GREMLIN Database
GCST - Probable aminomethyltransferase
UniProt: Q9HPJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (349)
Sequences: 6723 (4386)
Seq/√Len: 234.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_R215_D3.7611.00
157_D160_D3.7481.00
301_A309_E3.2851.00
289_T324_E3.2261.00
45_A161_L3.0961.00
57_E111_A2.8551.00
343_A350_D2.8301.00
253_T278_T2.6811.00
9_H13_E2.6081.00
13_E19_F2.5741.00
288_L327_G2.5471.00
44_A157_D2.5441.00
302_V329_G2.5171.00
149_G210_A2.4911.00
39_A43_E2.4521.00
341_T352_Q2.4291.00
62_D65_R2.3491.00
46_G224_C2.2611.00
14_D215_D2.2331.00
291_D354_T2.2251.00
41_V46_G2.1691.00
243_Q298_H2.1241.00
289_T354_T2.1061.00
319_S322_L2.1011.00
174_G177_E2.0951.00
299_G312_T2.0941.00
59_S111_A2.0881.00
345_R348_G2.0831.00
80_P103_R2.0721.00
304_T308_D2.0671.00
345_R350_D2.0441.00
303_T350_D2.0441.00
68_Q74_D2.0101.00
70_L128_W1.9631.00
342_V353_A1.9551.00
341_T354_T1.9341.00
343_A352_Q1.9281.00
10_G13_E1.9261.00
182_G187_E1.9241.00
10_G14_D1.9171.00
310_I335_H1.8501.00
272_R276_A1.8481.00
169_G172_D1.8231.00
5_T26_N1.8071.00
40_A44_A1.8061.00
11_R15_R1.7971.00
206_P209_G1.7831.00
56_I125_F1.7281.00
308_D332_D1.7131.00
209_G212_A1.7071.00
10_G211_G1.7061.00
40_A222_Q1.7021.00
11_R14_D1.6781.00
82_D177_E1.6701.00
62_D138_D1.6691.00
39_A321_T1.6601.00
105_P111_A1.6561.00
64_E112_F1.6471.00
313_V327_G1.6231.00
273_D276_A1.6211.00
12_H31_F1.6101.00
205_F213_V1.5741.00
5_T9_H1.5661.00
161_L221_C1.5651.00
59_S140_S1.5631.00
61_P138_D1.5501.00
127_R131_H1.5471.00
303_T309_E1.5381.00
173_L177_E1.5341.00
57_E142_D1.5311.00
180_T187_E1.5311.00
59_S142_D1.5231.00
301_A345_R1.5191.00
15_R223_P1.5081.00
211_G215_D1.5061.00
214_W223_P1.5041.00
184_A216_A1.5021.00
173_L179_A1.4961.00
64_E103_R1.4861.00
71_T101_V1.4801.00
344_V353_A1.4781.00
56_I116_P1.4751.00
47_I218_A1.4621.00
87_A262_A1.4591.00
286_V331_V1.4581.00
216_A219_N1.4491.00
288_L329_G1.4341.00
47_I151_V1.4331.00
38_H231_T1.4241.00
70_L131_H1.4221.00
83_A100_V1.4221.00
186_V209_G1.4191.00
149_G207_A1.4181.00
125_F129_T1.4061.00
126_D130_D1.4041.00
165_R217_I1.4021.00
72_T89_T1.4011.00
7_P149_G1.3971.00
303_T345_R1.3961.00
71_T86_A1.3901.00
44_A222_Q1.3901.00
337_A340_T1.3811.00
256_E283_Q1.3781.00
121_D143_N1.3771.00
104_T111_A1.3721.00
255_F265_P1.3591.00
328_L358_P1.3581.00
17_A27_M1.3461.00
234_M317_T1.3331.00
57_E144_V1.3321.00
90_D247_P1.3221.00
153_V162_V1.3091.00
304_T335_H1.3031.00
87_A259_I1.2971.00
102_Y178_A1.2971.00
268_G272_R1.2941.00
58_V114_F1.2921.00
114_F128_W1.2881.00
302_V344_V1.2851.00
181_V190_V1.2671.00
332_D335_H1.2641.00
8_L151_V1.2611.00
20_T29_V1.2581.00
36_A222_Q1.2551.00
288_L353_A1.2531.00
252_R330_Y1.2481.00
80_P105_P1.2421.00
255_F281_P1.2401.00
142_D147_D1.2381.00
183_V188_C1.2381.00
64_E76_S1.2331.00
132_R141_V1.2231.00
11_R211_G1.2231.00
66_L139_A1.2061.00
62_D137_L1.2061.00
318_M323_G1.1931.00
9_H26_N1.1891.00
255_F275_L1.1771.00
257_A330_Y1.1751.00
307_G350_D1.1711.00
159_P199_A1.1661.00
291_D352_Q1.1511.00
160_D163_A1.1511.00
340_T355_I1.1441.00
68_Q76_S1.1441.00
63_A112_F1.1401.00
123_A247_P1.1401.00
103_R106_A1.1401.00
234_M315_S1.1391.00
75_V101_V1.1321.00
164_A220_D1.1291.00
331_V342_V1.1241.00
273_D277_D1.1241.00
35_Q39_A1.1231.00
246_D252_R1.1201.00
288_L344_V1.1191.00
122_A126_D1.1191.00
125_F141_V1.1161.00
69_R137_L1.1141.00
87_A95_M1.0981.00
44_A220_D1.0971.00
127_R270_V1.0971.00
80_P106_A1.0911.00
346_I351_K1.0901.00
131_H270_V1.0871.00
45_A221_C1.0861.00
144_V148_Y1.0841.00
66_L128_W1.0801.00
64_E75_V1.0731.00
205_F210_A1.0721.00
5_T10_G1.0701.00
151_V214_W1.0661.00
120_H123_A1.0581.00
212_A216_A1.0551.00
33_G36_A1.0531.00
303_T343_A1.0451.00
103_R112_F1.0451.00
287_G360_F1.0431.00
32_D36_A1.0421.00
79_D82_D1.0371.00
233_R315_S1.0351.00
289_T356_T1.0311.00
88_I128_W1.0301.00
39_A323_G1.0281.00
304_T310_I1.0241.00
256_E278_T1.0181.00
303_T307_G1.0171.00
101_V112_F1.0111.00
274_A278_T1.0071.00
69_R270_V1.0061.00
186_V212_A1.0021.00
290_L353_A1.0011.00
339_G354_T0.9921.00
342_V355_I0.9901.00
74_D77_R0.9901.00
159_P201_V0.9891.00
310_I342_V0.9861.00
36_A39_A0.9861.00
215_D219_N0.9811.00
58_V63_A0.9811.00
9_H19_F0.9801.00
239_L245_F0.9781.00
101_V114_F0.9621.00
58_V128_W0.9621.00
304_T343_A0.9621.00
292_E352_Q0.9601.00
73_N264_A0.9591.00
205_F209_G0.9581.00
34_I227_G0.9561.00
338_D357_T0.9551.00
7_P207_A0.9531.00
309_E312_T0.9461.00
186_V213_V0.9441.00
154_Q200_G0.9421.00
40_A220_D0.9401.00
67_M112_F0.9401.00
95_M245_F0.9191.00
265_P269_F0.9181.00
153_V161_L0.9171.00
12_H28_P0.9161.00
38_H232_L0.9061.00
173_L176_F0.9051.00
291_D341_T0.9031.00
132_R137_L0.9031.00
40_A224_C0.8991.00
57_E113_L0.8980.99
335_H340_T0.8960.99
55_E148_Y0.8930.99
6_S9_H0.8890.99
4_R122_A0.8860.99
166_A183_V0.8860.99
8_L210_A0.8860.99
50_V152_A0.8840.99
168_D179_A0.8820.99
159_P171_H0.8820.99
47_I214_W0.8800.99
166_A170_V0.8800.99
278_T281_P0.8750.99
104_T189_L0.8730.99
19_F26_N0.8710.99
281_P333_S0.8670.99
30_D34_I0.8660.99
163_A168_D0.8650.99
167_G182_G0.8640.99
182_G185_G0.8620.99
25_W121_D0.8600.99
144_V147_D0.8580.99
284_Q333_S0.8540.99
149_G205_F0.8520.99
67_M75_V0.8400.99
58_V141_V0.8340.99
111_A180_T0.8340.99
73_N86_A0.8340.99
265_P276_A0.8320.99
192_N199_A0.8310.99
91_D270_V0.8220.99
150_M204_V0.8220.99
71_T88_I0.8140.99
90_D96_I0.8120.99
15_R215_D0.8120.99
61_P107_D0.8110.99
47_I153_V0.8100.99
85_Y98_D0.8030.99
336_A340_T0.8020.99
304_T342_V0.8000.99
95_M257_A0.8000.99
15_R214_W0.7970.99
253_T256_E0.7960.99
255_F260_G0.7960.99
59_S107_D0.7920.99
4_R146_T0.7900.99
184_A188_C0.7900.99
265_P272_R0.7870.99
302_V342_V0.7870.99
62_D136_D0.7850.99
158_A199_A0.7850.99
282_E333_S0.7840.99
190_V203_I0.7840.99
356_T360_F0.7820.99
252_R283_Q0.7810.99
256_E282_E0.7810.99
96_I123_A0.7790.99
86_A101_V0.7790.99
180_T189_L0.7780.99
253_T274_A0.7760.99
72_T263_V0.7740.99
218_A221_C0.7720.98
54_G121_D0.7720.98
89_T275_L0.7690.98
269_F276_A0.7660.98
339_G355_I0.7630.98
88_I99_T0.7580.98
319_S326_I0.7580.98
296_P325_P0.7560.98
296_P300_Y0.7550.98
203_I217_I0.7520.98
184_A212_A0.7490.98
331_V355_I0.7480.98
55_E204_V0.7480.98
41_V232_L0.7460.98
160_D164_A0.7430.98
125_F143_N0.7420.98
71_T75_V0.7400.98
163_A171_H0.7390.98
64_E68_Q0.7390.98
255_F263_V0.7350.98
258_G284_Q0.7340.98
292_E351_K0.7330.98
72_T87_A0.7330.98
38_H321_T0.7300.98
173_L178_A0.7290.98
218_A223_P0.7280.98
95_M244_D0.7270.98
178_A189_L0.7260.98
190_V201_V0.7250.98
96_I247_P0.7240.98
126_D129_T0.7230.98
255_F280_S0.7190.98
13_E26_N0.7180.98
280_S333_S0.7170.98
269_F275_L0.7160.98
69_R136_D0.7160.98
77_R84_Q0.7150.98
178_A191_A0.7130.97
56_I128_W0.7110.97
104_T113_L0.7090.97
301_A312_T0.7080.97
288_L342_V0.7080.97
285_F328_L0.7060.97
15_R31_F0.7050.97
157_D220_D0.7040.97
14_D211_G0.7020.97
17_A29_V0.6990.97
42_R235_E0.6980.97
246_D312_T0.6950.97
18_S30_D0.6930.97
83_A102_Y0.6930.97
102_Y191_A0.6900.97
116_P124_A0.6890.97
173_L181_V0.6880.97
91_D131_H0.6870.97
318_M325_P0.6860.97
11_R214_W0.6850.97
212_A215_D0.6840.97
265_P268_G0.6830.97
296_P344_V0.6820.97
153_V203_I0.6800.97
283_Q332_D0.6790.97
11_R218_A0.6790.97
65_R137_L0.6790.97
66_L132_R0.6780.97
70_L127_R0.6770.97
41_V224_C0.6770.97
304_T340_T0.6700.96
300_Y344_V0.6700.96
256_E281_P0.6660.96
113_L148_Y0.6660.96
188_C203_I0.6630.96
15_R218_A0.6570.96
132_R139_A0.6550.96
296_P353_A0.6540.96
148_Y206_P0.6530.96
290_L325_P0.6470.96
187_E209_G0.6460.95
151_V210_A0.6460.95
224_C228_A0.6450.95
107_D111_A0.6450.95
166_A184_A0.6430.95
56_I141_V0.6430.95
55_E150_M0.6420.95
67_M71_T0.6420.95
284_Q336_A0.6410.95
78_L84_Q0.6410.95
186_V206_P0.6400.95
72_T262_A0.6390.95
168_D181_V0.6390.95
244_D285_F0.6370.95
127_R130_D0.6360.95
287_G358_P0.6350.95
286_V336_A0.6350.95
153_V221_C0.6320.95
263_V269_F0.6320.95
283_Q312_T0.6320.95
68_Q267_S0.6320.95
192_N201_V0.6310.95
86_A99_T0.6280.95
162_V201_V0.6280.95
50_V150_M0.6220.94
78_L82_D0.6220.94
176_F238_F0.6130.94
90_D94_I0.6100.94
161_L164_A0.6100.94
71_T84_Q0.6080.94
331_V336_A0.6070.94
161_L220_D0.6070.94
333_S336_A0.6060.94
44_A161_L0.6050.94
231_T319_S0.6020.93
128_W141_V0.6020.93
183_V213_V0.6010.93
96_I127_R0.5970.93
244_D252_R0.5970.93
104_T178_A0.5960.93
234_M326_I0.5960.93
183_V216_A0.5960.93
67_M114_F0.5960.93
66_L69_R0.5940.93
147_D206_P0.5940.93
58_V67_M0.5940.93
181_V187_E0.5930.93
132_R136_D0.5930.93
44_A221_C0.5920.93
42_R232_L0.5920.93
162_V170_V0.5920.93
173_L201_V0.5900.93
35_Q320_P0.5900.93
58_V66_L0.5880.93
54_G116_P0.5870.93
286_V355_I0.5860.93
48_F224_C0.5860.93
176_F193_T0.5860.93
92_D247_P0.5840.92
55_E145_T0.5830.92
62_D139_A0.5830.92
113_L204_V0.5830.92
196_T200_G0.5820.92
265_P275_L0.5810.92
31_F223_P0.5810.92
231_T317_T0.5780.92
346_I349_T0.5760.92
183_V186_V0.5760.92
67_M128_W0.5750.92
30_D33_G0.5730.92
42_R321_T0.5720.92
319_S324_E0.5720.92
99_T114_F0.5700.92
79_D177_E0.5700.92
195_Y240_L0.5700.92
166_A169_G0.5700.92
70_L88_I0.5700.92
51_S149_G0.5700.92
65_R76_S0.5680.91
57_E104_T0.5660.91
316_G325_P0.5660.91
237_G358_P0.5660.91
116_P125_F0.5650.91
12_H19_F0.5650.91
310_I332_D0.5650.91
191_A204_V0.5630.91
65_R69_R0.5610.91
143_N146_T0.5600.91
74_D264_A0.5580.91
83_A191_A0.5560.90
293_R325_P0.5550.90
17_A20_T0.5540.90
103_R107_D0.5530.90
92_D248_E0.5470.90
154_Q196_T0.5470.90
121_D146_T0.5450.90
241_S247_P0.5450.90
66_L137_L0.5450.90
254_P275_L0.5440.90
289_T326_I0.5440.90
167_G170_V0.5420.89
345_R349_T0.5400.89
85_Y193_T0.5400.89
338_D358_P0.5400.89
53_M115_V0.5380.89
176_F179_A0.5380.89
245_F252_R0.5370.89
274_A277_D0.5370.89
260_G284_Q0.5340.89
21_E26_N0.5340.89
324_E354_T0.5330.89
302_V353_A0.5310.88
290_L344_V0.5300.88
73_N84_Q0.5300.88
88_I124_A0.5290.88
12_H15_R0.5290.88
176_F204_V0.5280.88
269_F272_R0.5270.88
284_Q334_A0.5260.88
74_D266_E0.5250.88
191_A194_G0.5230.88
285_F330_Y0.5220.88
48_F154_Q0.5220.88
8_L12_H0.5200.87
32_D222_Q0.5170.87
240_L243_Q0.5170.87
89_T95_M0.5160.87
254_P263_V0.5140.87
237_G287_G0.5140.87
117_N240_L0.5140.87
248_E252_R0.5130.87
307_G343_A0.5130.87
123_A126_D0.5130.87
175_R238_F0.5130.87
321_T361_L0.5110.86
120_H247_P0.5100.86
4_R25_W0.5100.86
275_L278_T0.5100.86
88_I127_R0.5090.86
165_R216_A0.5090.86
106_A111_A0.5090.86
19_F27_M0.5080.86
343_A351_K0.5070.86
52_H226_L0.5070.86
188_C205_F0.5060.86
158_A161_L0.5060.86
245_F257_A0.5060.86
37_E225_G0.5050.86
71_T78_L0.5050.86
103_R111_A0.5050.86
338_D342_V0.5050.86
73_N262_A0.5040.86
241_S245_F0.5040.86
279_D282_E0.5030.86
199_A236_H0.5030.86
47_I221_C0.5030.86
121_D145_T0.5020.85
83_A193_T0.5010.85
170_V181_V0.5010.85
5_T13_E0.5000.85
70_L270_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yx2A 1 0.9697 100 0.13 Contact Map
2gagA 1 0.9807 100 0.139 Contact Map
1wosA 1 0.9669 100 0.141 Contact Map
3girA 1 0.9587 100 0.149 Contact Map
1v5vA 2 0.9752 100 0.15 Contact Map
4pabA 1 0.9752 100 0.158 Contact Map
1wsrA 2 0.9725 100 0.159 Contact Map
1pj5A 3 0.9669 100 0.166 Contact Map
1vloA 1 0.9421 100 0.171 Contact Map
3tfiA 2 0.9614 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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