GREMLIN Database
Y1595 - Uncharacterized solute-binding protein VNG_1595C
UniProt: Q9HPK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (239)
Sequences: 3752 (2799)
Seq/√Len: 181.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_R276_R3.9891.00
49_H287_D3.6271.00
109_F112_N3.3311.00
53_A277_F3.2501.00
162_M253_R3.1511.00
49_H288_A3.0951.00
76_I86_A3.0041.00
263_N268_T2.7891.00
50_I277_F2.6411.00
33_S63_R2.6401.00
53_A284_M2.5421.00
51_R64_P2.4791.00
98_L106_A2.4191.00
161_L165_T2.3171.00
176_L180_L2.2921.00
95_R99_F2.2881.00
177_R180_L2.2781.00
60_H270_G2.2351.00
268_T272_R2.2141.00
47_E66_Y2.1971.00
283_D287_D2.0921.00
74_Q78_D2.0561.00
32_A270_G1.9511.00
85_V275_V1.9381.00
55_E61_T1.8631.00
110_A285_V1.8461.00
54_F273_A1.8371.00
259_T275_V1.8301.00
69_S88_S1.8211.00
259_T278_L1.8171.00
77_S97_R1.6981.00
53_A56_D1.6891.00
107_L279_A1.6831.00
176_L179_D1.6661.00
33_S61_T1.6531.00
197_V205_A1.6481.00
54_F60_H1.6481.00
164_F206_V1.6341.00
77_S100_D1.6061.00
115_G212_A1.5861.00
43_T47_E1.5781.00
45_T284_M1.5731.00
87_I278_L1.5601.00
269_A273_A1.5191.00
261_V265_A1.5081.00
87_I259_T1.5071.00
116_I204_A1.4981.00
284_M288_A1.4901.00
193_L205_A1.4881.00
267_N270_G1.4811.00
91_A106_A1.4781.00
283_D286_R1.4751.00
75_L80_T1.4661.00
37_L65_E1.4581.00
161_L177_R1.4471.00
282_P292_V1.4471.00
51_R274_F1.4431.00
108_E256_T1.4401.00
98_L104_D1.4161.00
148_V160_T1.4051.00
145_T184_T1.4001.00
44_S191_S1.3951.00
147_A202_H1.3671.00
46_I87_I1.3591.00
47_E52_P1.3531.00
34_I270_G1.3501.00
90_D93_L1.3421.00
262_L265_A1.3181.00
18_A21_G1.3101.00
34_I62_L1.3041.00
45_T285_V1.3041.00
95_R106_A1.3011.00
45_T288_A1.2921.00
73_L93_L1.2831.00
261_V275_V1.2771.00
156_L160_T1.2701.00
282_P286_R1.2631.00
113_R291_A1.2531.00
112_N257_Y1.2381.00
262_L268_T1.2291.00
37_L83_P1.2291.00
94_L260_T1.2271.00
26_C30_A1.2131.00
73_L97_R1.1931.00
147_A184_T1.1891.00
109_F285_V1.1871.00
82_H265_A1.1831.00
111_S291_A1.1821.00
50_I280_A1.1781.00
38_A66_Y1.1741.00
273_A276_R1.1691.00
50_I285_V1.1651.00
269_A272_R1.1561.00
55_E62_L1.1521.00
148_V184_T1.1501.00
118_Y204_A1.1481.00
263_N272_R1.1441.00
49_H53_A1.1381.00
192_Q196_D1.1311.00
73_L96_T1.1181.00
40_G189_S1.1131.00
41_S290_L1.1121.00
45_T50_I1.1101.00
164_F176_L1.1081.00
51_R55_E1.1021.00
265_A268_T1.0981.00
209_E213_L1.0931.00
51_R61_T1.0831.00
26_C29_G1.0831.00
136_R140_D1.0821.00
76_I97_R1.0811.00
57_A277_F1.0791.00
54_F277_F1.0781.00
77_S102_H1.0711.00
91_A95_R1.0651.00
42_L87_I1.0631.00
139_V144_D1.0581.00
165_T177_R1.0561.00
50_I53_A1.0551.00
54_F270_G1.0421.00
177_R181_D1.0401.00
165_T178_A1.0381.00
43_T66_Y1.0381.00
32_A267_N1.0311.00
166_L251_H1.0311.00
51_R66_Y1.0230.99
118_Y122_T1.0150.99
185_V202_H1.0150.99
67_H72_L1.0110.99
91_A258_A1.0110.99
35_H63_R1.0000.99
71_T188_P0.9780.99
156_L159_R0.9770.99
38_A42_L0.9760.99
152_A161_L0.9740.99
213_L244_T0.9740.99
50_I57_A0.9740.99
130_A136_R0.9740.99
52_P56_D0.9730.99
70_T89_A0.9700.99
252_G255_I0.9590.99
21_G24_A0.9550.99
24_A27_L0.9530.99
178_A181_D0.9500.99
150_D153_L0.9430.99
91_A256_T0.9330.99
109_F257_Y0.9330.99
41_S208_Y0.9260.99
113_R209_E0.9250.99
68_G153_L0.9230.99
34_I271_G0.9220.99
261_V271_G0.9210.99
41_S257_Y0.9170.99
51_R62_L0.9070.99
39_A89_A0.9010.99
47_E51_R0.8930.99
38_A46_I0.8920.99
32_A60_H0.8900.99
113_R249_R0.8880.99
68_G71_T0.8840.99
137_A141_A0.8840.99
20_I23_T0.8750.98
51_R54_F0.8750.98
36_V51_R0.8720.98
67_H71_T0.8670.98
117_C197_V0.8650.98
84_D265_A0.8650.98
23_T26_C0.8560.98
54_F62_L0.8530.98
158_Y162_M0.8510.98
89_A208_Y0.8500.98
194_L207_V0.8470.98
47_E64_P0.8460.98
135_W247_G0.8440.98
92_T96_T0.8430.98
146_I184_T0.8430.98
32_A61_T0.8390.98
149_S156_L0.8360.98
195_A199_T0.8340.98
90_D158_Y0.8330.98
60_H273_A0.8190.98
249_R252_G0.8160.97
113_R252_G0.8130.97
67_H189_S0.8090.97
98_L102_H0.8080.97
45_T191_S0.8020.97
96_T99_F0.7830.97
122_T128_L0.7830.97
86_A93_L0.7820.97
34_I60_H0.7820.97
39_A155_P0.7800.97
19_I22_T0.7780.97
41_S112_N0.7720.96
84_D264_D0.7630.96
270_G273_A0.7620.96
20_I28_T0.7610.96
89_A157_G0.7600.96
150_D186_T0.7580.96
89_A155_P0.7560.96
188_P192_Q0.7560.96
111_S256_T0.7550.96
193_L197_V0.7540.96
85_V271_G0.7540.96
261_V268_T0.7510.96
189_S192_Q0.7500.96
196_D202_H0.7470.96
111_S293_P0.7410.96
82_H264_D0.7380.95
76_I88_S0.7370.95
96_T100_D0.7370.95
94_L97_R0.7340.95
77_S96_T0.7330.95
52_P55_E0.7300.95
180_L184_T0.7300.95
20_I24_A0.7270.95
27_L31_D0.7260.95
209_E246_D0.7190.95
17_G20_I0.7140.95
207_V212_A0.7120.95
49_H52_P0.7090.94
245_D248_T0.7080.94
31_D61_T0.7080.94
127_R141_A0.7070.94
73_L77_S0.7050.94
163_A167_A0.7000.94
206_V247_G0.6990.94
175_D178_A0.6950.94
195_A198_E0.6940.94
277_F280_A0.6880.93
42_L285_V0.6820.93
94_L258_A0.6790.93
49_H284_M0.6750.93
158_Y161_L0.6740.93
114_L163_A0.6720.93
135_W167_A0.6710.93
208_Y257_Y0.6670.92
276_R279_A0.6660.92
116_I206_V0.6660.92
92_T158_Y0.6650.92
190_E208_Y0.6640.92
167_A251_H0.6580.92
160_T206_V0.6580.92
25_G31_D0.6560.92
72_L86_A0.6560.92
144_D203_A0.6530.92
175_D179_D0.6500.91
76_I262_L0.6470.91
147_A185_V0.6440.91
146_I164_F0.6410.91
202_H205_A0.6390.91
190_E207_V0.6390.91
87_I109_F0.6360.91
40_G190_E0.6360.91
28_T32_A0.6320.90
286_R292_V0.6300.90
257_Y260_T0.6280.90
50_I54_F0.6260.90
189_S208_Y0.6230.90
93_L96_T0.6220.90
88_S93_L0.6220.90
195_A201_N0.6190.89
14_G17_G0.6130.89
122_T203_A0.6090.89
16_A19_I0.6090.89
231_P289_G0.6080.88
98_L103_A0.6080.88
275_V279_A0.6070.88
114_L255_I0.6050.88
163_A247_G0.6040.88
115_G246_D0.6030.88
117_C207_V0.6020.88
141_A144_D0.6000.88
128_L137_A0.5990.88
148_V162_M0.5980.88
50_I284_M0.5970.88
72_L76_I0.5950.87
16_A20_I0.5930.87
183_A187_K0.5930.87
130_A246_D0.5930.87
55_E58_T0.5930.87
232_E242_Y0.5920.87
197_V289_G0.5910.87
46_I64_P0.5870.87
256_T259_T0.5840.86
210_N290_L0.5840.86
25_G28_T0.5840.86
34_I268_T0.5830.86
213_L289_G0.5830.86
70_T90_D0.5820.86
231_P242_Y0.5820.86
104_D107_L0.5810.86
30_A33_S0.5790.86
109_F259_T0.5790.86
37_L196_D0.5770.86
247_G251_H0.5760.86
269_A281_N0.5760.86
143_P183_A0.5750.86
121_S243_T0.5740.85
187_K196_D0.5730.85
15_T18_A0.5720.85
196_D201_N0.5690.85
212_A244_T0.5690.85
94_L106_A0.5680.85
112_N208_Y0.5650.85
209_E244_T0.5650.85
113_R246_D0.5600.84
22_T25_G0.5600.84
145_T182_P0.5590.84
119_V204_A0.5560.84
156_L255_I0.5540.83
265_A271_G0.5520.83
41_S89_A0.5510.83
68_G189_S0.5500.83
37_L67_H0.5470.83
153_L156_L0.5460.83
124_L204_A0.5460.83
108_E258_A0.5450.82
192_Q195_A0.5430.82
15_T22_T0.5430.82
17_G23_T0.5410.82
106_A258_A0.5400.82
259_T279_A0.5360.81
124_L128_L0.5330.81
185_V196_D0.5330.81
159_R255_I0.5320.81
14_G18_A0.5320.81
46_I50_I0.5320.81
190_E211_M0.5300.81
148_V206_V0.5260.80
83_P262_L0.5260.80
74_Q77_S0.5240.80
162_M165_T0.5230.80
41_S210_N0.5230.80
68_G93_L0.5220.80
91_A108_E0.5220.80
44_S47_E0.5200.79
263_N266_S0.5160.79
20_I26_C0.5150.79
149_S193_L0.5150.79
149_S196_D0.5150.79
13_L17_G0.5150.79
103_A106_A0.5120.78
148_V156_L0.5120.78
34_I261_V0.5110.78
191_S194_L0.5110.78
193_L196_D0.5110.78
16_A28_T0.5100.78
247_G252_G0.5090.78
117_C242_Y0.5070.78
58_T273_A0.5060.78
119_V124_L0.5050.77
88_S155_P0.5040.77
13_L20_I0.5020.77
116_I247_G0.5020.77
156_L190_E0.5010.77
25_G30_A0.5010.77
150_D188_P0.5000.77
128_L245_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k6vA 1 0.8867 100 0.509 Contact Map
3r26A 1 0.7282 100 0.518 Contact Map
4rxlA 1 0.7217 100 0.53 Contact Map
3cfzA 1 0.8382 100 0.547 Contact Map
3cfxA 1 0.8382 100 0.558 Contact Map
3cijA 1 0.835 100 0.559 Contact Map
3cg1A 1 0.8382 100 0.571 Contact Map
4kd5C 3 0.7217 100 0.602 Contact Map
1sbpA 1 0.8058 100 0.613 Contact Map
4jb7A 2 0.7087 100 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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