304_L0.6270.67
59_R94_P0.6260.67
194_T221_L0.6260.67
73_R100_D0.6250.67
95_S101_R0.6250.67
282_V306_L0.6230.67
77_R81_N0.6220.67
211_A214_T0.6210.67
135_S151_Y0.6210.67
21_T26_L0.6200.66
34_F123_L0.6190.66
149_K160_H0.6190.66
71_G135_S0.6150.66
208_G213_D0.6140.66
32_F36_E0.6130.66
126_L226_V0.6110.65
117_L120_Q0.6110.65
305_A308_L0.6090.65
56_E89_G0.6080.65
188_E216_D0.6070.65
117_L121_A0.6060.65
202_K241_K0.6060.65
277_R280_E0.6060.65
144_D156_D0.6020.64
108_H111_N0.6020.64
301_Q305_A0.6000.64
137_D182_S0.6000.64
187_E217_W0.5990.64
107_E296_V0.5990.64
172_K274_G0.5980.64
30_L35_L0.5970.64
94_P230_A0.5970.64
56_E88_C0.5970.64
120_Q196_D0.5960.63
149_K154_T0.5930.63
281_S305_A0.5900.63
138_V290_T0.5880.62
66_Y308_L0.5870.62
111_N176_A0.5860.62
30_L34_F0.5860.62
268_T271_R0.5840.62
281_S313_A0.5840.62
163_G186_P0.5830.62
162_Y298_A0.5820.62
114_F177_A0.5750.61
215_L219_D0.5740.61
279_N283_K0.5730.60
51_D57_L0.5730.60
292_A302_V0.5710.60
259_Q267_E0.5710.60
50_R112_K0.5700.60
189_T220_H0.5680.60
32_F55_P0.5680.60
108_H222_L0.5670.60
174_P278_T0.5660.59
54_P73_R0.5660.59
213_D218_H0.5650.59
191_M217_W0.5630.59
64_C71_G0.5630.59
276_E283_K0.5620.59
263_S266_D0.5620.59
181_E191_M0.5610.59
100_D103_L0.5610.59
79_L94_P0.5600.59
142_P293_R0.5600.59
132_C169_T0.5580.58
270_N273_T0.5570.58
77_R80_R0.5560.58
27_F30_L0.5510.57
110_V113_V0.5510.57
54_P103_L0.5510.57
80_R85_W0.5490.57
52_H101_R0.5480.57
308_L313_A0.5460.57
130_T175_I0.5460.57
184_Q217_W0.5450.57
33_E37_E0.5450.57
40_V45_E0.5440.56
233_N241_K0.5440.56
165_T182_S0.5430.56
259_Q265_L0.5400.56
238_D241_K0.5390.56
228_P232_Y0.5380.56
262_Q266_D0.5380.56
266_D269_Y0.5370.56
54_P102_F0.5370.56
125_G201_A0.5350.55
52_H97_D0.5350.55
238_D242_D0.5320.55
213_D233_N0.5320.55
95_S100_D0.5300.55
298_A302_V0.5290.54
123_L226_V0.5280.54
146_D154_T0.5280.54
63_H75_V0.5260.54
95_S103_L0.5260.54
272_R283_K0.5250.54
140_A162_Y0.5240.54
127_L189_T0.5230.54
57_L89_G0.5220.53
29_H109_V0.5210.53
125_G198_L0.5200.53
78_E81_N0.5200.53
134_D209_D0.5190.53
186_P211_A0.5170.53
87_S97_D0.5160.53
151_Y158_Y0.5160.53
145_Q151_Y0.5150.52
167_V186_P0.5150.52
194_T220_H0.5140.52
214_T218_H0.5130.52
228_P264_T0.5120.52
204_I267_E0.5110.52
234_A264_T0.5100.52
154_T157_E0.5080.52
123_L191_M0.5070.51
195_R220_H0.5070.51
232_Y238_D0.5050.51
167_V211_A0.5040.51
40_V123_L0.5030.51
153_P158_Y0.5030.51
274_G280_E0.5010.51
297_H311_V0.5010.51
100_D104_T0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8333 98.6 0.869 Contact Map
4u7bA 2 0.8303 95 0.923 Contact Map
4mq3A 1 0.3848 84.4 0.94 Contact Map
3l3uA 2 0.4394 65.1 0.949 Contact Map
1c6vA 4 0.4152 62.5 0.95 Contact Map
3kksA 2 0.4303 57.9 0.951 Contact Map
4pa1A 2 0.4364 51.4 0.953 Contact Map
4dyqA 5 0.3697 50.7 0.953 Contact Map
1ex4A 5 0.4364 48.5 0.954 Contact Map
1bcoA 1 0.5 46.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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