GREMLIN Database
GCSPB - Probable glycine dehydrogenase (decarboxylating) subunit 2
UniProt: Q9HPK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (393)
Sequences: 5229 (2708)
Seq/√Len: 136.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_V238_G3.5131.00
231_E235_D3.3691.00
255_R258_D3.2461.00
369_P380_S3.0291.00
170_H218_T3.0051.00
128_D289_T3.0001.00
230_A240_L2.9741.00
90_A336_A2.9521.00
347_A351_A2.8721.00
162_E183_D2.8341.00
363_Q430_A2.7991.00
367_E434_N2.7541.00
204_L232_M2.7281.00
245_A285_P2.7201.00
127_M264_M2.7191.00
360_L417_P2.6181.00
199_A203_A2.5511.00
290_D293_A2.5411.00
112_A116_D2.5181.00
248_N353_A2.4131.00
362_D365_D2.3921.00
254_A258_D2.3731.00
163_V210_A2.2901.00
174_F186_E2.2861.00
148_A263_I2.2691.00
227_E231_E2.2321.00
162_E185_I2.2201.00
396_Y435_A2.1261.00
227_E254_A2.1221.00
55_A85_R2.1211.00
251_L346_L2.0521.00
164_I187_L2.0511.00
167_D188_P2.0391.00
162_E205_G1.9811.00
230_A259_M1.9791.00
130_V287_G1.9551.00
169_A174_F1.9341.00
49_L57_H1.9281.00
145_I212_M1.9261.00
381_A389_V1.9141.00
125_G266_F1.8941.00
246_N375_H1.8741.00
161_N183_D1.8491.00
50_E53_E1.8361.00
360_L426_L1.8191.00
361_A370_L1.8141.00
74_P78_C1.8061.00
381_A386_A1.8031.00
188_P199_A1.7981.00
162_E207_N1.7841.00
148_A241_Y1.7831.00
84_P87_T1.7611.00
242_Y261_F1.7591.00
268_V285_P1.7451.00
301_V309_Y1.7411.00
360_L377_F1.7381.00
66_Y71_G1.7241.00
82_Y333_K1.7171.00
400_P429_L1.6751.00
228_P231_E1.6731.00
398_V432_A1.6641.00
211_L233_V1.6511.00
360_L430_A1.6481.00
53_E422_S1.6461.00
242_Y259_M1.6391.00
129_A293_A1.6381.00
115_H303_Q1.6311.00
359_Y423_K1.6301.00
423_K427_D1.6231.00
352_K356_N1.6151.00
163_V212_M1.6121.00
113_V332_V1.6071.00
201_E228_P1.5991.00
151_Y292_L1.5961.00
78_C416_E1.5931.00
98_V107_L1.5861.00
231_E234_H1.5831.00
75_L78_C1.5611.00
198_D201_E1.5611.00
366_Y434_N1.5461.00
222_F253_R1.5451.00
201_E232_M1.5331.00
378_V412_A1.5331.00
241_Y265_H1.5321.00
204_L208_T1.5261.00
239_L291_E1.5081.00
86_F340_R1.5071.00
356_N426_L1.4971.00
128_D290_D1.4911.00
213_L226_I1.4841.00
120_Y339_D1.4841.00
380_S411_E1.4751.00
167_D186_E1.4671.00
401_P414_M1.4541.00
361_A373_F1.4451.00
119_D122_G1.4321.00
357_A377_F1.4271.00
390_A402_T1.4191.00
69_D397_G1.4181.00
113_V335_F1.4171.00
37_D40_T1.4131.00
79_T420_T1.4061.00
32_D40_T1.3991.00
363_Q431_D1.3961.00
168_A219_L1.3951.00
190_G194_R1.3891.00
328_W332_V1.3611.00
255_R259_M1.3611.00
364_L433_F1.3511.00
91_A333_K1.3501.00
227_E259_M1.3471.00
378_V414_M1.3361.00
70_S425_T1.3351.00
122_G130_V1.3191.00
404_K412_A1.3071.00
311_L314_P1.3021.00
341_L349_A1.2971.00
37_D42_D1.2921.00
288_V292_L1.2881.00
212_M244_G1.2811.00
363_Q427_D1.2781.00
116_D335_F1.2761.00
363_Q434_N1.2721.00
141_E212_M1.2691.00
225_D228_P1.2631.00
122_G128_D1.2581.00
150_A295_F1.2541.00
164_I203_A1.2531.00
173_N244_G1.2491.00
274_T330_V1.2341.00
370_L379_A1.2331.00
114_M132_L1.2291.00
358_N373_F1.2271.00
357_A417_P1.2251.00
205_G236_A1.2221.00
161_N207_N1.2201.00
102_R107_L1.2161.00
145_I163_V1.2161.00
385_D388_D1.2151.00
213_L240_L1.2141.00
72_P75_L1.2131.00
57_H61_L1.2111.00
36_P41_R1.2101.00
110_T328_W1.2081.00
162_E208_T1.2001.00
354_V358_N1.1981.00
148_A210_A1.1961.00
117_L331_L1.1921.00
391_K395_D1.1911.00
74_P80_M1.1901.00
199_A202_A1.1840.99
108_Q111_L1.1780.99
233_V240_L1.1780.99
430_A434_N1.1680.99
79_T418_T1.1650.99
166_P195_V1.1560.99
72_P78_C1.1480.99
368_I379_A1.1410.99
217_N224_R1.1400.99
169_A214_T1.1380.99
392_R396_Y1.1380.99
265_H286_V1.1350.99
273_A341_L1.1340.99
417_P421_E1.1320.99
286_V296_L1.1300.99
390_A394_L1.1260.99
87_T273_A1.1230.99
336_A340_R1.1180.99
74_P79_T1.1130.99
359_Y427_D1.1080.99
215_N253_R1.1010.99
166_P189_S1.0970.99
344_S348_D1.0930.99
206_E236_A1.0910.99
59_V62_S1.0910.99
392_R395_D1.0770.99
72_P425_T1.0750.99
204_L236_A1.0730.99
78_C170_H1.0720.99
119_D123_R1.0620.99
78_C418_T1.0620.99
294_G316_R1.0610.99
168_A217_N1.0610.99
387_A402_T1.0560.99
41_R44_V1.0540.99
144_G263_I1.0520.99
421_E425_T1.0510.99
66_Y397_G1.0470.99
159_H207_N1.0440.99
215_N259_M1.0400.99
247_L266_F1.0390.99
230_A234_H1.0380.99
398_V428_D1.0370.99
335_F339_D1.0340.99
126_G255_R1.0330.99
40_T43_T1.0310.99
96_A329_P1.0240.99
164_I185_I1.0220.99
36_P39_L1.0100.98
234_H238_G1.0060.98
246_N271_T1.0050.98
368_I437_A1.0050.98
71_G74_P1.0020.98
115_H118_Q0.9950.98
113_V336_A0.9940.98
141_E173_N0.9930.98
254_A259_M0.9930.98
118_Q129_A0.9920.98
169_A212_M0.9920.98
252_G354_V0.9920.98
356_N423_K0.9910.98
357_A373_F0.9910.98
201_E235_D0.9900.98
77_S282_G0.9890.98
98_V110_T0.9860.98
148_A239_L0.9830.98
247_L268_V0.9800.98
79_T276_H0.9790.98
403_T414_M0.9710.98
348_D351_A0.9660.98
121_L287_G0.9650.98
75_L79_T0.9620.98
35_L41_R0.9600.98
128_D288_V0.9600.98
234_H240_L0.9570.98
415_T429_L0.9540.98
210_A241_Y0.9460.98
165_V169_A0.9430.97
396_Y428_D0.9430.97
59_V63_Q0.9420.97
198_D202_A0.9390.97
147_I318_I0.9360.97
213_L230_A0.9350.97
135_P322_H0.9310.97
138_A176_S0.9290.97
242_Y264_M0.9280.97
396_Y432_A0.9260.97
160_R237_G0.9260.97
150_A153_E0.9200.97
230_A242_Y0.9110.97
379_A415_T0.9070.97
226_I259_M0.9040.97
361_A365_D0.9030.97
283_A331_L0.8980.97
153_E158_G0.8950.97
217_N221_L0.8940.97
63_Q70_S0.8940.97
57_H60_R0.8940.97
353_A375_H0.8940.97
386_A403_T0.8930.97
399_H402_T0.8900.96
120_Y338_I0.8830.96
116_D120_Y0.8820.96
72_P398_V0.8820.96
390_A413_L0.8810.96
368_I433_F0.8790.96
380_S412_A0.8780.96
80_M276_H0.8760.96
214_T244_G0.8740.96
81_K420_T0.8710.96
145_I177_A0.8710.96
386_A390_A0.8690.96
187_L203_A0.8690.96
35_L39_L0.8680.96
330_V333_K0.8630.96
428_D432_A0.8620.96
364_L368_I0.8540.96
298_D317_S0.8530.95
431_D434_N0.8520.95
348_D352_K0.8520.95
114_M283_A0.8510.95
128_D293_A0.8500.95
215_N249_A0.8500.95
147_I286_V0.8480.95
73_Y78_C0.8470.95
128_D291_E0.8460.95
205_G208_T0.8420.95
283_A334_A0.8400.95
86_F336_A0.8400.95
36_P44_V0.8360.95
131_T143_T0.8350.95
40_T44_V0.8290.95
354_V373_F0.8260.95
131_T286_V0.8260.95
116_D339_D0.8240.95
298_D313_T0.8230.95
66_Y69_D0.8220.94
211_L229_I0.8210.94
337_Y349_A0.8170.94
245_A249_A0.8160.94
429_L433_F0.8160.94
393_M400_P0.8150.94
276_H282_G0.8130.94
148_A163_V0.8100.94
242_Y245_A0.8100.94
197_L225_D0.8080.94
147_I288_V0.8070.94
268_V283_A0.8060.94
53_E424_R0.8040.94
253_R351_A0.8040.94
215_N222_F0.8030.94
36_P47_P0.8020.94
384_Q392_R0.8000.94
221_L371_G0.7970.94
364_L379_A0.7970.94
164_I208_T0.7970.94
295_F316_R0.7930.93
365_D370_L0.7920.93
52_P81_K0.7910.93
344_S351_A0.7910.93
114_M325_Q0.7910.93
70_S428_D0.7900.93
160_R209_A0.7900.93
273_A330_V0.7880.93
72_P421_E0.7870.93
245_A268_V0.7860.93
69_D394_L0.7840.93
247_L251_L0.7840.93
122_G127_M0.7810.93
165_V174_F0.7800.93
385_D411_E0.7800.93
77_S276_H0.7790.93
356_N417_P0.7790.93
127_M257_G0.7780.93
130_V286_V0.7750.93
88_E333_K0.7750.93
149_E209_A0.7750.93
127_M261_F0.7730.92
74_P77_S0.7730.92
117_L268_V0.7670.92
302_R311_L0.7670.92
398_V425_T0.7660.92
427_D430_A0.7650.92
35_L40_T0.7640.92
387_A391_K0.7620.92
384_Q411_E0.7620.92
388_D391_K0.7620.92
147_I151_Y0.7580.92
129_A300_H0.7570.92
107_L111_L0.7560.92
300_H320_K0.7550.92
242_Y255_R0.7510.91
72_P79_T0.7500.91
289_T292_L0.7470.91
382_G386_A0.7460.91
251_L349_A0.7440.91
167_D189_S0.7430.91
36_P45_E0.7430.91
72_P80_M0.7430.91
104_E325_Q0.7420.91
104_E302_R0.7390.91
149_E161_N0.7390.91
396_Y431_D0.7360.91
232_M236_A0.7350.90
124_I346_L0.7340.90
54_L58_Y0.7340.90
311_L315_P0.7330.90
62_S69_D0.7330.90
49_L54_L0.7320.90
239_L292_L0.7320.90
168_A189_S0.7280.90
146_L182_Y0.7280.90
232_M235_D0.7240.90
75_L80_M0.7230.90
149_E182_Y0.7230.90
234_H239_L0.7210.90
400_P414_M0.7180.89
337_Y341_L0.7180.89
398_V429_L0.7150.89
101_D299_P0.7150.89
185_I203_A0.7130.89
349_A353_A0.7130.89
104_E111_L0.7130.89
357_A416_E0.7100.89
117_L283_A0.7100.89
373_F377_F0.7090.89
427_D431_D0.7080.89
338_I346_L0.7070.89
182_Y210_A0.7070.89
151_Y295_F0.7070.89
360_L364_L0.7060.89
35_L44_V0.7040.88
169_A186_E0.7030.88
173_N214_T0.7020.88
420_T425_T0.7010.88
131_T296_L0.6990.88
75_L218_T0.6980.88
124_I338_I0.6960.88
71_G276_H0.6960.88
393_M398_V0.6950.88
422_S425_T0.6950.88
268_V272_F0.6940.88
381_A385_D0.6920.88
385_D389_V0.6910.88
60_R63_Q0.6900.87
387_A403_T0.6890.87
163_V209_A0.6880.87
79_T421_E0.6880.87
123_R343_D0.6860.87
368_I389_V0.6860.87
379_A433_F0.6850.87
168_A221_L0.6820.87
145_I176_S0.6800.87
123_R255_R0.6800.87
274_T333_K0.6800.87
75_L170_H0.6790.87
355_L359_Y0.6790.87
303_Q306_G0.6790.87
384_Q388_D0.6770.86
288_V296_L0.6750.86
266_F285_P0.6740.86
121_L268_V0.6730.86
75_L414_M0.6720.86
41_R45_E0.6710.86
127_M242_Y0.6710.86
111_L115_H0.6700.86
183_D207_N0.6690.86
194_R371_G0.6680.86
72_P417_P0.6680.86
424_R427_D0.6680.86
77_S139_A0.6670.86
118_Q300_H0.6660.86
401_P404_K0.6650.86
424_R428_D0.6650.86
107_L325_Q0.6650.86
360_L429_L0.6640.85
42_D45_E0.6630.85
197_L232_M0.6620.85
392_R436_V0.6600.85
81_K84_P0.6580.85
377_F415_T0.6570.85
298_D304_S0.6560.85
168_A195_V0.6550.85
88_E92_A0.6550.85
228_P232_M0.6530.84
389_V433_F0.6520.84
336_A339_D0.6470.84
196_D199_A0.6450.84
158_G209_A0.6430.84
267_N285_P0.6430.84
152_H160_R0.6410.83
82_Y87_T0.6410.83
312_Y317_S0.6380.83
381_A384_Q0.6320.83
98_V102_R0.6300.82
108_Q115_H0.6290.82
298_D311_L0.6270.82
146_L180_G0.6270.82
104_E118_Q0.6270.82
382_G411_E0.6260.82
143_T321_V0.6260.82
75_L401_P0.6250.82
351_A355_L0.6250.82
299_P302_R0.6250.82
356_N359_Y0.6240.82
226_I230_A0.6200.81
41_R47_P0.6160.81
46_L49_L0.6160.81
36_P43_T0.6150.81
189_S219_L0.6150.81
343_D346_L0.6150.81
298_D314_P0.6140.81
127_M287_G0.6120.80
242_Y250_L0.6110.80
194_R225_D0.6100.80
41_R46_L0.6080.80
298_D316_R0.6070.80
252_G351_A0.6060.80
299_P320_K0.6060.80
56_R81_K0.6020.79
252_G350_S0.6020.79
204_L233_V0.6000.79
98_V302_R0.6000.79
394_L400_P0.5980.79
267_N284_G0.5960.79
151_Y288_V0.5950.79
71_G79_T0.5950.79
35_L42_D0.5930.78
30_S34_S0.5920.78
222_F354_V0.5910.78
141_E244_G0.5910.78
134_P286_V0.5890.78
152_H158_G0.5890.78
310_E313_T0.5870.78
150_A318_I0.5870.78
30_S33_P0.5860.78
409_V412_A0.5850.77
415_T433_F0.5850.77
165_V212_M0.5840.77
218_T401_P0.5830.77
247_L267_N0.5820.77
83_N275_P0.5820.77
265_H332_V0.5810.77
36_P42_D0.5790.77
210_A238_G0.5790.77
305_A308_D0.5770.76
36_P40_T0.5750.76
384_Q389_V0.5740.76
194_R221_L0.5740.76
195_V229_I0.5730.76
300_H309_Y0.5720.76
151_Y289_T0.5710.76
298_D315_P0.5700.76
300_H314_P0.5700.76
121_L131_T0.5690.75
118_Q132_L0.5680.75
302_R325_Q0.5660.75
147_I263_I0.5650.75
148_A152_H0.5640.75
113_V328_W0.5640.75
343_D347_A0.5640.75
298_D312_Y0.5620.75
251_L350_S0.5620.75
298_D320_K0.5610.74
212_M241_Y0.5610.74
245_A264_M0.5610.74
248_N337_Y0.5610.74
152_H239_L0.5590.74
404_K411_E0.5590.74
144_G241_Y0.5580.74
421_E426_L0.5560.74
310_E314_P0.5560.74
35_L45_E0.5540.74
173_N212_M0.5540.74
197_L201_E0.5520.73
40_T45_E0.5490.73
392_R435_A0.5480.73
272_F353_A0.5470.73
111_L306_G0.5470.73
240_L261_F0.5460.72
201_E204_L0.5460.72
386_A389_V0.5450.72
417_P426_L0.5430.72
400_P404_K0.5430.72
87_T91_A0.5430.72
219_L378_V0.5410.72
309_Y314_P0.5410.72
250_L256_P0.5410.72
193_G221_L0.5380.71
377_F417_P0.5380.71
149_E153_E0.5370.71
134_P284_G0.5370.71
73_Y79_T0.5360.71
361_A377_F0.5360.71
248_N251_L0.5350.71
104_E323_G0.5340.71
353_A357_A0.5330.71
104_E108_Q0.5330.71
104_E304_S0.5320.71
298_D310_E0.5310.70
358_N361_A0.5300.70
301_V306_G0.5290.70
32_D37_D0.5280.70
120_Y335_F0.5270.70
115_H119_D0.5260.70
274_T277_G0.5250.70
98_V105_T0.5250.70
146_L150_A0.5250.70
114_M331_L0.5240.69
44_V47_P0.5240.69
386_A413_L0.5230.69
360_L415_T0.5230.69
39_L47_P0.5230.69
314_P317_S0.5220.69
151_Y239_L0.5220.69
101_D302_R0.5200.69
118_Q325_Q0.5190.69
263_I295_F0.5170.68
217_N378_V0.5170.68
248_N272_F0.5160.68
113_V331_L0.5160.68
319_G322_H0.5150.68
274_T334_A0.5150.68
108_Q112_A0.5140.68
363_Q366_Y0.5130.68
390_A400_P0.5100.67
250_L259_M0.5080.67
150_A319_G0.5050.67
111_L301_V0.5030.66
302_R316_R0.5030.66
72_P428_D0.5030.66
166_P217_N0.5020.66
37_D41_R0.5020.66
104_E107_L0.5020.66
90_A332_V0.5020.66
208_T232_M0.5020.66
126_G257_G0.5010.66
90_A93_L0.5010.66
73_Y399_H0.5010.66
167_D219_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9429 100 0.529 Contact Map
1wyuB 2 0.9789 100 0.613 Contact Map
1wyuA 2 0.871 100 0.63 Contact Map
3mc6A 2 0.8224 100 0.761 Contact Map
3wcnA 2 0.8393 100 0.772 Contact Map
2z67A 4 0.8097 100 0.797 Contact Map
3hl2A 3 0.8034 100 0.798 Contact Map
3bc8A 3 0.7907 100 0.806 Contact Map
4obuE 2 0.8732 100 0.814 Contact Map
4w8iA 2 0.7252 100 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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