Q9HPJ4 - HALSA - GREMLIN Contacts

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Q9HPJ4 - Uncharacterized protein

UniProt:	Q9HPJ4	Sequences: MHVDITHRPSYAHLVVDLDPGESILAEPGAMVSHSAGVSIDTSTTRDGLLSSAKSMLGGESAFANEFAADHEAGRVTLAPPKPGDIAQHDLDGETLYAVDGAFLASDPSLDVASEFGGLKSLLAGASITPLALSGTGTVFLEAFGGIERVDLDPGESYVVDNEHVVAWEESVDFDARRVGGLKSTLLSGEGLVMEFTGGGSVWYQTRGLDAFTSIIAGALPMTEHDSDGGIDIDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	235 (199)
Sequences:	2021 (1098)
Seq/√Len:	77.8

HALSA - Q9HPJ4 Q9HMA6 Q9HRV1
SULSO - Q97XI4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_R	201_S	4.625	1.00
103_F	106_S	3.374	1.00
133_L	139_V	3.132	1.00
177_R	195_E	3.057	1.00
15_V	75_R	2.955	1.00
14_L	140_F	2.948	1.00
23_S	68_A	2.777	1.00
95_T	170_E	2.677	1.00
33_S	77_T	2.491	1.00
89_H	96_L	2.471	1.00
158_Y	202_V	2.459	1.00
157_S	197_T	2.406	1.00
93_G	136_T	2.374	1.00
88_Q	138_T	2.306	1.00
90_D	138_T	2.299	1.00
155_G	199_G	2.285	1.00
96_L	167_A	2.169	1.00
149_R	203_W	2.106	1.00
95_T	132_A	2.030	1.00
86_I	104_L	1.982	1.00
69_A	74_G	1.977	1.00
98_A	141_L	1.924	1.00
169_E	201_S	1.889	1.00
41_D	68_A	1.863	1.00
43_S	66_E	1.855	1.00
152_L	156_E	1.853	1.00
172_V	199_G	1.794	1.00
48_G	53_A	1.791	1.00
165_V	168_W	1.755	1.00
16_V	24_I	1.742	1.00
151_D	201_S	1.739	1.00
54_K	113_A	1.728	1.00
46_R	52_S	1.719	1.00
111_D	134_S	1.718	1.00
152_L	199_G	1.716	1.00
173_D	197_T	1.670	1.00
172_V	196_F	1.668	1.00
23_S	66_E	1.661	1.00
95_T	134_S	1.655	1.00
88_Q	140_F	1.652	1.00
98_A	133_L	1.599	1.00
159_V	195_E	1.599	1.00
98_A	102_A	1.576	0.99
48_G	52_S	1.575	0.99
26_A	78_L	1.563	0.99
130_P	168_W	1.545	0.99
96_L	203_W	1.538	0.99
94_E	169_E	1.537	0.99
9_P	85_D	1.532	0.99
17_D	75_R	1.526	0.99
156_E	199_G	1.518	0.99
143_A	166_V	1.503	0.99
13_H	32_V	1.501	0.99
157_S	195_E	1.499	0.99
18_L	76_V	1.493	0.99
38_V	76_V	1.492	0.99
153_D	199_G	1.472	0.99
17_D	73_A	1.452	0.99
60_E	161_D	1.437	0.99
19_D	73_A	1.424	0.99
119_L	122_L	1.403	0.99
113_A	132_A	1.394	0.99
12_A	85_D	1.391	0.99
161_D	190_E	1.355	0.98
23_S	108_P	1.355	0.98
112_V	133_L	1.334	0.98
168_W	174_F	1.313	0.98
67_F	76_V	1.310	0.98
41_D	66_E	1.300	0.98
85_D	146_G	1.286	0.98
52_S	55_S	1.284	0.98
38_V	67_F	1.251	0.97
185_T	192_L	1.247	0.97
87_A	143_A	1.241	0.97
175_D	195_E	1.234	0.97
165_V	174_F	1.216	0.97
13_H	206_T	1.202	0.97
147_I	203_W	1.196	0.97
86_I	140_F	1.181	0.96
15_V	77_T	1.171	0.96
37_G	73_A	1.170	0.96
35_S	75_R	1.165	0.96
44_T	62_A	1.154	0.96
110_L	133_L	1.154	0.96
115_E	132_A	1.147	0.96
53_A	56_M	1.147	0.96
25_L	106_S	1.143	0.96
31_M	161_D	1.120	0.95
13_H	33_S	1.088	0.94
91_L	94_E	1.078	0.94
37_G	74_G	1.078	0.94
78_L	105_A	1.078	0.94
16_V	78_L	1.038	0.93
34_H	159_V	1.022	0.92
92_D	136_T	1.016	0.92
182_L	186_L	1.010	0.92
117_G	130_P	1.009	0.92
91_L	139_V	1.000	0.91
40_I	179_V	0.997	0.91
143_A	147_I	0.991	0.91
106_S	110_L	0.975	0.90
155_G	172_V	0.972	0.90
26_A	67_F	0.967	0.90
107_D	138_T	0.966	0.90
32_V	79_A	0.963	0.90
121_S	128_I	0.958	0.89
150_V	204_Y	0.956	0.89
58_G	131_L	0.946	0.89
27_E	63_F	0.933	0.88
160_V	204_Y	0.930	0.88
12_A	206_T	0.930	0.88
79_A	104_L	0.924	0.88
91_L	136_T	0.915	0.87
89_H	141_L	0.911	0.87
96_L	139_V	0.906	0.86
24_I	78_L	0.905	0.86
94_E	136_T	0.887	0.85
183_K	187_L	0.886	0.85
178_R	181_G	0.881	0.85
60_E	190_E	0.878	0.85
31_M	190_E	0.877	0.85
179_V	184_S	0.870	0.84
14_L	86_I	0.868	0.84
8_R	12_A	0.866	0.84
152_L	157_S	0.858	0.83
19_D	22_E	0.853	0.83
94_E	170_E	0.847	0.83
36_A	157_S	0.846	0.82
46_R	50_L	0.845	0.82
27_E	142_E	0.843	0.82
50_L	53_A	0.840	0.82
178_R	185_T	0.836	0.82
40_I	65_N	0.834	0.82
160_V	165_V	0.827	0.81
116_F	168_W	0.823	0.81
47_D	63_F	0.817	0.80
130_P	174_F	0.805	0.79
136_T	153_D	0.803	0.79
152_L	172_V	0.803	0.79
109_S	136_T	0.802	0.79
42_T	65_N	0.797	0.79
97_Y	115_E	0.796	0.78
177_R	180_G	0.796	0.78
110_L	171_S	0.796	0.78
134_S	170_E	0.794	0.78
35_S	74_G	0.792	0.78
48_G	51_S	0.788	0.78
36_A	74_G	0.788	0.78
120_K	175_D	0.781	0.77
169_E	203_W	0.781	0.77
97_Y	168_W	0.776	0.77
25_L	43_S	0.772	0.76
8_R	55_S	0.771	0.76
146_G	206_T	0.767	0.76
169_E	172_V	0.762	0.75
51_S	111_D	0.756	0.75
97_Y	132_A	0.753	0.75
196_F	204_Y	0.743	0.74
97_Y	130_P	0.738	0.73
177_R	197_T	0.736	0.73
176_A	192_L	0.736	0.73
132_A	170_E	0.731	0.72
25_L	66_E	0.728	0.72
159_V	193_V	0.727	0.72
180_G	184_S	0.726	0.72
87_A	149_R	0.722	0.71
91_L	95_T	0.721	0.71
9_P	146_G	0.718	0.71
117_G	121_S	0.714	0.71
115_E	174_F	0.714	0.71
150_V	158_Y	0.714	0.71
18_L	38_V	0.709	0.70
153_D	156_E	0.705	0.70
160_V	196_F	0.702	0.69
28_P	42_T	0.696	0.69
182_L	185_T	0.687	0.68
27_E	61_S	0.678	0.67
80_P	144_F	0.673	0.66
87_A	141_L	0.667	0.65
106_S	112_V	0.660	0.65
40_I	110_L	0.660	0.65
208_G	211_A	0.658	0.64
100_D	128_I	0.652	0.64
48_G	54_K	0.651	0.63
37_G	156_E	0.648	0.63
164_H	208_G	0.646	0.63
38_V	95_T	0.645	0.63
48_G	55_S	0.643	0.63
29_G	125_G	0.638	0.62
90_D	94_E	0.637	0.62
46_R	51_S	0.635	0.62
99_V	130_P	0.635	0.62
24_I	73_A	0.635	0.62
196_F	200_G	0.632	0.61
23_S	119_L	0.632	0.61
20_P	73_A	0.629	0.61
168_W	188_S	0.628	0.61
180_G	191_G	0.623	0.60
65_N	130_P	0.619	0.60
144_F	208_G	0.619	0.60
108_P	182_L	0.613	0.59
60_E	189_G	0.612	0.59
60_E	101_G	0.610	0.58
98_A	139_V	0.610	0.58
154_P	157_S	0.610	0.58
166_V	203_W	0.610	0.58
60_E	99_V	0.608	0.58
80_P	142_E	0.603	0.58
19_D	151_D	0.602	0.57
105_A	139_V	0.600	0.57
114_S	133_L	0.600	0.57
145_G	205_Q	0.600	0.57
46_R	62_A	0.599	0.57
99_V	126_A	0.595	0.57
126_A	166_V	0.593	0.56
30_A	161_D	0.593	0.56
159_V	177_R	0.591	0.56
20_P	69_A	0.591	0.56
110_L	139_V	0.588	0.56
133_L	141_L	0.588	0.56
164_H	211_A	0.587	0.56
52_S	111_D	0.585	0.55
126_A	163_E	0.585	0.55
49_L	106_S	0.585	0.55
15_V	87_A	0.584	0.55
25_L	64_A	0.583	0.55
107_D	110_L	0.582	0.55
143_A	167_A	0.580	0.55
59_G	189_G	0.579	0.55
99_V	131_L	0.577	0.54
59_G	125_G	0.575	0.54
168_W	196_F	0.574	0.54
126_A	162_N	0.574	0.54
62_A	131_L	0.572	0.54
124_A	174_F	0.572	0.54
124_A	163_E	0.572	0.54
89_H	147_I	0.571	0.54
164_H	206_T	0.570	0.53
184_S	194_M	0.570	0.53
160_V	164_H	0.568	0.53
25_L	112_V	0.567	0.53
95_T	173_D	0.566	0.53
99_V	162_N	0.565	0.53
39_S	68_A	0.564	0.53
165_V	196_F	0.563	0.53
32_V	168_W	0.563	0.53
31_M	104_L	0.561	0.52
153_D	171_S	0.561	0.52
60_E	162_N	0.558	0.52
46_R	66_E	0.556	0.52
82_K	142_E	0.549	0.51
144_F	206_T	0.547	0.50
101_G	159_V	0.545	0.50
26_A	30_A	0.544	0.50
33_S	158_Y	0.543	0.50
56_M	113_A	0.543	0.50
49_L	53_A	0.542	0.50
179_V	191_G	0.540	0.50
115_E	118_G	0.539	0.49
118_G	183_K	0.537	0.49
147_I	167_A	0.537	0.49
151_D	199_G	0.537	0.49
21_G	39_S	0.535	0.49
113_A	134_S	0.535	0.49
48_G	56_M	0.534	0.49
50_L	55_S	0.530	0.48
96_L	141_L	0.530	0.48
160_V	195_E	0.530	0.48
69_A	73_A	0.530	0.48
38_V	112_V	0.528	0.48
42_T	187_L	0.528	0.48
52_S	62_A	0.528	0.48
35_S	158_Y	0.527	0.48
56_M	134_S	0.527	0.48
147_I	201_S	0.527	0.48
167_A	196_F	0.525	0.48
96_L	201_S	0.523	0.47
146_G	203_W	0.521	0.47
19_D	24_I	0.521	0.47
42_T	179_V	0.519	0.47
144_F	207_R	0.515	0.46
115_E	166_V	0.515	0.46
41_D	183_K	0.515	0.46
52_S	56_M	0.515	0.46
33_S	128_I	0.513	0.46
109_S	124_A	0.512	0.46
103_F	133_L	0.511	0.46
154_P	199_G	0.508	0.46
47_D	55_S	0.508	0.46
80_P	207_R	0.505	0.45
152_L	155_G	0.504	0.45
97_Y	207_R	0.504	0.45
159_V	175_D	0.504	0.45
59_G	152_L	0.504	0.45
114_S	181_G	0.503	0.45
175_D	197_T	0.503	0.45
128_I	193_V	0.503	0.45
39_S	66_E	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pg6A	3	0.8979	100	0.176	Contact Map
1yoxA	3	0.8979	100	0.185	Contact Map
2eeaA	1	0.3532	15.2	0.959	Contact Map
2di8A	1	0.3106	9.3	0.963	Contact Map
2k9uA	1	0.3404	8.6	0.963	Contact Map
2eecA	1	0.3489	8.5	0.963	Contact Map
2dlwA	1	0.4426	7.6	0.964	Contact Map
2qnkA	1	0.7617	7.5	0.964	Contact Map
2d7oA	1	0.3106	6.9	0.965	Contact Map
2di9A	1	0.3957	6.6	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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