GREMLIN Database
Q9HPI2 - Malate dehydrogenase
UniProt: Q9HPI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 750 (738)
Sequences: 1161 (465)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_D112_A7.4701.00
441_I542_A6.8271.00
188_V209_V6.6291.00
225_E239_P5.4451.00
117_L121_V4.6521.00
47_A50_D4.4631.00
182_D185_D4.4031.00
523_V533_T4.3051.00
292_E311_Y4.0821.00
177_E353_K3.9231.00
501_Y534_M3.7011.00
395_D399_E3.6461.00
501_Y539_D3.6101.00
51_D54_E3.5931.00
250_M265_V3.5131.00
201_A216_M3.3440.99
109_L124_M3.3030.99
5_D9_D3.2740.99
276_D373_S3.2600.99
443_L738_A3.2590.99
646_L656_V3.2050.99
587_A688_I3.1390.99
12_A57_T3.1240.99
122_S151_A3.1020.99
395_D409_L3.0860.99
224_T229_V3.0760.99
54_E57_T3.0200.99
542_A741_A2.9650.99
596_D599_V2.9390.98
175_A278_I2.8890.98
467_V540_A2.8820.98
120_T123_A2.8580.98
604_A622_V2.8430.98
169_G203_F2.8200.98
147_R150_D2.8010.98
215_T238_Q2.7890.98
294_A297_A2.7840.98
116_E119_A2.7740.98
262_G286_D2.7040.97
641_R644_Q2.6870.97
54_E58_H2.6830.97
535_V540_A2.6450.97
438_Q742_A2.6260.97
202_K235_A2.5970.97
472_R492_D2.5910.96
667_V704_R2.5220.96
267_Q296_A2.4930.96
114_A118_V2.4890.96
176_A183_L2.4810.95
242_S248_D2.4530.95
247_A272_S2.4170.95
173_L346_T2.4000.95
294_A299_E2.3890.94
475_I490_V2.3790.94
114_A147_R2.3720.94
111_Q116_E2.3650.94
647_R656_V2.3560.94
115_D118_V2.3550.94
268_A271_R2.3450.94
442_A535_V2.3350.94
398_M406_E2.3330.94
202_K236_F2.3270.94
531_G543_F2.3150.93
117_L144_V2.2670.93
21_I93_G2.2370.92
19_V93_G2.2330.92
458_M738_A2.2170.92
698_G701_L2.2130.92
657_D679_D2.2130.92
125_E153_D2.2090.92
137_K140_E2.2080.92
111_Q123_A2.2030.92
45_C74_V2.1980.91
250_M272_S2.1950.91
293_S296_A2.1910.91
598_D641_R2.1840.91
586_C689_F2.1480.90
53_T404_R2.1420.90
338_E341_K2.1340.90
265_V272_S2.1340.90
172_L255_V2.1230.90
169_G207_L2.1090.90
251_A272_S2.1010.89
55_A82_A2.0900.89
647_R679_D2.0630.89
220_S233_K2.0590.88
224_T244_G2.0390.88
508_L536_E2.0290.88
594_D634_E2.0290.88
271_R297_A2.0220.87
294_A302_V2.0140.87
226_D229_V2.0100.87
248_D251_A2.0070.87
55_A83_Q2.0070.87
222_V240_A2.0030.87
443_L458_M2.0010.87
219_S261_V1.9950.87
558_P722_V1.9900.87
600_L642_A1.9800.86
109_L123_A1.9790.86
146_R150_D1.9660.86
220_S228_D1.9440.85
594_D638_K1.9410.85
431_I739_A1.9400.85
184_S210_D1.9380.85
186_L209_V1.9090.84
623_L697_I1.8980.84
286_D290_D1.8930.84
354_Q388_E1.8850.83
186_L255_V1.8850.83
107_I124_M1.8800.83
46_R49_A1.8790.83
56_F61_K1.8770.83
224_T228_D1.8560.82
534_M539_D1.8440.82
197_A259_L1.8370.82
465_D489_D1.8160.81
386_L389_V1.8160.81
657_D675_Y1.8130.81
118_V147_R1.8040.81
331_V398_M1.8030.81
600_L639_P1.8000.80
469_L531_G1.7900.80
215_T249_A1.7800.80
442_A540_A1.7800.80
93_G104_V1.7610.79
124_M152_M1.7600.79
121_V144_V1.7580.79
267_Q271_R1.7270.77
504_T536_E1.7170.77
545_T554_A1.7140.77
114_A143_E1.7070.77
56_F62_G1.6990.76
125_E152_M1.6940.76
219_S223_I1.6800.75
350_D354_Q1.6740.75
52_P83_Q1.6710.75
479_V484_L1.6700.75
256_F265_V1.6650.75
115_D147_R1.6650.75
443_L544_L1.6580.74
105_F127_T1.6560.74
219_S233_K1.6530.74
591_V715_L1.6460.74
576_M711_I1.6440.74
270_V297_A1.6350.73
226_D244_G1.6310.73
601_A645_Q1.6310.73
116_E120_T1.6300.73
206_S338_E1.6180.73
109_L117_L1.6000.72
339_E399_E1.5970.72
337_N400_T1.5940.71
198_I219_S1.5860.71
574_V716_V1.5830.71
460_E485_D1.5770.71
147_R151_A1.5760.71
270_V279_V1.5750.71
198_I230_N1.5740.70
8_L47_A1.5710.70
295_K304_M1.5570.70
441_I738_A1.5540.69
168_S204_Y1.5450.69
4_D43_A1.5440.69
217_C249_A1.5430.69
458_M464_A1.5340.68
47_A58_H1.5340.68
111_Q117_L1.5330.68
113_T116_E1.5320.68
604_A686_V1.5280.68
205_V236_F1.5250.68
267_Q293_S1.5190.68
439_Q742_A1.5140.67
286_D293_S1.5090.67
44_P58_H1.4970.66
442_A534_M1.4970.66
225_E234_A1.4940.66
344_A389_V1.4850.66
729_D733_D1.4810.66
209_V214_I1.4680.65
293_S297_A1.4620.65
104_V127_T1.4610.65
223_I233_K1.4550.64
585_F611_A1.4460.64
190_F201_A1.4420.63
350_D353_K1.4260.63
586_C702_L1.4250.63
172_L278_I1.4220.62
172_L280_F1.4200.62
207_L342_V1.4170.62
602_E649_D1.4130.62
290_D293_S1.4060.61
111_Q120_T1.4020.61
563_G719_N1.4010.61
189_V250_M1.3980.61
598_D645_Q1.3900.61
725_L734_I1.3740.60
245_D248_D1.3620.59
399_E409_L1.3480.58
655_P681_D1.3450.58
457_Q735_V1.3440.58
510_K677_F1.3440.58
267_Q270_V1.3400.58
240_A244_G1.3390.58
464_A738_A1.3380.58
178_I376_I1.3330.57
270_V293_S1.3330.57
190_F216_M1.3250.57
646_L654_F1.3000.55
562_V719_N1.2970.55
211_R238_Q1.2960.55
426_M576_M1.2850.54
723_H741_A1.2820.54
217_C222_V1.2780.54
523_V529_Y1.2760.54
443_L464_A1.2740.54
622_V646_L1.2730.54
219_S262_G1.2720.54
187_D410_V1.2680.53
252_G275_D1.2670.53
230_N233_K1.2630.53
612_R617_D1.2610.53
573_G590_T1.2540.53
199_A205_V1.2520.52
9_D13_S1.2510.52
215_T222_V1.2470.52
111_Q119_A1.2450.52
143_E147_R1.2410.52
615_N695_G1.2340.51
644_Q648_E1.2310.51
504_T537_A1.2300.51
222_V245_D1.2280.51
175_A280_F1.2220.51
531_G722_V1.2210.51
111_Q114_A1.2170.50
68_V109_L1.2120.50
172_L204_Y1.2120.50
231_E234_A1.2090.50
197_A216_M1.2000.49
153_D334_T1.1960.49
668_E672_Q1.1940.49
692_L696_N1.1920.49
217_C233_K1.1860.48
180_G271_R1.1850.48
536_E720_K1.1840.48
119_A151_A1.1840.48
622_V656_V1.1820.48
122_S148_L1.1800.48
207_L346_T1.1760.48
470_G475_I1.1710.48
149_G335_D1.1670.47
252_G694_A1.1650.47
279_V302_V1.1650.47
339_E400_T1.1610.47
205_V214_I1.1600.47
44_P49_A1.1500.46
496_G530_L1.1500.46
262_G266_N1.1490.46
266_N272_S1.1480.46
168_S219_S1.1450.46
570_Y599_V1.1450.46
619_R655_P1.1420.46
492_D495_E1.1390.46
492_D530_L1.1380.46
44_P54_E1.1320.45
265_V294_A1.1310.45
130_G193_A1.1290.45
198_I223_I1.1260.45
620_V686_V1.1230.45
197_A692_L1.1220.45
332_R405_T1.1220.45
559_L571_V1.1220.45
643_A647_R1.1150.44
714_M737_L1.1130.44
203_F345_A1.1110.44
295_K373_S1.1100.44
600_L622_V1.1090.44
188_V214_I1.1080.44
535_V705_L1.1070.44
645_Q649_D1.1040.44
109_L120_T1.1030.44
582_R707_G1.1020.43
217_C223_I1.1000.43
72_S112_A1.1000.43
198_I220_S1.0950.43
632_D637_R1.0930.43
461_A742_A1.0930.43
64_M104_V1.0920.43
205_V211_R1.0900.43
143_E146_R1.0800.42
69_S85_A1.0770.42
584_V705_L1.0760.42
101_D646_L1.0730.42
565_A609_D1.0710.42
290_D311_Y1.0680.41
597_A601_A1.0670.41
476_Q480_D1.0660.41
177_E371_F1.0660.41
504_T533_T1.0630.41
209_V255_V1.0630.41
590_T699_Y1.0620.41
479_V486_F1.0610.41
442_A467_V1.0570.41
671_L682_T1.0570.41
662_A697_I1.0540.41
265_V410_V1.0540.41
453_R730_E1.0470.40
216_M230_N1.0450.40
631_V636_T1.0450.40
669_D673_G1.0420.40
507_D510_K1.0360.40
176_A186_L1.0340.39
201_A214_I1.0320.39
14_D107_I1.0300.39
270_V294_A1.0260.39
169_G209_V1.0250.39
438_Q535_V1.0230.39
238_Q249_A1.0180.39
303_I376_I1.0170.39
291_Y297_A1.0160.38
388_E413_R1.0110.38
94_V128_F1.0080.38
449_E481_A1.0050.38
187_D242_S1.0040.38
144_V677_F1.0040.38
116_E123_A1.0010.38
171_A315_V1.0010.38
267_Q297_A0.9970.37
528_N545_T0.9920.37
571_V718_M0.9910.37
574_V610_L0.9890.37
572_A592_N0.9850.37
168_S282_M0.9850.37
472_R476_Q0.9830.37
102_I264_I0.9820.37
573_G715_L0.9820.37
389_V737_L0.9770.36
690_P697_I0.9730.36
611_A686_V0.9720.36
58_H85_A0.9720.36
193_A197_A0.9680.36
471_D474_T0.9670.36
398_M409_L0.9640.36
449_E453_R0.9630.35
452_I456_H0.9630.35
191_S247_A0.9630.35
645_Q648_E0.9620.35
655_P680_L0.9610.35
215_T240_A0.9610.35
492_D499_S0.9580.35
601_A646_L0.9560.35
220_S223_I0.9560.35
510_K675_Y0.9520.35
574_V611_A0.9470.35
219_S266_N0.9460.35
56_F85_A0.9430.34
627_N696_N0.9410.34
198_I261_V0.9410.34
58_H69_S0.9390.34
229_V232_F0.9380.34
696_N699_Y0.9370.34
247_A250_M0.9370.34
68_V117_L0.9360.34
263_G293_S0.9360.34
55_A342_V0.9330.34
226_D240_A0.9290.34
295_K299_E0.9270.34
664_T670_I0.9270.34
222_V249_A0.9240.33
9_D731_V0.9210.33
614_F736_N0.9190.33
66_G69_S0.9160.33
219_S269_M0.9140.33
592_N603_V0.9140.33
460_E493_P0.9140.33
543_F555_L0.9110.33
282_M305_A0.9090.33
188_V257_V0.9090.33
267_Q294_A0.9090.33
610_L716_V0.9070.32
153_D535_V0.9060.32
280_F356_V0.9060.32
577_L710_A0.9050.32
229_V244_G0.9040.32
210_D271_R0.9020.32
27_T98_R0.8990.32
661_Q728_G0.8980.32
119_A122_S0.8960.32
280_F305_A0.8930.32
647_R654_F0.8910.32
320_G324_I0.8900.32
481_A530_L0.8890.32
410_V413_R0.8880.31
198_I216_M0.8830.31
222_V244_G0.8830.31
642_A646_L0.8820.31
496_G499_S0.8820.31
617_D655_P0.8800.31
165_A318_V0.8800.31
178_I303_I0.8790.31
551_Y573_G0.8790.31
249_A600_L0.8770.31
20_E140_E0.8710.31
335_D402_V0.8700.31
332_R404_R0.8690.31
498_H502_A0.8680.30
373_S694_A0.8670.30
506_Y510_K0.8640.30
217_C264_I0.8620.30
99_F381_L0.8610.30
386_L688_I0.8610.30
625_Y693_E0.8610.30
587_A607_T0.8610.30
27_T45_C0.8610.30
619_R682_T0.8590.30
503_D507_D0.8580.30
74_V80_I0.8580.30
171_A280_F0.8580.30
605_Q646_L0.8570.30
197_A377_I0.8560.30
45_C80_I0.8560.30
529_Y557_P0.8550.30
572_A603_V0.8520.30
266_N269_M0.8510.30
444_G531_G0.8500.30
619_R684_A0.8500.30
492_D559_L0.8480.29
279_V291_Y0.8480.29
442_A473_D0.8460.29
597_A641_R0.8440.29
206_S342_V0.8440.29
467_V489_D0.8440.29
191_S264_I0.8410.29
278_I305_A0.8400.29
450_K695_G0.8400.29
47_A109_L0.8380.29
140_E702_L0.8370.29
202_K205_V0.8360.29
344_A359_E0.8350.29
257_V282_M0.8340.29
167_I323_F0.8310.29
225_E229_V0.8310.29
501_Y535_V0.8310.29
49_A54_E0.8280.28
573_G695_G0.8270.28
12_A58_H0.8270.28
604_A620_V0.8270.28
292_E304_M0.8240.28
101_D419_R0.8230.28
102_I223_I0.8200.28
263_G311_Y0.8190.28
337_N707_G0.8180.28
140_E323_F0.8170.28
625_Y633_N0.8160.28
570_Y592_N0.8130.28
605_Q651_D0.8110.28
652_I656_V0.8080.28
114_A120_T0.8070.27
441_I544_L0.8050.27
224_T240_A0.8040.27
4_D46_R0.8040.27
177_E350_D0.8040.27
259_L266_N0.8040.27
575_Y590_T0.8040.27
512_K632_D0.8030.27
623_L696_N0.8020.27
248_D437_E0.8020.27
15_P20_E0.7990.27
34_S101_D0.7980.27
255_V689_F0.7980.27
663_D703_Q0.7940.27
373_S376_I0.7930.27
502_A520_E0.7910.27
657_D678_S0.7910.27
232_F236_F0.7900.27
20_E128_F0.7900.27
189_V233_K0.7880.27
543_F558_P0.7880.27
204_Y291_Y0.7870.27
107_I127_T0.7860.26
599_V708_A0.7860.26
355_D485_D0.7860.26
173_L207_L0.7850.26
534_M540_A0.7850.26
591_V662_A0.7840.26
57_T62_G0.7830.26
623_L662_A0.7830.26
444_G597_A0.7820.26
263_G297_A0.7780.26
386_L666_V0.7770.26
265_V270_V0.7760.26
475_I585_F0.7740.26
598_D644_Q0.7730.26
93_G196_S0.7720.26
263_G286_D0.7700.26
34_S678_S0.7690.26
93_G105_F0.7690.26
572_A716_V0.7670.26
278_I667_V0.7670.26
215_T242_S0.7660.26
342_V346_T0.7660.26
432_N435_K0.7650.25
118_V144_V0.7640.25
60_T617_D0.7640.25
214_I374_E0.7630.25
381_L536_E0.7630.25
622_V639_P0.7630.25
459_H486_F0.7620.25
51_D334_T0.7610.25
114_A137_K0.7600.25
613_R711_I0.7590.25
117_L151_A0.7590.25
510_K657_D0.7580.25
581_N584_V0.7580.25
570_Y603_V0.7580.25
64_M105_F0.7570.25
331_V743_A0.7550.25
269_M272_S0.7530.25
601_A651_D0.7520.25
478_T481_A0.7520.25
564_T711_I0.7520.25
391_P563_G0.7510.25
111_Q147_R0.7510.25
64_M127_T0.7490.25
53_T734_I0.7490.25
637_R641_R0.7480.25
31_R640_R0.7460.25
47_A54_E0.7460.25
140_E469_L0.7450.25
643_A646_L0.7450.25
46_R50_D0.7450.25
66_G112_A0.7440.25
535_V600_L0.7430.25
699_Y710_A0.7420.24
574_V607_T0.7410.24
220_S740_V0.7410.24
635_G691_N0.7400.24
295_K374_E0.7390.24
318_V360_V0.7390.24
69_S458_M0.7390.24
149_G223_I0.7370.24
586_C687_L0.7370.24
115_D119_A0.7370.24
601_A608_A0.7370.24
252_G441_I0.7370.24
348_L389_V0.7340.24
46_R55_A0.7340.24
167_I377_I0.7340.24
179_A376_I0.7340.24
600_L603_V0.7330.24
500_A537_A0.7320.24
350_D388_E0.7310.24
598_D601_A0.7310.24
191_S217_C0.7300.24
522_L525_R0.7300.24
623_L690_P0.7290.24
426_M714_M0.7290.24
484_L574_V0.7280.24
55_A61_K0.7280.24
175_A266_N0.7280.24
29_T56_F0.7270.24
458_M463_I0.7270.24
558_P718_M0.7260.24
223_I229_V0.7240.24
23_T592_N0.7240.24
344_A576_M0.7230.24
564_T571_V0.7230.24
491_V534_M0.7210.24
204_Y209_V0.7210.24
404_R452_I0.7200.23
529_Y722_V0.7190.23
94_V168_S0.7190.23
469_L622_V0.7180.23
171_A733_D0.7180.23
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600_L738_A0.5390.17
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520_E530_L0.5380.17
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187_D214_I0.5140.16
687_L701_L0.5130.16
51_D120_T0.5130.16
586_C652_I0.5130.16
34_S315_V0.5130.16
556_K735_V0.5130.16
610_L686_V0.5130.16
356_V521_S0.5120.16
575_Y699_Y0.5120.16
555_L724_V0.5120.16
120_T152_M0.5120.16
252_G299_E0.5120.16
118_V503_D0.5110.16
672_Q681_D0.5110.16
445_E547_L0.5110.16
128_F168_S0.5110.16
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173_L262_G0.5100.16
55_A453_R0.5100.16
381_L615_N0.5100.16
323_F633_N0.5100.16
557_P699_Y0.5100.16
558_P575_Y0.5100.16
533_T537_A0.5100.16
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338_E438_Q0.5100.16
296_A339_E0.5100.16
110_D117_L0.5090.16
55_A450_K0.5090.16
614_F723_H0.5090.16
376_I503_D0.5080.16
457_Q730_E0.5080.16
385_V666_V0.5070.16
467_V599_V0.5070.16
188_V460_E0.5070.16
261_V297_A0.5060.16
315_V423_S0.5060.16
270_V345_A0.5060.16
232_F323_F0.5060.16
157_F355_D0.5060.16
282_M516_R0.5050.15
547_L729_D0.5040.15
415_E543_F0.5040.15
49_A573_G0.5030.15
279_V292_E0.5030.15
57_T405_T0.5030.15
673_G711_I0.5030.15
233_K740_V0.5030.15
46_R74_V0.5030.15
175_A439_Q0.5020.15
251_A376_I0.5020.15
115_D505_L0.5020.15
261_V348_L0.5020.15
43_A656_V0.5010.15
295_K302_V0.5010.15
249_A293_S0.5010.15
348_L390_A0.5010.15
409_L551_Y0.5010.15
29_T357_P0.5000.15
173_L617_D0.5000.15
178_I239_P0.5000.15
29_T445_E0.5000.15
635_G728_G0.5000.15
509_R726_Q0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nv9A 2 0.5827 100 0.599 Contact Map
1vl6A 4 0.4933 100 0.654 Contact Map
1pj3A 4 0.536 100 0.665 Contact Map
1gq2A 6 0.5453 100 0.666 Contact Map
1o0sA 4 0.5613 100 0.666 Contact Map
2dvmA 2 0.5653 100 0.69 Contact Map
2a9fA 2 0.5013 100 0.691 Contact Map
4e4rA 2 0.432 100 0.826 Contact Map
1td9A 3 0.428 100 0.833 Contact Map
1r5jA 4 0.428 100 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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