Q9HPJ3 - HALSA - GREMLIN Contacts

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Q9HPJ3 - Uncharacterized protein

UniProt:	Q9HPJ3	Sequences: MSEFDQPVLDDHLHLDAENQGLDAVRDFARAGGTHLLVVNKPSWHLGVEPDTGADFRPVFEETARLVEAAREILDGEAWPVLGVHPGLVSRLVEERGFSPGEARDLMCAGIDAAAAVASEGRAVALKSGRPHYDVSSAVWEASNAVIRHACERAADVGVSLQLHTESTDDLTAVGEWASAAGLAPEAVVKHYASGRLSGCTPSVMCDKEYLQDAVGSGERFLMETDFIDDADRPGAVMGPKTVPRRVRWLLESGHEDAVRRAHVETPAAVYGIDTEATLDG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (265)
Sequences:	158 (113)
Seq/√Len:	6.9

HALSA - Q9HPJ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_D	41_K	5.009	0.99
147_I	151_C	4.903	0.99
251_L	259_V	3.369	0.90
111_I	153_R	3.117	0.85
126_L	193_A	2.882	0.80
147_I	161_L	2.882	0.80
23_D	26_R	2.652	0.74
104_R	145_A	2.476	0.69
41_K	223_M	2.472	0.69
247_V	263_H	2.325	0.64
154_A	161_L	2.279	0.62
112_D	149_H	2.267	0.61
37_L	125_A	2.264	0.61
31_A	68_E	2.250	0.61
71_R	76_G	2.246	0.61
94_E	120_E	2.240	0.61
256_E	269_A	2.200	0.59
16_D	223_M	2.154	0.57
57_R	269_A	2.154	0.57
27_D	154_A	2.137	0.57
38_V	67_V	2.100	0.55
87_G	133_Y	2.059	0.54
85_H	162_Q	2.052	0.54
118_A	159_V	1.994	0.51
162_Q	239_G	1.964	0.50
81_V	84_V	1.912	0.48
38_V	78_A	1.889	0.47
223_M	263_H	1.879	0.47
64_A	187_A	1.868	0.47
189_V	265_E	1.863	0.46
11_D	126_L	1.837	0.45
85_H	133_Y	1.816	0.45
223_M	247_V	1.813	0.44
55_D	202_P	1.787	0.43
26_R	73_I	1.767	0.43
16_D	19_N	1.753	0.42
189_V	270_V	1.734	0.41
251_L	261_R	1.724	0.41
11_D	222_L	1.712	0.41
60_F	127_K	1.689	0.40
10_D	14_H	1.680	0.39
165_T	190_K	1.648	0.38
6_Q	259_V	1.644	0.38
114_A	123_A	1.615	0.37
225_T	238_M	1.612	0.37
18_E	62_E	1.602	0.37
67_V	71_R	1.593	0.36
233_R	236_A	1.579	0.36
104_R	108_C	1.571	0.36
11_D	158_G	1.558	0.35
31_A	228_I	1.554	0.35
160_S	212_Q	1.547	0.35
39_V	47_G	1.544	0.35
165_T	225_T	1.525	0.34
190_K	243_V	1.523	0.34
89_V	151_C	1.514	0.34
34_T	123_A	1.514	0.34
53_G	109_A	1.474	0.32
22_L	141_E	1.466	0.32
85_H	239_G	1.459	0.32
57_R	116_A	1.456	0.32
192_Y	236_A	1.432	0.31
85_H	88_L	1.429	0.31
9_L	37_L	1.427	0.31
225_T	241_K	1.417	0.30
7_P	46_L	1.408	0.30
206_C	210_Y	1.379	0.29
120_E	228_I	1.377	0.29
161_L	199_G	1.374	0.29
111_I	150_A	1.373	0.29
64_A	158_G	1.338	0.28
133_Y	162_Q	1.327	0.28
225_T	246_R	1.319	0.27
54_A	57_R	1.316	0.27
17_A	161_L	1.314	0.27
54_A	211_L	1.309	0.27
105_D	187_A	1.291	0.27
23_D	213_D	1.288	0.26
161_L	213_D	1.288	0.26
81_V	236_A	1.272	0.26
11_D	203_S	1.270	0.26
24_A	34_T	1.263	0.26
131_P	144_N	1.263	0.26
42_P	263_H	1.259	0.26
124_V	268_A	1.258	0.26
251_L	255_H	1.257	0.26
43_S	133_Y	1.256	0.25
147_I	163_L	1.254	0.25
106_L	227_F	1.250	0.25
90_S	133_Y	1.239	0.25
239_G	263_H	1.231	0.25
216_G	265_E	1.227	0.25
229_D	233_R	1.222	0.25
58_P	102_E	1.211	0.24
201_T	220_R	1.204	0.24
103_A	140_W	1.196	0.24
64_A	212_Q	1.175	0.23
203_S	243_V	1.173	0.23
212_Q	253_S	1.171	0.23
174_V	231_A	1.168	0.23
84_V	160_S	1.162	0.23
49_E	96_R	1.158	0.23
151_C	161_L	1.157	0.23
8_V	273_I	1.150	0.23
81_V	242_T	1.149	0.23
150_A	205_M	1.144	0.22
63_T	231_A	1.143	0.22
44_W	92_L	1.123	0.22
162_Q	241_K	1.121	0.22
144_N	178_A	1.120	0.22
29_A	75_D	1.120	0.22
35_H	127_K	1.112	0.22
85_H	233_R	1.111	0.22
223_M	241_K	1.104	0.21
84_V	162_Q	1.094	0.21
126_L	197_L	1.081	0.21
112_D	153_R	1.078	0.21
41_K	263_H	1.075	0.21
176_E	186_E	1.071	0.20
165_T	171_L	1.069	0.20
177_W	181_A	1.056	0.20
130_R	166_E	1.045	0.20
190_K	225_T	1.040	0.20
181_A	274_D	1.039	0.20
235_G	239_G	1.034	0.20
156_D	261_R	1.030	0.19
113_A	117_V	1.027	0.19
114_A	237_V	1.023	0.19
35_H	60_F	1.020	0.19
59_V	89_V	1.017	0.19
52_T	161_L	1.015	0.19
19_N	41_K	1.011	0.19
93_V	174_V	1.007	0.19
127_K	149_H	1.003	0.19
87_G	227_F	1.002	0.19
180_A	184_A	1.001	0.19
146_V	157_V	0.999	0.19
121_G	240_P	0.999	0.19
190_K	244_P	0.997	0.19
28_F	33_G	0.994	0.19
147_I	214_A	0.990	0.19
63_T	123_A	0.990	0.19
97_G	177_W	0.986	0.18
126_L	145_A	0.982	0.18
167_S	193_A	0.980	0.18
155_A	266_T	0.978	0.18
18_E	58_P	0.973	0.18
57_R	113_A	0.971	0.18
148_R	152_E	0.963	0.18
18_E	272_G	0.963	0.18
54_A	59_V	0.961	0.18
109_A	184_A	0.956	0.18
175_G	185_P	0.954	0.18
199_G	214_A	0.951	0.18
261_R	266_T	0.951	0.18
122_R	172_T	0.940	0.17
103_A	142_A	0.939	0.17
121_G	150_A	0.939	0.17
241_K	263_H	0.937	0.17
116_A	187_A	0.931	0.17
64_A	78_A	0.930	0.17
58_P	205_M	0.926	0.17
67_V	78_A	0.918	0.17
135_V	237_V	0.914	0.17
137_S	269_A	0.913	0.17
112_D	194_S	0.911	0.17
269_A	274_D	0.904	0.17
43_S	162_Q	0.903	0.17
9_L	239_G	0.901	0.17
117_V	127_K	0.896	0.16
56_F	88_L	0.896	0.16
39_V	240_P	0.894	0.16
18_E	87_G	0.894	0.16
99_S	138_A	0.891	0.16
145_A	180_A	0.888	0.16
264_V	268_A	0.888	0.16
23_D	65_R	0.881	0.16
174_V	209_E	0.879	0.16
35_H	128_S	0.875	0.16
13_L	19_N	0.874	0.16
26_R	179_S	0.866	0.16
102_E	112_D	0.863	0.16
118_A	202_P	0.861	0.16
88_L	247_V	0.858	0.16
130_R	144_N	0.857	0.16
67_V	80_P	0.857	0.16
42_P	110_G	0.856	0.16
41_K	230_D	0.854	0.16
158_G	205_M	0.852	0.16
23_D	102_E	0.847	0.15
153_R	157_V	0.847	0.15
27_D	62_E	0.847	0.15
225_T	242_T	0.847	0.15
163_L	184_A	0.845	0.15
241_K	247_V	0.844	0.15
120_E	213_D	0.841	0.15
204_V	216_G	0.838	0.15
141_E	273_I	0.837	0.15
40_N	225_T	0.826	0.15
58_P	61_E	0.826	0.15
32_G	234_P	0.823	0.15
42_P	244_P	0.820	0.15
78_A	84_V	0.810	0.15
76_G	205_M	0.804	0.15
34_T	267_P	0.802	0.15
108_C	118_A	0.798	0.15
64_A	186_E	0.797	0.15
162_Q	223_M	0.797	0.15
29_A	64_A	0.797	0.15
157_V	213_D	0.789	0.14
18_E	25_V	0.787	0.14
206_C	238_M	0.780	0.14
154_A	257_D	0.779	0.14
105_D	185_P	0.779	0.14
24_A	123_A	0.779	0.14
122_R	141_E	0.774	0.14
17_A	231_A	0.773	0.14
20_Q	27_D	0.770	0.14
67_V	168_T	0.768	0.14
69_A	158_G	0.767	0.14
180_A	265_E	0.766	0.14
24_A	103_A	0.764	0.14
110_G	221_F	0.761	0.14
26_R	151_C	0.760	0.14
123_A	195_G	0.760	0.14
124_V	181_A	0.759	0.14
117_V	174_V	0.757	0.14
72_E	149_H	0.756	0.14
139_V	213_D	0.755	0.14
47_G	116_A	0.751	0.14
199_G	204_V	0.748	0.14
54_A	186_E	0.747	0.14
171_L	193_A	0.746	0.14
112_D	157_V	0.743	0.14
63_T	267_P	0.740	0.13
181_A	200_C	0.739	0.13
122_R	260_R	0.736	0.13
209_E	212_Q	0.730	0.13
13_L	36_L	0.729	0.13
148_R	181_A	0.728	0.13
81_V	85_H	0.726	0.13
123_A	175_G	0.725	0.13
85_H	241_K	0.725	0.13
148_R	180_A	0.721	0.13
73_I	156_D	0.719	0.13
25_V	184_A	0.718	0.13
238_M	242_T	0.718	0.13
42_P	63_T	0.716	0.13
118_A	144_N	0.715	0.13
162_Q	263_H	0.712	0.13
105_D	136_S	0.711	0.13
54_A	183_L	0.704	0.13
210_Y	215_V	0.702	0.13
76_G	267_P	0.695	0.13
25_V	180_A	0.692	0.13
85_H	160_S	0.691	0.13
12_H	130_R	0.691	0.13
169_D	243_V	0.691	0.13
176_E	213_D	0.687	0.13
125_A	243_V	0.687	0.13
76_G	262_A	0.684	0.13
160_S	189_V	0.683	0.12
8_V	31_A	0.681	0.12
68_E	134_D	0.678	0.12
41_K	205_M	0.675	0.12
15_L	179_S	0.674	0.12
220_R	266_T	0.672	0.12
223_M	244_P	0.670	0.12
40_N	247_V	0.668	0.12
29_A	255_H	0.663	0.12
171_L	223_M	0.662	0.12
117_V	128_S	0.662	0.12
9_L	267_P	0.661	0.12
189_V	216_G	0.660	0.12
76_G	189_V	0.657	0.12
111_I	118_A	0.656	0.12
15_L	183_L	0.655	0.12
115_A	215_V	0.653	0.12
67_V	139_V	0.653	0.12
132_H	226_D	0.650	0.12
164_H	191_H	0.650	0.12
164_H	224_E	0.650	0.12
86_P	129_G	0.650	0.12
164_H	226_D	0.650	0.12
191_H	224_E	0.650	0.12
191_H	226_D	0.650	0.12
132_H	224_E	0.650	0.12
132_H	191_H	0.650	0.12
86_P	224_E	0.650	0.12
129_G	132_H	0.650	0.12
129_G	164_H	0.650	0.12
86_P	191_H	0.650	0.12
129_G	191_H	0.650	0.12
129_G	224_E	0.650	0.12
129_G	226_D	0.650	0.12
86_P	164_H	0.650	0.12
86_P	132_H	0.650	0.12
132_H	164_H	0.650	0.12
86_P	226_D	0.650	0.12
246_R	252_E	0.650	0.12
65_R	212_Q	0.649	0.12
175_G	200_C	0.649	0.12
20_Q	247_V	0.647	0.12
175_G	246_R	0.645	0.12
25_V	141_E	0.640	0.12
42_P	83_G	0.637	0.12
56_F	254_G	0.629	0.12
231_A	267_P	0.628	0.12
19_N	215_V	0.626	0.12
107_M	131_P	0.625	0.12
156_D	184_A	0.624	0.12
22_L	119_S	0.621	0.11
116_A	120_E	0.621	0.11
63_T	110_G	0.621	0.11
222_L	267_P	0.620	0.11
16_D	263_H	0.619	0.11
42_P	223_M	0.617	0.11
54_A	99_S	0.616	0.11
24_A	63_T	0.615	0.11
52_T	251_L	0.612	0.11
104_R	151_C	0.610	0.11
123_A	182_G	0.610	0.11
152_E	248_R	0.608	0.11
79_W	223_M	0.606	0.11
44_W	91_R	0.605	0.11
68_E	158_G	0.601	0.11
85_H	229_D	0.596	0.11
59_V	126_L	0.595	0.11
172_T	179_S	0.594	0.11
82_L	270_V	0.593	0.11
22_L	63_T	0.590	0.11
207_D	273_I	0.589	0.11
157_V	200_C	0.588	0.11
19_N	94_E	0.588	0.11
119_S	183_L	0.585	0.11
142_A	192_Y	0.585	0.11
114_A	131_P	0.582	0.11
61_E	179_S	0.582	0.11
42_P	271_Y	0.581	0.11
219_E	222_L	0.579	0.11
250_L	254_G	0.578	0.11
30_R	85_H	0.576	0.11
9_L	162_Q	0.573	0.11
40_N	250_L	0.573	0.11
11_D	37_L	0.572	0.11
11_D	131_P	0.570	0.11
170_D	251_L	0.567	0.11
11_D	206_C	0.567	0.11
75_D	148_R	0.566	0.11
139_V	193_A	0.566	0.11
110_G	231_A	0.564	0.11
13_L	147_I	0.559	0.11
161_L	200_C	0.558	0.11
203_S	272_G	0.555	0.11
142_A	246_R	0.555	0.11
33_G	166_E	0.554	0.10
260_R	264_V	0.553	0.10
20_Q	267_P	0.552	0.10
125_A	203_S	0.549	0.10
126_L	245_R	0.549	0.10
7_P	21_G	0.548	0.10
41_K	239_G	0.547	0.10
107_M	117_V	0.546	0.10
223_M	243_V	0.545	0.10
60_F	128_S	0.543	0.10
45_H	50_P	0.540	0.10
22_L	69_A	0.537	0.10
49_E	106_L	0.534	0.10
189_V	199_G	0.533	0.10
261_R	268_A	0.531	0.10
136_S	217_S	0.531	0.10
29_A	269_A	0.530	0.10
192_Y	205_M	0.529	0.10
41_K	85_H	0.529	0.10
120_E	253_S	0.529	0.10
61_E	228_I	0.525	0.10
211_L	262_A	0.522	0.10
46_L	66_L	0.521	0.10
193_A	248_R	0.521	0.10
6_Q	112_D	0.521	0.10
99_S	187_A	0.520	0.10
55_D	167_S	0.519	0.10
156_D	250_L	0.518	0.10
7_P	17_A	0.515	0.10
70_A	186_E	0.513	0.10
165_T	241_K	0.510	0.10
107_M	114_A	0.509	0.10
30_R	193_A	0.508	0.10
70_A	249_W	0.508	0.10
46_L	110_G	0.506	0.10
13_L	217_S	0.504	0.10
84_V	127_K	0.503	0.10
69_A	155_A	0.503	0.10
114_A	178_A	0.503	0.10
208_K	212_Q	0.501	0.10
71_R	78_A	0.501	0.10
52_T	97_G	0.500	0.10
213_D	253_S	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ipwA	1	0.8648	99.9	0.814	Contact Map
3ovgA	4	0.9324	99.8	0.819	Contact Map
3guwA	2	0.7794	99.8	0.825	Contact Map
3tn4A	2	0.8968	99.8	0.829	Contact Map
2ob3A	2	0.8932	99.8	0.83	Contact Map
3gtxA	2	0.8897	99.8	0.83	Contact Map
4kezA	2	0.8826	99.8	0.831	Contact Map
1bf6A	1	0.8719	99.8	0.833	Contact Map
4if2A	2	0.9075	99.8	0.835	Contact Map
3k2gA	3	0.8826	99.8	0.835	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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