GREMLIN Database
Q9HPH6 - Cobalt transport protein
UniProt: Q9HPH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (228)
Sequences: 5696 (4559)
Seq/√Len: 301.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_T228_V6.1181.00
22_N125_T4.1641.00
160_E198_R3.7181.00
12_A15_P3.2351.00
59_R63_G3.2151.00
22_N124_T3.1711.00
21_L223_T2.9851.00
25_F234_V2.8191.00
164_L191_L2.6761.00
162_A166_L2.6381.00
176_T179_T2.5101.00
157_L195_S2.3721.00
165_E169_S2.3471.00
86_P99_P2.3351.00
11_V16_R2.3211.00
17_V230_T2.2691.00
86_P98_W2.2681.00
89_V96_V2.1571.00
19_G221_P2.1561.00
42_Y113_S2.1111.00
49_F117_I2.1001.00
126_P129_E2.0871.00
164_L168_A2.0821.00
26_A121_L2.0201.00
46_L113_S2.0071.00
90_S95_A1.9901.00
166_L169_S1.9071.00
161_L191_L1.8621.00
135_Q141_R1.8581.00
228_V232_L1.8521.00
63_G66_R1.8501.00
76_L108_G1.8361.00
33_V45_A1.7701.00
88_A98_W1.7671.00
160_E163_R1.7581.00
176_T180_T1.7431.00
225_Y229_G1.6991.00
13_A55_D1.6811.00
21_L231_V1.6761.00
17_V21_L1.6281.00
170_S208_A1.6261.00
102_Q106_T1.6061.00
224_G227_Y1.5831.00
80_A96_V1.4931.00
84_P99_P1.4741.00
139_C143_V1.4711.00
26_A117_I1.4221.00
145_D211_Y1.4111.00
132_G136_S1.3741.00
134_L139_C1.3701.00
145_D149_L1.3261.00
223_T231_V1.3261.00
160_E194_R1.3131.00
20_R133_A1.2921.00
42_Y109_L1.2871.00
40_L44_G1.2861.00
206_M211_Y1.2801.00
150_T206_M1.2721.00
29_A117_I1.2711.00
146_V150_T1.2501.00
86_P90_S1.2491.00
52_L120_Y1.2391.00
33_V113_S1.2331.00
67_L70_Y1.2321.00
177_R181_L1.2311.00
53_G61_Y1.2281.00
223_T227_Y1.2231.00
88_A101_I1.2211.00
157_L161_L1.2071.00
75_T79_I1.1761.00
151_Y155_Q1.1721.00
77_A81_V1.1711.00
14_T56_A1.1611.00
235_L238_T1.1581.00
98_W102_Q1.1581.00
16_R226_G1.1411.00
178_R182_A1.1341.00
180_T183_T1.1331.00
177_R180_T1.1331.00
84_P97_S1.1241.00
226_G229_G1.1221.00
38_H41_A1.1091.00
203_D207_Q1.1041.00
66_R70_Y1.1021.00
32_L238_T1.0931.00
92_G95_A1.0931.00
229_G233_V1.0911.00
80_A104_T1.0901.00
90_S93_P1.0901.00
161_L187_L1.0881.00
213_G216_P1.0861.00
30_L114_S1.0761.00
132_G135_Q1.0751.00
138_R141_R1.0671.00
40_L43_A1.0651.00
27_V31_V1.0621.00
41_A44_G1.0551.00
102_Q105_L1.0521.00
197_S201_A1.0491.00
222_N225_Y1.0491.00
62_L66_R1.0481.00
127_V157_L1.0461.00
156_T202_L1.0391.00
149_L202_L1.0281.00
161_L165_E1.0181.00
134_L138_R1.0151.00
103_R107_T1.0091.00
43_A47_A1.0081.00
168_A186_A1.0001.00
28_A238_T0.9991.00
49_F113_S0.9991.00
109_L113_S0.9981.00
39_R102_Q0.9971.00
179_T183_T0.9971.00
121_L130_V0.9951.00
100_G104_T0.9811.00
89_V93_P0.9791.00
51_A54_V0.9781.00
36_A41_A0.9751.00
43_A46_L0.9741.00
129_E219_T0.9741.00
32_L36_A0.9731.00
79_I104_T0.9621.00
182_A186_A0.9571.00
89_V92_G0.9551.00
152_R156_T0.9521.00
185_K189_F0.9501.00
179_T182_A0.9441.00
125_T130_V0.9391.00
39_R43_A0.9351.00
51_A55_D0.9331.00
78_L82_F0.9301.00
60_D64_V0.9261.00
155_Q203_D0.9251.00
59_R62_L0.9211.00
88_A91_V0.9191.00
88_A92_G0.9141.00
146_V202_L0.9121.00
77_A80_A0.9081.00
155_Q190_S0.9021.00
79_I107_T0.9011.00
133_A136_S0.9011.00
172_L190_S0.8941.00
111_S115_V0.8931.00
153_A203_D0.8871.00
64_V75_T0.8831.00
153_A202_L0.8821.00
168_A183_T0.8801.00
133_A141_R0.8791.00
212_D215_L0.8761.00
23_A121_L0.8731.00
25_F29_A0.8731.00
219_T222_N0.8701.00
204_D207_Q0.8651.00
74_P78_L0.8631.00
152_R191_L0.8591.00
70_Y73_A0.8571.00
91_V95_A0.8541.00
233_V237_V0.8511.00
24_Y231_V0.8501.00
106_T110_R0.8461.00
30_L34_V0.8421.00
99_P102_Q0.8411.00
127_V151_Y0.8341.00
165_E187_L0.8341.00
37_P42_Y0.8261.00
32_L35_A0.8231.00
230_T234_V0.8211.00
39_R106_T0.8181.00
221_P227_Y0.8171.00
140_P144_V0.8121.00
14_T52_L0.8081.00
23_A133_A0.8061.00
70_Y74_P0.8041.00
141_R214_T0.8041.00
62_L67_L0.8041.00
88_A96_V0.8031.00
149_L206_M0.7991.00
76_L104_T0.7981.00
225_Y228_V0.7890.99
66_R69_V0.7850.99
228_V233_V0.7830.99
22_N129_E0.7820.99
33_V117_I0.7750.99
46_L109_L0.7700.99
120_Y124_T0.7680.99
133_A137_L0.7660.99
88_A99_P0.7620.99
32_L237_V0.7620.99
45_A113_S0.7610.99
183_T187_L0.7520.99
232_L236_A0.7510.99
54_V57_G0.7500.99
214_T217_T0.7450.99
71_F111_S0.7450.99
89_V95_A0.7450.99
26_A118_L0.7390.99
21_L228_V0.7380.99
141_R144_V0.7340.99
18_T21_L0.7300.99
75_T80_A0.7280.99
162_A165_E0.7250.99
76_L79_I0.7210.99
234_V238_T0.7200.99
164_L190_S0.7160.99
64_V123_V0.7140.99
207_Q210_A0.7130.99
157_L173_G0.7130.99
99_P103_R0.7100.99
49_F52_L0.7100.99
224_G228_V0.7100.99
25_F230_T0.7090.99
156_T160_E0.7080.99
228_V231_V0.7080.99
212_D216_P0.7070.99
21_L227_Y0.7050.99
198_R202_L0.7030.99
19_G133_A0.7010.99
46_L50_G0.7000.99
88_A97_S0.6990.99
72_L79_I0.6940.99
170_S205_A0.6910.99
168_A207_Q0.6900.99
170_S209_R0.6890.99
15_P22_N0.6880.99
138_R144_V0.6870.99
74_P81_V0.6860.99
164_L187_L0.6830.99
68_P71_F0.6830.99
105_L108_G0.6790.98
42_Y46_L0.6780.98
91_V94_L0.6780.98
199_A202_L0.6760.98
79_I83_T0.6750.98
142_F212_D0.6710.98
174_F180_T0.6710.98
203_D206_M0.6700.98
100_G146_V0.6670.98
158_F162_A0.6650.98
134_L147_S0.6640.98
156_T198_R0.6600.98
131_V141_R0.6530.98
108_G112_L0.6520.98
153_A193_V0.6510.98
118_L154_I0.6500.98
30_L118_L0.6450.98
163_R201_A0.6440.98
213_G217_T0.6420.98
159_D163_R0.6400.98
226_G237_V0.6380.98
125_T129_E0.6350.98
131_V144_V0.6340.98
135_Q138_R0.6330.98
121_L207_Q0.6330.98
145_D168_A0.6320.98
163_R194_R0.6310.98
79_I100_G0.6290.98
13_A45_A0.6260.97
58_G64_V0.6250.97
135_Q144_V0.6200.97
58_G123_V0.6190.97
232_L235_L0.6160.97
200_D204_D0.6150.97
32_L41_A0.6140.97
12_A73_A0.6140.97
108_G114_S0.6120.97
101_I105_L0.6110.97
47_A51_A0.6090.97
146_V168_A0.6070.97
15_P125_T0.6040.97
29_A33_V0.6020.97
166_L204_D0.6010.97
79_I82_F0.5990.97
168_A172_L0.5980.97
159_D162_A0.5960.97
21_L230_T0.5930.96
103_R106_T0.5920.96
193_V196_L0.5890.96
141_R212_D0.5880.96
115_V119_S0.5870.96
83_T103_R0.5870.96
114_S150_T0.5860.96
73_A76_L0.5850.96
61_Y116_T0.5830.96
199_A203_D0.5820.96
68_P78_L0.5820.96
17_V226_G0.5810.96
160_E191_L0.5780.96
47_A54_V0.5770.96
24_Y236_A0.5770.96
73_A81_V0.5750.96
144_V155_Q0.5740.96
42_Y106_T0.5680.96
194_R200_D0.5670.95
114_S153_A0.5660.95
82_F103_R0.5630.95
66_R78_L0.5610.95
132_G141_R0.5600.95
152_R159_D0.5590.95
226_G230_T0.5590.95
198_R201_A0.5580.95
233_V236_A0.5570.95
95_A98_W0.5550.95
44_G47_A0.5540.95
225_Y236_A0.5530.95
19_G125_T0.5530.95
225_Y232_L0.5520.95
189_F197_S0.5510.95
20_R24_Y0.5480.95
49_F120_Y0.5470.95
68_P115_V0.5460.94
224_G231_V0.5460.94
14_T120_Y0.5460.94
129_E220_T0.5450.94
84_P88_A0.5450.94
18_T221_P0.5430.94
154_I206_M0.5420.94
13_A16_R0.5390.94
61_Y64_V0.5390.94
64_V68_P0.5390.94
225_Y233_V0.5310.94
131_V148_L0.5300.94
49_F116_T0.5290.93
150_T154_I0.5290.93
146_V198_R0.5280.93
222_N227_Y0.5270.93
26_A108_G0.5250.93
80_A83_T0.5220.93
127_V155_Q0.5210.93
86_P95_A0.5170.93
21_L25_F0.5140.92
80_A101_I0.5110.92
29_A45_A0.5070.92
153_A160_E0.5050.92
149_L152_R0.5050.92
227_Y230_T0.5050.92
30_L146_V0.5040.92
163_R166_L0.5030.92
11_V54_V0.5020.92
168_A190_S0.5010.92
17_V82_F0.5000.91
12_A56_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4huqT 1 0.9463 100 0.183 Contact Map
2l0eA 1 0.1281 6.2 0.951 Contact Map
4mt1A 3 0.6653 3.6 0.957 Contact Map
4dx5A 3 0.8926 3.3 0.957 Contact Map
1n7lA 1 0.1983 2.9 0.958 Contact Map
2ww9C 1 0.0868 2.3 0.961 Contact Map
1t5hX 2 0.3347 2.3 0.961 Contact Map
2onkC 2 0.8926 2.2 0.961 Contact Map
3w9iA 3 0.6818 2.2 0.961 Contact Map
4y3uB 1 0.1116 2.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.008 seconds.