Q9HPH6 - HALSA - GREMLIN Contacts

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Q9HPH6 - Cobalt transport protein

UniProt:	Q9HPH6	Sequences: MHHTTIEQIQVAATPRVTGRLNAYFAVAALVLVVAAPHRLAYAGALACFGALGVDAGGRDYLGVLRLPVYFLAPTLALIAVFTPGPAAVSVGPLAVSWPGIQRTLTTGLRSLSSVTILSYLIVTTPVPEVVGALQSLRCPRFVVDVSLLTYRAIQTLFDELARLELAASSRLGFRTRRTTLATSKALAFSLFVRSLSRADALDDAMQARAYDGTLPTPTTPNTGYGYVGTVLVVLAVTGWGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	242 (228)
Sequences:	5696 (4559)
Seq/√Len:	301.9

BACSU - ECFT YKOC
HALSA - Q9HPH6
SULSO - Q97WT3 Q97X61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
223_T	228_V	6.118	1.00
22_N	125_T	4.164	1.00
160_E	198_R	3.718	1.00
12_A	15_P	3.235	1.00
59_R	63_G	3.215	1.00
22_N	124_T	3.171	1.00
21_L	223_T	2.985	1.00
25_F	234_V	2.819	1.00
164_L	191_L	2.676	1.00
162_A	166_L	2.638	1.00
176_T	179_T	2.510	1.00
157_L	195_S	2.372	1.00
165_E	169_S	2.347	1.00
86_P	99_P	2.335	1.00
11_V	16_R	2.321	1.00
17_V	230_T	2.269	1.00
86_P	98_W	2.268	1.00
89_V	96_V	2.157	1.00
19_G	221_P	2.156	1.00
42_Y	113_S	2.111	1.00
49_F	117_I	2.100	1.00
126_P	129_E	2.087	1.00
164_L	168_A	2.082	1.00
26_A	121_L	2.020	1.00
46_L	113_S	2.007	1.00
90_S	95_A	1.990	1.00
166_L	169_S	1.907	1.00
161_L	191_L	1.862	1.00
135_Q	141_R	1.858	1.00
228_V	232_L	1.852	1.00
63_G	66_R	1.850	1.00
76_L	108_G	1.836	1.00
33_V	45_A	1.770	1.00
88_A	98_W	1.767	1.00
160_E	163_R	1.758	1.00
176_T	180_T	1.743	1.00
225_Y	229_G	1.699	1.00
13_A	55_D	1.681	1.00
21_L	231_V	1.676	1.00
17_V	21_L	1.628	1.00
170_S	208_A	1.626	1.00
102_Q	106_T	1.606	1.00
224_G	227_Y	1.583	1.00
80_A	96_V	1.493	1.00
84_P	99_P	1.474	1.00
139_C	143_V	1.471	1.00
26_A	117_I	1.422	1.00
145_D	211_Y	1.411	1.00
132_G	136_S	1.374	1.00
134_L	139_C	1.370	1.00
145_D	149_L	1.326	1.00
223_T	231_V	1.326	1.00
160_E	194_R	1.313	1.00
20_R	133_A	1.292	1.00
42_Y	109_L	1.287	1.00
40_L	44_G	1.286	1.00
206_M	211_Y	1.280	1.00
150_T	206_M	1.272	1.00
29_A	117_I	1.271	1.00
146_V	150_T	1.250	1.00
86_P	90_S	1.249	1.00
52_L	120_Y	1.239	1.00
33_V	113_S	1.233	1.00
67_L	70_Y	1.232	1.00
177_R	181_L	1.231	1.00
53_G	61_Y	1.228	1.00
223_T	227_Y	1.223	1.00
88_A	101_I	1.221	1.00
157_L	161_L	1.207	1.00
75_T	79_I	1.176	1.00
151_Y	155_Q	1.172	1.00
77_A	81_V	1.171	1.00
14_T	56_A	1.161	1.00
235_L	238_T	1.158	1.00
98_W	102_Q	1.158	1.00
16_R	226_G	1.141	1.00
178_R	182_A	1.134	1.00
180_T	183_T	1.133	1.00
177_R	180_T	1.133	1.00
84_P	97_S	1.124	1.00
226_G	229_G	1.122	1.00
38_H	41_A	1.109	1.00
203_D	207_Q	1.104	1.00
66_R	70_Y	1.102	1.00
32_L	238_T	1.093	1.00
92_G	95_A	1.093	1.00
229_G	233_V	1.091	1.00
80_A	104_T	1.090	1.00
90_S	93_P	1.090	1.00
161_L	187_L	1.088	1.00
213_G	216_P	1.086	1.00
30_L	114_S	1.076	1.00
132_G	135_Q	1.075	1.00
138_R	141_R	1.067	1.00
40_L	43_A	1.065	1.00
27_V	31_V	1.062	1.00
41_A	44_G	1.055	1.00
102_Q	105_L	1.052	1.00
197_S	201_A	1.049	1.00
222_N	225_Y	1.049	1.00
62_L	66_R	1.048	1.00
127_V	157_L	1.046	1.00
156_T	202_L	1.039	1.00
149_L	202_L	1.028	1.00
161_L	165_E	1.018	1.00
134_L	138_R	1.015	1.00
103_R	107_T	1.009	1.00
43_A	47_A	1.008	1.00
168_A	186_A	1.000	1.00
28_A	238_T	0.999	1.00
49_F	113_S	0.999	1.00
109_L	113_S	0.998	1.00
39_R	102_Q	0.997	1.00
179_T	183_T	0.997	1.00
121_L	130_V	0.995	1.00
100_G	104_T	0.981	1.00
89_V	93_P	0.979	1.00
51_A	54_V	0.978	1.00
36_A	41_A	0.975	1.00
43_A	46_L	0.974	1.00
129_E	219_T	0.974	1.00
32_L	36_A	0.973	1.00
79_I	104_T	0.962	1.00
182_A	186_A	0.957	1.00
89_V	92_G	0.955	1.00
152_R	156_T	0.952	1.00
185_K	189_F	0.950	1.00
179_T	182_A	0.944	1.00
125_T	130_V	0.939	1.00
39_R	43_A	0.935	1.00
51_A	55_D	0.933	1.00
78_L	82_F	0.930	1.00
60_D	64_V	0.926	1.00
155_Q	203_D	0.925	1.00
59_R	62_L	0.921	1.00
88_A	91_V	0.919	1.00
88_A	92_G	0.914	1.00
146_V	202_L	0.912	1.00
77_A	80_A	0.908	1.00
155_Q	190_S	0.902	1.00
79_I	107_T	0.901	1.00
133_A	136_S	0.901	1.00
172_L	190_S	0.894	1.00
111_S	115_V	0.893	1.00
153_A	203_D	0.887	1.00
64_V	75_T	0.883	1.00
153_A	202_L	0.882	1.00
168_A	183_T	0.880	1.00
133_A	141_R	0.879	1.00
212_D	215_L	0.876	1.00
23_A	121_L	0.873	1.00
25_F	29_A	0.873	1.00
219_T	222_N	0.870	1.00
204_D	207_Q	0.865	1.00
74_P	78_L	0.863	1.00
152_R	191_L	0.859	1.00
70_Y	73_A	0.857	1.00
91_V	95_A	0.854	1.00
233_V	237_V	0.851	1.00
24_Y	231_V	0.850	1.00
106_T	110_R	0.846	1.00
30_L	34_V	0.842	1.00
99_P	102_Q	0.841	1.00
127_V	151_Y	0.834	1.00
165_E	187_L	0.834	1.00
37_P	42_Y	0.826	1.00
32_L	35_A	0.823	1.00
230_T	234_V	0.821	1.00
39_R	106_T	0.818	1.00
221_P	227_Y	0.817	1.00
140_P	144_V	0.812	1.00
14_T	52_L	0.808	1.00
23_A	133_A	0.806	1.00
70_Y	74_P	0.804	1.00
141_R	214_T	0.804	1.00
62_L	67_L	0.804	1.00
88_A	96_V	0.803	1.00
149_L	206_M	0.799	1.00
76_L	104_T	0.798	1.00
225_Y	228_V	0.789	0.99
66_R	69_V	0.785	0.99
228_V	233_V	0.783	0.99
22_N	129_E	0.782	0.99
33_V	117_I	0.775	0.99
46_L	109_L	0.770	0.99
120_Y	124_T	0.768	0.99
133_A	137_L	0.766	0.99
88_A	99_P	0.762	0.99
32_L	237_V	0.762	0.99
45_A	113_S	0.761	0.99
183_T	187_L	0.752	0.99
232_L	236_A	0.751	0.99
54_V	57_G	0.750	0.99
214_T	217_T	0.745	0.99
71_F	111_S	0.745	0.99
89_V	95_A	0.745	0.99
26_A	118_L	0.739	0.99
21_L	228_V	0.738	0.99
141_R	144_V	0.734	0.99
18_T	21_L	0.730	0.99
75_T	80_A	0.728	0.99
162_A	165_E	0.725	0.99
76_L	79_I	0.721	0.99
234_V	238_T	0.720	0.99
164_L	190_S	0.716	0.99
64_V	123_V	0.714	0.99
207_Q	210_A	0.713	0.99
157_L	173_G	0.713	0.99
99_P	103_R	0.710	0.99
49_F	52_L	0.710	0.99
224_G	228_V	0.710	0.99
25_F	230_T	0.709	0.99
156_T	160_E	0.708	0.99
228_V	231_V	0.708	0.99
212_D	216_P	0.707	0.99
21_L	227_Y	0.705	0.99
198_R	202_L	0.703	0.99
19_G	133_A	0.701	0.99
46_L	50_G	0.700	0.99
88_A	97_S	0.699	0.99
72_L	79_I	0.694	0.99
170_S	205_A	0.691	0.99
168_A	207_Q	0.690	0.99
170_S	209_R	0.689	0.99
15_P	22_N	0.688	0.99
138_R	144_V	0.687	0.99
74_P	81_V	0.686	0.99
164_L	187_L	0.683	0.99
68_P	71_F	0.683	0.99
105_L	108_G	0.679	0.98
42_Y	46_L	0.678	0.98
91_V	94_L	0.678	0.98
199_A	202_L	0.676	0.98
79_I	83_T	0.675	0.98
142_F	212_D	0.671	0.98
174_F	180_T	0.671	0.98
203_D	206_M	0.670	0.98
100_G	146_V	0.667	0.98
158_F	162_A	0.665	0.98
134_L	147_S	0.664	0.98
156_T	198_R	0.660	0.98
131_V	141_R	0.653	0.98
108_G	112_L	0.652	0.98
153_A	193_V	0.651	0.98
118_L	154_I	0.650	0.98
30_L	118_L	0.645	0.98
163_R	201_A	0.644	0.98
213_G	217_T	0.642	0.98
159_D	163_R	0.640	0.98
226_G	237_V	0.638	0.98
125_T	129_E	0.635	0.98
131_V	144_V	0.634	0.98
135_Q	138_R	0.633	0.98
121_L	207_Q	0.633	0.98
145_D	168_A	0.632	0.98
163_R	194_R	0.631	0.98
79_I	100_G	0.629	0.98
13_A	45_A	0.626	0.97
58_G	64_V	0.625	0.97
135_Q	144_V	0.620	0.97
58_G	123_V	0.619	0.97
232_L	235_L	0.616	0.97
200_D	204_D	0.615	0.97
32_L	41_A	0.614	0.97
12_A	73_A	0.614	0.97
108_G	114_S	0.612	0.97
101_I	105_L	0.611	0.97
47_A	51_A	0.609	0.97
146_V	168_A	0.607	0.97
15_P	125_T	0.604	0.97
29_A	33_V	0.602	0.97
166_L	204_D	0.601	0.97
79_I	82_F	0.599	0.97
168_A	172_L	0.598	0.97
159_D	162_A	0.596	0.97
21_L	230_T	0.593	0.96
103_R	106_T	0.592	0.96
193_V	196_L	0.589	0.96
141_R	212_D	0.588	0.96
115_V	119_S	0.587	0.96
83_T	103_R	0.587	0.96
114_S	150_T	0.586	0.96
73_A	76_L	0.585	0.96
61_Y	116_T	0.583	0.96
199_A	203_D	0.582	0.96
68_P	78_L	0.582	0.96
17_V	226_G	0.581	0.96
160_E	191_L	0.578	0.96
47_A	54_V	0.577	0.96
24_Y	236_A	0.577	0.96
73_A	81_V	0.575	0.96
144_V	155_Q	0.574	0.96
42_Y	106_T	0.568	0.96
194_R	200_D	0.567	0.95
114_S	153_A	0.566	0.95
82_F	103_R	0.563	0.95
66_R	78_L	0.561	0.95
132_G	141_R	0.560	0.95
152_R	159_D	0.559	0.95
226_G	230_T	0.559	0.95
198_R	201_A	0.558	0.95
233_V	236_A	0.557	0.95
95_A	98_W	0.555	0.95
44_G	47_A	0.554	0.95
225_Y	236_A	0.553	0.95
19_G	125_T	0.553	0.95
225_Y	232_L	0.552	0.95
189_F	197_S	0.551	0.95
20_R	24_Y	0.548	0.95
49_F	120_Y	0.547	0.95
68_P	115_V	0.546	0.94
224_G	231_V	0.546	0.94
14_T	120_Y	0.546	0.94
129_E	220_T	0.545	0.94
84_P	88_A	0.545	0.94
18_T	221_P	0.543	0.94
154_I	206_M	0.542	0.94
13_A	16_R	0.539	0.94
61_Y	64_V	0.539	0.94
64_V	68_P	0.539	0.94
225_Y	233_V	0.531	0.94
131_V	148_L	0.530	0.94
49_F	116_T	0.529	0.93
150_T	154_I	0.529	0.93
146_V	198_R	0.528	0.93
222_N	227_Y	0.527	0.93
26_A	108_G	0.525	0.93
80_A	83_T	0.522	0.93
127_V	155_Q	0.521	0.93
86_P	95_A	0.517	0.93
21_L	25_F	0.514	0.92
80_A	101_I	0.511	0.92
29_A	45_A	0.507	0.92
153_A	160_E	0.505	0.92
149_L	152_R	0.505	0.92
227_Y	230_T	0.505	0.92
30_L	146_V	0.504	0.92
163_R	166_L	0.503	0.92
11_V	54_V	0.502	0.92
168_A	190_S	0.501	0.92
17_V	82_F	0.500	0.91
12_A	56_A	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4huqT	1	0.9463	100	0.183	Contact Map
2l0eA	1	0.1281	6.2	0.951	Contact Map
4mt1A	3	0.6653	3.6	0.957	Contact Map
4dx5A	3	0.8926	3.3	0.957	Contact Map
1n7lA	1	0.1983	2.9	0.958	Contact Map
2ww9C	1	0.0868	2.3	0.961	Contact Map
1t5hX	2	0.3347	2.3	0.961	Contact Map
2onkC	2	0.8926	2.2	0.961	Contact Map
3w9iA	3	0.6818	2.2	0.961	Contact Map
4y3uB	1	0.1116	2.1	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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