GREMLIN Database
GCSPA - Probable glycine dehydrogenase (decarboxylating) subunit 1
UniProt: Q9HPJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (398)
Sequences: 5165 (2755)
Seq/√Len: 138.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_A234_A3.5981.00
227_D231_S3.4581.00
250_R253_D3.3711.00
370_V437_R3.2571.00
125_G282_R3.1381.00
350_V354_E3.0491.00
163_R214_T3.0141.00
374_T390_R2.9361.00
86_V339_I2.9341.00
366_R433_V2.9051.00
124_L259_V2.8191.00
151_A288_Q2.7701.00
240_S278_V2.7601.00
200_M228_L2.7051.00
155_R180_V2.7001.00
195_A199_A2.6921.00
363_L421_V2.6551.00
283_K286_L2.6391.00
365_A368_D2.6051.00
109_Q113_E2.5891.00
243_V356_M2.4541.00
249_Q253_D2.4041.00
145_A258_V2.3381.00
156_V206_M2.3261.00
223_C227_D2.2941.00
226_G236_F2.1691.00
223_C249_Q2.1581.00
246_S349_L2.1051.00
226_G254_V2.0481.00
127_A280_A2.0471.00
47_K55_G2.0291.00
158_V170_L2.0271.00
391_T398_V1.9781.00
122_T261_G1.9571.00
241_D385_R1.9321.00
142_A208_Y1.9081.00
48_S51_A1.9061.00
155_R201_D1.9061.00
366_R369_D1.8811.00
76_E424_A1.8801.00
155_R203_D1.8441.00
263_A278_V1.8421.00
363_L429_T1.8231.00
391_T395_A1.8041.00
145_A237_C1.7881.00
363_L433_V1.7801.00
126_V286_L1.7751.00
51_A426_E1.7741.00
53_L82_L1.7711.00
363_L387_F1.7701.00
207_V229_A1.7421.00
224_A227_D1.7401.00
79_V336_R1.7311.00
74_H275_G1.7261.00
409_V432_F1.7091.00
194_D197_E1.7081.00
112_F306_F1.7061.00
67_T428_A1.6891.00
75_Y420_C1.6751.00
110_V335_L1.6681.00
148_V285_F1.6671.00
227_D230_D1.6581.00
209_A222_L1.6521.00
355_R359_L1.6511.00
151_A315_Q1.6421.00
156_V208_Y1.6391.00
407_F435_A1.6311.00
197_E224_A1.6301.00
125_G283_K1.6261.00
117_L342_A1.6061.00
410_H418_Q1.6011.00
186_T190_N1.5921.00
95_S104_T1.5811.00
413_D416_T1.5741.00
359_L429_T1.5661.00
218_V248_L1.5531.00
64_D68_E1.5471.00
155_R182_E1.5371.00
112_F296_A1.5291.00
364_A383_H1.5221.00
388_Q416_T1.5201.00
364_A375_A1.5191.00
200_M204_V1.5011.00
399_A411_A1.4901.00
99_Y104_T1.4881.00
81_S84_D1.4691.00
197_E228_L1.4671.00
74_H270_T1.4671.00
390_R415_H1.4581.00
28_E31_D1.4571.00
170_L181_V1.4531.00
110_V338_A1.4511.00
161_F215_C1.4401.00
223_C254_V1.4381.00
360_P387_F1.4361.00
250_R254_V1.4201.00
116_S119_V1.4181.00
366_R434_A1.4171.00
213_T219_E1.4121.00
154_N178_D1.4071.00
237_C256_A1.4011.00
154_N203_D1.3901.00
66_L406_G1.3861.00
388_Q418_Q1.3811.00
367_L436_V1.3741.00
209_A236_F1.3701.00
87_S336_R1.3661.00
331_A335_L1.3651.00
237_C260_V1.3611.00
113_E338_A1.3611.00
160_G183_R1.3561.00
208_Y239_G1.3511.00
111_L129_C1.3451.00
38_F42_F1.3431.00
138_L208_Y1.3411.00
310_L313_R1.3351.00
344_L352_L1.3311.00
119_V125_G1.3181.00
119_V127_A1.3121.00
82_L343_W1.3101.00
366_R430_D1.3101.00
159_P191_V1.3071.00
69_F428_A1.3031.00
281_T285_F1.2971.00
55_G59_R1.2941.00
268_M333_V1.2931.00
157_L199_A1.2911.00
409_V413_D1.2831.00
366_R437_R1.2801.00
361_R383_H1.2711.00
107_F331_A1.2621.00
360_P421_V1.2611.00
114_Y334_A1.2591.00
195_A198_A1.2541.00
166_H239_G1.2481.00
357_V361_R1.2431.00
394_P397_A1.2431.00
147_R288_Q1.2401.00
105_Q108_L1.2381.00
162_V210_E1.2381.00
145_A206_M1.2371.00
401_A405_E1.2351.00
376_P390_R1.2311.00
142_A156_V1.2191.00
155_R204_V1.2151.00
76_E422_T1.2081.00
400_S404_A1.2011.00
396_P411_A1.1931.00
421_V425_N1.1921.00
267_G344_L1.1851.00
260_V279_F1.1831.00
69_F407_F1.1650.99
200_M232_H1.1640.99
347_D351_D1.1580.99
376_P416_T1.1570.99
362_D430_D1.1560.99
57_R60_L1.1560.99
34_P37_S1.1540.99
339_I343_W1.1450.99
399_A403_E1.1450.99
242_P263_A1.1430.99
64_D406_G1.1410.99
279_F289_V1.1400.99
83_V339_I1.1380.99
78_Y424_A1.1330.99
76_E425_N1.1310.99
401_A404_A1.1290.99
375_A389_A1.1160.99
152_D203_D1.1140.99
138_L170_L1.1130.99
211_N254_V1.1050.99
99_Y103_I1.1050.99
360_P383_H1.1030.99
407_F431_A1.0990.99
229_A236_F1.0980.99
338_A342_A1.0970.99
75_Y163_R1.0970.99
211_N248_L1.0940.99
161_F213_T1.0930.99
242_P261_G1.0820.99
230_D234_A1.0780.99
123_G250_R1.0780.99
145_A235_L1.0760.99
373_V389_A1.0750.99
226_G235_L1.0670.99
141_A258_V1.0670.99
202_A232_H1.0660.99
116_S120_E1.0610.99
34_P39_D1.0610.99
83_V343_W1.0560.99
75_Y422_T1.0500.99
183_R195_A1.0500.99
241_D265_V1.0470.99
425_N428_A1.0450.99
157_L182_E1.0420.99
433_V437_R1.0420.99
395_A412_V1.0350.99
112_F115_Q1.0340.99
135_A169_V1.0340.99
138_L166_H1.0330.99
419_V432_F1.0300.99
37_S40_G1.0270.99
351_D354_E1.0260.99
67_T431_A1.0240.99
220_E223_C1.0080.98
238_L254_V1.0080.98
118_L280_A1.0020.98
249_Q254_V1.0020.98
66_L403_E1.0010.98
115_Q126_V1.0010.98
110_V339_I0.9980.98
170_L208_Y0.9960.98
412_V418_Q0.9960.98
194_D198_A0.9860.98
405_E431_A0.9810.98
226_G230_D0.9790.98
93_I332_W0.9730.98
125_G281_T0.9670.98
197_E231_S0.9670.98
57_R61_S0.9650.98
356_M385_R0.9640.98
410_H413_D0.9630.98
276_L334_A0.9610.98
222_L254_V0.9600.98
187_D192_D0.9580.98
113_E117_L0.9580.98
83_V267_G0.9570.98
72_R163_R0.9570.98
55_G58_R0.9550.98
162_V208_Y0.9540.98
147_R150_A0.9540.98
226_G238_L0.9540.98
209_A226_G0.9470.98
390_R416_T0.9430.98
364_A368_D0.9430.98
247_I357_V0.9400.98
213_T217_T0.9390.98
291_G319_K0.9390.98
125_G286_L0.9380.97
158_V162_V0.9290.97
95_S107_F0.9270.97
230_D236_F0.9270.97
389_A419_V0.9240.97
367_L373_V0.9220.97
210_E239_G0.9180.97
132_Y321_R0.9170.97
117_L341_A0.9140.97
37_S42_F0.9130.97
405_E435_A0.9120.97
351_D355_R0.9040.97
431_A435_A0.9000.97
154_N180_V0.8990.97
77_H270_T0.8980.97
333_V336_R0.8930.97
149_R153_G0.8930.97
399_A417_I0.8920.97
144_L279_F0.8910.97
287_R315_Q0.8900.97
407_F428_A0.8880.97
111_L328_T0.8860.96
267_G333_V0.8840.96
395_A399_A0.8840.96
276_L337_A0.8810.96
157_L204_V0.8780.96
201_D204_V0.8780.96
144_L281_T0.8770.96
357_V383_H0.8760.96
101_P108_L0.8740.96
402_L409_V0.8730.96
248_L354_E0.8650.96
432_F436_V0.8650.96
201_D232_H0.8630.96
211_N244_A0.8620.96
104_T108_L0.8610.96
240_S244_A0.8580.96
206_M237_C0.8570.96
211_N218_V0.8570.96
38_F41_E0.8560.96
207_V225_V0.8550.96
76_E270_T0.8550.96
111_L276_L0.8540.96
125_G284_E0.8520.96
128_N279_F0.8510.96
113_E342_A0.8510.96
50_Q78_Y0.8490.95
242_P246_S0.8490.95
153_G205_V0.8480.95
145_A156_V0.8460.95
78_Y81_S0.8460.95
69_F425_N0.8440.95
190_N381_R0.8420.95
146_K205_V0.8410.95
240_S263_A0.8400.95
153_G233_D0.8380.95
124_L252_V0.8330.95
90_S93_I0.8320.95
434_A437_R0.8280.95
149_R205_V0.8280.95
376_P388_Q0.8270.95
33_P36_V0.8230.95
128_N140_E0.8220.95
340_H352_L0.8200.95
396_P412_V0.8190.95
370_V373_V0.8160.94
72_R214_T0.8150.94
119_V124_L0.8130.94
192_D195_A0.8130.94
392_E395_A0.8110.94
84_D336_R0.8100.94
51_A427_H0.8100.94
295_G310_L0.8090.94
360_P420_C0.8070.94
263_A276_L0.8070.94
121_L341_A0.8050.94
217_T381_R0.8000.94
52_A56_V0.7980.94
108_L112_F0.7970.94
26_V30_F0.7970.94
396_P400_S0.7960.94
146_K154_N0.7950.94
292_R327_C0.7950.94
347_D354_E0.7950.94
189_G219_E0.7920.94
367_L389_A0.7900.93
142_A170_L0.7890.93
394_P398_V0.7860.93
126_V293_L0.7850.93
394_P415_H0.7840.93
40_G43_G0.7840.93
341_A349_L0.7830.93
397_A400_S0.7820.93
72_R418_Q0.7810.93
359_L421_V0.7780.93
282_R285_F0.7760.93
144_L148_V0.7760.93
124_L256_A0.7740.93
383_H387_F0.7740.93
370_V433_V0.7700.93
237_C254_V0.7690.92
127_A279_F0.7670.92
340_H344_L0.7670.92
120_E250_R0.7640.92
193_L197_E0.7640.92
193_L228_L0.7640.92
68_E270_T0.7630.92
270_T275_G0.7630.92
121_L349_L0.7610.92
427_H430_D0.7600.92
114_Y263_A0.7520.92
58_R61_S0.7510.92
246_S352_L0.7490.91
228_L232_H0.7490.91
407_F432_F0.7480.91
430_D434_A0.7480.91
408_G411_A0.7450.91
296_A304_R0.7450.91
228_L231_S0.7430.91
161_F217_T0.7420.91
105_Q112_F0.7420.91
162_V183_R0.7400.91
219_E222_L0.7400.91
47_K52_A0.7370.91
405_E434_A0.7360.91
373_V376_P0.7360.91
409_V412_V0.7330.91
61_S67_T0.7330.91
237_C245_M0.7310.90
69_F421_V0.7310.90
118_L263_A0.7300.90
389_A436_V0.7290.90
430_D433_V0.7280.90
291_G312_T0.7260.90
238_L250_R0.7240.90
128_N289_V0.7230.90
352_L356_M0.7210.90
281_T289_V0.7210.90
403_E409_V0.7200.90
261_G278_V0.7180.90
146_K179_V0.7160.90
114_Y276_L0.7160.90
310_L314_E0.7110.89
166_H210_E0.7110.89
148_V288_Q0.7110.89
358_E362_D0.7090.89
391_T394_P0.7080.89
268_M336_R0.7070.89
363_L432_F0.7060.89
120_E346_A0.7060.89
427_H431_A0.7040.89
224_A228_L0.7040.89
263_A266_L0.7020.89
238_L259_V0.7000.88
238_L256_A0.6980.88
373_V436_V0.6980.88
291_G297_S0.6980.88
392_E415_H0.6970.88
171_R183_R0.6960.88
222_L238_L0.6960.88
156_V205_V0.6950.88
220_E224_A0.6930.88
311_Q316_H0.6920.88
98_Q292_R0.6920.88
393_Q415_H0.6910.88
101_P328_T0.6900.88
293_L322_A0.6890.88
74_H136_T0.6890.88
318_R321_R0.6880.88
115_Q293_L0.6880.88
424_A428_A0.6880.88
291_G313_R0.6880.88
174_T179_V0.6860.87
145_A149_R0.6850.87
262_D278_V0.6850.87
375_A380_D0.6840.87
69_F432_F0.6800.87
142_A171_R0.6800.87
354_E358_E0.6790.87
387_F419_V0.6740.87
363_L367_L0.6740.87
171_R175_S0.6720.86
409_V418_Q0.6700.86
146_K150_A0.6670.86
376_P380_D0.6630.86
402_L407_F0.6590.85
142_A174_T0.6580.85
161_F191_V0.6560.85
292_R295_G0.6550.85
291_G310_L0.6540.85
104_T328_T0.6540.85
101_P295_G0.6500.85
398_V436_V0.6480.84
242_P262_D0.6430.84
200_M229_A0.6420.84
143_L179_V0.6410.84
339_I342_A0.6370.83
293_L313_R0.6370.83
366_R370_V0.6360.83
197_E201_D0.6340.83
295_G328_T0.6300.83
247_I354_E0.6300.83
102_E105_Q0.6300.83
260_V335_L0.6290.83
425_N429_T0.6290.83
222_L226_G0.6290.83
346_A349_L0.6280.82
247_I353_A0.6270.82
359_L362_D0.6260.82
131_M279_F0.6230.82
395_A417_I0.6220.82
346_A350_V0.6210.82
124_L280_A0.6200.82
82_L85_S0.6190.82
144_L258_V0.6160.81
104_T319_K0.6130.81
115_Q129_C0.6120.81
110_V334_A0.6110.81
68_E76_E0.6110.81
421_V429_T0.6100.81
246_S353_A0.6070.80
291_G322_A0.6040.80
118_L128_N0.6040.80
72_R410_H0.6030.80
240_S259_V0.6010.80
32_I37_S0.6010.80
79_V84_D0.6000.80
395_A398_V0.5980.79
291_G314_E0.5980.79
204_V228_L0.5970.79
230_D235_L0.5970.79
288_Q315_Q0.5960.79
373_V391_T0.5950.79
408_G413_D0.5950.79
296_A306_F0.5940.79
99_Y102_E0.5940.79
291_G311_Q0.5930.79
67_T407_F0.5920.79
94_T101_P0.5920.79
197_E200_M0.5900.78
262_D277_G0.5890.78
111_L334_A0.5880.78
182_E199_A0.5880.78
148_V282_R0.5870.78
158_V208_Y0.5870.78
399_A409_V0.5860.78
206_M234_A0.5850.78
138_L239_G0.5850.78
102_E297_S0.5850.78
218_V357_V0.5850.78
291_G321_R0.5850.78
131_M277_G0.5840.78
364_A387_F0.5840.78
155_R178_D0.5830.78
368_D375_A0.5830.78
369_D437_R0.5830.78
148_V281_T0.5820.77
243_V246_S0.5800.77
27_D37_S0.5790.77
287_R313_R0.5770.77
356_M360_P0.5760.77
298_E304_R0.5740.77
110_V331_A0.5740.77
190_N217_T0.5720.76
393_Q398_V0.5720.76
156_V237_C0.5710.76
363_L419_V0.5710.76
362_D366_R0.5690.76
397_A401_A0.5680.76
95_S335_L0.5680.76
387_F421_V0.5660.76
209_A225_V0.5630.75
191_V225_V0.5620.75
149_R152_D0.5620.75
166_H208_Y0.5620.75
105_Q109_Q0.5570.74
330_Q333_V0.5560.74
115_Q328_T0.5560.74
287_R314_E0.5550.74
361_R364_A0.5520.74
395_A413_D0.5510.74
214_T410_H0.5500.73
215_C388_Q0.5480.73
95_S331_A0.5480.73
433_V436_V0.5480.73
92_F110_V0.5470.73
306_F310_L0.5440.73
243_V340_H0.5440.73
72_R75_Y0.5420.72
68_E71_G0.5400.72
297_S305_A0.5400.72
143_L177_S0.5380.72
162_V170_L0.5380.72
364_A373_V0.5370.72
104_T295_G0.5340.71
87_S93_I0.5340.71
258_V288_Q0.5340.71
266_L356_M0.5330.71
121_L242_P0.5330.71
248_L350_V0.5320.71
403_E411_A0.5320.71
82_L86_V0.5320.71
149_R233_D0.5320.71
157_L225_V0.5310.71
297_S301_A0.5310.71
159_P213_T0.5310.71
245_M251_P0.5300.71
131_M326_I0.5300.71
243_V266_L0.5300.71
292_R319_K0.5300.71
124_L207_V0.5290.71
421_V424_A0.5290.71
362_D433_V0.5280.70
374_T392_E0.5270.70
245_M254_V0.5270.70
268_M337_A0.5260.70
98_Q323_T0.5250.70
160_G181_V0.5240.70
256_A259_V0.5240.70
258_V279_F0.5230.70
140_E320_E0.5230.70
95_S99_Y0.5230.70
373_V398_V0.5230.70
160_G215_C0.5220.70
215_C413_D0.5220.70
176_G205_V0.5220.70
112_F116_S0.5220.70
98_Q327_C0.5220.70
265_V385_R0.5210.69
124_L237_C0.5210.69
262_D270_T0.5210.69
143_L147_R0.5200.69
108_L294_V0.5200.69
67_T425_N0.5190.69
123_G252_V0.5170.69
365_A369_D0.5170.69
235_L285_F0.5160.69
419_V436_V0.5160.69
213_T388_Q0.5160.69
268_M271_S0.5160.69
72_R164_D0.5150.69
392_E414_D0.5140.68
153_G204_V0.5130.68
412_V417_I0.5130.68
222_L236_F0.5130.68
109_Q295_G0.5120.68
380_D387_F0.5100.68
217_T380_D0.5090.68
374_T415_H0.5060.67
70_L408_G0.5050.67
80_P83_V0.5050.67
193_L225_V0.5040.67
239_G260_V0.5030.67
54_R78_Y0.5030.67
391_T419_V0.5030.67
368_D380_D0.5020.67
187_D190_N0.5020.67
84_D87_S0.5010.66
368_D381_R0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9683 100 0.464 Contact Map
1wyuA 2 0.9683 100 0.593 Contact Map
1wyuB 2 0.9342 100 0.688 Contact Map
3mc6A 2 0.8367 100 0.754 Contact Map
3wcnA 2 0.9002 100 0.783 Contact Map
3hl2A 3 0.8526 100 0.809 Contact Map
2z67A 4 0.8617 100 0.813 Contact Map
3bc8A 3 0.8322 100 0.815 Contact Map
2jisA 2 0.9206 100 0.822 Contact Map
4obuE 2 0.8821 100 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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