GREMLIN Database
RFCL - Replication factor C large subunit
UniProt: Q9HPI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (376)
Sequences: 6997 (3912)
Seq/√Len: 201.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
377_H381_R5.2701.00
165_V185_A4.9681.00
172_C184_L3.5961.00
165_V169_R3.4891.00
84_G88_R3.3151.00
248_A251_V3.1051.00
178_T181_E3.0251.00
362_T366_D2.9631.00
351_H354_E2.9301.00
168_L195_L2.9041.00
175_E223_D2.8261.00
172_C199_V2.6261.00
211_T227_G2.6061.00
240_S243_E2.4301.00
310_A314_A2.3921.00
331_Y355_T2.3751.00
199_V228_V2.3061.00
20_D163_S2.2991.00
381_R385_V2.2961.00
303_Y306_D2.2441.00
380_N383_L2.1801.00
286_D367_V2.1591.00
265_N284_N2.1131.00
377_H380_N2.1071.00
310_A313_A2.0931.00
169_R181_E2.0831.00
372_R376_H2.0761.00
295_T300_Y2.0121.00
297_N372_R2.0031.00
390_A397_H1.9891.00
26_L57_L1.9771.00
383_L387_M1.9461.00
279_Y283_S1.9401.00
168_L184_L1.9081.00
380_N387_M1.9021.00
224_R227_G1.8911.00
166_P169_R1.8821.00
178_T211_T1.8821.00
361_A365_N1.8561.00
321_G325_R1.8421.00
175_E199_V1.8161.00
368_L372_R1.8151.00
241_A244_A1.7871.00
261_W399_A1.7811.00
384_T387_M1.7761.00
338_S342_R1.7661.00
367_V370_F1.7651.00
289_L314_A1.7611.00
378_C382_E1.7591.00
377_H383_L1.7391.00
274_E281_F1.7241.00
211_T224_R1.7211.00
160_S163_S1.7081.00
259_L287_V1.7061.00
331_Y359_S1.6511.00
209_D227_G1.6421.00
354_E358_C1.6411.00
292_V295_T1.6381.00
395_T399_A1.6361.00
386_A390_A1.6301.00
74_R113_N1.5681.00
379_K382_E1.5671.00
377_H387_M1.5661.00
74_R111_H1.5651.00
332_W337_S1.5551.00
24_D27_A1.5521.00
297_N368_L1.5511.00
331_Y358_C1.5491.00
53_A156_F1.5421.00
299_A377_H1.5401.00
87_A128_D1.5401.00
241_A245_L1.5301.00
378_C383_L1.5181.00
286_D319_D1.5091.00
287_V367_V1.4981.00
209_D230_D1.4951.00
57_L134_V1.4911.00
315_A364_R1.4841.00
321_G326_Y1.4801.00
170_D174_R1.4791.00
314_A317_R1.4781.00
400_F405_G1.4761.00
382_E386_A1.4721.00
34_P196_R1.4661.00
311_G315_A1.4651.00
339_R342_R1.4521.00
61_A132_P1.4421.00
369_P373_V1.4421.00
243_E246_Q1.4411.00
241_A246_Q1.4401.00
75_T78_V1.4391.00
180_E222_R1.4381.00
260_S288_W1.4341.00
286_D363_A1.4241.00
103_L136_V1.4171.00
367_V371_L1.4171.00
380_N384_T1.4061.00
299_A381_R1.4041.00
111_H147_L1.4031.00
378_C385_V1.4031.00
280_E302_R1.4021.00
317_R321_G1.3941.00
277_D281_F1.3911.00
313_A317_R1.3841.00
287_V371_L1.3731.00
266_V284_N1.3691.00
243_E247_A1.3651.00
298_Y302_R1.3641.00
295_T298_Y1.3631.00
379_K383_L1.3611.00
172_C177_V1.3591.00
178_T222_R1.3551.00
165_V184_L1.3421.00
66_V89_S1.3411.00
281_F285_A1.3141.00
298_Y375_T1.3131.00
280_E284_N1.3111.00
20_D166_P1.3101.00
340_A343_E1.2991.00
323_W363_A1.2911.00
380_N385_V1.2781.00
16_V53_A1.2771.00
29_W40_V1.2771.00
162_R166_P1.2661.00
285_A290_G1.2661.00
283_S367_V1.2651.00
283_S286_D1.2381.00
204_A208_Q1.2381.00
254_T383_L1.2291.00
365_N369_P1.2201.00
284_N287_V1.2071.00
186_A189_E1.2051.00
121_A125_L1.2051.00
14_S27_A1.2011.00
329_P359_S1.1991.00
283_S287_V1.1921.00
385_V389_A1.1821.00
338_S341_T1.1751.00
287_V370_F1.1731.00
86_A102_V1.1721.00
263_A266_V1.1721.00
369_P372_R1.1651.00
294_A372_R1.1651.00
335_L364_R1.1641.00
240_S246_Q1.1491.00
27_A31_E1.1451.00
286_D292_V1.1421.00
366_D369_P1.1401.00
359_S362_T1.1371.00
19_N22_A1.1361.00
386_A393_L1.1311.00
226_E230_D1.1311.00
275_L281_F1.1311.00
355_T358_C1.1301.00
167_V170_D1.1281.00
284_N289_L1.1271.00
43_H155_E1.1241.00
365_N368_L1.1231.00
285_A292_V1.1191.00
240_S245_L1.1171.00
162_R165_V1.1161.00
301_W306_D1.1131.00
284_N370_F1.1131.00
345_R348_V1.1101.00
23_R27_A1.1071.00
26_L29_W1.1071.00
351_H355_T1.1061.00
333_R337_S1.1031.00
396_E399_A1.1011.00
172_C228_V1.1011.00
297_N300_Y1.0911.00
186_A225_T1.0911.00
331_Y334_K1.0891.00
396_E400_F1.0861.00
334_K337_S1.0851.00
72_D121_A1.0851.00
378_C381_R1.0821.00
290_G293_R1.0761.00
357_G360_M1.0721.00
286_D290_G1.0691.00
331_Y335_L1.0651.00
363_A367_V1.0651.00
79_V83_A1.0581.00
360_M367_V1.0471.00
370_F373_V1.0461.00
381_R384_T1.0421.00
185_A189_E1.0381.00
394_D397_H1.0361.00
348_V353_A1.0361.00
378_C384_T1.0361.00
308_V312_V1.0311.00
162_R185_A1.0281.00
377_H385_V1.0201.00
283_S290_G1.0201.00
161_K185_A1.0121.00
382_E385_V1.0101.00
282_L318_H1.0091.00
186_A229_F1.0091.00
164_I195_L1.0081.00
300_Y304_A1.0061.00
240_S244_A1.0041.00
16_V23_R1.0031.00
312_V315_A0.9961.00
378_C387_M0.9951.00
276_A279_Y0.9931.00
297_N301_W0.9921.00
355_T359_S0.9831.00
284_N290_G0.9781.00
263_A284_N0.9751.00
20_D24_D0.9751.00
290_G295_T0.9741.00
69_N124_R0.9731.00
295_T301_W0.9690.99
382_E387_M0.9670.99
12_S15_E0.9660.99
295_T299_A0.9620.99
16_V56_A0.9610.99
109_N124_R0.9590.99
302_R306_D0.9420.99
286_D295_T0.9410.99
43_H153_E0.9410.99
367_V375_T0.9390.99
286_D293_R0.9370.99
293_R299_A0.9360.99
308_V311_G0.9310.99
295_T302_R0.9280.99
65_V103_L0.9250.99
172_C202_L0.9220.99
299_A302_R0.9190.99
19_N163_S0.9150.99
41_V140_Y0.9130.99
266_V288_W0.9120.99
19_N57_L0.9110.99
22_A157_R0.9060.99
341_T348_V0.8970.99
331_Y337_S0.8940.99
339_R343_E0.8920.99
325_R336_G0.8910.99
303_Y308_V0.8910.99
400_F403_G0.8880.99
292_V296_Q0.8870.99
148_R153_E0.8830.99
292_V299_A0.8820.99
379_K386_A0.8810.99
206_A227_G0.8800.99
373_V376_H0.8800.99
168_L187_I0.8790.99
294_A298_Y0.8780.99
249_Y276_A0.8780.99
190_Q232_L0.8750.99
383_L386_A0.8730.99
29_W33_W0.8710.99
386_A389_A0.8680.99
161_K189_E0.8680.99
123_T127_D0.8660.99
83_A87_A0.8660.99
309_A312_V0.8640.99
302_R305_T0.8620.99
344_K349_A0.8590.99
40_V154_I0.8570.99
285_A289_L0.8560.99
26_L40_V0.8560.99
278_A285_A0.8540.99
337_S356_A0.8540.99
169_R184_L0.8520.99
350_R353_A0.8430.99
383_L398_V0.8420.99
332_W336_G0.8420.99
371_L374_L0.8410.99
279_Y286_D0.8380.99
51_T105_D0.8370.99
262_V374_L0.8350.98
43_H140_Y0.8340.98
260_S264_D0.8320.98
167_V195_L0.8310.98
183_A186_A0.8310.98
244_A247_A0.8310.98
301_W304_A0.8310.98
293_R296_Q0.8310.98
284_N288_W0.8300.98
397_H400_F0.8290.98
346_D353_A0.8250.98
177_V184_L0.8220.98
286_D291_R0.8220.98
123_T150_A0.8220.98
356_A360_M0.8190.98
325_R328_P0.8180.98
287_V290_G0.8170.98
259_L371_L0.8140.98
252_D255_P0.8120.98
146_S149_S0.8090.98
233_D237_A0.8060.98
368_L375_T0.8000.98
203_Q207_E0.7960.98
169_R172_C0.7950.98
252_D256_D0.7950.98
281_F290_G0.7930.98
123_T137_A0.7930.98
261_W264_D0.7920.98
271_R274_E0.7920.98
74_R115_D0.7910.98
261_W266_V0.7900.98
398_V402_T0.7900.98
279_Y290_G0.7860.98
42_V156_F0.7840.98
400_F404_S0.7840.98
25_A152_R0.7830.98
289_L318_H0.7790.98
280_E283_S0.7760.98
144_S149_S0.7720.97
169_R173_R0.7700.97
260_S266_V0.7690.97
171_V199_V0.7690.97
273_G285_A0.7680.97
256_D261_W0.7660.97
112_G116_R0.7620.97
252_D257_D0.7620.97
223_D228_V0.7590.97
298_Y305_T0.7580.97
371_L375_T0.7570.97
241_A247_A0.7550.97
323_W328_P0.7550.97
381_R387_M0.7530.97
36_H132_P0.7510.97
54_A103_L0.7500.97
76_A113_N0.7490.97
108_D138_N0.7480.97
40_V132_P0.7470.97
232_L269_D0.7470.97
296_Q301_W0.7470.97
299_A303_Y0.7460.97
383_L401_V0.7450.97
398_V406_E0.7410.97
300_Y303_Y0.7370.97
242_R245_L0.7360.97
387_M391_Y0.7320.97
261_W398_V0.7310.97
285_A314_A0.7300.96
359_S364_R0.7290.96
278_A281_F0.7280.96
229_F268_K0.7270.96
287_V291_R0.7250.96
301_W305_T0.7240.96
350_R354_E0.7230.96
279_Y330_S0.7230.96
383_L393_L0.7200.96
283_S292_V0.7160.96
267_P285_A0.7150.96
20_D23_R0.7140.96
261_W267_P0.7130.96
334_K365_N0.7120.96
85_E88_R0.7110.96
17_R170_D0.7100.96
100_K131_Q0.7070.96
140_Y155_E0.7070.96
242_R246_Q0.7070.96
140_Y153_E0.7070.96
298_Y301_W0.7060.96
372_R375_T0.7030.96
175_E196_R0.7030.96
394_D398_V0.6950.95
366_D370_F0.6940.95
246_Q249_Y0.6920.95
146_S150_A0.6910.95
388_A398_V0.6890.95
254_T258_L0.6890.95
288_W291_R0.6870.95
191_N198_A0.6860.95
248_A300_Y0.6850.95
299_A380_N0.6850.95
323_W327_G0.6840.95
246_Q250_D0.6840.95
81_R85_E0.6830.95
390_A404_S0.6820.95
278_A283_S0.6790.95
45_S158_D0.6780.95
341_T344_K0.6770.95
298_Y306_D0.6770.95
394_D402_T0.6760.95
356_A364_R0.6760.95
293_R301_W0.6720.94
385_V390_A0.6710.94
356_A371_L0.6710.94
123_T146_S0.6670.94
296_Q302_R0.6650.94
345_R350_R0.6610.94
112_G142_E0.6610.94
294_A376_H0.6600.94
54_A134_V0.6600.94
198_A232_L0.6590.94
377_H384_T0.6570.94
124_R127_D0.6570.94
126_V133_I0.6570.94
278_A286_D0.6540.94
380_N388_A0.6530.94
264_D267_P0.6520.94
276_A290_G0.6510.93
234_D237_A0.6500.93
283_S370_F0.6500.93
346_D350_R0.6480.93
186_A190_Q0.6460.93
190_Q234_D0.6460.93
187_I195_L0.6440.93
70_A135_L0.6440.93
252_D258_L0.6430.93
55_H98_G0.6430.93
180_E183_A0.6430.93
281_F284_N0.6420.93
277_D285_A0.6410.93
309_A313_A0.6410.93
334_K342_R0.6410.93
401_V404_S0.6380.93
242_R247_A0.6370.93
191_N194_D0.6350.93
118_G125_L0.6350.93
377_H382_E0.6350.93
247_A251_V0.6340.93
393_L397_H0.6340.93
127_D150_A0.6340.93
159_V163_S0.6330.93
89_S100_K0.6330.93
167_V171_V0.6330.93
360_M363_A0.6320.92
247_A250_D0.6290.92
28_E152_R0.6260.92
45_S194_D0.6250.92
283_S366_D0.6250.92
359_S367_V0.6210.92
263_A287_V0.6210.92
48_I167_V0.6200.92
331_Y336_G0.6200.92
178_T224_R0.6190.92
298_Y303_Y0.6190.92
383_L397_H0.6180.92
263_A267_P0.6180.92
46_P138_N0.6180.92
401_V405_G0.6170.92
211_T226_E0.6160.91
341_T349_A0.6150.91
205_L230_D0.6150.91
82_V102_V0.6140.91
352_I364_R0.6130.91
106_E138_N0.6130.91
237_A281_F0.6110.91
41_V107_A0.6090.91
11_A15_E0.6090.91
274_E278_A0.6070.91
256_D259_L0.6070.91
357_G367_V0.6060.91
273_G281_F0.6060.91
123_T126_V0.6040.91
340_A344_K0.6040.91
37_R152_R0.6030.91
379_K384_T0.6000.90
76_A117_G0.5990.90
85_E89_S0.5990.90
292_V297_N0.5990.90
164_I188_A0.5970.90
285_A288_W0.5960.90
76_A111_H0.5950.90
358_C362_T0.5940.90
76_A80_E0.5930.90
402_T405_G0.5920.90
195_L198_A0.5910.90
19_N156_F0.5910.90
403_G406_E0.5900.90
232_L237_A0.5890.90
144_S147_L0.5870.89
261_W265_N0.5870.89
72_D109_N0.5850.89
310_A315_A0.5840.89
289_L300_Y0.5810.89
120_A123_T0.5800.89
329_P333_R0.5800.89
395_T398_V0.5780.89
357_G371_L0.5770.89
286_D289_L0.5750.88
274_E277_D0.5750.88
338_S344_K0.5740.88
227_G230_D0.5740.88
308_V316_R0.5730.88
379_K402_T0.5720.88
338_S343_E0.5720.88
392_E395_T0.5720.88
344_K348_V0.5690.88
384_T388_A0.5680.88
44_G49_G0.5680.88
332_W355_T0.5670.88
273_G277_D0.5670.88
68_L113_N0.5660.88
70_A106_E0.5640.87
383_L388_A0.5630.87
51_T106_E0.5620.87
240_S247_A0.5610.87
171_V174_R0.5610.87
280_E303_Y0.5600.87
237_A243_E0.5600.87
275_L290_G0.5600.87
356_A375_T0.5590.87
273_G276_A0.5580.87
164_I168_L0.5570.87
255_P258_L0.5550.87
311_G314_A0.5520.86
386_A400_F0.5520.86
353_A364_R0.5510.86
39_A109_N0.5510.86
328_P335_L0.5500.86
72_D124_R0.5480.86
395_T403_G0.5480.86
293_R297_N0.5470.86
107_A135_L0.5460.86
100_K130_P0.5460.86
68_L83_A0.5430.85
345_R349_A0.5420.85
75_T87_A0.5420.85
296_Q300_Y0.5410.85
352_I355_T0.5410.85
231_Y234_D0.5380.85
25_A239_H0.5360.85
13_L30_A0.5350.85
281_F289_L0.5330.84
189_E205_L0.5330.84
356_A359_S0.5320.84
382_E402_T0.5300.84
205_L239_H0.5290.84
109_N119_S0.5290.84
351_H358_C0.5290.84
278_A292_V0.5280.84
379_K395_T0.5270.84
39_A151_C0.5270.84
281_F286_D0.5260.84
19_N45_S0.5250.84
205_L227_G0.5230.83
230_D233_D0.5230.83
387_M390_A0.5210.83
120_A137_A0.5210.83
48_I256_D0.5190.83
380_N391_Y0.5190.83
382_E389_A0.5180.83
99_R132_P0.5180.83
75_T79_V0.5180.83
314_A318_H0.5170.83
56_A60_D0.5150.82
165_V188_A0.5150.82
229_F233_D0.5140.82
398_V405_G0.5140.82
275_L278_A0.5130.82
159_V195_L0.5130.82
260_S263_A0.5120.82
369_P374_L0.5100.82
73_Q118_G0.5080.82
187_I193_G0.5080.82
298_Y376_H0.5070.81
360_M370_F0.5070.81
387_M398_V0.5060.81
19_N166_P0.5050.81
337_S340_A0.5040.81
17_R163_S0.5040.81
71_S138_N0.5040.81
204_A207_E0.5040.81
368_L371_L0.5030.81
392_E402_T0.5020.81
244_A248_A0.5010.81
250_D253_E0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sxjA 1 0.7473 100 0.445 Contact Map
1sxjD 1 0.6369 100 0.544 Contact Map
2chqA 3 0.6369 100 0.552 Contact Map
1iqpA 5 0.6433 100 0.558 Contact Map
1sxjE 1 0.6178 100 0.565 Contact Map
1sxjC 1 0.6433 100 0.566 Contact Map
4ww0A 4 0.811 100 0.572 Contact Map
3u61B 3 0.6391 100 0.58 Contact Map
1sxjB 1 0.6391 100 0.599 Contact Map
3pvsA 4 0.811 100 0.601 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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