GREMLIN Database
Q9HPI3 - Cytochrome aa3 controlling protein
UniProt: Q9HPI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (257)
Sequences: 155 (117)
Seq/√Len: 7.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_I182_V4.5190.98
35_C42_C4.1720.97
100_P135_I3.6440.94
40_P62_R3.1810.88
39_W42_C2.8680.82
71_F105_L2.4470.70
95_A139_V2.2540.63
5_S12_T2.2350.63
218_A221_T2.1040.58
20_I31_S2.0980.57
231_Q235_G2.0700.56
59_Q103_V2.0570.56
210_L258_A2.0440.55
89_K97_V2.0290.55
42_C62_R2.0270.55
65_A102_Q2.0040.54
35_C62_R1.9550.52
35_C39_W1.9410.51
11_V228_S1.9190.50
76_G139_V1.8850.49
59_Q74_G1.8450.48
13_A68_V1.8230.47
23_G62_R1.7960.46
18_A256_I1.7940.46
21_L44_G1.7870.45
213_N226_L1.7850.45
43_S49_F1.7760.45
201_A258_A1.7600.44
165_L171_E1.7140.43
42_C110_V1.6690.41
127_V218_A1.6680.41
29_S34_T1.6590.40
21_L108_T1.6430.40
33_A58_E1.6240.39
165_L258_A1.6140.39
43_S55_D1.6120.39
66_M70_F1.6100.39
23_G128_H1.6060.38
41_D46_F1.6040.38
78_A232_V1.6020.38
162_L240_P1.6000.38
67_V71_F1.5650.37
32_G110_V1.5630.37
253_A256_I1.5600.37
59_Q135_I1.5580.37
55_D59_Q1.5490.36
86_R90_L1.5400.36
35_C40_P1.5360.36
227_L252_L1.5290.36
240_P247_L1.5230.35
244_T262_A1.5210.35
56_F59_Q1.5170.35
99_L127_V1.5090.35
19_L127_V1.4940.34
69_G135_I1.4880.34
178_T229_T1.4780.34
46_F92_G1.4740.34
19_L65_A1.4720.34
235_G256_I1.4700.34
44_G186_W1.4650.33
16_T21_L1.4590.33
23_G35_C1.4540.33
19_L27_A1.4510.33
20_I44_G1.4400.33
136_L185_S1.4270.32
69_G88_I1.3880.31
30_G109_T1.3870.31
106_G128_H1.3860.31
248_A263_T1.3740.30
30_G58_E1.3710.30
227_L253_A1.3600.30
165_L201_A1.3500.30
102_Q106_G1.3450.29
40_P106_G1.3430.29
82_N161_V1.3310.29
26_T103_V1.3230.29
69_G100_P1.3220.29
12_T75_T1.3040.28
48_P81_R1.2940.28
9_A174_F1.2870.27
208_W254_V1.2820.27
59_Q185_S1.2810.27
244_T258_A1.2760.27
165_L262_A1.2630.27
12_T21_L1.2630.27
244_T248_A1.2620.27
56_F74_G1.2530.26
58_E110_V1.2420.26
55_D125_Q1.2340.26
173_A199_F1.2330.26
83_F150_A1.2250.26
31_S92_G1.2200.25
213_N217_S1.2190.25
96_I190_I1.2190.25
258_A263_T1.2140.25
238_L241_F1.2010.25
163_A206_F1.1980.25
57_I219_A1.1920.25
45_Q49_F1.1910.25
105_L157_V1.1880.25
251_A268_A1.1750.24
53_V105_L1.1720.24
259_L267_R1.1700.24
60_F70_F1.1670.24
222_G269_H1.1660.24
221_T256_I1.1660.24
30_G42_C1.1650.24
85_A105_L1.1620.24
85_A132_A1.1590.24
193_T214_A1.1570.24
44_G265_R1.1460.23
81_R100_P1.1440.23
85_A89_K1.1370.23
169_P209_S1.1330.23
23_G40_P1.1320.23
229_T248_A1.1240.23
204_T229_T1.1210.23
32_G58_E1.1160.22
61_H128_H1.1150.22
45_Q95_A1.1120.22
22_L120_Y1.1080.22
22_L30_G1.1010.22
77_A138_T1.0980.22
39_W62_R1.0930.22
91_A164_A1.0900.22
38_Q48_P1.0820.22
154_L157_V1.0820.22
66_M188_Q1.0790.21
30_G68_V1.0780.21
19_L102_Q1.0740.21
247_L250_Y1.0700.21
14_V26_T1.0590.21
41_D112_F1.0580.21
194_F243_P1.0550.21
73_L105_L1.0540.21
69_G87_D1.0370.20
165_L217_S1.0360.20
43_S51_L1.0350.20
42_C58_E1.0330.20
212_R250_Y1.0290.20
186_W240_P1.0270.20
20_I71_F1.0210.20
119_G124_T1.0200.20
109_T188_Q1.0170.20
94_L232_V1.0090.20
213_N258_A1.0090.20
177_G238_L1.0070.20
166_A258_A1.0050.20
216_R254_V0.9920.19
67_V137_G0.9910.19
46_F73_L0.9880.19
219_A230_A0.9870.19
70_F74_G0.9870.19
56_F66_M0.9830.19
23_G42_C0.9760.19
251_A259_L0.9740.19
62_R107_G0.9730.19
84_D261_V0.9690.19
258_A262_A0.9690.19
182_V190_I0.9640.19
35_C107_G0.9610.19
91_A138_T0.9550.18
72_I101_L0.9470.18
14_V124_T0.9410.18
97_V222_G0.9390.18
44_G243_P0.9390.18
160_A267_R0.9370.18
20_I29_S0.9360.18
249_Y256_I0.9340.18
44_G155_G0.9330.18
94_L103_V0.9280.18
248_A261_V0.9250.18
96_I134_A0.9190.18
95_A185_S0.9160.18
35_C110_V0.9150.17
61_H180_F0.9130.17
30_G33_A0.9030.17
48_P77_A0.8990.17
229_T259_L0.8960.17
6_Y250_Y0.8950.17
80_Y93_V0.8910.17
150_A230_A0.8860.17
29_S218_A0.8790.17
181_T184_G0.8750.17
90_L235_G0.8720.17
241_F248_A0.8660.16
40_P107_G0.8650.16
160_A165_L0.8590.16
120_Y234_L0.8580.16
27_A65_A0.8570.16
165_L244_T0.8540.16
238_L259_L0.8530.16
262_A267_R0.8470.16
79_A193_T0.8460.16
241_F251_A0.8430.16
259_L264_A0.8420.16
75_T140_T0.8420.16
160_A235_G0.8400.16
173_A198_L0.8360.16
158_R218_A0.8290.16
199_F233_L0.8260.16
210_L263_T0.8240.16
171_E213_N0.8240.16
57_I73_L0.8220.15
129_H193_T0.8150.15
171_E210_L0.8130.15
59_Q109_T0.8120.15
56_F188_Q0.8020.15
251_A255_V0.8010.15
198_L267_R0.8010.15
160_A172_V0.7930.15
167_V262_A0.7930.15
85_A99_L0.7930.15
168_L254_V0.7920.15
93_V127_V0.7910.15
47_L55_D0.7910.15
13_A26_T0.7910.15
150_A168_L0.7890.15
193_T253_A0.7850.15
43_S59_Q0.7850.15
168_L181_T0.7840.15
18_A60_F0.7820.15
24_E55_D0.7810.15
219_A241_F0.7800.15
25_F144_L0.7780.15
229_T233_L0.7750.15
35_C58_E0.7740.15
99_L132_A0.7680.14
11_V223_G0.7680.14
11_V149_A0.7650.14
75_T80_Y0.7580.14
250_Y258_A0.7550.14
131_A134_A0.7520.14
60_F72_I0.7510.14
105_L138_T0.7500.14
62_R106_G0.7470.14
229_T254_V0.7460.14
167_V263_T0.7440.14
201_A248_A0.7410.14
46_F94_L0.7400.14
97_V260_L0.7380.14
44_G51_L0.7380.14
5_S236_V0.7370.14
60_F66_M0.7350.14
241_F257_A0.7330.14
65_A205_A0.7290.14
67_V73_L0.7210.14
29_S93_V0.7210.14
59_Q191_H0.7200.14
56_F103_V0.7200.14
36_G119_G0.7180.13
57_I187_I0.7150.13
14_V20_I0.7150.13
20_I164_A0.7120.13
206_F215_T0.7120.13
168_L215_T0.7090.13
152_I161_V0.7070.13
95_A142_T0.7070.13
56_F183_Y0.7060.13
170_F267_R0.7040.13
55_D81_R0.7030.13
171_E262_A0.7020.13
9_A16_T0.6970.13
50_G55_D0.6970.13
198_L217_S0.6950.13
48_P51_L0.6920.13
33_A109_T0.6890.13
210_L262_A0.6880.13
72_I75_T0.6870.13
159_T226_L0.6860.13
71_F195_E0.6850.13
18_A137_G0.6850.13
45_Q194_F0.6810.13
31_S138_T0.6800.13
30_G139_V0.6780.13
217_S226_L0.6710.13
143_A176_R0.6710.13
48_P100_P0.6700.13
23_G106_G0.6670.13
68_V214_A0.6650.13
92_G141_Y0.6640.13
42_C107_G0.6630.12
30_G214_A0.6620.12
163_A166_A0.6620.12
205_A251_A0.6570.12
246_Q262_A0.6550.12
57_I68_V0.6500.12
6_Y253_A0.6490.12
21_L192_H0.6490.12
62_R128_H0.6430.12
39_W106_G0.6370.12
73_L150_A0.6340.12
22_L74_G0.6320.12
43_S70_F0.6300.12
213_N244_T0.6270.12
246_Q266_I0.6270.12
97_V216_R0.6260.12
248_A266_I0.6260.12
229_T266_I0.6240.12
195_E204_T0.6210.12
144_L205_A0.6200.12
166_A201_A0.6180.12
88_I174_F0.6170.12
91_A161_V0.6120.12
167_V210_L0.6100.12
30_G57_I0.6090.12
165_L230_A0.6090.12
34_T54_N0.6060.12
96_I138_T0.6010.11
47_L193_T0.6010.11
24_E234_L0.5980.11
48_P232_V0.5960.11
226_L229_T0.5940.11
56_F109_T0.5940.11
251_A254_V0.5930.11
79_A109_T0.5920.11
217_S248_A0.5910.11
160_A210_L0.5890.11
12_T71_F0.5890.11
263_T266_I0.5880.11
5_S71_F0.5880.11
103_V240_P0.5870.11
239_F242_G0.5840.11
141_Y200_T0.5830.11
103_V202_A0.5830.11
217_S267_R0.5800.11
51_L55_D0.5790.11
36_G44_G0.5790.11
30_G59_Q0.5770.11
76_G156_R0.5760.11
77_A94_L0.5760.11
160_A171_E0.5740.11
153_G235_G0.5740.11
142_T176_R0.5730.11
104_I182_V0.5710.11
206_F255_V0.5710.11
213_N266_I0.5700.11
195_E229_T0.5690.11
74_G86_R0.5680.11
212_R216_R0.5680.11
201_A215_T0.5680.11
230_A262_A0.5650.11
70_F94_L0.5620.11
14_V104_I0.5620.11
56_F200_T0.5580.11
155_G265_R0.5560.11
112_F122_P0.5550.11
105_L131_A0.5540.11
212_R247_L0.5530.11
84_D105_L0.5480.11
247_L258_A0.5470.11
244_T263_T0.5470.11
104_I155_G0.5470.11
30_G188_Q0.5460.11
30_G35_C0.5450.11
30_G54_N0.5450.11
165_L168_L0.5420.11
8_L12_T0.5410.11
26_T132_A0.5410.11
136_L176_R0.5400.11
57_I84_D0.5400.11
30_G110_V0.5360.10
27_A34_T0.5340.10
60_F234_L0.5330.10
95_A100_P0.5320.10
55_D103_V0.5310.10
111_T243_P0.5290.10
250_Y265_R0.5270.10
93_V157_V0.5210.10
16_T202_A0.5200.10
247_L266_I0.5190.10
178_T252_L0.5190.10
87_D135_I0.5180.10
21_L161_V0.5170.10
44_G153_G0.5160.10
85_A153_G0.5160.10
130_L150_A0.5150.10
166_A262_A0.5140.10
28_V161_V0.5100.10
47_L103_V0.5090.10
164_A258_A0.5080.10
232_V245_I0.5080.10
20_I122_P0.5030.10
258_A267_R0.5030.10
38_Q55_D0.5010.10
213_N262_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.4043 97.9 0.885 Contact Map
4tq3A 1 0.4224 97.2 0.9 Contact Map
1wazA 1 0.1661 10.6 0.965 Contact Map
3wdoA 1 0.6498 3.2 0.973 Contact Map
4k1fA 3 0.2202 2.6 0.974 Contact Map
2kv5A 1 0.1191 2.3 0.975 Contact Map
2h01A 1 0.1516 2.2 0.975 Contact Map
2losA 1 0.3285 2 0.975 Contact Map
4rqxA 3 0.1155 1.9 0.975 Contact Map
4b19A 1 0.1083 1.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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