GREMLIN Database
Q9HPJ3 - Uncharacterized protein
UniProt: Q9HPJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (265)
Sequences: 158 (113)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_D41_K5.0090.99
147_I151_C4.9030.99
251_L259_V3.3690.90
111_I153_R3.1170.85
126_L193_A2.8820.80
147_I161_L2.8820.80
23_D26_R2.6520.74
104_R145_A2.4760.69
41_K223_M2.4720.69
247_V263_H2.3250.64
154_A161_L2.2790.62
112_D149_H2.2670.61
37_L125_A2.2640.61
31_A68_E2.2500.61
71_R76_G2.2460.61
94_E120_E2.2400.61
256_E269_A2.2000.59
16_D223_M2.1540.57
57_R269_A2.1540.57
27_D154_A2.1370.57
38_V67_V2.1000.55
87_G133_Y2.0590.54
85_H162_Q2.0520.54
118_A159_V1.9940.51
162_Q239_G1.9640.50
81_V84_V1.9120.48
38_V78_A1.8890.47
223_M263_H1.8790.47
64_A187_A1.8680.47
189_V265_E1.8630.46
11_D126_L1.8370.45
85_H133_Y1.8160.45
223_M247_V1.8130.44
55_D202_P1.7870.43
26_R73_I1.7670.43
16_D19_N1.7530.42
189_V270_V1.7340.41
251_L261_R1.7240.41
11_D222_L1.7120.41
60_F127_K1.6890.40
10_D14_H1.6800.39
165_T190_K1.6480.38
6_Q259_V1.6440.38
114_A123_A1.6150.37
225_T238_M1.6120.37
18_E62_E1.6020.37
67_V71_R1.5930.36
233_R236_A1.5790.36
104_R108_C1.5710.36
11_D158_G1.5580.35
31_A228_I1.5540.35
160_S212_Q1.5470.35
39_V47_G1.5440.35
165_T225_T1.5250.34
190_K243_V1.5230.34
89_V151_C1.5140.34
34_T123_A1.5140.34
53_G109_A1.4740.32
22_L141_E1.4660.32
85_H239_G1.4590.32
57_R116_A1.4560.32
192_Y236_A1.4320.31
85_H88_L1.4290.31
9_L37_L1.4270.31
225_T241_K1.4170.30
7_P46_L1.4080.30
206_C210_Y1.3790.29
120_E228_I1.3770.29
161_L199_G1.3740.29
111_I150_A1.3730.29
64_A158_G1.3380.28
133_Y162_Q1.3270.28
225_T246_R1.3190.27
54_A57_R1.3160.27
17_A161_L1.3140.27
54_A211_L1.3090.27
105_D187_A1.2910.27
23_D213_D1.2880.26
161_L213_D1.2880.26
81_V236_A1.2720.26
11_D203_S1.2700.26
24_A34_T1.2630.26
131_P144_N1.2630.26
42_P263_H1.2590.26
124_V268_A1.2580.26
251_L255_H1.2570.26
43_S133_Y1.2560.25
147_I163_L1.2540.25
106_L227_F1.2500.25
90_S133_Y1.2390.25
239_G263_H1.2310.25
216_G265_E1.2270.25
229_D233_R1.2220.25
58_P102_E1.2110.24
201_T220_R1.2040.24
103_A140_W1.1960.24
64_A212_Q1.1750.23
203_S243_V1.1730.23
212_Q253_S1.1710.23
174_V231_A1.1680.23
84_V160_S1.1620.23
49_E96_R1.1580.23
151_C161_L1.1570.23
8_V273_I1.1500.23
81_V242_T1.1490.23
150_A205_M1.1440.22
63_T231_A1.1430.22
44_W92_L1.1230.22
162_Q241_K1.1210.22
144_N178_A1.1200.22
29_A75_D1.1200.22
35_H127_K1.1120.22
85_H233_R1.1110.22
223_M241_K1.1040.21
84_V162_Q1.0940.21
126_L197_L1.0810.21
112_D153_R1.0780.21
41_K263_H1.0750.21
176_E186_E1.0710.20
165_T171_L1.0690.20
177_W181_A1.0560.20
130_R166_E1.0450.20
190_K225_T1.0400.20
181_A274_D1.0390.20
235_G239_G1.0340.20
156_D261_R1.0300.19
113_A117_V1.0270.19
114_A237_V1.0230.19
35_H60_F1.0200.19
59_V89_V1.0170.19
52_T161_L1.0150.19
19_N41_K1.0110.19
93_V174_V1.0070.19
127_K149_H1.0030.19
87_G227_F1.0020.19
180_A184_A1.0010.19
146_V157_V0.9990.19
121_G240_P0.9990.19
190_K244_P0.9970.19
28_F33_G0.9940.19
147_I214_A0.9900.19
63_T123_A0.9900.19
97_G177_W0.9860.18
126_L145_A0.9820.18
167_S193_A0.9800.18
155_A266_T0.9780.18
18_E58_P0.9730.18
57_R113_A0.9710.18
148_R152_E0.9630.18
18_E272_G0.9630.18
54_A59_V0.9610.18
109_A184_A0.9560.18
175_G185_P0.9540.18
199_G214_A0.9510.18
261_R266_T0.9510.18
122_R172_T0.9400.17
103_A142_A0.9390.17
121_G150_A0.9390.17
241_K263_H0.9370.17
116_A187_A0.9310.17
64_A78_A0.9300.17
58_P205_M0.9260.17
67_V78_A0.9180.17
135_V237_V0.9140.17
137_S269_A0.9130.17
112_D194_S0.9110.17
269_A274_D0.9040.17
43_S162_Q0.9030.17
9_L239_G0.9010.17
117_V127_K0.8960.16
56_F88_L0.8960.16
39_V240_P0.8940.16
18_E87_G0.8940.16
99_S138_A0.8910.16
145_A180_A0.8880.16
264_V268_A0.8880.16
23_D65_R0.8810.16
174_V209_E0.8790.16
35_H128_S0.8750.16
13_L19_N0.8740.16
26_R179_S0.8660.16
102_E112_D0.8630.16
118_A202_P0.8610.16
88_L247_V0.8580.16
130_R144_N0.8570.16
67_V80_P0.8570.16
42_P110_G0.8560.16
41_K230_D0.8540.16
158_G205_M0.8520.16
23_D102_E0.8470.15
153_R157_V0.8470.15
27_D62_E0.8470.15
225_T242_T0.8470.15
163_L184_A0.8450.15
241_K247_V0.8440.15
120_E213_D0.8410.15
204_V216_G0.8380.15
141_E273_I0.8370.15
40_N225_T0.8260.15
58_P61_E0.8260.15
32_G234_P0.8230.15
42_P244_P0.8200.15
78_A84_V0.8100.15
76_G205_M0.8040.15
34_T267_P0.8020.15
108_C118_A0.7980.15
64_A186_E0.7970.15
162_Q223_M0.7970.15
29_A64_A0.7970.15
157_V213_D0.7890.14
18_E25_V0.7870.14
206_C238_M0.7800.14
154_A257_D0.7790.14
105_D185_P0.7790.14
24_A123_A0.7790.14
122_R141_E0.7740.14
17_A231_A0.7730.14
20_Q27_D0.7700.14
67_V168_T0.7680.14
69_A158_G0.7670.14
180_A265_E0.7660.14
24_A103_A0.7640.14
110_G221_F0.7610.14
26_R151_C0.7600.14
123_A195_G0.7600.14
124_V181_A0.7590.14
117_V174_V0.7570.14
72_E149_H0.7560.14
139_V213_D0.7550.14
47_G116_A0.7510.14
199_G204_V0.7480.14
54_A186_E0.7470.14
171_L193_A0.7460.14
112_D157_V0.7430.14
63_T267_P0.7400.13
181_A200_C0.7390.13
122_R260_R0.7360.13
209_E212_Q0.7300.13
13_L36_L0.7290.13
148_R181_A0.7280.13
81_V85_H0.7260.13
123_A175_G0.7250.13
85_H241_K0.7250.13
148_R180_A0.7210.13
73_I156_D0.7190.13
25_V184_A0.7180.13
238_M242_T0.7180.13
42_P63_T0.7160.13
118_A144_N0.7150.13
162_Q263_H0.7120.13
105_D136_S0.7110.13
54_A183_L0.7040.13
210_Y215_V0.7020.13
76_G267_P0.6950.13
25_V180_A0.6920.13
85_H160_S0.6910.13
12_H130_R0.6910.13
169_D243_V0.6910.13
176_E213_D0.6870.13
125_A243_V0.6870.13
76_G262_A0.6840.13
160_S189_V0.6830.12
8_V31_A0.6810.12
68_E134_D0.6780.12
41_K205_M0.6750.12
15_L179_S0.6740.12
220_R266_T0.6720.12
223_M244_P0.6700.12
40_N247_V0.6680.12
29_A255_H0.6630.12
171_L223_M0.6620.12
117_V128_S0.6620.12
9_L267_P0.6610.12
189_V216_G0.6600.12
76_G189_V0.6570.12
111_I118_A0.6560.12
15_L183_L0.6550.12
115_A215_V0.6530.12
67_V139_V0.6530.12
132_H226_D0.6500.12
164_H191_H0.6500.12
164_H224_E0.6500.12
86_P129_G0.6500.12
164_H226_D0.6500.12
191_H224_E0.6500.12
191_H226_D0.6500.12
132_H224_E0.6500.12
132_H191_H0.6500.12
86_P224_E0.6500.12
129_G132_H0.6500.12
129_G164_H0.6500.12
86_P191_H0.6500.12
129_G191_H0.6500.12
129_G224_E0.6500.12
129_G226_D0.6500.12
86_P164_H0.6500.12
86_P132_H0.6500.12
132_H164_H0.6500.12
86_P226_D0.6500.12
246_R252_E0.6500.12
65_R212_Q0.6490.12
175_G200_C0.6490.12
20_Q247_V0.6470.12
175_G246_R0.6450.12
25_V141_E0.6400.12
42_P83_G0.6370.12
56_F254_G0.6290.12
231_A267_P0.6280.12
19_N215_V0.6260.12
107_M131_P0.6250.12
156_D184_A0.6240.12
22_L119_S0.6210.11
116_A120_E0.6210.11
63_T110_G0.6210.11
222_L267_P0.6200.11
16_D263_H0.6190.11
42_P223_M0.6170.11
54_A99_S0.6160.11
24_A63_T0.6150.11
52_T251_L0.6120.11
104_R151_C0.6100.11
123_A182_G0.6100.11
152_E248_R0.6080.11
79_W223_M0.6060.11
44_W91_R0.6050.11
68_E158_G0.6010.11
85_H229_D0.5960.11
59_V126_L0.5950.11
172_T179_S0.5940.11
82_L270_V0.5930.11
22_L63_T0.5900.11
207_D273_I0.5890.11
157_V200_C0.5880.11
19_N94_E0.5880.11
119_S183_L0.5850.11
142_A192_Y0.5850.11
114_A131_P0.5820.11
61_E179_S0.5820.11
42_P271_Y0.5810.11
219_E222_L0.5790.11
250_L254_G0.5780.11
30_R85_H0.5760.11
9_L162_Q0.5730.11
40_N250_L0.5730.11
11_D37_L0.5720.11
11_D131_P0.5700.11
170_D251_L0.5670.11
11_D206_C0.5670.11
75_D148_R0.5660.11
139_V193_A0.5660.11
110_G231_A0.5640.11
13_L147_I0.5590.11
161_L200_C0.5580.11
203_S272_G0.5550.11
142_A246_R0.5550.11
33_G166_E0.5540.10
260_R264_V0.5530.10
20_Q267_P0.5520.10
125_A203_S0.5490.10
126_L245_R0.5490.10
7_P21_G0.5480.10
41_K239_G0.5470.10
107_M117_V0.5460.10
223_M243_V0.5450.10
60_F128_S0.5430.10
45_H50_P0.5400.10
22_L69_A0.5370.10
49_E106_L0.5340.10
189_V199_G0.5330.10
261_R268_A0.5310.10
136_S217_S0.5310.10
29_A269_A0.5300.10
192_Y205_M0.5290.10
41_K85_H0.5290.10
120_E253_S0.5290.10
61_E228_I0.5250.10
211_L262_A0.5220.10
46_L66_L0.5210.10
193_A248_R0.5210.10
6_Q112_D0.5210.10
99_S187_A0.5200.10
55_D167_S0.5190.10
156_D250_L0.5180.10
7_P17_A0.5150.10
70_A186_E0.5130.10
165_T241_K0.5100.10
107_M114_A0.5090.10
30_R193_A0.5080.10
70_A249_W0.5080.10
46_L110_G0.5060.10
13_L217_S0.5040.10
84_V127_K0.5030.10
69_A155_A0.5030.10
114_A178_A0.5030.10
208_K212_Q0.5010.10
71_R78_A0.5010.10
52_T97_G0.5000.10
213_D253_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ipwA 1 0.8648 99.9 0.814 Contact Map
3ovgA 4 0.9324 99.8 0.819 Contact Map
3guwA 2 0.7794 99.8 0.825 Contact Map
3tn4A 2 0.8968 99.8 0.829 Contact Map
2ob3A 2 0.8932 99.8 0.83 Contact Map
3gtxA 2 0.8897 99.8 0.83 Contact Map
4kezA 2 0.8826 99.8 0.831 Contact Map
1bf6A 1 0.8719 99.8 0.833 Contact Map
4if2A 2 0.9075 99.8 0.835 Contact Map
3k2gA 3 0.8826 99.8 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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