GREMLIN Database
Q9HPK3 - Sulfate transport system permease protein
UniProt: Q9HPK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (238)
Sequences: 72510 (46241)
Seq/√Len: 2997.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_A184_T3.7641.00
58_R62_A3.2321.00
172_R181_T3.0531.00
157_R161_D2.9111.00
159_G193_A2.5921.00
55_A58_R2.5611.00
66_A141_V2.4801.00
171_A181_T2.4581.00
56_A225_R2.4251.00
168_E186_S2.4161.00
84_R168_E2.4131.00
70_L145_T2.3791.00
177_G180_A2.3771.00
220_R228_I2.3621.00
45_G49_T2.3571.00
178_P181_T2.3091.00
42_A45_G2.2971.00
68_T198_I2.2661.00
54_R58_R2.2601.00
234_G237_A2.2531.00
39_T44_I2.1881.00
179_L183_W2.1311.00
156_A194_I2.1091.00
87_F90_K2.1021.00
42_A46_S2.0981.00
176_R180_A2.0451.00
180_A183_W1.9601.00
152_L197_G1.9071.00
62_A137_A1.8781.00
33_V37_A1.8701.00
94_N157_R1.8671.00
83_A161_D1.8601.00
76_V182_F1.8391.00
167_F189_L1.8371.00
171_A176_R1.8251.00
160_F190_A1.7931.00
76_V190_A1.7731.00
168_E181_T1.7261.00
55_A59_T1.7211.00
172_R178_P1.7161.00
72_T198_I1.6981.00
254_G258_R1.6951.00
225_R229_A1.6831.00
67_A205_A1.6561.00
168_E172_R1.6421.00
64_A202_F1.6321.00
46_S237_A1.6031.00
62_A66_A1.5881.00
76_V156_A1.5591.00
78_L153_V1.5261.00
75_G152_L1.5221.00
165_P168_E1.5211.00
82_L153_V1.5161.00
152_L201_T1.5071.00
73_V77_P1.4721.00
46_S49_T1.4431.00
34_A38_H1.4391.00
89_G92_L1.4311.00
18_V22_A1.4261.00
86_T90_K1.4201.00
30_V34_A1.4081.00
220_R225_R1.4031.00
229_A232_S1.3991.00
209_F213_M1.3911.00
52_D55_A1.3901.00
36_L243_V1.3801.00
83_A157_R1.3711.00
40_G43_D1.3501.00
71_A201_T1.3311.00
160_F186_S1.3291.00
187_I194_I1.3181.00
156_A197_G1.3171.00
41_A45_G1.3161.00
79_A156_A1.3061.00
196_A200_L1.3041.00
63_T221_T1.2971.00
165_P169_D1.2791.00
166_R169_D1.2431.00
84_R165_P1.2381.00
80_Y160_F1.2361.00
92_L95_G1.2241.00
143_A215_V1.2061.00
59_T62_A1.2011.00
76_V194_I1.1941.00
211_A215_V1.1811.00
69_V73_V1.1771.00
22_A26_A1.1681.00
171_A185_V1.1611.00
191_R195_L1.1471.00
209_F227_W1.1391.00
72_T194_I1.1361.00
60_S222_V1.1301.00
66_A69_V1.1291.00
116_V139_G1.1231.00
12_R16_L1.1161.00
163_V189_L1.1111.00
177_G181_T1.1071.00
229_A234_G1.0911.00
83_A160_F1.0861.00
149_A153_V1.0831.00
225_R228_I1.0831.00
15_W19_A1.0791.00
70_L141_V1.0751.00
46_S50_A1.0731.00
34_A37_A1.0681.00
114_T118_R1.0641.00
35_F243_V1.0551.00
13_R17_P1.0551.00
92_L96_L1.0481.00
228_I231_R1.0431.00
15_W18_V1.0391.00
48_L54_R1.0331.00
208_E211_A1.0251.00
12_R15_W1.0191.00
141_V145_T1.0161.00
255_A259_L1.0151.00
133_L138_I1.0141.00
140_V212_T1.0141.00
258_R261_E1.0131.00
221_T224_I1.0121.00
67_A144_Q1.0091.00
66_A70_L1.0051.00
212_T221_T1.0041.00
77_P81_T0.9951.00
38_H239_V0.9911.00
225_R241_L0.9901.00
220_R224_I0.9871.00
189_L192_P0.9861.00
168_E178_P0.9861.00
176_R181_T0.9771.00
80_Y182_F0.9761.00
156_A193_A0.9761.00
181_T184_T0.9721.00
67_A71_A0.9661.00
27_Y31_P0.9581.00
44_I243_V0.9541.00
155_A197_G0.9491.00
61_L65_T0.9461.00
176_R184_T0.9451.00
137_A141_V0.9351.00
80_Y178_P0.9331.00
69_V198_I0.9311.00
79_A83_A0.9291.00
14_H18_V0.9271.00
43_D46_S0.9271.00
62_A65_T0.9251.00
90_K161_D0.9221.00
25_V29_V0.9181.00
208_E212_T0.9081.00
53_A241_L0.9061.00
138_I142_L0.9001.00
62_A138_I0.8971.00
67_A141_V0.8971.00
65_T69_V0.8891.00
63_T137_A0.8871.00
144_Q205_A0.8861.00
57_I222_V0.8841.00
59_T137_A0.8821.00
75_G153_V0.8671.00
190_A193_A0.8651.00
112_L143_A0.8631.00
191_R194_I0.8621.00
17_P21_G0.8571.00
105_P147_V0.8531.00
81_T87_F0.8531.00
181_T186_S0.8511.00
229_A237_A0.8481.00
143_A211_A0.8441.00
88_P91_R0.8441.00
98_V154_V0.8431.00
91_R94_N0.8421.00
48_L51_P0.8401.00
112_L215_V0.8351.00
156_A190_A0.8341.00
255_A258_R0.8311.00
229_A241_L0.8301.00
71_A75_G0.8291.00
213_M224_I0.8231.00
136_S139_G0.8191.00
57_I61_L0.8141.00
159_G190_A0.8131.00
113_L117_G0.8091.00
63_T144_Q0.8071.00
183_W187_I0.8061.00
58_R61_L0.8001.00
79_A160_F0.7961.00
70_L73_V0.7891.00
152_L156_A0.7861.00
35_F239_V0.7841.00
201_T205_A0.7831.00
249_T253_V0.7791.00
109_G210_G0.7771.00
251_F255_A0.7721.00
75_G156_A0.7691.00
47_Q244_A0.7651.00
82_L94_N0.7581.00
71_A148_A0.7571.00
71_A152_L0.7511.00
182_F187_I0.7511.00
43_D236_D0.7491.00
178_P182_F0.7481.00
191_R259_L0.7451.00
82_L157_R0.7431.00
79_A153_V0.7421.00
138_I141_V0.7361.00
66_A145_T0.7311.00
68_T202_F0.7301.00
78_L149_A0.7291.00
45_G48_L0.7241.00
19_A22_A0.7191.00
245_L249_T0.7181.00
167_F185_V0.7101.00
24_L28_L0.7101.00
35_F242_A0.7061.00
72_T156_A0.7041.00
170_A174_L0.7021.00
30_V33_V0.7011.00
256_V259_L0.7001.00
98_V101_L0.7001.00
165_P172_R0.6981.00
105_P210_G0.6981.00
71_A205_A0.6981.00
226_I241_L0.6961.00
228_I232_S0.6961.00
182_F186_S0.6951.00
25_V28_L0.6941.00
216_A219_P0.6931.00
170_A173_S0.6901.00
250_L254_G0.6891.00
139_G143_A0.6891.00
64_A68_T0.6871.00
237_A241_L0.6861.00
81_T85_A0.6841.00
82_L93_V0.6841.00
74_F145_T0.6811.00
16_L20_L0.6801.00
117_G134_T0.6791.00
108_G146_F0.6751.00
50_A54_R0.6741.00
109_G214_M0.6731.00
222_V245_L0.6721.00
56_A59_T0.6721.00
216_A220_R0.6701.00
87_F93_V0.6651.00
148_A201_T0.6641.00
156_A160_F0.6631.00
224_I228_I0.6601.00
54_R57_I0.6591.00
194_I197_G0.6561.00
114_T117_G0.6561.00
235_I239_V0.6551.00
193_A197_G0.6531.00
21_G25_V0.6511.00
94_N154_V0.6461.00
163_V190_A0.6451.00
16_L19_A0.6441.00
71_A145_T0.6441.00
63_T140_V0.6421.00
41_A44_I0.6421.00
52_D225_R0.6411.00
148_A204_R0.6371.00
186_S189_L0.6361.00
210_G213_M0.6321.00
235_I238_V0.6311.00
208_E221_T0.6301.00
224_I227_W0.6281.00
88_P92_L0.6281.00
140_V216_A0.6251.00
60_S206_L0.6231.00
56_A222_V0.6231.00
20_L24_L0.6231.00
78_L97_V0.6231.00
135_N218_T0.6221.00
183_W186_S0.6211.00
221_T225_R0.6201.00
223_P245_L0.6181.00
194_I198_I0.6181.00
68_T72_T0.6151.00
239_V243_V0.6131.00
46_S234_G0.6121.00
86_T91_R0.6121.00
51_P55_A0.6111.00
80_Y186_S0.6081.00
91_R95_G0.6051.00
74_F149_A0.6031.00
47_Q237_A0.6001.00
51_P54_R0.6001.00
239_V242_A0.5981.00
106_L214_M0.5971.00
40_G44_I0.5941.00
79_A157_R0.5921.00
113_L134_T0.5901.00
181_T185_V0.5881.00
64_A206_L0.5881.00
29_V33_V0.5871.00
101_L150_P0.5861.00
140_V144_Q0.5861.00
63_T141_V0.5841.00
31_P39_T0.5841.00
89_G93_V0.5831.00
198_I201_T0.5801.00
14_H17_P0.5771.00
186_S190_A0.5741.00
195_L198_I0.5741.00
60_S223_P0.5731.00
212_T216_A0.5661.00
85_A178_P0.5661.00
144_Q147_V0.5641.00
39_T240_P0.5631.00
205_A208_E0.5631.00
237_A240_P0.5611.00
112_L115_V0.5611.00
55_A62_A0.5601.00
44_I240_P0.5601.00
63_T67_A0.5551.00
31_P35_F0.5531.00
204_R207_G0.5511.00
40_G45_G0.5501.00
223_P227_W0.5471.00
72_T76_V0.5461.00
90_K94_N0.5451.00
67_A145_T0.5421.00
95_G99_L0.5411.00
212_T224_I0.5411.00
78_L81_T0.5401.00
26_A30_V0.5381.00
52_D220_R0.5371.00
253_V257_H0.5351.00
96_L100_P0.5341.00
203_A207_G0.5331.00
18_V21_G0.5321.00
155_A193_A0.5321.00
133_L136_S0.5311.00
94_N161_D0.5301.00
248_I251_F0.5291.00
64_A205_A0.5281.00
23_V27_Y0.5271.00
101_L151_F0.5271.00
177_G183_W0.5261.00
47_Q241_L0.5231.00
105_P109_G0.5231.00
80_Y84_R0.5211.00
144_Q208_E0.5191.00
86_T165_P0.5191.00
144_Q148_A0.5181.00
210_G214_M0.5181.00
52_D56_A0.5171.00
145_T148_A0.5171.00
169_D172_R0.5151.00
109_G113_L0.5141.00
73_V76_V0.5141.00
74_F77_P0.5101.00
31_P34_A0.5091.00
59_T221_T0.5081.00
93_V97_V0.5061.00
87_F91_R0.5021.00
139_G215_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9257 100 0.246 Contact Map
3d31C 2 0.9108 100 0.25 Contact Map
4tquM 1 0.9814 100 0.31 Contact Map
4tquN 1 0.9108 100 0.383 Contact Map
3rlfF 1 0.9442 100 0.384 Contact Map
3rlfG 1 0.9331 100 0.385 Contact Map
4ymuD 2 0.7918 99.9 0.476 Contact Map
3tuiA 2 0.7732 99.9 0.52 Contact Map
2a65A 2 0.8178 12.7 0.945 Contact Map
4humA 1 0.8736 11.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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