Q9HPK7 - HALSA - GREMLIN Contacts

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Q9HPK7 - Uncharacterized protein

UniProt:	Q9HPK7	Sequences: MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (283)
Sequences:	2078 (1548)
Seq/√Len:	92.0

ECOLI - INSH5 INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11 INSH6
HALSA - TH11 Q9HPK7 Q9HSX5 Q7LYM0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_V	230_A	8.141	1.00
78_E	82_T	3.898	1.00
73_R	96_R	3.618	1.00
177_A	303_F	3.180	1.00
165_T	180_T	3.029	1.00
60_G	79_L	2.965	1.00
167_V	275_V	2.753	1.00
176_A	196_D	2.718	1.00
230_A	233_N	2.652	1.00
174_P	306_L	2.593	1.00
262_Q	265_L	2.559	1.00
221_L	226_V	2.512	1.00
219_D	223_A	2.497	1.00
64_C	75_V	2.491	1.00
21_T	24_L	2.353	1.00
227_V	233_N	2.349	1.00
55_P	59_R	2.247	1.00
38_F	112_K	2.235	1.00
79_L	88_C	2.232	1.00
230_A	236_N	2.227	1.00
177_A	306_L	2.185	1.00
165_T	212_Y	2.083	1.00
136_T	283_K	2.031	1.00
36_E	53_E	2.030	1.00
236_N	239_D	2.028	1.00
147_A	150_C	1.986	1.00
294_G	297_H	1.986	1.00
130_T	205_W	1.899	1.00
195_R	224_A	1.892	1.00
164_C	302_V	1.888	1.00
56_E	90_F	1.869	1.00
190_A	217_W	1.858	1.00
121_A	314_I	1.838	1.00
239_D	242_D	1.798	1.00
97_D	101_R	1.791	1.00
174_P	310_L	1.781	1.00
166_I	279_N	1.779	1.00
292_A	297_H	1.770	1.00
116_H	119_E	1.769	1.00
135_S	163_G	1.752	1.00
227_V	236_N	1.751	1.00
119_E	123_L	1.742	1.00
131_Y	175_I	1.697	1.00
34_F	116_H	1.680	1.00
198_L	224_A	1.672	1.00
60_G	99_V	1.671	1.00
191_M	220_H	1.620	1.00
27_F	89_G	1.603	1.00
180_T	189_T	1.574	1.00
76_E	96_R	1.562	1.00
36_E	55_P	1.538	1.00
227_V	232_Y	1.533	1.00
178_E	299_R	1.532	1.00
221_L	230_A	1.518	1.00
114_F	306_L	1.493	1.00
129_L	204_I	1.490	1.00
63_H	84_V	1.477	1.00
175_I	197_A	1.476	1.00
57_L	102_F	1.476	1.00
65_Y	301_Q	1.449	1.00
205_W	229_V	1.438	0.99
287_L	305_A	1.433	0.99
290_T	298_A	1.415	0.99
59_R	88_C	1.413	0.99
33_E	36_E	1.407	0.99
43_P	105_D	1.399	0.99
97_D	100_D	1.382	0.99
173_I	313_A	1.378	0.99
190_A	194_T	1.376	0.99
302_V	306_L	1.373	0.99
179_F	299_R	1.369	0.99
166_I	278_T	1.366	0.99
20_E	24_L	1.360	0.99
217_W	220_H	1.359	0.99
282_V	305_A	1.352	0.99
139_R	289_R	1.339	0.99
74_P	78_E	1.331	0.99
189_T	193_V	1.330	0.99
205_W	268_T	1.324	0.99
152_D	182_S	1.317	0.99
22_E	27_F	1.301	0.99
155_D	158_Y	1.295	0.99
147_A	151_Y	1.291	0.99
38_F	41_F	1.289	0.99
236_N	242_D	1.288	0.99
168_S	171_Q	1.285	0.99
78_E	84_V	1.283	0.99
173_I	314_I	1.271	0.99
148_S	151_Y	1.267	0.99
290_T	301_Q	1.267	0.99
229_V	232_Y	1.265	0.99
111_N	115_D	1.260	0.99
235_R	239_D	1.259	0.99
31_S	34_F	1.259	0.99
237_T	240_P	1.235	0.98
148_S	154_T	1.233	0.98
20_E	27_F	1.231	0.98
136_T	279_N	1.230	0.98
135_S	186_P	1.229	0.98
85_W	93_P	1.222	0.98
273_T	277_R	1.221	0.98
214_T	217_W	1.219	0.98
133_I	190_A	1.192	0.98
235_R	238_D	1.181	0.98
236_N	241_K	1.180	0.98
146_D	149_K	1.177	0.98
57_L	98_A	1.173	0.98
176_A	193_V	1.166	0.98
184_Q	189_T	1.159	0.98
282_V	309_R	1.149	0.97
285_C	309_R	1.144	0.97
196_D	203_P	1.137	0.97
185_A	188_E	1.132	0.97
32_F	35_L	1.123	0.97
237_T	242_D	1.114	0.97
152_D	163_G	1.113	0.97
178_E	189_T	1.104	0.97
76_E	95_S	1.101	0.97
228_P	233_N	1.101	0.97
52_H	56_E	1.096	0.97
76_E	93_P	1.091	0.96
71_G	103_L	1.090	0.96
265_L	268_T	1.082	0.96
236_N	240_P	1.082	0.96
60_G	94_P	1.079	0.96
132_C	274_G	1.078	0.96
67_K	84_V	1.074	0.96
167_V	278_T	1.069	0.96
63_H	67_K	1.064	0.96
128_D	170_G	1.062	0.96
154_T	161_G	1.053	0.96
22_E	26_L	1.053	0.96
299_R	303_F	1.053	0.96
275_V	278_T	1.052	0.96
139_R	159_Y	1.047	0.96
52_H	102_F	1.045	0.95
205_W	227_V	1.043	0.95
271_R	274_G	1.042	0.95
234_A	237_T	1.037	0.95
292_A	301_Q	1.032	0.95
135_S	165_T	1.023	0.95
191_M	195_R	1.022	0.95
60_G	75_V	1.018	0.95
235_R	242_D	1.017	0.95
133_I	208_G	1.016	0.95
76_E	99_V	1.010	0.95
189_T	192_R	1.005	0.94
165_T	193_V	1.004	0.94
110_V	303_F	1.003	0.94
136_T	164_C	0.998	0.94
281_S	309_R	0.994	0.94
117_L	307_C	0.993	0.94
313_A	316_N	0.987	0.94
69_I	98_A	0.984	0.94
76_E	80_R	0.969	0.93
229_V	233_N	0.965	0.93
90_F	93_P	0.961	0.93
283_K	287_L	0.960	0.93
38_F	116_H	0.957	0.93
121_A	173_I	0.956	0.93
278_T	309_R	0.954	0.93
164_C	179_F	0.939	0.92
228_P	231_P	0.937	0.92
198_L	202_K	0.935	0.92
130_T	268_T	0.935	0.92
25_A	29_H	0.929	0.92
236_N	260_L	0.925	0.92
187_E	214_T	0.924	0.91
62_L	66_Y	0.923	0.91
21_T	25_A	0.918	0.91
280_E	284_D	0.912	0.91
230_A	237_T	0.911	0.91
313_A	317_Y	0.908	0.91
151_Y	160_H	0.908	0.91
234_A	239_D	0.905	0.91
111_N	196_D	0.904	0.91
96_R	100_D	0.903	0.91
229_V	268_T	0.901	0.90
179_F	302_V	0.898	0.90
165_T	186_P	0.897	0.90
310_L	313_A	0.893	0.90
281_S	312_V	0.892	0.90
202_K	225_G	0.887	0.90
69_I	78_E	0.885	0.90
113_V	307_C	0.883	0.90
150_C	181_E	0.882	0.89
60_G	88_C	0.879	0.89
231_P	234_A	0.877	0.89
35_L	39_D	0.874	0.89
234_A	241_K	0.873	0.89
67_K	81_N	0.873	0.89
165_T	189_T	0.868	0.89
59_R	87_S	0.865	0.89
237_T	241_K	0.865	0.89
259_Q	262_Q	0.862	0.88
285_C	290_T	0.861	0.88
308_L	312_V	0.859	0.88
101_R	104_T	0.858	0.88
146_D	162_Y	0.857	0.88
178_E	193_V	0.853	0.88
87_S	160_H	0.851	0.88
220_H	224_A	0.850	0.88
192_R	195_R	0.848	0.88
235_R	240_P	0.846	0.87
178_E	192_R	0.846	0.87
192_R	225_G	0.846	0.87
208_G	230_A	0.839	0.87
274_G	277_R	0.834	0.87
272_R	276_E	0.834	0.87
137_D	186_P	0.832	0.87
149_K	152_D	0.831	0.87
234_A	238_D	0.825	0.86
208_G	211_A	0.823	0.86
141_M	293_R	0.822	0.86
292_A	298_A	0.814	0.85
147_A	152_D	0.813	0.85
42_A	45_E	0.809	0.85
149_K	162_Y	0.805	0.85
21_T	27_F	0.801	0.84
54_P	142_P	0.801	0.84
190_A	208_G	0.798	0.84
188_E	217_W	0.797	0.84
164_C	306_L	0.797	0.84
111_N	299_R	0.790	0.84
36_E	39_D	0.785	0.83
210_S	265_L	0.785	0.83
166_I	174_P	0.780	0.83
295_R	299_R	0.778	0.83
130_T	207_V	0.775	0.82
172_K	313_A	0.775	0.82
135_S	212_Y	0.773	0.82
154_T	159_Y	0.768	0.82
104_T	297_H	0.766	0.82
172_K	309_R	0.763	0.81
260_L	265_L	0.759	0.81
285_C	312_V	0.756	0.81
76_E	79_L	0.755	0.81
24_L	27_F	0.753	0.81
170_G	267_E	0.749	0.80
120_Q	124_R	0.743	0.80
193_V	196_D	0.743	0.80
203_P	226_V	0.742	0.80
291_H	301_Q	0.742	0.80
281_S	284_D	0.738	0.79
76_E	100_D	0.737	0.79
231_P	236_N	0.736	0.79
221_L	224_A	0.736	0.79
138_V	164_C	0.731	0.79
176_A	197_A	0.730	0.79
54_P	57_L	0.722	0.78
80_R	200_V	0.722	0.78
52_H	60_G	0.721	0.78
174_P	177_A	0.718	0.77
162_Y	295_R	0.717	0.77
261_K	265_L	0.715	0.77
70_Y	161_G	0.711	0.77
142_P	160_H	0.709	0.76
75_V	99_V	0.707	0.76
282_V	287_L	0.707	0.76
209_D	276_E	0.700	0.76
166_I	275_V	0.700	0.76
223_A	226_V	0.699	0.75
22_E	25_A	0.697	0.75
281_S	285_C	0.693	0.75
172_K	281_S	0.687	0.74
126_L	173_I	0.686	0.74
144_D	160_H	0.685	0.74
185_A	211_A	0.683	0.74
79_L	93_P	0.681	0.74
110_V	300_A	0.680	0.73
208_G	217_W	0.680	0.73
157_E	166_I	0.676	0.73
150_C	154_T	0.676	0.73
168_S	275_V	0.675	0.73
174_P	313_A	0.674	0.73
180_T	193_V	0.672	0.73
33_E	45_E	0.671	0.72
190_A	206_M	0.670	0.72
137_D	152_D	0.668	0.72
165_T	184_Q	0.668	0.72
135_S	152_D	0.666	0.72
129_L	170_G	0.663	0.72
265_L	269_Y	0.658	0.71
185_A	283_K	0.655	0.71
129_L	199_A	0.655	0.71
45_E	50_R	0.647	0.70
235_R	241_K	0.646	0.70
298_A	307_C	0.642	0.69
71_G	207_V	0.641	0.69
56_E	92_R	0.640	0.69
153_P	159_Y	0.639	0.69
30_L	38_F	0.639	0.69
131_Y	203_P	0.637	0.69
290_T	302_V	0.636	0.68
76_E	94_P	0.631	0.68
21_T	86_L	0.630	0.68
185_A	214_T	0.630	0.68
187_E	211_A	0.630	0.68
309_R	313_A	0.629	0.68
207_V	229_V	0.629	0.68
300_A	304_L	0.627	0.67
59_R	94_P	0.626	0.67
194_T	221_L	0.626	0.67
73_R	100_D	0.625	0.67
95_S	101_R	0.625	0.67
282_V	306_L	0.623	0.67
77_R	81_N	0.622	0.67
211_A	214_T	0.621	0.67
135_S	151_Y	0.621	0.67
21_T	26_L	0.620	0.66
34_F	123_L	0.619	0.66
149_K	160_H	0.619	0.66
71_G	135_S	0.615	0.66
208_G	213_D	0.614	0.66
32_F	36_E	0.613	0.66
126_L	226_V	0.611	0.65
117_L	120_Q	0.611	0.65
305_A	308_L	0.609	0.65
56_E	89_G	0.608	0.65
188_E	216_D	0.607	0.65
117_L	121_A	0.606	0.65
202_K	241_K	0.606	0.65
277_R	280_E	0.606	0.65
144_D	156_D	0.602	0.64
108_H	111_N	0.602	0.64
301_Q	305_A	0.600	0.64
137_D	182_S	0.600	0.64
187_E	217_W	0.599	0.64
107_E	296_V	0.599	0.64
172_K	274_G	0.598	0.64
30_L	35_L	0.597	0.64
94_P	230_A	0.597	0.64
56_E	88_C	0.597	0.64
120_Q	196_D	0.596	0.63
149_K	154_T	0.593	0.63
281_S	305_A	0.590	0.63
138_V	290_T	0.588	0.62
66_Y	308_L	0.587	0.62
111_N	176_A	0.586	0.62
30_L	34_F	0.586	0.62
268_T	271_R	0.584	0.62
281_S	313_A	0.584	0.62
163_G	186_P	0.583	0.62
162_Y	298_A	0.582	0.62
114_F	177_A	0.575	0.61
215_L	219_D	0.574	0.61
279_N	283_K	0.573	0.60
51_D	57_L	0.573	0.60
292_A	302_V	0.571	0.60
259_Q	267_E	0.571	0.60
50_R	112_K	0.570	0.60
189_T	220_H	0.568	0.60
32_F	55_P	0.568	0.60
108_H	222_L	0.567	0.60
174_P	278_T	0.566	0.59
54_P	73_R	0.566	0.59
213_D	218_H	0.565	0.59
191_M	217_W	0.563	0.59
64_C	71_G	0.563	0.59
276_E	283_K	0.562	0.59
263_S	266_D	0.562	0.59
181_E	191_M	0.561	0.59
100_D	103_L	0.561	0.59
79_L	94_P	0.560	0.59
142_P	293_R	0.560	0.59
132_C	169_T	0.558	0.58
270_N	273_T	0.557	0.58
77_R	80_R	0.556	0.58
27_F	30_L	0.551	0.57
110_V	113_V	0.551	0.57
54_P	103_L	0.551	0.57
80_R	85_W	0.549	0.57
52_H	101_R	0.548	0.57
308_L	313_A	0.546	0.57
130_T	175_I	0.546	0.57
184_Q	217_W	0.545	0.57
33_E	37_E	0.545	0.57
40_V	45_E	0.544	0.56
233_N	241_K	0.544	0.56
165_T	182_S	0.543	0.56
259_Q	265_L	0.540	0.56
238_D	241_K	0.539	0.56
228_P	232_Y	0.538	0.56
262_Q	266_D	0.538	0.56
266_D	269_Y	0.537	0.56
54_P	102_F	0.537	0.56
125_G	201_A	0.535	0.55
52_H	97_D	0.535	0.55
238_D	242_D	0.532	0.55
213_D	233_N	0.532	0.55
95_S	100_D	0.530	0.55
298_A	302_V	0.529	0.54
123_L	226_V	0.528	0.54
146_D	154_T	0.528	0.54
63_H	75_V	0.526	0.54
95_S	103_L	0.526	0.54
272_R	283_K	0.525	0.54
140_A	162_Y	0.524	0.54
127_L	189_T	0.523	0.54
57_L	89_G	0.522	0.53
29_H	109_V	0.521	0.53
125_G	198_L	0.520	0.53
78_E	81_N	0.520	0.53
134_D	209_D	0.519	0.53
186_P	211_A	0.517	0.53
87_S	97_D	0.516	0.53
151_Y	158_Y	0.516	0.53
145_Q	151_Y	0.515	0.52
167_V	186_P	0.515	0.52
194_T	220_H	0.514	0.52
214_T	218_H	0.513	0.52
228_P	264_T	0.512	0.52
204_I	267_E	0.511	0.52
234_A	264_T	0.510	0.52
154_T	157_E	0.508	0.52
123_L	191_M	0.507	0.51
195_R	220_H	0.507	0.51
232_Y	238_D	0.505	0.51
167_V	211_A	0.504	0.51
40_V	123_L	0.503	0.51
153_P	158_Y	0.503	0.51
274_G	280_E	0.501	0.51
297_H	311_V	0.501	0.51
100_D	104_T	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8333	98.6	0.869	Contact Map
4u7bA	2	0.8303	95	0.923	Contact Map
4mq3A	1	0.3848	84.4	0.94	Contact Map
3l3uA	2	0.4394	65.1	0.949	Contact Map
1c6vA	4	0.4152	62.5	0.95	Contact Map
3kksA	2	0.4303	57.9	0.951	Contact Map
4pa1A	2	0.4364	51.4	0.953	Contact Map
4dyqA	5	0.3697	50.7	0.953	Contact Map
1ex4A	5	0.4364	48.5	0.954	Contact Map
1bcoA	1	0.5	46.4	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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