Q9HPK3 - HALSA - GREMLIN Contacts

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Q9HPK3 - Sulfate transport system permease protein

UniProt:	Q9HPK3	Sequences: MTAGTPIGEATRRHWLPVALGAVLVAYLVVPFVAFLAHTGAADIGSQLTAPDARAAIRTSLATATAATVLATVFGVPLAYTLARATFPGKRLVNGLVVLPLVVPPLVGGTMLLTVVGRFTPLGAWAAAAGVPLTNSAIGVVLAQTFVAAPFLVVAARSGFDGVDPRFEDAARSLGRGPLATFWTVSIPLARPAILAGIVLTFARALGEFGATMMVATTPRTVPIRIWIAFRSDGIDAVVPLAVALLVITLFVVGAVHRLGEQAAAVPPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (238)
Sequences:	72510 (46241)
Seq/√Len:	2997.4

ECOLI - CYST POTH CYSW YCJO THIP PSTC UGPA YDCU POTB PSTA MALG YNJC YDCV MODB YCJP MALF POTI POTC UGPE YEHY TAUC SSUC PHNE YEHW PROW METI YECS GLNP
BACSU - GANP YESP AMYD ARAP YTEP MDXF LPLB YURN YQGI GANQ MDXG YESQ YVGM YQGH YURM AMYC LPLC ARAQ YTCP SSUC OPUAB YTLD METP OPUCB YXEN TCYB TCYL OPUBB OPUBD OPUCD ARTQ
HALSA - Q9HPK3 Q9HMT4 Q9HR05 Q9HP01 Q9HML6 Q9HP02 Q9HHQ7 Q9HS11 Q9HHQ6 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97YY2 Q97UZ0 Q97UF3 Q97Z98 Q97YY3 Q97UF4 Q97ZC1 Q97UY9 Q97ZT7 Q97VC0 Q97ZC2 Q97ZT6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
180_A	184_T	3.764	1.00
58_R	62_A	3.232	1.00
172_R	181_T	3.053	1.00
157_R	161_D	2.911	1.00
159_G	193_A	2.592	1.00
55_A	58_R	2.561	1.00
66_A	141_V	2.480	1.00
171_A	181_T	2.458	1.00
56_A	225_R	2.425	1.00
168_E	186_S	2.416	1.00
84_R	168_E	2.413	1.00
70_L	145_T	2.379	1.00
177_G	180_A	2.377	1.00
220_R	228_I	2.362	1.00
45_G	49_T	2.357	1.00
178_P	181_T	2.309	1.00
42_A	45_G	2.297	1.00
68_T	198_I	2.266	1.00
54_R	58_R	2.260	1.00
234_G	237_A	2.253	1.00
39_T	44_I	2.188	1.00
179_L	183_W	2.131	1.00
156_A	194_I	2.109	1.00
87_F	90_K	2.102	1.00
42_A	46_S	2.098	1.00
176_R	180_A	2.045	1.00
180_A	183_W	1.960	1.00
152_L	197_G	1.907	1.00
62_A	137_A	1.878	1.00
33_V	37_A	1.870	1.00
94_N	157_R	1.867	1.00
83_A	161_D	1.860	1.00
76_V	182_F	1.839	1.00
167_F	189_L	1.837	1.00
171_A	176_R	1.825	1.00
160_F	190_A	1.793	1.00
76_V	190_A	1.773	1.00
168_E	181_T	1.726	1.00
55_A	59_T	1.721	1.00
172_R	178_P	1.716	1.00
72_T	198_I	1.698	1.00
254_G	258_R	1.695	1.00
225_R	229_A	1.683	1.00
67_A	205_A	1.656	1.00
168_E	172_R	1.642	1.00
64_A	202_F	1.632	1.00
46_S	237_A	1.603	1.00
62_A	66_A	1.588	1.00
76_V	156_A	1.559	1.00
78_L	153_V	1.526	1.00
75_G	152_L	1.522	1.00
165_P	168_E	1.521	1.00
82_L	153_V	1.516	1.00
152_L	201_T	1.507	1.00
73_V	77_P	1.472	1.00
46_S	49_T	1.443	1.00
34_A	38_H	1.439	1.00
89_G	92_L	1.431	1.00
18_V	22_A	1.426	1.00
86_T	90_K	1.420	1.00
30_V	34_A	1.408	1.00
220_R	225_R	1.403	1.00
229_A	232_S	1.399	1.00
209_F	213_M	1.391	1.00
52_D	55_A	1.390	1.00
36_L	243_V	1.380	1.00
83_A	157_R	1.371	1.00
40_G	43_D	1.350	1.00
71_A	201_T	1.331	1.00
160_F	186_S	1.329	1.00
187_I	194_I	1.318	1.00
156_A	197_G	1.317	1.00
41_A	45_G	1.316	1.00
79_A	156_A	1.306	1.00
196_A	200_L	1.304	1.00
63_T	221_T	1.297	1.00
165_P	169_D	1.279	1.00
166_R	169_D	1.243	1.00
84_R	165_P	1.238	1.00
80_Y	160_F	1.236	1.00
92_L	95_G	1.224	1.00
143_A	215_V	1.206	1.00
59_T	62_A	1.201	1.00
76_V	194_I	1.194	1.00
211_A	215_V	1.181	1.00
69_V	73_V	1.177	1.00
22_A	26_A	1.168	1.00
171_A	185_V	1.161	1.00
191_R	195_L	1.147	1.00
209_F	227_W	1.139	1.00
72_T	194_I	1.136	1.00
60_S	222_V	1.130	1.00
66_A	69_V	1.129	1.00
116_V	139_G	1.123	1.00
12_R	16_L	1.116	1.00
163_V	189_L	1.111	1.00
177_G	181_T	1.107	1.00
229_A	234_G	1.091	1.00
83_A	160_F	1.086	1.00
149_A	153_V	1.083	1.00
225_R	228_I	1.083	1.00
15_W	19_A	1.079	1.00
70_L	141_V	1.075	1.00
46_S	50_A	1.073	1.00
34_A	37_A	1.068	1.00
114_T	118_R	1.064	1.00
35_F	243_V	1.055	1.00
13_R	17_P	1.055	1.00
92_L	96_L	1.048	1.00
228_I	231_R	1.043	1.00
15_W	18_V	1.039	1.00
48_L	54_R	1.033	1.00
208_E	211_A	1.025	1.00
12_R	15_W	1.019	1.00
141_V	145_T	1.016	1.00
255_A	259_L	1.015	1.00
133_L	138_I	1.014	1.00
140_V	212_T	1.014	1.00
258_R	261_E	1.013	1.00
221_T	224_I	1.012	1.00
67_A	144_Q	1.009	1.00
66_A	70_L	1.005	1.00
212_T	221_T	1.004	1.00
77_P	81_T	0.995	1.00
38_H	239_V	0.991	1.00
225_R	241_L	0.990	1.00
220_R	224_I	0.987	1.00
189_L	192_P	0.986	1.00
168_E	178_P	0.986	1.00
176_R	181_T	0.977	1.00
80_Y	182_F	0.976	1.00
156_A	193_A	0.976	1.00
181_T	184_T	0.972	1.00
67_A	71_A	0.966	1.00
27_Y	31_P	0.958	1.00
44_I	243_V	0.954	1.00
155_A	197_G	0.949	1.00
61_L	65_T	0.946	1.00
176_R	184_T	0.945	1.00
137_A	141_V	0.935	1.00
80_Y	178_P	0.933	1.00
69_V	198_I	0.931	1.00
79_A	83_A	0.929	1.00
14_H	18_V	0.927	1.00
43_D	46_S	0.927	1.00
62_A	65_T	0.925	1.00
90_K	161_D	0.922	1.00
25_V	29_V	0.918	1.00
208_E	212_T	0.908	1.00
53_A	241_L	0.906	1.00
138_I	142_L	0.900	1.00
62_A	138_I	0.897	1.00
67_A	141_V	0.897	1.00
65_T	69_V	0.889	1.00
63_T	137_A	0.887	1.00
144_Q	205_A	0.886	1.00
57_I	222_V	0.884	1.00
59_T	137_A	0.882	1.00
75_G	153_V	0.867	1.00
190_A	193_A	0.865	1.00
112_L	143_A	0.863	1.00
191_R	194_I	0.862	1.00
17_P	21_G	0.857	1.00
105_P	147_V	0.853	1.00
81_T	87_F	0.853	1.00
181_T	186_S	0.851	1.00
229_A	237_A	0.848	1.00
143_A	211_A	0.844	1.00
88_P	91_R	0.844	1.00
98_V	154_V	0.843	1.00
91_R	94_N	0.842	1.00
48_L	51_P	0.840	1.00
112_L	215_V	0.835	1.00
156_A	190_A	0.834	1.00
255_A	258_R	0.831	1.00
229_A	241_L	0.830	1.00
71_A	75_G	0.829	1.00
213_M	224_I	0.823	1.00
136_S	139_G	0.819	1.00
57_I	61_L	0.814	1.00
159_G	190_A	0.813	1.00
113_L	117_G	0.809	1.00
63_T	144_Q	0.807	1.00
183_W	187_I	0.806	1.00
58_R	61_L	0.800	1.00
79_A	160_F	0.796	1.00
70_L	73_V	0.789	1.00
152_L	156_A	0.786	1.00
35_F	239_V	0.784	1.00
201_T	205_A	0.783	1.00
249_T	253_V	0.779	1.00
109_G	210_G	0.777	1.00
251_F	255_A	0.772	1.00
75_G	156_A	0.769	1.00
47_Q	244_A	0.765	1.00
82_L	94_N	0.758	1.00
71_A	148_A	0.757	1.00
71_A	152_L	0.751	1.00
182_F	187_I	0.751	1.00
43_D	236_D	0.749	1.00
178_P	182_F	0.748	1.00
191_R	259_L	0.745	1.00
82_L	157_R	0.743	1.00
79_A	153_V	0.742	1.00
138_I	141_V	0.736	1.00
66_A	145_T	0.731	1.00
68_T	202_F	0.730	1.00
78_L	149_A	0.729	1.00
45_G	48_L	0.724	1.00
19_A	22_A	0.719	1.00
245_L	249_T	0.718	1.00
167_F	185_V	0.710	1.00
24_L	28_L	0.710	1.00
35_F	242_A	0.706	1.00
72_T	156_A	0.704	1.00
170_A	174_L	0.702	1.00
30_V	33_V	0.701	1.00
256_V	259_L	0.700	1.00
98_V	101_L	0.700	1.00
165_P	172_R	0.698	1.00
105_P	210_G	0.698	1.00
71_A	205_A	0.698	1.00
226_I	241_L	0.696	1.00
228_I	232_S	0.696	1.00
182_F	186_S	0.695	1.00
25_V	28_L	0.694	1.00
216_A	219_P	0.693	1.00
170_A	173_S	0.690	1.00
250_L	254_G	0.689	1.00
139_G	143_A	0.689	1.00
64_A	68_T	0.687	1.00
237_A	241_L	0.686	1.00
81_T	85_A	0.684	1.00
82_L	93_V	0.684	1.00
74_F	145_T	0.681	1.00
16_L	20_L	0.680	1.00
117_G	134_T	0.679	1.00
108_G	146_F	0.675	1.00
50_A	54_R	0.674	1.00
109_G	214_M	0.673	1.00
222_V	245_L	0.672	1.00
56_A	59_T	0.672	1.00
216_A	220_R	0.670	1.00
87_F	93_V	0.665	1.00
148_A	201_T	0.664	1.00
156_A	160_F	0.663	1.00
224_I	228_I	0.660	1.00
54_R	57_I	0.659	1.00
194_I	197_G	0.656	1.00
114_T	117_G	0.656	1.00
235_I	239_V	0.655	1.00
193_A	197_G	0.653	1.00
21_G	25_V	0.651	1.00
94_N	154_V	0.646	1.00
163_V	190_A	0.645	1.00
16_L	19_A	0.644	1.00
71_A	145_T	0.644	1.00
63_T	140_V	0.642	1.00
41_A	44_I	0.642	1.00
52_D	225_R	0.641	1.00
148_A	204_R	0.637	1.00
186_S	189_L	0.636	1.00
210_G	213_M	0.632	1.00
235_I	238_V	0.631	1.00
208_E	221_T	0.630	1.00
224_I	227_W	0.628	1.00
88_P	92_L	0.628	1.00
140_V	216_A	0.625	1.00
60_S	206_L	0.623	1.00
56_A	222_V	0.623	1.00
20_L	24_L	0.623	1.00
78_L	97_V	0.623	1.00
135_N	218_T	0.622	1.00
183_W	186_S	0.621	1.00
221_T	225_R	0.620	1.00
223_P	245_L	0.618	1.00
194_I	198_I	0.618	1.00
68_T	72_T	0.615	1.00
239_V	243_V	0.613	1.00
46_S	234_G	0.612	1.00
86_T	91_R	0.612	1.00
51_P	55_A	0.611	1.00
80_Y	186_S	0.608	1.00
91_R	95_G	0.605	1.00
74_F	149_A	0.603	1.00
47_Q	237_A	0.600	1.00
51_P	54_R	0.600	1.00
239_V	242_A	0.598	1.00
106_L	214_M	0.597	1.00
40_G	44_I	0.594	1.00
79_A	157_R	0.592	1.00
113_L	134_T	0.590	1.00
181_T	185_V	0.588	1.00
64_A	206_L	0.588	1.00
29_V	33_V	0.587	1.00
101_L	150_P	0.586	1.00
140_V	144_Q	0.586	1.00
63_T	141_V	0.584	1.00
31_P	39_T	0.584	1.00
89_G	93_V	0.583	1.00
198_I	201_T	0.580	1.00
14_H	17_P	0.577	1.00
186_S	190_A	0.574	1.00
195_L	198_I	0.574	1.00
60_S	223_P	0.573	1.00
212_T	216_A	0.566	1.00
85_A	178_P	0.566	1.00
144_Q	147_V	0.564	1.00
39_T	240_P	0.563	1.00
205_A	208_E	0.563	1.00
237_A	240_P	0.561	1.00
112_L	115_V	0.561	1.00
55_A	62_A	0.560	1.00
44_I	240_P	0.560	1.00
63_T	67_A	0.555	1.00
31_P	35_F	0.553	1.00
204_R	207_G	0.551	1.00
40_G	45_G	0.550	1.00
223_P	227_W	0.547	1.00
72_T	76_V	0.546	1.00
90_K	94_N	0.545	1.00
67_A	145_T	0.542	1.00
95_G	99_L	0.541	1.00
212_T	224_I	0.541	1.00
78_L	81_T	0.540	1.00
26_A	30_V	0.538	1.00
52_D	220_R	0.537	1.00
253_V	257_H	0.535	1.00
96_L	100_P	0.534	1.00
203_A	207_G	0.533	1.00
18_V	21_G	0.532	1.00
155_A	193_A	0.532	1.00
133_L	136_S	0.531	1.00
94_N	161_D	0.530	1.00
248_I	251_F	0.529	1.00
64_A	205_A	0.528	1.00
23_V	27_Y	0.527	1.00
101_L	151_F	0.527	1.00
177_G	183_W	0.526	1.00
47_Q	241_L	0.523	1.00
105_P	109_G	0.523	1.00
80_Y	84_R	0.521	1.00
144_Q	208_E	0.519	1.00
86_T	165_P	0.519	1.00
144_Q	148_A	0.518	1.00
210_G	214_M	0.518	1.00
52_D	56_A	0.517	1.00
145_T	148_A	0.517	1.00
169_D	172_R	0.515	1.00
109_G	113_L	0.514	1.00
73_V	76_V	0.514	1.00
74_F	77_P	0.510	1.00
31_P	34_A	0.509	1.00
59_T	221_T	0.508	1.00
93_V	97_V	0.506	1.00
87_F	91_R	0.502	1.00
139_G	215_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.9257	100	0.246	Contact Map
3d31C	2	0.9108	100	0.25	Contact Map
4tquM	1	0.9814	100	0.31	Contact Map
4tquN	1	0.9108	100	0.383	Contact Map
3rlfF	1	0.9442	100	0.384	Contact Map
3rlfG	1	0.9331	100	0.385	Contact Map
4ymuD	2	0.7918	99.9	0.476	Contact Map
3tuiA	2	0.7732	99.9	0.52	Contact Map
2a65A	2	0.8178	12.7	0.945	Contact Map
4humA	1	0.8736	11.4	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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