GREMLIN Database
Q9HPI9 - Uncharacterized protein
UniProt: Q9HPI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (170)
Sequences: 6723 (4521)
Seq/√Len: 346.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D70_R4.2391.00
8_V74_A3.1111.00
6_H40_T3.0981.00
87_S126_H2.9381.00
88_Y130_V2.7771.00
62_G66_A2.6001.00
69_A73_D2.5241.00
153_G156_E2.4961.00
30_G167_R2.4641.00
113_C120_P2.3751.00
109_V136_A2.3141.00
21_R25_R2.2551.00
131_C136_A2.2091.00
9_A24_L2.1841.00
93_K97_D1.9821.00
65_P69_A1.9601.00
110_G169_L1.9511.00
11_C21_R1.9161.00
111_L124_L1.9091.00
6_H73_D1.8601.00
66_A70_R1.8311.00
160_D164_A1.8311.00
24_L80_G1.8281.00
87_S130_V1.8171.00
67_L95_A1.7781.00
126_H129_G1.7441.00
20_T114_V1.7041.00
6_H42_D1.6601.00
163_A167_R1.6191.00
7_V76_A1.5661.00
76_A173_A1.5401.00
79_L109_V1.5261.00
21_R45_D1.5241.00
45_D48_E1.5091.00
105_G135_D1.5051.00
25_R28_F1.4931.00
9_A28_F1.4641.00
141_H172_Q1.4131.00
11_C24_L1.3881.00
28_F43_L1.3621.00
29_D156_E1.3591.00
147_N150_T1.3471.00
139_L176_Y1.3361.00
8_V44_I1.3341.00
71_V99_C1.3261.00
84_Y90_A1.3181.00
162_I165_R1.3171.00
96_L134_L1.3101.00
137_W176_Y1.2911.00
109_V131_C1.2901.00
27_V78_V1.2851.00
7_V39_V1.2841.00
83_M123_A1.2831.00
27_V112_V1.2751.00
110_G173_A1.2701.00
81_T113_C1.2671.00
81_T127_L1.2651.00
160_D163_A1.2611.00
63_D66_A1.2581.00
79_L131_C1.2441.00
69_A72_A1.2431.00
86_G122_Q1.2251.00
39_V174_V1.1911.00
90_A97_D1.1691.00
77_L104_L1.1681.00
151_T159_D1.1681.00
20_T80_G1.1661.00
71_V77_L1.1611.00
88_Y126_H1.1551.00
113_C124_L1.1541.00
53_P94_N1.1291.00
67_L99_C1.1231.00
42_D74_A1.1131.00
10_I79_L1.1071.00
120_P124_L1.0961.00
143_V169_L1.0951.00
62_G65_P1.0871.00
174_V178_N1.0751.00
53_P91_P1.0731.00
64_A98_Y1.0631.00
76_A177_A1.0631.00
5_T177_A1.0631.00
25_R43_L1.0521.00
17_D22_T1.0421.00
115_A144_G1.0421.00
68_R99_C1.0331.00
122_Q125_S1.0191.00
71_V95_A1.0171.00
145_V162_I1.0021.00
164_A168_T0.9981.00
30_G163_A0.9961.00
132_D138_T0.9901.00
27_V166_A0.9881.00
50_S63_D0.9851.00
48_E66_A0.9821.00
30_G170_G0.9821.00
9_A43_L0.9721.00
79_L92_L0.9621.00
139_L173_A0.9611.00
167_R171_E0.9461.00
79_L96_L0.9301.00
11_C20_T0.9271.00
9_A41_T0.9201.00
169_L173_A0.9191.00
19_G148_A0.9171.00
23_A114_V0.9171.00
164_A167_R0.9171.00
26_T29_D0.9131.00
90_A93_K0.9111.00
66_A69_A0.9101.00
161_D164_A0.9061.00
83_M122_Q0.9011.00
23_A145_V0.9001.00
53_P90_A0.8961.00
171_E175_A0.8901.00
153_G158_T0.8871.00
81_T123_A0.8711.00
31_A41_T0.8671.00
31_A170_G0.8621.00
173_A177_A0.8541.00
78_V110_G0.8511.00
7_V177_A0.8491.00
28_F41_T0.8331.00
77_L107_T0.8281.00
70_R73_D0.8281.00
88_Y93_K0.8241.00
16_D47_R0.8211.00
44_I70_R0.8121.00
93_K130_V0.8071.00
8_V70_R0.8041.00
68_R103_E0.8001.00
46_L95_A0.7941.00
106_G137_W0.7931.00
87_S93_K0.7851.00
135_D172_Q0.7841.00
111_L131_C0.7831.00
9_A80_G0.7821.00
25_R29_D0.7761.00
128_R132_D0.7731.00
81_T89_S0.7631.00
96_L127_L0.7511.00
96_L130_V0.7451.00
51_L95_A0.7441.00
86_G133_A0.7421.00
61_A98_Y0.7411.00
70_R74_A0.7391.00
22_T25_R0.7371.00
151_T162_I0.7340.99
131_C138_T0.7330.99
54_R59_R0.7320.99
12_G81_T0.7290.99
102_D105_G0.7280.99
44_I67_L0.7270.99
128_R142_Q0.7250.99
36_D39_V0.7250.99
14_L90_A0.7200.99
159_D162_I0.7110.99
137_W140_P0.7090.99
161_D165_R0.7080.99
14_L91_P0.7050.99
21_R43_L0.7010.99
122_Q129_G0.7010.99
175_A179_V0.7010.99
152_I157_I0.6990.99
85_H100_G0.6950.99
15_S56_G0.6940.99
54_R58_D0.6890.99
121_R125_S0.6880.99
125_S129_G0.6870.99
87_S97_D0.6870.99
168_T172_Q0.6850.99
79_L127_L0.6830.99
51_L55_D0.6830.99
104_L136_A0.6800.99
72_A103_E0.6670.99
76_A108_T0.6630.99
38_E174_V0.6620.99
116_G149_A0.6610.99
77_L109_V0.6590.99
47_R55_D0.6530.99
11_C43_L0.6520.99
27_V170_G0.6440.99
18_S21_R0.6410.99
88_Y127_L0.6400.99
31_A174_V0.6400.99
55_D58_D0.6390.99
7_V31_A0.6390.99
80_G112_V0.6390.99
52_P55_D0.6300.98
85_H101_R0.6290.98
42_D73_D0.6270.98
171_E174_V0.6240.98
95_A99_C0.6200.98
8_V77_L0.6200.98
37_T171_E0.6150.98
77_L136_A0.6120.98
94_N98_Y0.6110.98
96_L131_C0.6090.98
31_A39_V0.6090.98
26_T163_A0.6080.98
68_R72_A0.6040.98
170_G174_V0.6030.98
82_P89_S0.6020.98
46_L91_P0.6020.98
23_A112_V0.6010.98
19_G22_T0.6000.98
106_G135_D0.6000.98
99_C104_L0.5970.98
22_T152_I0.5970.98
91_P95_A0.5940.98
27_V80_G0.5910.98
115_A119_F0.5910.98
121_R124_L0.5870.98
132_D140_P0.5840.97
145_V151_T0.5820.97
78_V112_V0.5750.97
10_I67_L0.5740.97
124_L142_Q0.5600.97
139_L172_Q0.5590.97
110_G139_L0.5570.97
126_H130_V0.5550.97
12_G92_L0.5540.97
124_L144_G0.5510.96
83_M120_P0.5500.96
133_A140_P0.5490.96
62_G69_A0.5480.96
8_V71_V0.5440.96
14_L55_D0.5420.96
9_A78_V0.5410.96
36_D171_E0.5400.96
25_R45_D0.5400.96
81_T92_L0.5390.96
118_G147_N0.5360.96
51_L94_N0.5280.95
23_A148_A0.5260.95
65_P68_R0.5240.95
125_S128_R0.5230.95
18_S45_D0.5230.95
52_P63_D0.5200.95
54_R57_D0.5140.95
24_L41_T0.5110.95
71_V103_E0.5090.94
64_A67_L0.5090.94
11_C46_L0.5080.94
6_H70_R0.5080.94
150_T158_T0.5060.94
86_G129_G0.5050.94
135_D141_H0.5040.94
21_R47_R0.5040.94
8_V42_D0.5030.94
175_A178_N0.5030.94
52_P59_R0.5020.94
56_G59_R0.5020.94
38_E171_E0.5010.94
156_E163_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fzvA 5 0.9794 100 0.364 Contact Map
2q62A 4 0.9742 100 0.394 Contact Map
3svlA 4 0.8763 100 0.403 Contact Map
1rttA 1 0.8505 100 0.432 Contact Map
3fvwA 1 0.8711 100 0.436 Contact Map
3u7rA 4 0.8918 100 0.436 Contact Map
4hs4A 6 0.8918 100 0.437 Contact Map
4ltnA 4 0.9381 100 0.449 Contact Map
4c76A 1 0.9072 100 0.46 Contact Map
3k1yA 4 0.8918 100 0.463 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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