GREMLIN Database
GCSH - Probable glycine cleavage system H protein
UniProt: Q9HPJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (119)
Sequences: 3709 (2307)
Seq/√Len: 211.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_D118_D4.1911.00
93_A96_G3.5211.00
75_E104_D3.4941.00
56_L101_V3.1731.00
24_R102_E3.0731.00
78_A102_E2.7781.00
29_E32_Q2.2161.00
23_G105_F2.1711.00
93_A97_D2.0651.00
73_S109_D2.0281.00
22_T102_E2.0101.00
21_A104_D1.9861.00
114_L122_Q1.9351.00
49_A75_E1.9051.00
50_L70_A1.8391.00
116_S120_R1.8191.00
108_D111_E1.7791.00
106_D109_D1.7661.00
86_E89_L1.7571.00
9_L95_F1.7271.00
90_V100_L1.5691.00
72_V105_F1.5691.00
29_E33_D1.5411.00
58_V65_V1.4991.00
82_A86_E1.4931.00
57_G68_L1.4921.00
51_D54_D1.4741.00
45_S48_D1.4571.00
52_Q112_A1.4551.00
51_D73_S1.3991.00
55_E67_D1.3881.00
82_A97_D1.3781.00
13_E122_Q1.3701.00
22_T104_D1.3611.00
47_G75_E1.3541.00
83_L100_L1.3191.00
89_L98_G1.3141.00
32_Q91_N1.2891.00
18_I23_G1.2871.00
56_L68_L1.2541.00
43_L79_V1.2531.00
58_V62_I1.2191.00
30_F34_E1.1981.00
82_A89_L1.1871.00
50_L56_L1.1761.00
25_V101_V1.1381.00
81_D84_T1.1371.00
10_Q110_L1.1341.00
16_E62_I1.1311.00
86_E92_E1.1101.00
42_E58_V1.1071.00
7_D117_D1.1071.00
52_Q109_D1.0851.00
39_V62_I1.0821.00
22_T77_T1.0711.00
118_D121_A1.0611.00
77_T104_D1.0571.00
117_D120_R1.0551.00
74_G103_I1.0431.00
41_V83_L0.9981.00
43_L100_L0.9801.00
18_I72_V0.9621.00
48_D54_D0.9611.00
23_G72_V0.9611.00
12_L18_I0.9501.00
10_Q111_E0.9481.00
5_V120_R0.9430.99
46_V79_V0.9380.99
72_V103_I0.9210.99
78_A81_D0.9100.99
12_L16_E0.9000.99
89_L92_E0.8960.99
7_D120_R0.8920.99
41_V59_V0.8840.99
27_I59_V0.8720.99
89_L97_D0.8690.99
14_S69_Y0.8490.99
58_V67_D0.8450.99
68_L101_V0.8440.99
95_F116_S0.8360.99
17_W26_G0.8360.99
82_A85_N0.8330.99
5_V116_S0.8280.99
12_L28_S0.8220.99
107_S110_L0.8070.98
14_S64_A0.8070.98
70_A103_I0.8000.98
39_V65_V0.7900.98
106_D110_L0.7860.98
46_V78_A0.7850.98
88_E92_E0.7680.98
37_D88_E0.7650.98
35_L66_S0.7600.98
81_D85_N0.7600.98
11_Y95_F0.7560.98
10_Q115_D0.7550.98
6_P116_S0.7500.97
25_V103_I0.7500.97
15_H36_G0.7490.97
29_E95_F0.7470.97
23_G110_L0.7460.97
83_L89_L0.7460.97
32_Q95_F0.7440.97
5_V95_F0.7230.97
38_V59_V0.7190.97
22_T78_A0.7090.96
107_S111_E0.6950.96
5_V123_I0.6900.96
34_E61_S0.6890.96
68_L100_L0.6680.95
50_L76_V0.6670.95
21_A105_F0.6640.95
50_L73_S0.6640.95
44_P76_V0.6580.95
63_K66_S0.6560.94
114_L118_D0.6540.94
31_A66_S0.6530.94
19_D22_T0.6520.94
44_P79_V0.6420.94
45_S85_N0.6390.94
6_P28_S0.6350.93
35_L64_A0.6340.93
13_E118_D0.6280.93
16_E39_V0.6240.93
44_P61_S0.6180.93
92_E97_D0.6180.93
23_G109_D0.6130.92
46_V81_D0.6110.92
13_E112_A0.6110.92
14_S53_H0.6080.92
8_D116_S0.6060.92
39_V60_E0.6020.92
28_S94_P0.6010.91
11_Y28_S0.5990.91
29_E91_N0.5960.91
106_D111_E0.5950.91
38_V57_G0.5950.91
41_V87_P0.5920.91
61_S64_A0.5900.91
93_A98_G0.5880.91
12_L113_T0.5860.90
70_A76_V0.5840.90
117_D121_A0.5840.90
16_E69_Y0.5830.90
60_E63_K0.5800.90
25_V71_P0.5790.90
34_E66_S0.5650.89
47_G77_T0.5640.89
48_D51_D0.5610.88
105_F110_L0.5580.88
21_A24_R0.5560.88
76_V101_V0.5530.88
38_V58_V0.5510.88
22_T105_F0.5500.87
6_P11_Y0.5470.87
5_V29_E0.5450.87
16_E31_A0.5440.87
16_E64_A0.5430.87
32_Q64_A0.5410.87
38_V91_N0.5390.86
27_I31_A0.5380.86
61_S65_V0.5370.86
19_D23_G0.5330.86
36_G66_S0.5320.86
46_V75_E0.5310.86
40_F60_E0.5220.85
55_E64_A0.5170.84
37_D62_I0.5140.84
11_Y116_S0.5140.84
9_L116_S0.5120.84
55_E84_T0.5120.84
57_G101_V0.5080.83
10_Q37_D0.5080.83
40_F63_K0.5070.83
38_V56_L0.5020.82
31_A63_K0.5010.82
48_D85_N0.5010.82
19_D102_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.9919 100 0.163 Contact Map
3tzuA 2 0.9516 100 0.216 Contact Map
3mxuA 3 0.9919 100 0.223 Contact Map
1hpcA 2 0.9839 100 0.259 Contact Map
3a7lA 1 0.9839 100 0.265 Contact Map
3wdnA 1 0.9516 100 0.29 Contact Map
1onlA 1 0.9758 100 0.305 Contact Map
1zkoA 2 1 100 0.321 Contact Map
5a35A 1 0.879 100 0.361 Contact Map
1gjxA 1 0.6532 96.3 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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