Q9HPI8 - HALSA - GREMLIN Contacts

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Q9HPI8 - Uncharacterized protein

UniProt:	Q9HPI8	Sequences: MPAPSSRRGLAVAVRAGVVLDGFFPGVSQTEGMDTDDDPREGLAVRISGEVTLSDDPGATLRKWRTDFDVSQTALADELDVSSSVISDYESGRRESPGIALVSRLVNALLDIDERRGGTHIGQFARVLSAGFDSDVVLDLREYPAAVELDALYDAVDATEVVPGDRDTVSGHTVIDSIKAIQRLSGDGFYRLYGQSTSRVLGFTNVSRGESPLVAMRVVDPTPSAVLLHGLSPDDLWEHAPALAKRDGFSLAVTEMPVEDMLASLRQHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (228)
Sequences:	139 (95)
Seq/√Len:	6.3

HALSA - Q9HPI8
SULSO - Q980C9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_A	252_A	4.247	0.96
142_E	214_V	3.810	0.93
152_L	200_V	3.312	0.86
142_E	188_G	3.251	0.85
62_R	70_V	2.962	0.79
161_V	236_L	2.933	0.78
50_E	60_T	2.821	0.75
153_Y	158_A	2.799	0.75
210_E	237_W	2.684	0.71
139_D	266_R	2.571	0.68
242_A	245_K	2.512	0.66
152_L	156_V	2.501	0.66
173_T	194_G	2.476	0.65
45_V	254_T	2.465	0.64
43_L	50_E	2.331	0.60
243_L	247_D	2.290	0.58
202_G	207_S	2.143	0.53
143_Y	172_H	2.121	0.52
76_A	243_L	2.086	0.51
83_S	200_V	2.080	0.51
256_M	264_S	2.023	0.49
76_A	106_V	2.007	0.48
61_L	105_L	1.937	0.46
142_E	220_D	1.888	0.44
152_L	227_L	1.881	0.44
96_S	172_H	1.880	0.43
87_S	194_G	1.865	0.43
56_D	236_L	1.847	0.42
56_D	142_E	1.791	0.40
87_S	173_T	1.769	0.40
156_V	254_T	1.740	0.39
217_R	240_A	1.716	0.38
77_D	105_L	1.712	0.38
105_L	124_F	1.651	0.36
157_D	178_I	1.612	0.34
79_L	254_T	1.577	0.33
229_H	254_T	1.565	0.33
45_V	53_L	1.556	0.32
50_E	110_L	1.544	0.32
51_V	106_V	1.506	0.31
72_Q	158_A	1.496	0.31
168_T	227_L	1.469	0.30
218_V	230_G	1.456	0.29
140_L	242_A	1.454	0.29
77_D	124_F	1.408	0.28
123_Q	183_R	1.399	0.28
43_L	241_P	1.392	0.27
156_V	200_V	1.372	0.27
153_Y	252_A	1.364	0.27
128_L	230_G	1.355	0.26
81_V	110_L	1.352	0.26
217_R	222_T	1.337	0.26
189_F	228_L	1.336	0.26
194_G	230_G	1.322	0.25
149_L	225_A	1.314	0.25
143_Y	192_L	1.307	0.25
53_L	217_R	1.307	0.25
51_V	103_S	1.306	0.25
51_V	257_P	1.305	0.25
136_V	179_K	1.285	0.24
112_I	225_A	1.276	0.24
46_R	196_S	1.275	0.24
44_A	143_Y	1.273	0.24
62_R	207_S	1.264	0.24
60_T	251_L	1.252	0.24
137_V	155_A	1.248	0.23
104_R	179_K	1.226	0.23
103_S	106_V	1.224	0.23
180_A	184_L	1.212	0.23
138_L	142_E	1.208	0.22
175_I	184_L	1.208	0.22
119_T	137_V	1.204	0.22
156_V	193_Y	1.201	0.22
175_I	205_N	1.197	0.22
157_D	264_S	1.189	0.22
61_L	197_T	1.184	0.22
91_S	193_Y	1.181	0.22
182_Q	242_A	1.163	0.21
169_V	205_N	1.163	0.21
185_S	188_G	1.163	0.21
46_R	105_L	1.155	0.21
63_K	213_L	1.155	0.21
105_L	147_V	1.146	0.21
87_S	251_L	1.136	0.21
165_D	253_V	1.129	0.21
236_L	253_V	1.125	0.20
85_V	215_A	1.112	0.20
69_D	120_H	1.110	0.20
152_L	225_A	1.103	0.20
112_I	131_G	1.098	0.20
154_D	257_P	1.094	0.20
121_I	138_L	1.094	0.20
106_V	118_G	1.081	0.19
123_Q	217_R	1.081	0.19
51_V	111_D	1.071	0.19
216_M	249_F	1.071	0.19
143_Y	197_T	1.070	0.19
83_S	193_Y	1.063	0.19
48_S	172_H	1.063	0.19
80_D	236_L	1.061	0.19
85_V	204_T	1.061	0.19
99_I	124_F	1.058	0.19
127_V	248_G	1.058	0.19
101_L	140_L	1.055	0.19
87_S	230_G	1.053	0.19
40_R	196_S	1.051	0.19
137_V	249_F	1.049	0.19
81_V	128_L	1.048	0.19
43_L	124_F	1.037	0.18
108_A	240_A	1.033	0.18
72_Q	176_D	1.033	0.18
95_E	179_K	1.021	0.18
123_Q	198_S	1.016	0.18
62_R	225_A	1.012	0.18
181_I	201_L	1.007	0.18
62_R	120_H	0.997	0.18
108_A	125_A	0.993	0.17
51_V	161_V	0.990	0.17
189_F	208_R	0.980	0.17
118_G	195_Q	0.977	0.17
146_A	263_A	0.973	0.17
123_Q	146_A	0.972	0.17
93_R	199_R	0.971	0.17
79_L	137_V	0.971	0.17
91_S	175_I	0.970	0.17
82_S	193_Y	0.967	0.17
133_D	146_A	0.962	0.17
46_R	254_T	0.960	0.17
184_L	247_D	0.954	0.17
80_D	260_D	0.945	0.16
44_A	189_F	0.941	0.16
52_T	124_F	0.938	0.16
154_D	161_V	0.937	0.16
109_L	116_R	0.932	0.16
210_E	247_D	0.928	0.16
91_S	96_S	0.926	0.16
147_V	191_R	0.926	0.16
173_T	230_G	0.920	0.16
158_A	193_Y	0.917	0.16
81_V	185_S	0.916	0.16
79_L	102_V	0.915	0.16
192_L	238_E	0.910	0.16
79_L	220_D	0.907	0.16
45_V	124_F	0.904	0.16
88_D	94_R	0.900	0.16
233_P	243_L	0.896	0.16
68_F	117_G	0.892	0.15
121_I	134_S	0.888	0.15
161_V	242_A	0.887	0.15
47_I	109_L	0.887	0.15
96_S	191_R	0.886	0.15
44_A	79_L	0.884	0.15
50_E	75_L	0.884	0.15
76_A	252_A	0.880	0.15
56_D	104_R	0.880	0.15
214_V	263_A	0.878	0.15
46_R	62_R	0.876	0.15
157_D	256_M	0.874	0.15
70_V	169_V	0.873	0.15
51_V	61_L	0.873	0.15
184_L	213_L	0.869	0.15
208_R	218_V	0.869	0.15
139_D	228_L	0.868	0.15
233_P	263_A	0.866	0.15
147_V	151_A	0.863	0.15
110_L	188_G	0.858	0.15
191_R	261_M	0.849	0.15
42_G	151_A	0.848	0.15
91_S	148_E	0.843	0.15
102_V	244_A	0.837	0.14
126_R	239_H	0.834	0.14
221_P	224_S	0.833	0.14
194_G	199_R	0.822	0.14
46_R	96_S	0.815	0.14
83_S	96_S	0.815	0.14
70_V	153_Y	0.812	0.14
69_D	169_V	0.806	0.14
70_V	147_V	0.801	0.14
217_R	251_L	0.797	0.14
148_E	191_R	0.794	0.14
220_D	239_H	0.792	0.14
62_R	77_D	0.789	0.14
80_D	234_D	0.789	0.14
78_E	248_G	0.788	0.14
124_F	170_S	0.788	0.14
97_P	244_A	0.787	0.14
83_S	236_L	0.787	0.14
83_S	87_S	0.781	0.13
158_A	226_V	0.780	0.13
86_I	253_V	0.780	0.13
61_L	266_R	0.777	0.13
39_P	261_M	0.775	0.13
86_I	96_S	0.772	0.13
102_V	250_S	0.771	0.13
104_R	145_A	0.768	0.13
152_L	166_R	0.767	0.13
45_V	50_E	0.765	0.13
92_G	199_R	0.761	0.13
108_A	192_L	0.759	0.13
135_D	143_Y	0.759	0.13
175_I	224_S	0.756	0.13
39_P	81_V	0.756	0.13
86_I	216_M	0.755	0.13
79_L	85_V	0.755	0.13
62_R	257_P	0.749	0.13
157_D	258_V	0.748	0.13
184_L	189_F	0.745	0.13
181_I	184_L	0.740	0.13
248_G	266_R	0.737	0.13
122_G	243_L	0.737	0.13
69_D	239_H	0.737	0.13
153_Y	202_G	0.734	0.13
43_L	60_T	0.732	0.13
46_R	156_V	0.732	0.13
143_Y	157_D	0.732	0.13
88_D	98_G	0.728	0.13
94_R	98_G	0.728	0.13
79_L	204_T	0.724	0.13
43_L	46_R	0.723	0.13
70_V	229_H	0.722	0.12
71_S	86_I	0.722	0.12
194_G	197_T	0.722	0.12
56_D	122_G	0.720	0.12
161_V	182_Q	0.717	0.12
174_V	202_G	0.717	0.12
55_D	139_D	0.717	0.12
73_T	197_T	0.715	0.12
216_M	254_T	0.713	0.12
50_E	63_K	0.712	0.12
116_R	204_T	0.712	0.12
189_F	219_V	0.709	0.12
147_V	155_A	0.707	0.12
102_V	205_N	0.706	0.12
176_D	237_W	0.697	0.12
96_S	124_F	0.694	0.12
74_A	80_D	0.694	0.12
156_V	242_A	0.691	0.12
53_L	260_D	0.691	0.12
66_T	239_H	0.689	0.12
204_T	215_A	0.688	0.12
163_P	258_V	0.687	0.12
46_R	71_S	0.682	0.12
122_G	125_A	0.681	0.12
74_A	176_D	0.678	0.12
52_T	105_L	0.678	0.12
149_L	163_P	0.675	0.12
157_D	165_D	0.673	0.12
107_N	161_V	0.669	0.12
175_I	261_M	0.668	0.12
57_P	67_D	0.664	0.12
81_V	149_L	0.663	0.12
173_T	198_S	0.663	0.12
118_G	193_Y	0.660	0.12
159_T	243_L	0.657	0.11
160_E	258_V	0.656	0.11
197_T	252_A	0.655	0.11
195_Q	213_L	0.655	0.11
110_L	241_P	0.654	0.11
83_S	95_E	0.651	0.11
105_L	224_S	0.650	0.11
74_A	264_S	0.650	0.11
51_V	86_I	0.648	0.11
140_L	262_L	0.648	0.11
136_V	178_I	0.647	0.11
99_I	184_L	0.645	0.11
180_A	201_L	0.643	0.11
81_V	96_S	0.641	0.11
198_S	202_G	0.640	0.11
43_L	110_L	0.639	0.11
52_T	196_S	0.634	0.11
131_G	238_E	0.634	0.11
190_Y	231_L	0.632	0.11
184_L	231_L	0.631	0.11
177_S	265_L	0.630	0.11
112_I	116_R	0.629	0.11
62_R	153_Y	0.626	0.11
227_L	245_K	0.623	0.11
95_E	245_K	0.621	0.11
178_I	261_M	0.620	0.11
181_I	189_F	0.618	0.11
96_S	178_I	0.617	0.11
69_D	106_V	0.610	0.11
169_V	192_L	0.608	0.11
112_I	247_D	0.606	0.11
92_G	193_Y	0.602	0.11
48_S	196_S	0.600	0.11
39_P	264_S	0.596	0.11
137_V	252_A	0.595	0.11
40_R	114_E	0.595	0.11
43_L	121_I	0.594	0.11
75_L	81_V	0.592	0.11
48_S	69_D	0.590	0.11
214_V	239_H	0.590	0.11
74_A	112_I	0.586	0.10
61_L	255_E	0.586	0.10
177_S	186_G	0.582	0.10
249_F	254_T	0.582	0.10
47_I	176_D	0.581	0.10
143_Y	196_S	0.580	0.10
67_D	146_A	0.579	0.10
63_K	68_F	0.577	0.10
140_L	150_D	0.576	0.10
52_T	185_S	0.574	0.10
207_S	260_D	0.573	0.10
55_D	221_P	0.570	0.10
140_L	245_K	0.570	0.10
52_T	103_S	0.567	0.10
41_E	186_G	0.564	0.10
221_P	250_S	0.562	0.10
156_V	186_G	0.558	0.10
143_Y	256_M	0.557	0.10
180_A	189_F	0.555	0.10
172_H	192_L	0.551	0.10
71_S	80_D	0.550	0.10
109_L	183_R	0.550	0.10
59_A	221_P	0.550	0.10
180_A	211_S	0.550	0.10
134_S	143_Y	0.550	0.10
79_L	108_A	0.546	0.10
124_F	147_V	0.543	0.10
104_R	264_S	0.539	0.10
43_L	196_S	0.537	0.10
51_V	74_A	0.535	0.10
220_D	254_T	0.533	0.10
60_T	217_R	0.533	0.10
40_R	101_L	0.531	0.10
74_A	246_R	0.527	0.10
143_Y	149_L	0.525	0.10
77_D	96_S	0.522	0.10
91_S	258_V	0.522	0.10
194_G	251_L	0.521	0.10
115_R	246_R	0.519	0.10
71_S	124_F	0.518	0.10
189_F	218_V	0.515	0.10
198_S	248_G	0.514	0.10
79_L	207_S	0.509	0.09
72_Q	85_V	0.506	0.09
216_M	222_T	0.504	0.09
120_H	169_V	0.504	0.09
108_A	166_R	0.503	0.09
78_E	111_D	0.500	0.09
96_S	105_L	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2l49A	2	0.3643	98.4	0.919	Contact Map
2mqkA	1	0.2416	98.4	0.92	Contact Map
2auwA	2	0.4164	98.3	0.921	Contact Map
3cecA	1	0.3309	98.3	0.921	Contact Map
1s4kA	2	0.4275	98.3	0.921	Contact Map
3b7hA	2	0.2825	98.3	0.921	Contact Map
2b5aA	2	0.2862	98.3	0.922	Contact Map
3op9A	4	0.3978	98.3	0.922	Contact Map
4mctA	2	0.2825	98.3	0.923	Contact Map
2ebyA	2	0.368	98.2	0.923	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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