GREMLIN Database
Q9HPJ4 - Uncharacterized protein
UniProt: Q9HPJ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (199)
Sequences: 2021 (1098)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_R201_S4.6251.00
103_F106_S3.3741.00
133_L139_V3.1321.00
177_R195_E3.0571.00
15_V75_R2.9551.00
14_L140_F2.9481.00
23_S68_A2.7771.00
95_T170_E2.6771.00
33_S77_T2.4911.00
89_H96_L2.4711.00
158_Y202_V2.4591.00
157_S197_T2.4061.00
93_G136_T2.3741.00
88_Q138_T2.3061.00
90_D138_T2.2991.00
155_G199_G2.2851.00
96_L167_A2.1691.00
149_R203_W2.1061.00
95_T132_A2.0301.00
86_I104_L1.9821.00
69_A74_G1.9771.00
98_A141_L1.9241.00
169_E201_S1.8891.00
41_D68_A1.8631.00
43_S66_E1.8551.00
152_L156_E1.8531.00
172_V199_G1.7941.00
48_G53_A1.7911.00
165_V168_W1.7551.00
16_V24_I1.7421.00
151_D201_S1.7391.00
54_K113_A1.7281.00
46_R52_S1.7191.00
111_D134_S1.7181.00
152_L199_G1.7161.00
173_D197_T1.6701.00
172_V196_F1.6681.00
23_S66_E1.6611.00
95_T134_S1.6551.00
88_Q140_F1.6521.00
98_A133_L1.5991.00
159_V195_E1.5991.00
98_A102_A1.5760.99
48_G52_S1.5750.99
26_A78_L1.5630.99
130_P168_W1.5450.99
96_L203_W1.5380.99
94_E169_E1.5370.99
9_P85_D1.5320.99
17_D75_R1.5260.99
156_E199_G1.5180.99
143_A166_V1.5030.99
13_H32_V1.5010.99
157_S195_E1.4990.99
18_L76_V1.4930.99
38_V76_V1.4920.99
153_D199_G1.4720.99
17_D73_A1.4520.99
60_E161_D1.4370.99
19_D73_A1.4240.99
119_L122_L1.4030.99
113_A132_A1.3940.99
12_A85_D1.3910.99
161_D190_E1.3550.98
23_S108_P1.3550.98
112_V133_L1.3340.98
168_W174_F1.3130.98
67_F76_V1.3100.98
41_D66_E1.3000.98
85_D146_G1.2860.98
52_S55_S1.2840.98
38_V67_F1.2510.97
185_T192_L1.2470.97
87_A143_A1.2410.97
175_D195_E1.2340.97
165_V174_F1.2160.97
13_H206_T1.2020.97
147_I203_W1.1960.97
86_I140_F1.1810.96
15_V77_T1.1710.96
37_G73_A1.1700.96
35_S75_R1.1650.96
44_T62_A1.1540.96
110_L133_L1.1540.96
115_E132_A1.1470.96
53_A56_M1.1470.96
25_L106_S1.1430.96
31_M161_D1.1200.95
13_H33_S1.0880.94
91_L94_E1.0780.94
37_G74_G1.0780.94
78_L105_A1.0780.94
16_V78_L1.0380.93
34_H159_V1.0220.92
92_D136_T1.0160.92
182_L186_L1.0100.92
117_G130_P1.0090.92
91_L139_V1.0000.91
40_I179_V0.9970.91
143_A147_I0.9910.91
106_S110_L0.9750.90
155_G172_V0.9720.90
26_A67_F0.9670.90
107_D138_T0.9660.90
32_V79_A0.9630.90
121_S128_I0.9580.89
150_V204_Y0.9560.89
58_G131_L0.9460.89
27_E63_F0.9330.88
160_V204_Y0.9300.88
12_A206_T0.9300.88
79_A104_L0.9240.88
91_L136_T0.9150.87
89_H141_L0.9110.87
96_L139_V0.9060.86
24_I78_L0.9050.86
94_E136_T0.8870.85
183_K187_L0.8860.85
178_R181_G0.8810.85
60_E190_E0.8780.85
31_M190_E0.8770.85
179_V184_S0.8700.84
14_L86_I0.8680.84
8_R12_A0.8660.84
152_L157_S0.8580.83
19_D22_E0.8530.83
94_E170_E0.8470.83
36_A157_S0.8460.82
46_R50_L0.8450.82
27_E142_E0.8430.82
50_L53_A0.8400.82
178_R185_T0.8360.82
40_I65_N0.8340.82
160_V165_V0.8270.81
116_F168_W0.8230.81
47_D63_F0.8170.80
130_P174_F0.8050.79
136_T153_D0.8030.79
152_L172_V0.8030.79
109_S136_T0.8020.79
42_T65_N0.7970.79
97_Y115_E0.7960.78
177_R180_G0.7960.78
110_L171_S0.7960.78
134_S170_E0.7940.78
35_S74_G0.7920.78
48_G51_S0.7880.78
36_A74_G0.7880.78
120_K175_D0.7810.77
169_E203_W0.7810.77
97_Y168_W0.7760.77
25_L43_S0.7720.76
8_R55_S0.7710.76
146_G206_T0.7670.76
169_E172_V0.7620.75
51_S111_D0.7560.75
97_Y132_A0.7530.75
196_F204_Y0.7430.74
97_Y130_P0.7380.73
177_R197_T0.7360.73
176_A192_L0.7360.73
132_A170_E0.7310.72
25_L66_E0.7280.72
159_V193_V0.7270.72
180_G184_S0.7260.72
87_A149_R0.7220.71
91_L95_T0.7210.71
9_P146_G0.7180.71
117_G121_S0.7140.71
115_E174_F0.7140.71
150_V158_Y0.7140.71
18_L38_V0.7090.70
153_D156_E0.7050.70
160_V196_F0.7020.69
28_P42_T0.6960.69
182_L185_T0.6870.68
27_E61_S0.6780.67
80_P144_F0.6730.66
87_A141_L0.6670.65
106_S112_V0.6600.65
40_I110_L0.6600.65
208_G211_A0.6580.64
100_D128_I0.6520.64
48_G54_K0.6510.63
37_G156_E0.6480.63
164_H208_G0.6460.63
38_V95_T0.6450.63
48_G55_S0.6430.63
29_G125_G0.6380.62
90_D94_E0.6370.62
46_R51_S0.6350.62
99_V130_P0.6350.62
24_I73_A0.6350.62
196_F200_G0.6320.61
23_S119_L0.6320.61
20_P73_A0.6290.61
168_W188_S0.6280.61
180_G191_G0.6230.60
65_N130_P0.6190.60
144_F208_G0.6190.60
108_P182_L0.6130.59
60_E189_G0.6120.59
60_E101_G0.6100.58
98_A139_V0.6100.58
154_P157_S0.6100.58
166_V203_W0.6100.58
60_E99_V0.6080.58
80_P142_E0.6030.58
19_D151_D0.6020.57
105_A139_V0.6000.57
114_S133_L0.6000.57
145_G205_Q0.6000.57
46_R62_A0.5990.57
99_V126_A0.5950.57
126_A166_V0.5930.56
30_A161_D0.5930.56
159_V177_R0.5910.56
20_P69_A0.5910.56
110_L139_V0.5880.56
133_L141_L0.5880.56
164_H211_A0.5870.56
52_S111_D0.5850.55
126_A163_E0.5850.55
49_L106_S0.5850.55
15_V87_A0.5840.55
25_L64_A0.5830.55
107_D110_L0.5820.55
143_A167_A0.5800.55
59_G189_G0.5790.55
99_V131_L0.5770.54
59_G125_G0.5750.54
168_W196_F0.5740.54
126_A162_N0.5740.54
62_A131_L0.5720.54
124_A174_F0.5720.54
124_A163_E0.5720.54
89_H147_I0.5710.54
164_H206_T0.5700.53
184_S194_M0.5700.53
160_V164_H0.5680.53
25_L112_V0.5670.53
95_T173_D0.5660.53
99_V162_N0.5650.53
39_S68_A0.5640.53
165_V196_F0.5630.53
32_V168_W0.5630.53
31_M104_L0.5610.52
153_D171_S0.5610.52
60_E162_N0.5580.52
46_R66_E0.5560.52
82_K142_E0.5490.51
144_F206_T0.5470.50
101_G159_V0.5450.50
26_A30_A0.5440.50
33_S158_Y0.5430.50
56_M113_A0.5430.50
49_L53_A0.5420.50
179_V191_G0.5400.50
115_E118_G0.5390.49
118_G183_K0.5370.49
147_I167_A0.5370.49
151_D199_G0.5370.49
21_G39_S0.5350.49
113_A134_S0.5350.49
48_G56_M0.5340.49
50_L55_S0.5300.48
96_L141_L0.5300.48
160_V195_E0.5300.48
69_A73_A0.5300.48
38_V112_V0.5280.48
42_T187_L0.5280.48
52_S62_A0.5280.48
35_S158_Y0.5270.48
56_M134_S0.5270.48
147_I201_S0.5270.48
167_A196_F0.5250.48
96_L201_S0.5230.47
146_G203_W0.5210.47
19_D24_I0.5210.47
42_T179_V0.5190.47
144_F207_R0.5150.46
115_E166_V0.5150.46
41_D183_K0.5150.46
52_S56_M0.5150.46
33_S128_I0.5130.46
109_S124_A0.5120.46
103_F133_L0.5110.46
154_P199_G0.5080.46
47_D55_S0.5080.46
80_P207_R0.5050.45
152_L155_G0.5040.45
97_Y207_R0.5040.45
159_V175_D0.5040.45
59_G152_L0.5040.45
114_S181_G0.5030.45
175_D197_T0.5030.45
128_I193_V0.5030.45
39_S66_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg6A 3 0.8979 100 0.176 Contact Map
1yoxA 3 0.8979 100 0.185 Contact Map
2eeaA 1 0.3532 15.2 0.959 Contact Map
2di8A 1 0.3106 9.3 0.963 Contact Map
2k9uA 1 0.3404 8.6 0.963 Contact Map
2eecA 1 0.3489 8.5 0.963 Contact Map
2dlwA 1 0.4426 7.6 0.964 Contact Map
2qnkA 1 0.7617 7.5 0.964 Contact Map
2d7oA 1 0.3106 6.9 0.965 Contact Map
2di9A 1 0.3957 6.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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