GREMLIN Database
Q9HPJ0 - 3-hydroxy-3-methylglutaryl-coenzyme A synthase
UniProt: Q9HPJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (423)
Sequences: 487 (269)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_L72_P6.4391.00
334_V359_V5.7471.00
130_A144_A5.0391.00
131_V181_E4.7841.00
110_H229_A4.3251.00
431_D442_T4.2881.00
335_H371_H4.2171.00
66_E443_Y4.0041.00
53_I149_T3.9891.00
17_K397_D3.7450.99
434_G438_E3.5340.99
419_E432_G3.4420.99
111_A145_L3.3680.98
42_H324_S3.3300.98
339_F386_S3.1800.98
77_R129_D3.0810.97
128_D369_E3.0760.97
63_R67_R2.8660.96
98_G192_D2.8650.96
387_T390_E2.7840.95
356_R372_S2.5420.92
342_L383_V2.4980.91
60_A168_A2.4520.90
182_L374_T2.4320.90
62_H66_E2.4080.89
3_S176_D2.4040.89
123_G361_S2.4020.89
191_A217_A2.3920.89
179_I373_E2.3860.89
7_D403_Y2.3410.88
226_F238_Y2.3030.87
127_L173_I2.2860.87
290_A293_D2.2720.86
8_A172_W2.2680.86
404_E407_H2.1440.83
28_M157_D2.1360.82
43_A325_Q2.1100.82
334_V371_H2.0970.81
241_I358_L2.0880.81
349_G353_A2.0790.81
65_L111_A2.0640.80
401_A405_Q2.0620.80
132_N138_R2.0600.80
227_E264_R2.0520.80
130_A148_A2.0150.78
148_A368_A2.0090.78
306_D309_R1.9600.76
81_A122_A1.9360.76
21_A32_P1.9230.75
134_I173_I1.9190.75
54_V92_V1.9140.75
19_D43_A1.8630.73
103_V108_F1.8530.72
163_T395_R1.8480.72
222_S370_I1.8370.71
56_M78_I1.8220.71
42_H325_Q1.8140.70
198_K204_P1.7960.70
226_F372_S1.7950.70
9_I179_I1.7930.70
240_F341_A1.7850.69
124_T335_H1.7850.69
399_S404_E1.7840.69
337_A340_S1.7770.69
254_A360_A1.7480.68
56_M166_A1.6870.65
238_Y358_L1.6800.64
16_L48_D1.6510.63
71_E74_D1.6460.63
354_G384_A1.6290.62
26_P32_P1.6260.62
127_L335_H1.6220.62
7_D143_G1.6220.62
381_E385_A1.6180.61
70_L337_A1.6130.61
18_L41_L1.5910.60
3_S376_Q1.5870.60
128_D335_H1.5770.59
210_R362_Y1.5710.59
299_V303_T1.5680.59
153_L407_H1.5570.58
432_G440_K1.5400.57
408_D412_H1.5260.57
167_G215_Y1.5170.56
116_R254_A1.5170.56
18_L400_F1.5140.56
248_P320_L1.4910.55
207_D210_R1.4860.55
123_G147_I1.4840.54
352_L356_R1.4730.54
313_D317_Q1.4670.54
358_L370_I1.4630.53
72_P111_A1.4620.53
225_D228_R1.4400.52
68_K385_A1.4350.52
399_S402_E1.4230.51
163_T211_S1.4090.51
291_F295_I1.4080.50
188_Y357_L1.3790.49
193_E362_Y1.3630.48
25_A33_E1.3620.48
115_E190_S1.3490.47
310_E314_A1.3380.47
68_K307_A1.3340.47
217_A292_E1.3320.47
375_V378_G1.3140.46
144_A167_G1.3100.45
82_T92_V1.3080.45
325_Q388_I1.3080.45
121_I369_E1.2940.45
128_D371_H1.2860.44
230_T235_P1.2830.44
147_I163_T1.2820.44
11_I339_F1.2780.44
121_I125_Q1.2780.44
156_R404_E1.2700.43
67_R391_Q1.2680.43
117_K254_A1.2680.43
54_V95_Y1.2540.42
9_I355_K1.2450.42
357_L375_V1.2380.42
103_V107_D1.2360.42
311_W436_M1.2340.41
316_I341_A1.2270.41
205_S436_M1.2200.41
3_S145_L1.2190.41
47_P406_V1.2180.41
28_M35_Y1.2120.40
323_S370_I1.2110.40
323_S337_A1.2090.40
110_H436_M1.2030.40
248_P358_L1.1850.39
97_A111_A1.1840.39
240_F316_I1.1830.39
239_A355_K1.1760.39
125_Q162_A1.1720.38
356_R374_T1.1590.38
156_R415_S1.1550.38
415_S431_D1.1540.37
332_G368_A1.1520.37
5_G14_G1.1510.37
189_G221_E1.1450.37
70_L368_A1.1390.37
223_L226_F1.1380.37
242_P334_V1.1360.37
94_T369_E1.1260.36
81_A129_D1.1210.36
77_R249_G1.1190.36
65_L412_H1.1180.36
242_P319_T1.1170.36
53_I92_V1.1150.36
182_L185_E1.1140.36
147_I169_V1.1140.36
189_G358_L1.1130.35
250_M254_A1.1090.35
79_D129_D1.1050.35
61_A100_L1.1040.35
93_S113_K1.0950.35
247_F252_R1.0770.34
146_V169_V1.0740.34
221_E225_D1.0710.33
166_A190_S1.0690.33
267_D297_E1.0660.33
58_A95_Y1.0610.33
398_I406_V1.0610.33
33_E36_T1.0600.33
367_Q375_V1.0520.33
259_Y263_I1.0470.32
179_I319_T1.0460.32
38_G52_D1.0460.32
31_D70_L1.0450.32
179_I375_V1.0430.32
309_R313_D1.0420.32
168_A332_G1.0380.32
179_I351_D1.0300.32
57_G96_I1.0280.32
343_K391_Q1.0260.31
323_S336_L1.0260.31
60_A317_Q1.0240.31
380_T384_A1.0210.31
75_V418_L1.0190.31
421_F432_G1.0150.31
408_D413_E1.0150.31
92_V414_K1.0140.31
189_G225_D1.0140.31
145_L322_I1.0130.31
315_A326_V1.0090.31
74_D143_G1.0070.31
29_G433_W0.9960.30
221_E224_Q0.9950.30
72_P403_Y0.9940.30
13_T433_W0.9930.30
125_Q371_H0.9930.30
60_A332_G0.9890.30
213_Q307_A0.9830.30
196_F208_G0.9800.29
341_A369_E0.9780.29
117_K334_V0.9780.29
264_R342_L0.9730.29
301_G329_W0.9690.29
358_L368_A0.9670.29
190_S194_T0.9640.29
169_V361_S0.9620.29
274_A277_G0.9590.28
196_F199_P0.9550.28
191_A326_V0.9540.28
216_L337_A0.9530.28
361_S395_R0.9530.28
326_V391_Q0.9520.28
275_D393_E0.9510.28
416_V428_F0.9480.28
84_S149_T0.9430.28
403_Y416_V0.9420.28
256_V261_H0.9390.28
212_M247_F0.9380.28
231_G264_R0.9380.28
294_A309_R0.9380.28
123_G366_A0.9360.27
211_S362_Y0.9330.27
148_A331_T0.9330.27
39_L52_D0.9310.27
247_F250_M0.9270.27
24_F41_L0.9240.27
132_N335_H0.9220.27
11_I404_E0.9200.27
156_R408_D0.9170.27
216_L312_Y0.9130.27
43_A191_A0.9040.26
61_A111_A0.9040.26
337_A368_A0.9010.26
357_L378_G0.8980.26
373_E381_E0.8970.26
220_R256_V0.8920.26
74_D173_I0.8910.26
10_E13_T0.8910.26
125_Q369_E0.8880.26
161_E164_Q0.8850.25
26_P176_D0.8820.25
22_E192_D0.8780.25
214_V325_Q0.8780.25
25_A38_G0.8770.25
123_G169_V0.8770.25
266_T273_A0.8750.25
275_D279_Q0.8740.25
136_A140_R0.8740.25
27_E41_L0.8730.25
11_I21_A0.8730.25
362_Y365_G0.8720.25
326_V388_I0.8720.25
183_S229_A0.8680.25
63_R69_G0.8630.25
209_K415_S0.8610.24
147_I361_S0.8600.24
312_Y316_I0.8600.24
13_T47_P0.8590.24
135_L140_R0.8580.24
63_R314_A0.8560.24
291_F294_A0.8520.24
49_A91_P0.8520.24
188_Y369_E0.8510.24
114_G134_I0.8510.24
417_E433_W0.8500.24
24_F28_M0.8440.24
13_T67_R0.8430.24
188_Y368_A0.8420.24
84_S111_A0.8410.24
245_T337_A0.8410.24
332_G376_Q0.8400.24
273_A276_I0.8360.24
115_E329_W0.8360.24
238_Y304_D0.8350.23
214_V254_A0.8330.23
132_N187_G0.8300.23
149_T173_I0.8290.23
116_R200_N0.8280.23
276_I431_D0.8270.23
423_Q435_P0.8220.23
92_V95_Y0.8220.23
413_E418_L0.8210.23
45_S317_Q0.8190.23
144_A151_T0.8190.23
76_G133_W0.8180.23
86_F307_A0.8170.23
112_N128_D0.8130.23
190_S367_Q0.8130.23
359_V405_Q0.8120.23
19_D47_P0.8110.23
358_L376_Q0.8100.23
53_I414_K0.8080.22
54_V252_R0.8050.22
148_A191_A0.8050.22
357_L401_A0.8040.22
173_I387_T0.8020.22
210_R403_Y0.8010.22
216_L407_H0.8010.22
98_G116_R0.7990.22
418_L425_D0.7980.22
168_A199_P0.7980.22
127_L205_S0.7980.22
48_D316_I0.7970.22
155_A339_F0.7950.22
171_M224_Q0.7940.22
100_L111_A0.7920.22
51_E243_F0.7920.22
359_V373_E0.7910.22
64_L198_K0.7910.22
17_K395_R0.7890.22
186_Q395_R0.7860.22
125_Q128_D0.7820.22
110_H310_E0.7820.22
9_I45_S0.7810.22
212_M216_L0.7790.21
48_D422_T0.7780.21
80_V144_A0.7770.21
9_I300_D0.7760.21
276_I280_P0.7730.21
163_T322_I0.7690.21
174_T178_D0.7690.21
125_Q168_A0.7690.21
218_R366_A0.7680.21
210_R252_R0.7670.21
236_D436_M0.7650.21
370_I416_V0.7650.21
216_L225_D0.7620.21
116_R125_Q0.7570.21
224_Q368_A0.7550.21
264_R383_V0.7550.21
222_S254_A0.7530.21
320_L362_Y0.7530.21
42_H78_I0.7500.20
183_S403_Y0.7500.20
195_D199_P0.7480.20
65_L74_D0.7470.20
21_A351_D0.7460.20
145_L291_F0.7450.20
342_L408_D0.7450.20
277_G280_P0.7440.20
312_Y326_V0.7440.20
206_V239_A0.7430.20
50_Y91_P0.7420.20
243_F371_H0.7390.20
61_A145_L0.7370.20
74_D326_V0.7330.20
379_F382_A0.7310.20
21_A237_D0.7310.20
169_V265_G0.7300.20
94_T358_L0.7290.20
38_G44_S0.7280.20
415_S440_K0.7280.20
24_F38_G0.7280.20
378_G422_T0.7270.20
65_L405_Q0.7240.20
187_G225_D0.7220.19
210_R216_L0.7220.19
36_T39_L0.7170.19
54_V210_R0.7160.19
22_E350_I0.7150.19
54_V413_E0.7130.19
190_S229_A0.7120.19
172_W401_A0.7110.19
93_S97_A0.7110.19
278_R357_L0.7110.19
4_V78_I0.7100.19
390_E393_E0.7100.19
57_G183_S0.7090.19
310_E313_D0.7080.19
53_I57_G0.7080.19
125_Q443_Y0.7070.19
194_T211_S0.7070.19
70_L355_K0.7050.19
143_G174_T0.7050.19
112_N157_D0.7040.19
69_G380_T0.7040.19
16_L248_P0.7040.19
162_A214_V0.7030.19
73_A176_D0.7030.19
187_G370_I0.7010.19
64_L145_L0.7010.19
80_V253_K0.7010.19
125_Q247_F0.7010.19
292_E435_P0.6960.19
222_S360_A0.6960.19
114_G360_A0.6960.19
199_P364_S0.6950.19
259_Y318_P0.6930.19
236_D311_W0.6910.18
242_P303_T0.6910.18
10_E63_R0.6880.18
271_E310_E0.6880.18
70_L74_D0.6880.18
72_P108_F0.6870.18
19_D183_S0.6870.18
248_P324_S0.6870.18
89_S270_E0.6860.18
171_M230_T0.6850.18
9_I228_R0.6850.18
169_V366_A0.6830.18
152_A244_H0.6820.18
357_L373_E0.6820.18
276_I303_T0.6810.18
232_A287_S0.6800.18
47_P312_Y0.6800.18
75_V239_A0.6780.18
61_A148_A0.6760.18
49_A96_I0.6750.18
304_D358_L0.6730.18
32_P306_D0.6710.18
310_E387_T0.6690.18
287_S336_L0.6680.18
53_I82_T0.6680.18
179_I416_V0.6670.18
4_V230_T0.6660.18
209_K325_Q0.6660.18
265_G270_E0.6630.18
237_D436_M0.6600.18
85_A117_K0.6600.18
15_K424_P0.6590.18
56_M205_S0.6590.18
48_D403_Y0.6580.17
127_L432_G0.6580.17
272_L337_A0.6580.17
56_M404_E0.6570.17
303_T443_Y0.6570.17
169_V431_D0.6570.17
64_L170_A0.6560.17
173_I411_N0.6560.17
342_L351_D0.6560.17
299_V443_Y0.6550.17
110_H125_Q0.6540.17
52_D90_K0.6540.17
212_M323_S0.6530.17
161_E177_P0.6520.17
155_A436_M0.6520.17
106_G296_S0.6510.17
267_D415_S0.6500.17
252_R326_V0.6500.17
73_A233_S0.6480.17
59_N127_L0.6470.17
110_H402_E0.6470.17
78_I186_Q0.6460.17
63_R387_T0.6450.17
277_G407_H0.6440.17
421_F437_N0.6440.17
36_T41_L0.6440.17
117_K322_I0.6430.17
61_A374_T0.6420.17
163_T186_Q0.6410.17
80_V113_K0.6410.17
33_E223_L0.6410.17
48_D337_A0.6390.17
26_P416_V0.6380.17
55_T96_I0.6360.17
4_V61_A0.6360.17
111_A193_E0.6350.17
323_S326_V0.6340.17
65_L236_D0.6330.17
260_R294_A0.6320.17
187_G339_F0.6320.17
209_K413_E0.6300.17
252_R295_I0.6290.17
222_S250_M0.6290.17
63_R385_A0.6290.17
163_T404_E0.6290.17
272_L300_D0.6260.17
124_T361_S0.6250.16
127_L371_H0.6210.16
12_H263_I0.6200.16
300_D304_D0.6180.16
68_K382_A0.6180.16
206_V253_K0.6180.16
267_D432_G0.6170.16
180_V376_Q0.6160.16
329_W332_G0.6160.16
79_D222_S0.6160.16
309_R323_S0.6150.16
216_L250_M0.6140.16
232_A288_D0.6120.16
148_A322_I0.6110.16
425_D437_N0.6100.16
143_G172_W0.6100.16
4_V65_L0.6100.16
27_E404_E0.6090.16
15_K332_G0.6090.16
334_V367_Q0.6090.16
353_A377_D0.6080.16
250_M323_S0.6080.16
25_A39_L0.6080.16
56_M316_I0.6070.16
4_V54_V0.6060.16
56_M248_P0.6050.16
56_M114_G0.6040.16
169_V345_A0.6020.16
224_Q275_D0.6010.16
127_L419_E0.6010.16
134_I433_W0.5990.16
131_V271_E0.5990.16
45_S332_G0.5980.16
394_Q442_T0.5970.16
179_I334_V0.5940.16
257_L261_H0.5940.16
361_S366_A0.5920.16
222_S362_Y0.5920.16
395_R400_F0.5920.16
94_T336_L0.5910.16
69_G404_E0.5890.15
408_D433_W0.5880.15
171_M335_H0.5860.15
314_A388_I0.5850.15
67_R331_T0.5840.15
424_P431_D0.5830.15
131_V432_G0.5830.15
94_T125_Q0.5810.15
132_N197_L0.5800.15
108_F353_A0.5790.15
121_I174_T0.5770.15
301_G306_D0.5770.15
195_D364_S0.5760.15
323_S388_I0.5750.15
233_S399_S0.5740.15
8_A171_M0.5720.15
182_L375_V0.5720.15
243_F319_T0.5720.15
388_I391_Q0.5700.15
68_K316_I0.5700.15
164_Q177_P0.5700.15
191_A265_G0.5660.15
243_F254_A0.5640.15
342_L370_I0.5640.15
361_S372_S0.5630.15
92_V320_L0.5620.15
29_G50_Y0.5620.15
375_V433_W0.5600.15
194_T197_L0.5600.15
240_F387_T0.5590.15
199_P215_Y0.5590.15
131_V373_E0.5590.15
398_I402_E0.5580.15
61_A72_P0.5580.15
230_T331_T0.5570.15
50_Y429_V0.5550.15
293_D401_A0.5550.15
211_S215_Y0.5550.15
376_Q387_T0.5550.15
35_Y38_G0.5540.15
421_F427_E0.5530.15
211_S360_A0.5530.15
67_R416_V0.5530.15
27_E373_E0.5520.14
49_A126_S0.5490.14
11_I264_R0.5490.14
343_K440_K0.5470.14
171_M200_N0.5470.14
49_A409_R0.5460.14
3_S67_R0.5460.14
417_E432_G0.5450.14
135_L139_N0.5450.14
10_E45_S0.5440.14
70_L405_Q0.5440.14
309_R314_A0.5440.14
92_V410_H0.5430.14
4_V72_P0.5410.14
166_A342_L0.5410.14
412_H419_E0.5410.14
119_A246_P0.5400.14
83_E246_P0.5400.14
83_E119_A0.5400.14
20_L395_R0.5380.14
240_F417_E0.5380.14
214_V362_Y0.5380.14
96_I429_V0.5360.14
157_D161_E0.5360.14
86_F117_K0.5350.14
222_S312_Y0.5320.14
8_A46_F0.5320.14
22_E386_S0.5310.14
414_K420_P0.5310.14
209_K247_F0.5300.14
359_V381_E0.5300.14
431_D440_K0.5290.14
349_G379_F0.5280.14
16_L19_D0.5250.14
190_S262_M0.5230.14
412_H436_M0.5230.14
383_V391_Q0.5230.14
289_D378_G0.5230.14
401_A425_D0.5220.14
176_D398_I0.5210.14
311_W404_E0.5190.14
69_G228_R0.5190.14
179_I336_L0.5190.14
91_P239_A0.5170.14
211_S323_S0.5160.14
86_F408_D0.5160.14
173_I353_A0.5150.14
264_R399_S0.5150.14
92_V157_D0.5150.14
308_Y351_D0.5150.14
59_N332_G0.5140.14
298_Y301_G0.5140.14
117_K443_Y0.5140.14
74_D383_V0.5130.14
85_A413_E0.5120.13
274_A387_T0.5110.13
243_F362_Y0.5100.13
88_N251_V0.5100.13
155_A252_R0.5090.13
312_Y336_L0.5090.13
43_A437_N0.5090.13
202_Q410_H0.5080.13
176_D188_Y0.5080.13
240_F296_S0.5080.13
148_A267_D0.5080.13
63_R391_Q0.5080.13
391_Q402_E0.5080.13
26_P61_A0.5070.13
382_A394_Q0.5060.13
153_L245_T0.5060.13
296_S417_E0.5040.13
27_E401_A0.5040.13
195_D198_K0.5040.13
75_V389_D0.5030.13
155_A388_I0.5030.13
332_G381_E0.5020.13
309_R403_Y0.5020.13
426_A443_Y0.5020.13
245_T323_S0.5020.13
229_A399_S0.5020.13
89_S207_D0.5020.13
410_H420_P0.5020.13
18_L160_G0.5010.13
128_D334_V0.5000.13
415_S437_N0.5000.13
48_D132_N0.5000.13
110_H233_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p8uA 2 0.9618 100 0.523 Contact Map
2wyaA 2 0.9618 100 0.524 Contact Map
2f82A 2 0.9596 100 0.53 Contact Map
1xpmA 2 0.8607 100 0.61 Contact Map
3sqzA 2 0.8629 100 0.616 Contact Map
3v4nA 2 0.8584 100 0.619 Contact Map
3il3A 2 0.6764 100 0.84 Contact Map
1u0mA 2 0.6809 100 0.843 Contact Map
3s21A 2 0.6652 100 0.843 Contact Map
4rybA 2 0.6787 100 0.845 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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