Q9HPI0 - HALSA - GREMLIN Contacts

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Q9HPI0 - Uncharacterized protein

UniProt:	Q9HPI0	Sequences: MVAYAALVADDWLPRSRTDWTTVGIAAVLMIAAYHAFLFVGEQTTSSAVAAIVVSLSPVLTAGFARAVLPGERLSIGGVVGLGLGLAGVVVLSNPDPSNLVSSTSQGVGLVFAATASFALGSVLTQRIDDALDSEALEAWAMVFGAVVMHVASIAAGEPQTIPWTAEAVFAVAYLSVGASAVGFLIYFRLLDSLGPIEINLVGYVAPVFAAAVGLLWRGEAITTPTIGGFCIVFTGFCVLKRRAIAAELRALSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (223)
Sequences:	38155 (27883)
Seq/√Len:	1867.2

ECOLI - YTFF YICL YIJE YHBE EAMA YEDA RARD YDDG RHTA YIGM
BACSU - YWFM YCXC YBFH YETK YOAV YCBK YDFC YVBV YYAM YDED YDEK YXXF YRDR YOJE
HALSA - Q9HPI0 Q9HHP6 Q9HQ34
SULSO - Q97UX3 Q97X73 Q97UE8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_G	111_V	3.349	1.00
49_V	108_V	3.004	1.00
189_R	193_S	2.900	1.00
214_G	220_E	2.874	1.00
40_V	110_L	2.689	1.00
37_F	113_A	2.450	1.00
81_G	236_G	2.366	1.00
189_R	192_D	2.357	1.00
60_L	115_T	2.291	1.00
51_A	210_A	2.268	1.00
16_S	19_D	2.224	1.00
37_F	110_L	2.210	1.00
72_E	126_Q	2.152	1.00
64_F	123_V	2.042	1.00
166_A	170_F	1.969	1.00
65_A	72_E	1.951	1.00
66_R	74_L	1.944	1.00
133_D	136_A	1.896	1.00
45_T	107_G	1.892	1.00
33_A	117_S	1.868	1.00
62_A	82_L	1.864	1.00
45_T	108_V	1.827	1.00
44_T	106_Q	1.807	1.00
75_S	78_G	1.799	1.00
85_G	204_Y	1.795	1.00
238_C	242_R	1.785	1.00
61_T	200_N	1.781	1.00
109_G	113_A	1.759	1.00
56_L	60_L	1.747	1.00
176_S	181_A	1.717	1.00
37_F	117_S	1.708	1.00
19_D	131_A	1.675	1.00
81_G	240_L	1.659	1.00
223_T	226_T	1.646	1.00
165_T	168_A	1.638	1.00
151_V	154_I	1.635	1.00
195_G	198_E	1.631	1.00
50_A	111_V	1.624	1.00
40_V	44_T	1.603	1.00
147_V	151_V	1.598	1.00
60_L	119_A	1.597	1.00
125_T	188_F	1.561	1.00
105_S	108_V	1.533	1.00
161_T	164_W	1.515	1.00
148_V	151_V	1.451	1.00
209_F	213_V	1.443	1.00
40_V	43_Q	1.438	1.00
60_L	116_A	1.426	1.00
205_V	209_F	1.424	1.00
65_A	69_L	1.415	1.00
47_S	214_G	1.408	1.00
224_T	228_G	1.394	1.00
119_A	123_V	1.391	1.00
17_R	21_T	1.366	1.00
21_T	25_I	1.355	1.00
88_G	229_G	1.355	1.00
85_G	236_G	1.354	1.00
38_L	42_E	1.347	1.00
213_V	217_W	1.346	1.00
42_E	50_A	1.346	1.00
81_G	239_V	1.346	1.00
45_T	49_V	1.339	1.00
227_I	231_C	1.327	1.00
76_I	80_V	1.325	1.00
44_T	110_L	1.324	1.00
18_T	22_T	1.321	1.00
166_A	169_V	1.296	1.00
22_T	124_L	1.295	1.00
91_V	232_I	1.288	1.00
231_C	235_T	1.275	1.00
167_E	170_F	1.272	1.00
52_I	230_F	1.253	1.00
46_S	49_V	1.239	1.00
88_G	233_V	1.238	1.00
91_V	225_P	1.226	1.00
48_A	211_A	1.223	1.00
24_G	144_F	1.218	1.00
77_G	239_V	1.214	1.00
105_S	109_G	1.210	1.00
79_V	83_G	1.206	1.00
64_F	68_V	1.202	1.00
170_F	174_Y	1.199	1.00
18_T	21_T	1.192	1.00
32_A	148_V	1.189	1.00
32_A	149_M	1.181	1.00
64_F	120_L	1.176	1.00
92_L	229_G	1.171	1.00
45_T	111_V	1.166	1.00
167_E	171_A	1.166	1.00
126_Q	195_G	1.161	1.00
83_G	87_A	1.157	1.00
30_M	121_G	1.154	1.00
127_R	130_D	1.144	1.00
222_I	227_I	1.140	1.00
25_I	124_L	1.136	1.00
106_Q	110_L	1.129	1.00
44_T	104_T	1.121	1.00
22_T	26_A	1.121	1.00
61_T	196_P	1.120	1.00
69_L	123_V	1.116	1.00
126_Q	130_D	1.112	1.00
22_T	128_I	1.101	1.00
44_T	107_G	1.091	1.00
61_T	122_S	1.074	1.00
61_T	119_A	1.071	1.00
191_L	199_I	1.064	1.00
19_D	132_L	1.061	1.00
126_Q	196_P	1.058	1.00
194_L	199_I	1.056	1.00
17_R	20_W	1.052	1.00
66_R	73_R	1.051	1.00
72_E	78_G	1.049	1.00
76_I	79_V	1.049	1.00
64_F	119_A	1.042	1.00
190_L	199_I	1.041	1.00
173_A	176_S	1.039	1.00
152_A	156_A	1.035	1.00
107_G	111_V	1.030	1.00
106_Q	109_G	1.028	1.00
77_G	243_R	1.026	1.00
28_V	148_V	1.024	1.00
74_L	79_V	1.021	1.00
77_G	242_R	1.010	1.00
170_F	173_A	1.008	1.00
20_W	144_F	0.992	1.00
19_D	22_T	0.991	1.00
27_A	144_F	0.991	1.00
62_A	74_L	0.985	1.00
64_F	67_A	0.982	1.00
53_V	108_V	0.980	1.00
90_V	94_N	0.980	1.00
56_L	89_V	0.977	1.00
75_S	79_V	0.973	1.00
53_V	111_V	0.970	1.00
47_S	218_R	0.964	1.00
115_T	119_A	0.962	1.00
151_V	155_A	0.960	1.00
194_L	198_E	0.949	1.00
21_T	24_G	0.949	1.00
53_V	115_T	0.946	1.00
64_F	116_A	0.943	1.00
34_Y	121_G	0.939	1.00
169_V	173_A	0.937	1.00
195_G	199_I	0.933	1.00
224_T	227_I	0.930	1.00
191_L	195_G	0.930	1.00
111_V	115_T	0.926	1.00
36_A	40_V	0.924	1.00
25_I	28_V	0.921	1.00
152_A	155_A	0.916	1.00
171_A	174_Y	0.915	1.00
215_L	222_I	0.912	1.00
102_S	105_S	0.907	1.00
118_F	187_Y	0.905	1.00
67_A	71_G	0.903	1.00
52_I	90_V	0.902	1.00
94_N	223_T	0.895	1.00
29_L	117_S	0.893	1.00
143_V	147_V	0.890	1.00
84_L	236_G	0.880	1.00
139_A	143_V	0.877	1.00
47_S	220_E	0.877	1.00
208_V	230_F	0.876	1.00
26_A	30_M	0.876	1.00
230_F	234_F	0.871	1.00
68_V	71_G	0.868	1.00
182_V	186_I	0.853	1.00
91_V	228_G	0.845	1.00
29_L	120_L	0.843	1.00
34_Y	117_S	0.843	1.00
211_A	222_I	0.841	1.00
89_V	93_S	0.836	1.00
205_V	208_V	0.830	1.00
160_Q	163_P	0.830	1.00
59_V	85_G	0.827	1.00
87_A	91_V	0.825	1.00
132_L	137_L	0.824	1.00
87_A	232_I	0.824	1.00
146_A	150_H	0.824	1.00
104_T	108_V	0.820	1.00
45_T	50_A	0.819	1.00
94_N	97_P	0.818	1.00
32_A	36_A	0.811	1.00
69_L	72_E	0.800	1.00
22_T	127_R	0.797	1.00
63_G	67_A	0.795	1.00
185_L	189_R	0.790	1.00
120_L	124_L	0.790	1.00
23_V	132_L	0.786	1.00
222_I	226_T	0.786	1.00
144_F	147_V	0.784	1.00
172_V	176_S	0.782	1.00
228_G	232_I	0.777	1.00
88_G	236_G	0.776	1.00
136_A	140_W	0.775	1.00
39_F	43_Q	0.774	1.00
165_T	169_V	0.773	1.00
73_R	77_G	0.773	1.00
62_A	78_G	0.772	1.00
168_A	171_A	0.770	1.00
144_F	148_V	0.768	1.00
122_S	187_Y	0.762	1.00
118_F	122_S	0.757	1.00
66_R	71_G	0.755	1.00
56_L	59_V	0.750	1.00
55_S	89_V	0.749	1.00
174_Y	178_G	0.749	1.00
61_T	123_V	0.747	1.00
225_P	228_G	0.744	1.00
73_R	76_I	0.744	1.00
203_G	206_A	0.739	1.00
74_L	78_G	0.738	1.00
51_A	55_S	0.737	1.00
20_W	24_G	0.735	1.00
214_G	218_R	0.734	1.00
22_T	25_I	0.731	1.00
60_L	112_F	0.730	1.00
165_T	170_F	0.729	1.00
215_L	221_A	0.727	1.00
211_A	230_F	0.726	1.00
190_L	194_L	0.725	1.00
35_H	180_S	0.722	1.00
23_V	27_A	0.722	1.00
186_I	189_R	0.719	1.00
235_T	239_V	0.713	1.00
164_W	169_V	0.707	1.00
33_A	37_F	0.701	1.00
80_V	84_L	0.698	1.00
140_W	144_F	0.695	1.00
27_A	32_A	0.695	1.00
58_P	204_Y	0.695	1.00
32_A	152_A	0.694	1.00
122_S	200_N	0.694	1.00
72_E	197_I	0.690	1.00
41_G	50_A	0.690	1.00
154_I	157_G	0.690	1.00
27_A	30_M	0.687	1.00
20_W	23_V	0.686	1.00
201_L	240_L	0.685	1.00
226_T	230_F	0.682	1.00
173_A	177_V	0.679	1.00
213_V	216_L	0.677	1.00
55_S	58_P	0.673	1.00
38_L	50_A	0.668	1.00
223_T	227_I	0.668	1.00
52_I	93_S	0.666	1.00
41_G	107_G	0.665	1.00
16_S	20_W	0.665	1.00
178_G	182_V	0.661	1.00
121_G	141_A	0.656	1.00
56_L	115_T	0.653	1.00
55_S	115_T	0.653	1.00
138_E	188_F	0.652	1.00
211_A	215_L	0.648	1.00
62_A	66_R	0.648	1.00
29_L	124_L	0.647	1.00
53_V	112_F	0.645	1.00
127_R	131_A	0.644	1.00
78_G	195_G	0.639	1.00
121_G	188_F	0.637	1.00
24_G	148_V	0.637	1.00
147_V	150_H	0.634	1.00
163_P	166_A	0.634	1.00
103_S	106_Q	0.630	1.00
34_Y	55_S	0.629	1.00
138_E	141_A	0.628	1.00
34_Y	54_V	0.626	1.00
211_A	214_G	0.626	1.00
24_G	27_A	0.624	1.00
155_A	158_E	0.621	1.00
20_W	140_W	0.620	1.00
16_S	21_T	0.619	1.00
38_L	114_A	0.619	1.00
78_G	82_L	0.618	1.00
121_G	125_T	0.615	1.00
236_G	240_L	0.614	1.00
102_S	106_Q	0.610	1.00
221_A	225_P	0.606	1.00
84_L	239_V	0.605	1.00
216_L	219_G	0.605	1.00
125_T	137_L	0.603	1.00
143_V	146_A	0.602	1.00
162_I	165_T	0.595	1.00
65_A	197_I	0.595	1.00
186_I	190_L	0.592	1.00
37_F	114_A	0.589	1.00
132_L	136_A	0.589	1.00
95_P	225_P	0.587	1.00
142_M	146_A	0.587	1.00
145_G	149_M	0.584	1.00
24_G	28_V	0.582	1.00
34_Y	38_L	0.580	1.00
140_W	143_V	0.579	1.00
148_V	152_A	0.578	1.00
150_H	154_I	0.575	1.00
212_A	215_L	0.573	1.00
212_A	216_L	0.573	1.00
34_Y	118_F	0.571	1.00
138_E	142_M	0.567	1.00
69_L	126_Q	0.564	1.00
23_V	137_L	0.563	1.00
204_Y	237_F	0.562	1.00
110_L	113_A	0.561	1.00
86_L	204_Y	0.561	1.00
174_Y	177_V	0.560	1.00
35_H	38_L	0.560	1.00
142_M	184_F	0.559	1.00
52_I	92_L	0.555	1.00
125_T	191_L	0.553	1.00
237_F	240_L	0.552	1.00
36_A	149_M	0.548	1.00
227_I	230_F	0.547	1.00
89_V	233_V	0.546	1.00
215_L	227_I	0.544	1.00
86_L	90_V	0.538	1.00
69_L	127_R	0.538	1.00
181_A	185_L	0.536	1.00
30_M	141_A	0.535	1.00
93_S	108_V	0.535	1.00
125_T	129_D	0.532	1.00
80_V	87_A	0.531	1.00
203_G	207_P	0.530	1.00
88_G	232_I	0.530	1.00
75_S	243_R	0.524	1.00
116_A	120_L	0.518	1.00
122_S	191_L	0.516	1.00
63_G	82_L	0.513	1.00
81_G	85_G	0.512	1.00
23_V	26_A	0.510	1.00
61_T	65_A	0.510	1.00
136_A	139_A	0.508	1.00
68_V	120_L	0.505	1.00
57_S	118_F	0.501	1.00
28_V	32_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.3031	98.9	0.708	Contact Map
3b5dA	2	0.3976	98.3	0.763	Contact Map
1pw4A	1	0.9764	35.6	0.916	Contact Map
2cfqA	1	0.7087	25	0.922	Contact Map
2rddB	1	0.1299	23.6	0.923	Contact Map
4he8J	1	0.6063	20	0.926	Contact Map
4j05A	3	0.9528	19.8	0.926	Contact Map
3l1lA	2	0.5236	18.2	0.927	Contact Map
2kluA	1	0.1732	15.2	0.93	Contact Map
4pypA	1	0.689	14.9	0.93	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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