GCST - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

GCST - Probable aminomethyltransferase

UniProt:	Q9HPJ7	Sequences: MGLRTSPLHGRHEDRGASFTEFGGWNMPVDFDGIQAEHAAVREAAGIFDVSHMGEIEVSGPDAERLMQRLTTNDVSRLDPGDAQYAAITDDDGIMIDDTVVYRTPADWPGAFLFVPNAGHDAAAFDRWTDHRDAHDLDASVDNVTTDYGMVAVQGPDAPDLVAARAGDGVHDLGRFEAATVGVAGVECLVANTGYTGEAGVEIVFPADGAGAVWDAIANDCQPCGLGARDTLRMEHGFLLSGQDFDPEENPRTPFEAGIGFAVAPESGFVGRDALADTDSPEQQFVGLTLDERGVPRHGYAVTTPAGDEIGTVTSGTMSPTLGEPIGLGYVDSAHAADGTTVAVRIRGTDKQATITTPPFLDQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (349)
Sequences:	6723 (4386)
Seq/√Len:	234.8

ECOLI - GCST YGFZ
BACSU - GCST
HALSA - GCST Q9HM98
SULSO - Q97ZI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_R	215_D	3.761	1.00
157_D	160_D	3.748	1.00
301_A	309_E	3.285	1.00
289_T	324_E	3.226	1.00
45_A	161_L	3.096	1.00
57_E	111_A	2.855	1.00
343_A	350_D	2.830	1.00
253_T	278_T	2.681	1.00
9_H	13_E	2.608	1.00
13_E	19_F	2.574	1.00
288_L	327_G	2.547	1.00
44_A	157_D	2.544	1.00
302_V	329_G	2.517	1.00
149_G	210_A	2.491	1.00
39_A	43_E	2.452	1.00
341_T	352_Q	2.429	1.00
62_D	65_R	2.349	1.00
46_G	224_C	2.261	1.00
14_D	215_D	2.233	1.00
291_D	354_T	2.225	1.00
41_V	46_G	2.169	1.00
243_Q	298_H	2.124	1.00
289_T	354_T	2.106	1.00
319_S	322_L	2.101	1.00
174_G	177_E	2.095	1.00
299_G	312_T	2.094	1.00
59_S	111_A	2.088	1.00
345_R	348_G	2.083	1.00
80_P	103_R	2.072	1.00
304_T	308_D	2.067	1.00
345_R	350_D	2.044	1.00
303_T	350_D	2.044	1.00
68_Q	74_D	2.010	1.00
70_L	128_W	1.963	1.00
342_V	353_A	1.955	1.00
341_T	354_T	1.934	1.00
343_A	352_Q	1.928	1.00
10_G	13_E	1.926	1.00
182_G	187_E	1.924	1.00
10_G	14_D	1.917	1.00
310_I	335_H	1.850	1.00
272_R	276_A	1.848	1.00
169_G	172_D	1.823	1.00
5_T	26_N	1.807	1.00
40_A	44_A	1.806	1.00
11_R	15_R	1.797	1.00
206_P	209_G	1.783	1.00
56_I	125_F	1.728	1.00
308_D	332_D	1.713	1.00
209_G	212_A	1.707	1.00
10_G	211_G	1.706	1.00
40_A	222_Q	1.702	1.00
11_R	14_D	1.678	1.00
82_D	177_E	1.670	1.00
62_D	138_D	1.669	1.00
39_A	321_T	1.660	1.00
105_P	111_A	1.656	1.00
64_E	112_F	1.647	1.00
313_V	327_G	1.623	1.00
273_D	276_A	1.621	1.00
12_H	31_F	1.610	1.00
205_F	213_V	1.574	1.00
5_T	9_H	1.566	1.00
161_L	221_C	1.565	1.00
59_S	140_S	1.563	1.00
61_P	138_D	1.550	1.00
127_R	131_H	1.547	1.00
303_T	309_E	1.538	1.00
173_L	177_E	1.534	1.00
57_E	142_D	1.531	1.00
180_T	187_E	1.531	1.00
59_S	142_D	1.523	1.00
301_A	345_R	1.519	1.00
15_R	223_P	1.508	1.00
211_G	215_D	1.506	1.00
214_W	223_P	1.504	1.00
184_A	216_A	1.502	1.00
173_L	179_A	1.496	1.00
64_E	103_R	1.486	1.00
71_T	101_V	1.480	1.00
344_V	353_A	1.478	1.00
56_I	116_P	1.475	1.00
47_I	218_A	1.462	1.00
87_A	262_A	1.459	1.00
286_V	331_V	1.458	1.00
216_A	219_N	1.449	1.00
288_L	329_G	1.434	1.00
47_I	151_V	1.433	1.00
38_H	231_T	1.424	1.00
70_L	131_H	1.422	1.00
83_A	100_V	1.422	1.00
186_V	209_G	1.419	1.00
149_G	207_A	1.418	1.00
125_F	129_T	1.406	1.00
126_D	130_D	1.404	1.00
165_R	217_I	1.402	1.00
72_T	89_T	1.401	1.00
7_P	149_G	1.397	1.00
303_T	345_R	1.396	1.00
71_T	86_A	1.390	1.00
44_A	222_Q	1.390	1.00
337_A	340_T	1.381	1.00
256_E	283_Q	1.378	1.00
121_D	143_N	1.377	1.00
104_T	111_A	1.372	1.00
255_F	265_P	1.359	1.00
328_L	358_P	1.358	1.00
17_A	27_M	1.346	1.00
234_M	317_T	1.333	1.00
57_E	144_V	1.332	1.00
90_D	247_P	1.322	1.00
153_V	162_V	1.309	1.00
304_T	335_H	1.303	1.00
87_A	259_I	1.297	1.00
102_Y	178_A	1.297	1.00
268_G	272_R	1.294	1.00
58_V	114_F	1.292	1.00
114_F	128_W	1.288	1.00
302_V	344_V	1.285	1.00
181_V	190_V	1.267	1.00
332_D	335_H	1.264	1.00
8_L	151_V	1.261	1.00
20_T	29_V	1.258	1.00
36_A	222_Q	1.255	1.00
288_L	353_A	1.253	1.00
252_R	330_Y	1.248	1.00
80_P	105_P	1.242	1.00
255_F	281_P	1.240	1.00
142_D	147_D	1.238	1.00
183_V	188_C	1.238	1.00
64_E	76_S	1.233	1.00
132_R	141_V	1.223	1.00
11_R	211_G	1.223	1.00
66_L	139_A	1.206	1.00
62_D	137_L	1.206	1.00
318_M	323_G	1.193	1.00
9_H	26_N	1.189	1.00
255_F	275_L	1.177	1.00
257_A	330_Y	1.175	1.00
307_G	350_D	1.171	1.00
159_P	199_A	1.166	1.00
291_D	352_Q	1.151	1.00
160_D	163_A	1.151	1.00
340_T	355_I	1.144	1.00
68_Q	76_S	1.144	1.00
63_A	112_F	1.140	1.00
123_A	247_P	1.140	1.00
103_R	106_A	1.140	1.00
234_M	315_S	1.139	1.00
75_V	101_V	1.132	1.00
164_A	220_D	1.129	1.00
331_V	342_V	1.124	1.00
273_D	277_D	1.124	1.00
35_Q	39_A	1.123	1.00
246_D	252_R	1.120	1.00
288_L	344_V	1.119	1.00
122_A	126_D	1.119	1.00
125_F	141_V	1.116	1.00
69_R	137_L	1.114	1.00
87_A	95_M	1.098	1.00
44_A	220_D	1.097	1.00
127_R	270_V	1.097	1.00
80_P	106_A	1.091	1.00
346_I	351_K	1.090	1.00
131_H	270_V	1.087	1.00
45_A	221_C	1.086	1.00
144_V	148_Y	1.084	1.00
66_L	128_W	1.080	1.00
64_E	75_V	1.073	1.00
205_F	210_A	1.072	1.00
5_T	10_G	1.070	1.00
151_V	214_W	1.066	1.00
120_H	123_A	1.058	1.00
212_A	216_A	1.055	1.00
33_G	36_A	1.053	1.00
303_T	343_A	1.045	1.00
103_R	112_F	1.045	1.00
287_G	360_F	1.043	1.00
32_D	36_A	1.042	1.00
79_D	82_D	1.037	1.00
233_R	315_S	1.035	1.00
289_T	356_T	1.031	1.00
88_I	128_W	1.030	1.00
39_A	323_G	1.028	1.00
304_T	310_I	1.024	1.00
256_E	278_T	1.018	1.00
303_T	307_G	1.017	1.00
101_V	112_F	1.011	1.00
274_A	278_T	1.007	1.00
69_R	270_V	1.006	1.00
186_V	212_A	1.002	1.00
290_L	353_A	1.001	1.00
339_G	354_T	0.992	1.00
342_V	355_I	0.990	1.00
74_D	77_R	0.990	1.00
159_P	201_V	0.989	1.00
310_I	342_V	0.986	1.00
36_A	39_A	0.986	1.00
215_D	219_N	0.981	1.00
58_V	63_A	0.981	1.00
9_H	19_F	0.980	1.00
239_L	245_F	0.978	1.00
101_V	114_F	0.962	1.00
58_V	128_W	0.962	1.00
304_T	343_A	0.962	1.00
292_E	352_Q	0.960	1.00
73_N	264_A	0.959	1.00
205_F	209_G	0.958	1.00
34_I	227_G	0.956	1.00
338_D	357_T	0.955	1.00
7_P	207_A	0.953	1.00
309_E	312_T	0.946	1.00
186_V	213_V	0.944	1.00
154_Q	200_G	0.942	1.00
40_A	220_D	0.940	1.00
67_M	112_F	0.940	1.00
95_M	245_F	0.919	1.00
265_P	269_F	0.918	1.00
153_V	161_L	0.917	1.00
12_H	28_P	0.916	1.00
38_H	232_L	0.906	1.00
173_L	176_F	0.905	1.00
291_D	341_T	0.903	1.00
132_R	137_L	0.903	1.00
40_A	224_C	0.899	1.00
57_E	113_L	0.898	0.99
335_H	340_T	0.896	0.99
55_E	148_Y	0.893	0.99
6_S	9_H	0.889	0.99
4_R	122_A	0.886	0.99
166_A	183_V	0.886	0.99
8_L	210_A	0.886	0.99
50_V	152_A	0.884	0.99
168_D	179_A	0.882	0.99
159_P	171_H	0.882	0.99
47_I	214_W	0.880	0.99
166_A	170_V	0.880	0.99
278_T	281_P	0.875	0.99
104_T	189_L	0.873	0.99
19_F	26_N	0.871	0.99
281_P	333_S	0.867	0.99
30_D	34_I	0.866	0.99
163_A	168_D	0.865	0.99
167_G	182_G	0.864	0.99
182_G	185_G	0.862	0.99
25_W	121_D	0.860	0.99
144_V	147_D	0.858	0.99
284_Q	333_S	0.854	0.99
149_G	205_F	0.852	0.99
67_M	75_V	0.840	0.99
58_V	141_V	0.834	0.99
111_A	180_T	0.834	0.99
73_N	86_A	0.834	0.99
265_P	276_A	0.832	0.99
192_N	199_A	0.831	0.99
91_D	270_V	0.822	0.99
150_M	204_V	0.822	0.99
71_T	88_I	0.814	0.99
90_D	96_I	0.812	0.99
15_R	215_D	0.812	0.99
61_P	107_D	0.811	0.99
47_I	153_V	0.810	0.99
85_Y	98_D	0.803	0.99
336_A	340_T	0.802	0.99
304_T	342_V	0.800	0.99
95_M	257_A	0.800	0.99
15_R	214_W	0.797	0.99
253_T	256_E	0.796	0.99
255_F	260_G	0.796	0.99
59_S	107_D	0.792	0.99
4_R	146_T	0.790	0.99
184_A	188_C	0.790	0.99
265_P	272_R	0.787	0.99
302_V	342_V	0.787	0.99
62_D	136_D	0.785	0.99
158_A	199_A	0.785	0.99
282_E	333_S	0.784	0.99
190_V	203_I	0.784	0.99
356_T	360_F	0.782	0.99
252_R	283_Q	0.781	0.99
256_E	282_E	0.781	0.99
96_I	123_A	0.779	0.99
86_A	101_V	0.779	0.99
180_T	189_L	0.778	0.99
253_T	274_A	0.776	0.99
72_T	263_V	0.774	0.99
218_A	221_C	0.772	0.98
54_G	121_D	0.772	0.98
89_T	275_L	0.769	0.98
269_F	276_A	0.766	0.98
339_G	355_I	0.763	0.98
88_I	99_T	0.758	0.98
319_S	326_I	0.758	0.98
296_P	325_P	0.756	0.98
296_P	300_Y	0.755	0.98
203_I	217_I	0.752	0.98
184_A	212_A	0.749	0.98
331_V	355_I	0.748	0.98
55_E	204_V	0.748	0.98
41_V	232_L	0.746	0.98
160_D	164_A	0.743	0.98
125_F	143_N	0.742	0.98
71_T	75_V	0.740	0.98
163_A	171_H	0.739	0.98
64_E	68_Q	0.739	0.98
255_F	263_V	0.735	0.98
258_G	284_Q	0.734	0.98
292_E	351_K	0.733	0.98
72_T	87_A	0.733	0.98
38_H	321_T	0.730	0.98
173_L	178_A	0.729	0.98
218_A	223_P	0.728	0.98
95_M	244_D	0.727	0.98
178_A	189_L	0.726	0.98
190_V	201_V	0.725	0.98
96_I	247_P	0.724	0.98
126_D	129_T	0.723	0.98
255_F	280_S	0.719	0.98
13_E	26_N	0.718	0.98
280_S	333_S	0.717	0.98
269_F	275_L	0.716	0.98
69_R	136_D	0.716	0.98
77_R	84_Q	0.715	0.98
178_A	191_A	0.713	0.97
56_I	128_W	0.711	0.97
104_T	113_L	0.709	0.97
301_A	312_T	0.708	0.97
288_L	342_V	0.708	0.97
285_F	328_L	0.706	0.97
15_R	31_F	0.705	0.97
157_D	220_D	0.704	0.97
14_D	211_G	0.702	0.97
17_A	29_V	0.699	0.97
42_R	235_E	0.698	0.97
246_D	312_T	0.695	0.97
18_S	30_D	0.693	0.97
83_A	102_Y	0.693	0.97
102_Y	191_A	0.690	0.97
116_P	124_A	0.689	0.97
173_L	181_V	0.688	0.97
91_D	131_H	0.687	0.97
318_M	325_P	0.686	0.97
11_R	214_W	0.685	0.97
212_A	215_D	0.684	0.97
265_P	268_G	0.683	0.97
296_P	344_V	0.682	0.97
153_V	203_I	0.680	0.97
283_Q	332_D	0.679	0.97
11_R	218_A	0.679	0.97
65_R	137_L	0.679	0.97
66_L	132_R	0.678	0.97
70_L	127_R	0.677	0.97
41_V	224_C	0.677	0.97
304_T	340_T	0.670	0.96
300_Y	344_V	0.670	0.96
256_E	281_P	0.666	0.96
113_L	148_Y	0.666	0.96
188_C	203_I	0.663	0.96
15_R	218_A	0.657	0.96
132_R	139_A	0.655	0.96
296_P	353_A	0.654	0.96
148_Y	206_P	0.653	0.96
290_L	325_P	0.647	0.96
187_E	209_G	0.646	0.95
151_V	210_A	0.646	0.95
224_C	228_A	0.645	0.95
107_D	111_A	0.645	0.95
166_A	184_A	0.643	0.95
56_I	141_V	0.643	0.95
55_E	150_M	0.642	0.95
67_M	71_T	0.642	0.95
284_Q	336_A	0.641	0.95
78_L	84_Q	0.641	0.95
186_V	206_P	0.640	0.95
72_T	262_A	0.639	0.95
168_D	181_V	0.639	0.95
244_D	285_F	0.637	0.95
127_R	130_D	0.636	0.95
287_G	358_P	0.635	0.95
286_V	336_A	0.635	0.95
153_V	221_C	0.632	0.95
263_V	269_F	0.632	0.95
283_Q	312_T	0.632	0.95
68_Q	267_S	0.632	0.95
192_N	201_V	0.631	0.95
86_A	99_T	0.628	0.95
162_V	201_V	0.628	0.95
50_V	150_M	0.622	0.94
78_L	82_D	0.622	0.94
176_F	238_F	0.613	0.94
90_D	94_I	0.610	0.94
161_L	164_A	0.610	0.94
71_T	84_Q	0.608	0.94
331_V	336_A	0.607	0.94
161_L	220_D	0.607	0.94
333_S	336_A	0.606	0.94
44_A	161_L	0.605	0.94
231_T	319_S	0.602	0.93
128_W	141_V	0.602	0.93
183_V	213_V	0.601	0.93
96_I	127_R	0.597	0.93
244_D	252_R	0.597	0.93
104_T	178_A	0.596	0.93
234_M	326_I	0.596	0.93
183_V	216_A	0.596	0.93
67_M	114_F	0.596	0.93
66_L	69_R	0.594	0.93
147_D	206_P	0.594	0.93
58_V	67_M	0.594	0.93
181_V	187_E	0.593	0.93
132_R	136_D	0.593	0.93
44_A	221_C	0.592	0.93
42_R	232_L	0.592	0.93
162_V	170_V	0.592	0.93
173_L	201_V	0.590	0.93
35_Q	320_P	0.590	0.93
58_V	66_L	0.588	0.93
54_G	116_P	0.587	0.93
286_V	355_I	0.586	0.93
48_F	224_C	0.586	0.93
176_F	193_T	0.586	0.93
92_D	247_P	0.584	0.92
55_E	145_T	0.583	0.92
62_D	139_A	0.583	0.92
113_L	204_V	0.583	0.92
196_T	200_G	0.582	0.92
265_P	275_L	0.581	0.92
31_F	223_P	0.581	0.92
231_T	317_T	0.578	0.92
346_I	349_T	0.576	0.92
183_V	186_V	0.576	0.92
67_M	128_W	0.575	0.92
30_D	33_G	0.573	0.92
42_R	321_T	0.572	0.92
319_S	324_E	0.572	0.92
99_T	114_F	0.570	0.92
79_D	177_E	0.570	0.92
195_Y	240_L	0.570	0.92
166_A	169_G	0.570	0.92
70_L	88_I	0.570	0.92
51_S	149_G	0.570	0.92
65_R	76_S	0.568	0.91
57_E	104_T	0.566	0.91
316_G	325_P	0.566	0.91
237_G	358_P	0.566	0.91
116_P	125_F	0.565	0.91
12_H	19_F	0.565	0.91
310_I	332_D	0.565	0.91
191_A	204_V	0.563	0.91
65_R	69_R	0.561	0.91
143_N	146_T	0.560	0.91
74_D	264_A	0.558	0.91
83_A	191_A	0.556	0.90
293_R	325_P	0.555	0.90
17_A	20_T	0.554	0.90
103_R	107_D	0.553	0.90
92_D	248_E	0.547	0.90
154_Q	196_T	0.547	0.90
121_D	146_T	0.545	0.90
241_S	247_P	0.545	0.90
66_L	137_L	0.545	0.90
254_P	275_L	0.544	0.90
289_T	326_I	0.544	0.90
167_G	170_V	0.542	0.89
345_R	349_T	0.540	0.89
85_Y	193_T	0.540	0.89
338_D	358_P	0.540	0.89
53_M	115_V	0.538	0.89
176_F	179_A	0.538	0.89
245_F	252_R	0.537	0.89
274_A	277_D	0.537	0.89
260_G	284_Q	0.534	0.89
21_E	26_N	0.534	0.89
324_E	354_T	0.533	0.89
302_V	353_A	0.531	0.88
290_L	344_V	0.530	0.88
73_N	84_Q	0.530	0.88
88_I	124_A	0.529	0.88
12_H	15_R	0.529	0.88
176_F	204_V	0.528	0.88
269_F	272_R	0.527	0.88
284_Q	334_A	0.526	0.88
74_D	266_E	0.525	0.88
191_A	194_G	0.523	0.88
285_F	330_Y	0.522	0.88
48_F	154_Q	0.522	0.88
8_L	12_H	0.520	0.87
32_D	222_Q	0.517	0.87
240_L	243_Q	0.517	0.87
89_T	95_M	0.516	0.87
254_P	263_V	0.514	0.87
237_G	287_G	0.514	0.87
117_N	240_L	0.514	0.87
248_E	252_R	0.513	0.87
307_G	343_A	0.513	0.87
123_A	126_D	0.513	0.87
175_R	238_F	0.513	0.87
321_T	361_L	0.511	0.86
120_H	247_P	0.510	0.86
4_R	25_W	0.510	0.86
275_L	278_T	0.510	0.86
88_I	127_R	0.509	0.86
165_R	216_A	0.509	0.86
106_A	111_A	0.509	0.86
19_F	27_M	0.508	0.86
343_A	351_K	0.507	0.86
52_H	226_L	0.507	0.86
188_C	205_F	0.506	0.86
158_A	161_L	0.506	0.86
245_F	257_A	0.506	0.86
37_E	225_G	0.505	0.86
71_T	78_L	0.505	0.86
103_R	111_A	0.505	0.86
338_D	342_V	0.505	0.86
73_N	262_A	0.504	0.86
241_S	245_F	0.504	0.86
279_D	282_E	0.503	0.86
199_A	236_H	0.503	0.86
47_I	221_C	0.503	0.86
121_D	145_T	0.502	0.85
83_A	193_T	0.501	0.85
170_V	181_V	0.501	0.85
5_T	13_E	0.500	0.85
70_L	270_V	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yx2A	1	0.9697	100	0.13	Contact Map
2gagA	1	0.9807	100	0.139	Contact Map
1wosA	1	0.9669	100	0.141	Contact Map
3girA	1	0.9587	100	0.149	Contact Map
1v5vA	2	0.9752	100	0.15	Contact Map
4pabA	1	0.9752	100	0.158	Contact Map
1wsrA	2	0.9725	100	0.159	Contact Map
1pj5A	3	0.9669	100	0.166	Contact Map
1vloA	1	0.9421	100	0.171	Contact Map
3tfiA	2	0.9614	100	0.18	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.