GREMLIN Database
CBIN - Cobalt transport protein CbiN
UniProt: Q9HPH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (86)
Sequences: 433 (319)
Seq/√Len: 34.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_S59_I4.2601.00
72_G76_G4.0381.00
52_W55_P3.6651.00
81_R84_P2.9371.00
24_G56_S2.7701.00
77_Y83_R2.7081.00
84_P88_S2.4911.00
65_S68_A2.4051.00
26_W65_S2.0790.99
34_G60_E2.0040.98
5_L9_G1.9820.98
36_T39_T1.9350.98
10_I13_G1.9140.98
78_Y82_D1.8160.97
68_A76_G1.7800.96
21_V24_G1.7650.96
13_G17_V1.7230.95
7_A11_L1.7210.95
59_I62_L1.5780.93
24_G59_I1.4850.90
27_G32_V1.4540.89
17_V26_W1.4270.88
86_G89_Q1.4050.87
82_D85_R1.3840.87
12_L51_L1.2980.83
38_T43_S1.2400.80
65_S69_A1.2360.80
6_A73_I1.1990.77
37_I44_Y1.1680.76
74_I78_Y1.1550.75
5_L45_E1.1520.75
40_I43_S1.1390.74
69_A76_G1.1370.74
76_G81_R1.1230.73
4_W7_A1.0670.69
7_A12_L1.0270.66
68_A72_G1.0250.65
31_G45_E1.0240.65
35_D49_Q0.9870.62
31_G35_D0.9720.61
34_G53_T0.9110.56
6_A10_I0.9020.56
9_G13_G0.8960.55
18_F51_L0.8850.54
46_P50_S0.8830.54
81_R85_R0.8800.54
4_W8_G0.8700.53
6_A17_V0.8550.52
25_A62_L0.8500.51
50_S85_R0.8500.51
24_G31_G0.8410.50
7_A19_S0.8340.50
31_G57_G0.8270.49
12_L16_V0.8260.49
39_T53_T0.8240.49
23_A79_L0.8180.48
22_S73_I0.8080.48
62_L75_I0.8060.47
11_L88_S0.8040.47
17_V73_I0.7920.46
69_A72_G0.7720.44
65_S75_I0.7640.44
5_L51_L0.7530.43
13_G48_F0.7520.43
29_A65_S0.7430.42
36_T40_I0.7350.41
6_A9_G0.7320.41
15_L51_L0.7070.39
55_P59_I0.6930.38
34_G38_T0.6860.37
29_A55_P0.6740.36
65_S76_G0.6740.36
11_L15_L0.6720.36
38_T41_N0.6650.36
16_V46_P0.6620.36
13_G22_S0.6560.35
27_G43_S0.6490.35
33_A48_F0.6470.34
34_G45_E0.6460.34
8_G12_L0.6440.34
12_L74_I0.6280.33
33_A66_I0.6250.33
21_V25_A0.6180.32
12_L21_V0.6120.32
27_G31_G0.6050.31
31_G62_L0.6000.31
40_I70_V0.5990.31
8_G88_S0.5960.31
37_I78_Y0.5910.30
39_T45_E0.5880.30
6_A87_Q0.5840.30
4_W41_N0.5760.29
55_P60_E0.5730.29
49_Q88_S0.5730.29
74_I81_R0.5720.29
8_G89_Q0.5710.29
27_G56_S0.5710.29
40_I46_P0.5700.29
27_G49_Q0.5670.29
10_I85_R0.5670.29
32_V35_D0.5660.28
13_G42_P0.5660.28
23_A26_W0.5640.28
22_S86_G0.5630.28
32_V56_S0.5600.28
4_W11_L0.5570.28
79_L87_Q0.5550.28
52_W89_Q0.5540.28
21_V52_W0.5540.28
77_Y81_R0.5510.27
69_A89_Q0.5500.27
55_P69_A0.5480.27
37_I66_I0.5470.27
16_V78_Y0.5450.27
12_L78_Y0.5450.27
48_F79_L0.5420.27
52_W74_I0.5370.26
11_L63_L0.5360.26
17_V21_V0.5330.26
50_S79_L0.5320.26
53_T72_G0.5310.26
8_G11_L0.5310.26
29_A84_P0.5200.25
6_A26_W0.5170.25
29_A68_A0.5170.25
17_V20_F0.5150.25
27_G59_I0.5100.25
57_G74_I0.5090.25
42_P70_V0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9792 24.9 0.93 Contact Map
4tquN 1 0.9688 17 0.935 Contact Map
3d31C 2 0.8125 13.9 0.938 Contact Map
1tacA 1 0.5729 12.2 0.939 Contact Map
3mi9C 1 0.4167 11.3 0.94 Contact Map
4ymuD 2 0.5938 11.2 0.94 Contact Map
4ok4A 2 0.75 11 0.94 Contact Map
2onkC 2 0.8229 10.7 0.941 Contact Map
1p7bA 3 0.8646 10.4 0.941 Contact Map
1mhsA 2 0.7292 9.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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