GREMLIN Database
Q9HPI8 - Uncharacterized protein
UniProt: Q9HPI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (228)
Sequences: 139 (95)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_A252_A4.2470.96
142_E214_V3.8100.93
152_L200_V3.3120.86
142_E188_G3.2510.85
62_R70_V2.9620.79
161_V236_L2.9330.78
50_E60_T2.8210.75
153_Y158_A2.7990.75
210_E237_W2.6840.71
139_D266_R2.5710.68
242_A245_K2.5120.66
152_L156_V2.5010.66
173_T194_G2.4760.65
45_V254_T2.4650.64
43_L50_E2.3310.60
243_L247_D2.2900.58
202_G207_S2.1430.53
143_Y172_H2.1210.52
76_A243_L2.0860.51
83_S200_V2.0800.51
256_M264_S2.0230.49
76_A106_V2.0070.48
61_L105_L1.9370.46
142_E220_D1.8880.44
152_L227_L1.8810.44
96_S172_H1.8800.43
87_S194_G1.8650.43
56_D236_L1.8470.42
56_D142_E1.7910.40
87_S173_T1.7690.40
156_V254_T1.7400.39
217_R240_A1.7160.38
77_D105_L1.7120.38
105_L124_F1.6510.36
157_D178_I1.6120.34
79_L254_T1.5770.33
229_H254_T1.5650.33
45_V53_L1.5560.32
50_E110_L1.5440.32
51_V106_V1.5060.31
72_Q158_A1.4960.31
168_T227_L1.4690.30
218_V230_G1.4560.29
140_L242_A1.4540.29
77_D124_F1.4080.28
123_Q183_R1.3990.28
43_L241_P1.3920.27
156_V200_V1.3720.27
153_Y252_A1.3640.27
128_L230_G1.3550.26
81_V110_L1.3520.26
217_R222_T1.3370.26
189_F228_L1.3360.26
194_G230_G1.3220.25
149_L225_A1.3140.25
143_Y192_L1.3070.25
53_L217_R1.3070.25
51_V103_S1.3060.25
51_V257_P1.3050.25
136_V179_K1.2850.24
112_I225_A1.2760.24
46_R196_S1.2750.24
44_A143_Y1.2730.24
62_R207_S1.2640.24
60_T251_L1.2520.24
137_V155_A1.2480.23
104_R179_K1.2260.23
103_S106_V1.2240.23
180_A184_L1.2120.23
138_L142_E1.2080.22
175_I184_L1.2080.22
119_T137_V1.2040.22
156_V193_Y1.2010.22
175_I205_N1.1970.22
157_D264_S1.1890.22
61_L197_T1.1840.22
91_S193_Y1.1810.22
182_Q242_A1.1630.21
169_V205_N1.1630.21
185_S188_G1.1630.21
46_R105_L1.1550.21
63_K213_L1.1550.21
105_L147_V1.1460.21
87_S251_L1.1360.21
165_D253_V1.1290.21
236_L253_V1.1250.20
85_V215_A1.1120.20
69_D120_H1.1100.20
152_L225_A1.1030.20
112_I131_G1.0980.20
154_D257_P1.0940.20
121_I138_L1.0940.20
106_V118_G1.0810.19
123_Q217_R1.0810.19
51_V111_D1.0710.19
216_M249_F1.0710.19
143_Y197_T1.0700.19
83_S193_Y1.0630.19
48_S172_H1.0630.19
80_D236_L1.0610.19
85_V204_T1.0610.19
99_I124_F1.0580.19
127_V248_G1.0580.19
101_L140_L1.0550.19
87_S230_G1.0530.19
40_R196_S1.0510.19
137_V249_F1.0490.19
81_V128_L1.0480.19
43_L124_F1.0370.18
108_A240_A1.0330.18
72_Q176_D1.0330.18
95_E179_K1.0210.18
123_Q198_S1.0160.18
62_R225_A1.0120.18
181_I201_L1.0070.18
62_R120_H0.9970.18
108_A125_A0.9930.17
51_V161_V0.9900.17
189_F208_R0.9800.17
118_G195_Q0.9770.17
146_A263_A0.9730.17
123_Q146_A0.9720.17
93_R199_R0.9710.17
79_L137_V0.9710.17
91_S175_I0.9700.17
82_S193_Y0.9670.17
133_D146_A0.9620.17
46_R254_T0.9600.17
184_L247_D0.9540.17
80_D260_D0.9450.16
44_A189_F0.9410.16
52_T124_F0.9380.16
154_D161_V0.9370.16
109_L116_R0.9320.16
210_E247_D0.9280.16
91_S96_S0.9260.16
147_V191_R0.9260.16
173_T230_G0.9200.16
158_A193_Y0.9170.16
81_V185_S0.9160.16
79_L102_V0.9150.16
192_L238_E0.9100.16
79_L220_D0.9070.16
45_V124_F0.9040.16
88_D94_R0.9000.16
233_P243_L0.8960.16
68_F117_G0.8920.15
121_I134_S0.8880.15
161_V242_A0.8870.15
47_I109_L0.8870.15
96_S191_R0.8860.15
44_A79_L0.8840.15
50_E75_L0.8840.15
76_A252_A0.8800.15
56_D104_R0.8800.15
214_V263_A0.8780.15
46_R62_R0.8760.15
157_D256_M0.8740.15
70_V169_V0.8730.15
51_V61_L0.8730.15
184_L213_L0.8690.15
208_R218_V0.8690.15
139_D228_L0.8680.15
233_P263_A0.8660.15
147_V151_A0.8630.15
110_L188_G0.8580.15
191_R261_M0.8490.15
42_G151_A0.8480.15
91_S148_E0.8430.15
102_V244_A0.8370.14
126_R239_H0.8340.14
221_P224_S0.8330.14
194_G199_R0.8220.14
46_R96_S0.8150.14
83_S96_S0.8150.14
70_V153_Y0.8120.14
69_D169_V0.8060.14
70_V147_V0.8010.14
217_R251_L0.7970.14
148_E191_R0.7940.14
220_D239_H0.7920.14
62_R77_D0.7890.14
80_D234_D0.7890.14
78_E248_G0.7880.14
124_F170_S0.7880.14
97_P244_A0.7870.14
83_S236_L0.7870.14
83_S87_S0.7810.13
158_A226_V0.7800.13
86_I253_V0.7800.13
61_L266_R0.7770.13
39_P261_M0.7750.13
86_I96_S0.7720.13
102_V250_S0.7710.13
104_R145_A0.7680.13
152_L166_R0.7670.13
45_V50_E0.7650.13
92_G199_R0.7610.13
108_A192_L0.7590.13
135_D143_Y0.7590.13
175_I224_S0.7560.13
39_P81_V0.7560.13
86_I216_M0.7550.13
79_L85_V0.7550.13
62_R257_P0.7490.13
157_D258_V0.7480.13
184_L189_F0.7450.13
181_I184_L0.7400.13
248_G266_R0.7370.13
122_G243_L0.7370.13
69_D239_H0.7370.13
153_Y202_G0.7340.13
43_L60_T0.7320.13
46_R156_V0.7320.13
143_Y157_D0.7320.13
88_D98_G0.7280.13
94_R98_G0.7280.13
79_L204_T0.7240.13
43_L46_R0.7230.13
70_V229_H0.7220.12
71_S86_I0.7220.12
194_G197_T0.7220.12
56_D122_G0.7200.12
161_V182_Q0.7170.12
174_V202_G0.7170.12
55_D139_D0.7170.12
73_T197_T0.7150.12
216_M254_T0.7130.12
50_E63_K0.7120.12
116_R204_T0.7120.12
189_F219_V0.7090.12
147_V155_A0.7070.12
102_V205_N0.7060.12
176_D237_W0.6970.12
96_S124_F0.6940.12
74_A80_D0.6940.12
156_V242_A0.6910.12
53_L260_D0.6910.12
66_T239_H0.6890.12
204_T215_A0.6880.12
163_P258_V0.6870.12
46_R71_S0.6820.12
122_G125_A0.6810.12
74_A176_D0.6780.12
52_T105_L0.6780.12
149_L163_P0.6750.12
157_D165_D0.6730.12
107_N161_V0.6690.12
175_I261_M0.6680.12
57_P67_D0.6640.12
81_V149_L0.6630.12
173_T198_S0.6630.12
118_G193_Y0.6600.12
159_T243_L0.6570.11
160_E258_V0.6560.11
197_T252_A0.6550.11
195_Q213_L0.6550.11
110_L241_P0.6540.11
83_S95_E0.6510.11
105_L224_S0.6500.11
74_A264_S0.6500.11
51_V86_I0.6480.11
140_L262_L0.6480.11
136_V178_I0.6470.11
99_I184_L0.6450.11
180_A201_L0.6430.11
81_V96_S0.6410.11
198_S202_G0.6400.11
43_L110_L0.6390.11
52_T196_S0.6340.11
131_G238_E0.6340.11
190_Y231_L0.6320.11
184_L231_L0.6310.11
177_S265_L0.6300.11
112_I116_R0.6290.11
62_R153_Y0.6260.11
227_L245_K0.6230.11
95_E245_K0.6210.11
178_I261_M0.6200.11
181_I189_F0.6180.11
96_S178_I0.6170.11
69_D106_V0.6100.11
169_V192_L0.6080.11
112_I247_D0.6060.11
92_G193_Y0.6020.11
48_S196_S0.6000.11
39_P264_S0.5960.11
137_V252_A0.5950.11
40_R114_E0.5950.11
43_L121_I0.5940.11
75_L81_V0.5920.11
48_S69_D0.5900.11
214_V239_H0.5900.11
74_A112_I0.5860.10
61_L255_E0.5860.10
177_S186_G0.5820.10
249_F254_T0.5820.10
47_I176_D0.5810.10
143_Y196_S0.5800.10
67_D146_A0.5790.10
63_K68_F0.5770.10
140_L150_D0.5760.10
52_T185_S0.5740.10
207_S260_D0.5730.10
55_D221_P0.5700.10
140_L245_K0.5700.10
52_T103_S0.5670.10
41_E186_G0.5640.10
221_P250_S0.5620.10
156_V186_G0.5580.10
143_Y256_M0.5570.10
180_A189_F0.5550.10
172_H192_L0.5510.10
71_S80_D0.5500.10
109_L183_R0.5500.10
59_A221_P0.5500.10
180_A211_S0.5500.10
134_S143_Y0.5500.10
79_L108_A0.5460.10
124_F147_V0.5430.10
104_R264_S0.5390.10
43_L196_S0.5370.10
51_V74_A0.5350.10
220_D254_T0.5330.10
60_T217_R0.5330.10
40_R101_L0.5310.10
74_A246_R0.5270.10
143_Y149_L0.5250.10
77_D96_S0.5220.10
91_S258_V0.5220.10
194_G251_L0.5210.10
115_R246_R0.5190.10
71_S124_F0.5180.10
189_F218_V0.5150.10
198_S248_G0.5140.10
79_L207_S0.5090.09
72_Q85_V0.5060.09
216_M222_T0.5040.09
120_H169_V0.5040.09
108_A166_R0.5030.09
78_E111_D0.5000.09
96_S105_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l49A 2 0.3643 98.4 0.919 Contact Map
2mqkA 1 0.2416 98.4 0.92 Contact Map
2auwA 2 0.4164 98.3 0.921 Contact Map
3cecA 1 0.3309 98.3 0.921 Contact Map
1s4kA 2 0.4275 98.3 0.921 Contact Map
3b7hA 2 0.2825 98.3 0.921 Contact Map
2b5aA 2 0.2862 98.3 0.922 Contact Map
3op9A 4 0.3978 98.3 0.922 Contact Map
4mctA 2 0.2825 98.3 0.923 Contact Map
2ebyA 2 0.368 98.2 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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