GREMLIN Database
Q9HPH9 - Aryl-alcohol dehydrogenase
UniProt: Q9HPH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (267)
Sequences: 31910 (20013)
Seq/√Len: 1224.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A300_R3.1441.00
38_E73_D2.9401.00
112_D152_T2.9271.00
76_A119_G2.8041.00
268_V314_Q2.7421.00
7_P14_R2.4611.00
311_T314_Q2.4431.00
111_V147_F2.4371.00
108_R146_G2.4141.00
42_H77_D2.3911.00
108_R150_E2.3471.00
47_A51_A2.2841.00
267_A317_R2.2171.00
262_E266_D2.0671.00
145_D149_R2.0651.00
42_H73_D2.0411.00
282_H315_R2.0251.00
267_A314_Q1.9781.00
122_Y154_H1.9581.00
6_V17_E1.9431.00
312_A316_D1.9411.00
113_N117_R1.9331.00
146_G150_E1.9331.00
204_M208_Y1.9231.00
296_P300_R1.8901.00
263_A317_R1.8871.00
205_C212_V1.8341.00
47_A296_P1.8181.00
104_R146_G1.7981.00
19_A55_F1.7881.00
270_A308_I1.7611.00
51_A300_R1.7401.00
169_A173_E1.7301.00
79_D82_R1.7101.00
283_H319_T1.7101.00
127_Y185_V1.7101.00
69_R117_R1.6901.00
85_I120_T1.6881.00
146_G149_R1.6801.00
87_S123_I1.6491.00
260_A263_A1.6441.00
104_R108_R1.6401.00
37_G40_R1.6361.00
169_A204_M1.6151.00
42_H46_D1.6091.00
51_A303_M1.6091.00
304_A307_N1.6051.00
271_T301_E1.6021.00
89_V107_L1.5931.00
278_A308_I1.5881.00
46_D78_R1.5881.00
89_V126_L1.5841.00
42_H74_W1.5731.00
211_G288_A1.5711.00
108_R112_D1.5641.00
143_T146_G1.5591.00
47_A50_N1.5551.00
87_S114_I1.5521.00
46_D77_D1.5511.00
22_T56_I1.5421.00
111_V126_L1.5411.00
48_Y53_G1.5291.00
145_D181_E1.5221.00
316_D320_D1.5101.00
200_N203_E1.4851.00
86_A127_Y1.4841.00
13_L155_Y1.4731.00
109_A113_N1.4571.00
49_A83_Y1.4421.00
270_A274_Q1.4311.00
60_D110_S1.4261.00
127_Y213_V1.4051.00
162_H167_K1.3951.00
38_E42_H1.3861.00
112_D116_D1.3811.00
40_R43_E1.3811.00
206_R284_D1.3751.00
203_E207_E1.3741.00
45_L74_W1.3681.00
123_I153_V1.3571.00
172_N208_Y1.3481.00
148_V181_E1.3421.00
46_D50_N1.3351.00
300_R304_A1.3231.00
13_L84_V1.3031.00
104_R142_R1.3021.00
317_R320_D1.2971.00
172_N204_M1.2961.00
43_E47_A1.2791.00
278_A282_H1.2761.00
113_N116_D1.2641.00
188_P212_V1.2631.00
263_A267_A1.2591.00
80_R120_T1.2571.00
260_A317_R1.2561.00
147_F153_V1.2551.00
108_R143_T1.2541.00
153_V156_L1.2541.00
270_A275_V1.2371.00
104_R143_T1.2321.00
118_L123_I1.2221.00
138_D174_I1.2191.00
165_A204_M1.2181.00
155_Y184_T1.2171.00
72_G119_G1.2031.00
293_A298_Q1.2001.00
39_Q43_E1.1981.00
202_L206_R1.1831.00
271_T274_Q1.1751.00
264_V275_V1.1721.00
293_A299_L1.1581.00
73_D119_G1.1551.00
84_V125_I1.1531.00
111_V123_I1.1491.00
169_A207_E1.1471.00
56_I71_I1.1441.00
125_I185_V1.1291.00
297_A300_R1.1291.00
131_W167_K1.1291.00
262_E272_P1.1271.00
69_R73_D1.1231.00
68_E114_I1.1191.00
105_K109_A1.1181.00
106_H109_A1.1081.00
80_R122_Y1.1001.00
145_D148_V1.0841.00
112_D150_E1.0811.00
280_L289_P1.0801.00
190_F283_H1.0801.00
169_A208_Y1.0721.00
139_A142_R1.0701.00
55_F213_V1.0701.00
192_A318_I1.0681.00
54_R84_V1.0661.00
189_R194_N1.0641.00
11_T155_Y1.0621.00
148_V184_T1.0611.00
44_L299_L1.0601.00
128_I144_L1.0521.00
55_F86_A1.0471.00
144_L156_L1.0461.00
22_T71_I1.0451.00
103_N106_H1.0421.00
259_D263_A1.0311.00
261_V272_P1.0231.00
43_E296_P1.0181.00
259_D262_E1.0141.00
274_Q304_A1.0141.00
7_P12_G1.0131.00
102_L128_I1.0111.00
263_A266_D1.0081.00
165_A169_A1.0051.00
10_R184_T1.0031.00
170_K174_I0.9981.00
199_G203_E0.9971.00
281_R305_A0.9891.00
138_D170_K0.9881.00
192_A276_S0.9851.00
75_L83_Y0.9821.00
46_D74_W0.9821.00
17_E281_R0.9781.00
147_F152_T0.9761.00
16_T53_G0.9701.00
197_I212_V0.9661.00
158_A183_F0.9611.00
73_D77_D0.9581.00
49_A78_R0.9571.00
16_T54_R0.9541.00
299_L303_M0.9541.00
124_D154_H0.9501.00
142_R146_G0.9421.00
69_R116_D0.9401.00
185_V213_V0.9351.00
162_H166_W0.9311.00
213_V288_A0.9311.00
274_Q301_E0.9291.00
203_E206_R0.9191.00
147_F150_E0.9141.00
11_T184_T0.9121.00
43_E46_D0.9101.00
301_E304_A0.9021.00
206_R286_V0.8991.00
68_E117_R0.8981.00
108_R111_V0.8961.00
277_L305_A0.8951.00
297_A301_E0.8951.00
143_T147_F0.8941.00
45_L56_I0.8941.00
282_H309_E0.8881.00
60_D93_T0.8811.00
316_D319_T0.8791.00
158_A168_I0.8771.00
17_E306_T0.8761.00
313_T316_D0.8731.00
104_R139_A0.8721.00
168_I210_L0.8671.00
186_A205_C0.8611.00
92_P101_G0.8601.00
145_D156_L0.8591.00
109_A112_D0.8571.00
156_L183_F0.8531.00
142_R145_D0.8521.00
283_H315_R0.8521.00
86_A213_V0.8511.00
313_T317_R0.8501.00
108_R147_F0.8441.00
60_D106_H0.8421.00
86_A125_I0.8401.00
267_A311_T0.8361.00
295_T298_Q0.8351.00
170_K173_E0.8351.00
264_V268_V0.8271.00
162_H165_A0.8261.00
268_V311_T0.8231.00
11_T148_V0.8221.00
20_F48_Y0.8151.00
195_R319_T0.8061.00
22_T67_A0.8031.00
202_L212_V0.7981.00
282_H312_A0.7811.00
278_A305_A0.7801.00
60_D117_R0.7791.00
165_A201_Y0.7741.00
276_S280_L0.7701.00
115_L152_T0.7671.00
141_M171_A0.7661.00
39_Q42_H0.7661.00
228_E231_A0.7651.00
160_T215_W0.7611.00
204_M207_E0.7591.00
228_E262_E0.7591.00
195_R198_V0.7531.00
51_A304_A0.7491.00
130_R160_T0.7471.00
190_F202_L0.7461.00
20_F25_F0.7461.00
172_N182_P0.7431.00
87_S126_L0.7421.00
47_A299_L0.7401.00
217_P291_T0.7361.00
266_D269_D0.7351.00
19_A291_T0.7321.00
165_A200_N0.7241.00
214_P217_P0.7201.00
255_F259_D0.7161.00
41_A70_Y0.7151.00
136_P139_A0.7131.00
81_D122_Y0.7101.00
53_G303_M0.7071.00
111_V152_T0.7061.00
270_A307_N0.7041.00
60_D113_N0.7031.00
279_W319_T0.7011.00
107_L147_F0.7001.00
201_Y205_C0.6991.00
115_L120_T0.6971.00
158_A161_F0.6961.00
44_L296_P0.6961.00
102_L140_L0.6951.00
228_E259_D0.6931.00
256_D259_D0.6931.00
141_M183_F0.6921.00
264_V314_Q0.6921.00
214_P289_P0.6911.00
58_T71_I0.6891.00
13_L154_H0.6891.00
45_L49_A0.6861.00
110_S113_N0.6831.00
310_L315_R0.6811.00
141_M156_L0.6781.00
18_L281_R0.6781.00
107_L140_L0.6771.00
205_C210_L0.6741.00
49_A56_I0.6741.00
261_V276_S0.6731.00
275_V310_L0.6691.00
260_A321_A0.6691.00
6_V211_G0.6681.00
294_R298_Q0.6651.00
273_A301_E0.6631.00
229_R259_D0.6621.00
202_L283_H0.6611.00
25_F44_L0.6611.00
158_A186_A0.6601.00
137_A174_I0.6591.00
268_V275_V0.6531.00
75_L78_R0.6491.00
51_A299_L0.6471.00
54_R82_R0.6451.00
190_F280_L0.6441.00
195_R199_G0.6431.00
40_R296_P0.6421.00
270_A304_A0.6411.00
298_Q301_E0.6381.00
264_V317_R0.6371.00
15_V288_A0.6371.00
144_L148_V0.6371.00
265_A275_V0.6351.00
114_I126_L0.6301.00
140_L143_T0.6301.00
211_G287_A0.6291.00
217_P280_L0.6291.00
148_V155_Y0.6271.00
280_L287_A0.6261.00
255_F258_L0.6261.00
61_M90_Y0.6251.00
127_Y157_G0.6251.00
115_L123_I0.6241.00
107_L143_T0.6231.00
24_R220_G0.6201.00
261_V318_I0.6201.00
123_I126_L0.6151.00
78_R82_R0.6121.00
19_A288_A0.6121.00
310_L314_Q0.6111.00
190_F212_V0.6081.00
10_R182_P0.6081.00
137_A140_L0.6081.00
169_A172_N0.6071.00
27_R70_Y0.6071.00
108_R152_T0.6041.00
256_D260_A0.6031.00
167_K170_K0.6031.00
148_V153_V0.5991.00
115_L122_Y0.5971.00
25_F41_A0.5961.00
270_A278_A0.5951.00
111_V115_L0.5951.00
265_A272_P0.5931.00
49_A54_R0.5931.00
314_Q317_R0.5911.00
44_L293_A0.5871.00
23_W216_S0.5851.00
45_L71_I0.5851.00
132_D135_T0.5841.00
74_W78_R0.5821.00
225_G228_E0.5801.00
50_N296_P0.5791.00
158_A171_A0.5791.00
38_E70_Y0.5791.00
281_R289_P0.5791.00
275_V308_I0.5791.00
115_L121_D0.5761.00
89_V102_L0.5751.00
197_I202_L0.5741.00
258_L262_E0.5741.00
216_S220_G0.5721.00
49_A82_R0.5711.00
190_F287_A0.5691.00
103_N140_L0.5671.00
10_R209_G0.5661.00
172_N210_L0.5661.00
190_F195_R0.5651.00
8_L211_G0.5541.00
283_H287_A0.5531.00
275_V314_Q0.5511.00
15_V55_F0.5511.00
275_V318_I0.5491.00
166_W169_A0.5491.00
111_V143_T0.5471.00
261_V265_A0.5461.00
93_T106_H0.5451.00
224_T227_Y0.5431.00
192_A279_W0.5431.00
18_L306_T0.5411.00
101_G106_H0.5401.00
274_Q308_I0.5391.00
89_V110_S0.5351.00
278_A309_E0.5321.00
128_I140_L0.5301.00
49_A74_W0.5301.00
148_V182_P0.5271.00
138_D142_R0.5271.00
19_A290_I0.5261.00
126_L144_L0.5251.00
26_G67_A0.5251.00
50_N78_R0.5241.00
264_V321_A0.5241.00
265_A268_V0.5211.00
57_D187_Q0.5201.00
20_F44_L0.5191.00
188_P201_Y0.5181.00
214_P286_V0.5181.00
60_D90_Y0.5171.00
149_R181_E0.5171.00
131_W161_F0.5161.00
126_L153_V0.5131.00
315_R319_T0.5131.00
68_E87_S0.5111.00
73_D76_A0.5111.00
58_T67_A0.5101.00
137_A170_K0.5101.00
104_R107_L0.5071.00
42_H70_Y0.5061.00
268_V308_I0.5041.00
296_P299_L0.5041.00
25_F292_G0.5031.00
69_R119_G0.5011.00
148_V156_L0.5001.00
156_L181_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xk2A 5 0.9074 100 0.07 Contact Map
1pyfA 1 0.9568 100 0.076 Contact Map
3n2tA 1 0.9568 100 0.08 Contact Map
1pz1A 1 0.9568 100 0.08 Contact Map
3v0sA 1 0.8333 100 0.093 Contact Map
3eauA 3 0.963 100 0.098 Contact Map
3erpA 6 0.9074 100 0.099 Contact Map
1lqaA 2 0.9599 100 0.104 Contact Map
3lutA 3 0.9599 100 0.109 Contact Map
3n6qA 5 0.9074 100 0.11 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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