GREMLIN Database
Q9HPK4 - Uncharacterized protein
UniProt: Q9HPK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 57 (46)
Sequences: 18859 (14579)
Seq/√Len: 2149.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_P37_P3.8111.00
21_T50_D2.6361.00
11_N38_D2.4261.00
17_A46_I2.2331.00
8_H35_S2.2291.00
14_A41_Y2.0061.00
35_S42_G1.9771.00
45_R48_A1.9311.00
14_A43_F1.6741.00
17_A21_T1.6381.00
13_E40_E1.5591.00
16_R19_Y1.5371.00
46_I50_D1.4571.00
21_T24_M1.3631.00
35_S40_E1.2381.00
15_E44_I1.2151.00
19_Y22_A1.2081.00
18_F47_A1.1801.00
11_N24_M1.1751.00
10_P24_M1.1501.00
16_R45_R1.1261.00
23_A27_H0.9621.00
37_P42_G0.9471.00
9_C23_A0.9421.00
8_H13_E0.9381.00
19_Y48_A0.9341.00
44_I48_A0.9261.00
36_C39_C0.9131.00
18_F22_A0.9051.00
15_E19_Y0.8931.00
12_C27_H0.8851.00
12_C23_A0.8001.00
14_A26_V0.7811.00
39_C49_D0.7351.00
12_C20_R0.7311.00
7_H20_R0.7301.00
7_H12_C0.7191.00
26_V44_I0.7161.00
45_R49_D0.7091.00
31_K42_G0.6671.00
35_S38_D0.6571.00
22_A25_N0.6501.00
29_G44_I0.6331.00
31_K34_W0.6321.00
36_C43_F0.6181.00
34_W39_C0.6121.00
38_D49_D0.6081.00
5_L26_V0.5981.00
9_C19_Y0.5861.00
31_K36_C0.5861.00
8_H11_N0.5851.00
7_H34_W0.5781.00
43_F49_D0.5651.00
32_T42_G0.5621.00
47_A50_D0.5541.00
17_A20_R0.5481.00
10_P42_G0.5471.00
5_L15_E0.5461.00
7_H27_H0.5401.00
9_C20_R0.5391.00
46_I49_D0.5381.00
19_Y23_A0.5321.00
20_R23_A0.5301.00
24_M50_D0.5241.00
38_D41_Y0.5131.00
25_N30_L0.5071.00
8_H37_P0.5071.00
15_E18_F0.5001.00
5_L31_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w5kB 1 0.9474 98.7 0.327 Contact Map
2i13A 1 0.9649 98.7 0.328 Contact Map
1ej6B 7 0.7719 98.7 0.332 Contact Map
1x6eA 1 0.9825 98.7 0.333 Contact Map
2lv2A 1 0.9825 98.7 0.338 Contact Map
3uk3C 1 0.8772 98.7 0.339 Contact Map
2lceA 1 0.9825 98.7 0.342 Contact Map
2n25A 1 0.0877 98.7 0.347 Contact Map
2wbtA 2 0.9474 98.6 0.349 Contact Map
2gqjA 1 0.9825 98.6 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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