GREMLIN Database
Q9HPI0 - Uncharacterized protein
UniProt: Q9HPI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (223)
Sequences: 38155 (27883)
Seq/√Len: 1867.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G111_V3.3491.00
49_V108_V3.0041.00
189_R193_S2.9001.00
214_G220_E2.8741.00
40_V110_L2.6891.00
37_F113_A2.4501.00
81_G236_G2.3661.00
189_R192_D2.3571.00
60_L115_T2.2911.00
51_A210_A2.2681.00
16_S19_D2.2241.00
37_F110_L2.2101.00
72_E126_Q2.1521.00
64_F123_V2.0421.00
166_A170_F1.9691.00
65_A72_E1.9511.00
66_R74_L1.9441.00
133_D136_A1.8961.00
45_T107_G1.8921.00
33_A117_S1.8681.00
62_A82_L1.8641.00
45_T108_V1.8271.00
44_T106_Q1.8071.00
75_S78_G1.7991.00
85_G204_Y1.7951.00
238_C242_R1.7851.00
61_T200_N1.7811.00
109_G113_A1.7591.00
56_L60_L1.7471.00
176_S181_A1.7171.00
37_F117_S1.7081.00
19_D131_A1.6751.00
81_G240_L1.6591.00
223_T226_T1.6461.00
165_T168_A1.6381.00
151_V154_I1.6351.00
195_G198_E1.6311.00
50_A111_V1.6241.00
40_V44_T1.6031.00
147_V151_V1.5981.00
60_L119_A1.5971.00
125_T188_F1.5611.00
105_S108_V1.5331.00
161_T164_W1.5151.00
148_V151_V1.4511.00
209_F213_V1.4431.00
40_V43_Q1.4381.00
60_L116_A1.4261.00
205_V209_F1.4241.00
65_A69_L1.4151.00
47_S214_G1.4081.00
224_T228_G1.3941.00
119_A123_V1.3911.00
17_R21_T1.3661.00
21_T25_I1.3551.00
88_G229_G1.3551.00
85_G236_G1.3541.00
38_L42_E1.3471.00
213_V217_W1.3461.00
42_E50_A1.3461.00
81_G239_V1.3461.00
45_T49_V1.3391.00
227_I231_C1.3271.00
76_I80_V1.3251.00
44_T110_L1.3241.00
18_T22_T1.3211.00
166_A169_V1.2961.00
22_T124_L1.2951.00
91_V232_I1.2881.00
231_C235_T1.2751.00
167_E170_F1.2721.00
52_I230_F1.2531.00
46_S49_V1.2391.00
88_G233_V1.2381.00
91_V225_P1.2261.00
48_A211_A1.2231.00
24_G144_F1.2181.00
77_G239_V1.2141.00
105_S109_G1.2101.00
79_V83_G1.2061.00
64_F68_V1.2021.00
170_F174_Y1.1991.00
18_T21_T1.1921.00
32_A148_V1.1891.00
32_A149_M1.1811.00
64_F120_L1.1761.00
92_L229_G1.1711.00
45_T111_V1.1661.00
167_E171_A1.1661.00
126_Q195_G1.1611.00
83_G87_A1.1571.00
30_M121_G1.1541.00
127_R130_D1.1441.00
222_I227_I1.1401.00
25_I124_L1.1361.00
106_Q110_L1.1291.00
44_T104_T1.1211.00
22_T26_A1.1211.00
61_T196_P1.1201.00
69_L123_V1.1161.00
126_Q130_D1.1121.00
22_T128_I1.1011.00
44_T107_G1.0911.00
61_T122_S1.0741.00
61_T119_A1.0711.00
191_L199_I1.0641.00
19_D132_L1.0611.00
126_Q196_P1.0581.00
194_L199_I1.0561.00
17_R20_W1.0521.00
66_R73_R1.0511.00
72_E78_G1.0491.00
76_I79_V1.0491.00
64_F119_A1.0421.00
190_L199_I1.0411.00
173_A176_S1.0391.00
152_A156_A1.0351.00
107_G111_V1.0301.00
106_Q109_G1.0281.00
77_G243_R1.0261.00
28_V148_V1.0241.00
74_L79_V1.0211.00
77_G242_R1.0101.00
170_F173_A1.0081.00
20_W144_F0.9921.00
19_D22_T0.9911.00
27_A144_F0.9911.00
62_A74_L0.9851.00
64_F67_A0.9821.00
53_V108_V0.9801.00
90_V94_N0.9801.00
56_L89_V0.9771.00
75_S79_V0.9731.00
53_V111_V0.9701.00
47_S218_R0.9641.00
115_T119_A0.9621.00
151_V155_A0.9601.00
194_L198_E0.9491.00
21_T24_G0.9491.00
53_V115_T0.9461.00
64_F116_A0.9431.00
34_Y121_G0.9391.00
169_V173_A0.9371.00
195_G199_I0.9331.00
224_T227_I0.9301.00
191_L195_G0.9301.00
111_V115_T0.9261.00
36_A40_V0.9241.00
25_I28_V0.9211.00
152_A155_A0.9161.00
171_A174_Y0.9151.00
215_L222_I0.9121.00
102_S105_S0.9071.00
118_F187_Y0.9051.00
67_A71_G0.9031.00
52_I90_V0.9021.00
94_N223_T0.8951.00
29_L117_S0.8931.00
143_V147_V0.8901.00
84_L236_G0.8801.00
139_A143_V0.8771.00
47_S220_E0.8771.00
208_V230_F0.8761.00
26_A30_M0.8761.00
230_F234_F0.8711.00
68_V71_G0.8681.00
182_V186_I0.8531.00
91_V228_G0.8451.00
29_L120_L0.8431.00
34_Y117_S0.8431.00
211_A222_I0.8411.00
89_V93_S0.8361.00
205_V208_V0.8301.00
160_Q163_P0.8301.00
59_V85_G0.8271.00
87_A91_V0.8251.00
132_L137_L0.8241.00
87_A232_I0.8241.00
146_A150_H0.8241.00
104_T108_V0.8201.00
45_T50_A0.8191.00
94_N97_P0.8181.00
32_A36_A0.8111.00
69_L72_E0.8001.00
22_T127_R0.7971.00
63_G67_A0.7951.00
185_L189_R0.7901.00
120_L124_L0.7901.00
23_V132_L0.7861.00
222_I226_T0.7861.00
144_F147_V0.7841.00
172_V176_S0.7821.00
228_G232_I0.7771.00
88_G236_G0.7761.00
136_A140_W0.7751.00
39_F43_Q0.7741.00
165_T169_V0.7731.00
73_R77_G0.7731.00
62_A78_G0.7721.00
168_A171_A0.7701.00
144_F148_V0.7681.00
122_S187_Y0.7621.00
118_F122_S0.7571.00
66_R71_G0.7551.00
56_L59_V0.7501.00
55_S89_V0.7491.00
174_Y178_G0.7491.00
61_T123_V0.7471.00
225_P228_G0.7441.00
73_R76_I0.7441.00
203_G206_A0.7391.00
74_L78_G0.7381.00
51_A55_S0.7371.00
20_W24_G0.7351.00
214_G218_R0.7341.00
22_T25_I0.7311.00
60_L112_F0.7301.00
165_T170_F0.7291.00
215_L221_A0.7271.00
211_A230_F0.7261.00
190_L194_L0.7251.00
35_H180_S0.7221.00
23_V27_A0.7221.00
186_I189_R0.7191.00
235_T239_V0.7131.00
164_W169_V0.7071.00
33_A37_F0.7011.00
80_V84_L0.6981.00
140_W144_F0.6951.00
27_A32_A0.6951.00
58_P204_Y0.6951.00
32_A152_A0.6941.00
122_S200_N0.6941.00
72_E197_I0.6901.00
41_G50_A0.6901.00
154_I157_G0.6901.00
27_A30_M0.6871.00
20_W23_V0.6861.00
201_L240_L0.6851.00
226_T230_F0.6821.00
173_A177_V0.6791.00
213_V216_L0.6771.00
55_S58_P0.6731.00
38_L50_A0.6681.00
223_T227_I0.6681.00
52_I93_S0.6661.00
41_G107_G0.6651.00
16_S20_W0.6651.00
178_G182_V0.6611.00
121_G141_A0.6561.00
56_L115_T0.6531.00
55_S115_T0.6531.00
138_E188_F0.6521.00
211_A215_L0.6481.00
62_A66_R0.6481.00
29_L124_L0.6471.00
53_V112_F0.6451.00
127_R131_A0.6441.00
78_G195_G0.6391.00
121_G188_F0.6371.00
24_G148_V0.6371.00
147_V150_H0.6341.00
163_P166_A0.6341.00
103_S106_Q0.6301.00
34_Y55_S0.6291.00
138_E141_A0.6281.00
34_Y54_V0.6261.00
211_A214_G0.6261.00
24_G27_A0.6241.00
155_A158_E0.6211.00
20_W140_W0.6201.00
16_S21_T0.6191.00
38_L114_A0.6191.00
78_G82_L0.6181.00
121_G125_T0.6151.00
236_G240_L0.6141.00
102_S106_Q0.6101.00
221_A225_P0.6061.00
84_L239_V0.6051.00
216_L219_G0.6051.00
125_T137_L0.6031.00
143_V146_A0.6021.00
162_I165_T0.5951.00
65_A197_I0.5951.00
186_I190_L0.5921.00
37_F114_A0.5891.00
132_L136_A0.5891.00
95_P225_P0.5871.00
142_M146_A0.5871.00
145_G149_M0.5841.00
24_G28_V0.5821.00
34_Y38_L0.5801.00
140_W143_V0.5791.00
148_V152_A0.5781.00
150_H154_I0.5751.00
212_A215_L0.5731.00
212_A216_L0.5731.00
34_Y118_F0.5711.00
138_E142_M0.5671.00
69_L126_Q0.5641.00
23_V137_L0.5631.00
204_Y237_F0.5621.00
110_L113_A0.5611.00
86_L204_Y0.5611.00
174_Y177_V0.5601.00
35_H38_L0.5601.00
142_M184_F0.5591.00
52_I92_L0.5551.00
125_T191_L0.5531.00
237_F240_L0.5521.00
36_A149_M0.5481.00
227_I230_F0.5471.00
89_V233_V0.5461.00
215_L227_I0.5441.00
86_L90_V0.5381.00
69_L127_R0.5381.00
181_A185_L0.5361.00
30_M141_A0.5351.00
93_S108_V0.5351.00
125_T129_D0.5321.00
80_V87_A0.5311.00
203_G207_P0.5301.00
88_G232_I0.5301.00
75_S243_R0.5241.00
116_A120_L0.5181.00
122_S191_L0.5161.00
63_G82_L0.5131.00
81_G85_G0.5121.00
23_V26_A0.5101.00
61_T65_A0.5101.00
136_A139_A0.5081.00
68_V120_L0.5051.00
57_S118_F0.5011.00
28_V32_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.3031 98.9 0.708 Contact Map
3b5dA 2 0.3976 98.3 0.763 Contact Map
1pw4A 1 0.9764 35.6 0.916 Contact Map
2cfqA 1 0.7087 25 0.922 Contact Map
2rddB 1 0.1299 23.6 0.923 Contact Map
4he8J 1 0.6063 20 0.926 Contact Map
4j05A 3 0.9528 19.8 0.926 Contact Map
3l1lA 2 0.5236 18.2 0.927 Contact Map
2kluA 1 0.1732 15.2 0.93 Contact Map
4pypA 1 0.689 14.9 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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