GREMLIN Database
Q9HPH4 - Putative cobalt transport protein CbiM
UniProt: Q9HPH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (207)
Sequences: 1305 (910)
Seq/√Len: 63.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_S162_A4.7131.00
90_A112_V4.4661.00
20_A113_V4.1371.00
24_I90_A3.7601.00
89_S116_G3.5801.00
176_I180_A3.2541.00
145_V195_G3.0351.00
118_V154_V3.0351.00
75_I201_L2.7461.00
76_A85_T2.5991.00
128_R132_P2.5901.00
49_A88_L2.5501.00
16_W113_V2.5051.00
20_A24_I2.4521.00
16_W110_A2.4111.00
122_A150_T2.3791.00
144_A198_A2.2421.00
13_A17_F2.2231.00
10_G14_L2.1551.00
20_A112_V2.1471.00
141_F195_G2.0011.00
123_G147_A1.9051.00
26_Y83_A1.8791.00
24_I112_V1.7961.00
145_V149_W1.7581.00
144_A199_A1.7460.99
209_R212_I1.7250.99
108_L112_V1.7180.99
71_T119_G1.6970.99
31_T87_F1.6750.99
118_V122_A1.6690.99
193_V197_L1.6690.99
114_S158_Q1.6470.99
125_V129_A1.6280.99
130_L134_L1.6180.99
26_Y29_L1.5910.99
52_I76_A1.5650.99
83_A121_V1.5250.99
23_V117_V1.5230.99
186_T190_I1.4970.98
48_A79_L1.4890.98
153_L184_S1.4890.98
75_I198_A1.4420.98
14_L18_V1.4240.98
68_S190_I1.4190.98
94_L108_L1.4040.98
128_R131_N1.3970.97
131_N136_L1.3950.97
29_L33_R1.3900.97
204_Y208_S1.3700.97
20_A117_V1.3590.97
73_T123_G1.3530.97
78_V127_F1.3500.97
68_S187_Q1.3420.97
8_L110_A1.3390.97
52_I73_T1.3320.97
41_N44_H1.3310.97
48_A76_A1.3280.97
74_G145_V1.3210.96
113_V117_V1.3030.96
19_V113_V1.3020.96
140_T144_A1.2980.96
17_F21_I1.2900.96
136_L206_A1.2890.96
90_A94_L1.2740.96
130_L133_Y1.2650.95
120_P127_F1.2470.95
66_S179_F1.2430.95
192_I196_A1.2430.95
9_P12_W1.2390.95
52_I85_T1.2160.94
59_K102_H1.2150.94
64_T178_R1.2130.94
21_I24_I1.2120.94
55_L70_P1.2060.94
17_F105_L1.1930.94
151_T155_T1.1880.94
66_S182_V1.1700.93
148_D152_Y1.1680.93
22_P25_S1.1610.93
130_L139_A1.1610.93
92_V184_S1.1520.93
177_V181_S1.1340.92
135_D138_K1.1290.92
138_K142_A1.1080.91
4_M7_F1.1000.91
113_V118_V1.0900.90
119_G122_A1.0880.90
57_A100_L1.0870.90
28_A87_F1.0860.90
160_G176_I1.0830.90
178_R181_S1.0680.89
198_A202_I1.0680.89
168_G174_D1.0650.89
59_K187_Q1.0500.89
3_I7_F1.0430.88
196_A200_G1.0300.88
115_M155_T1.0280.87
82_P124_W1.0260.87
25_S28_A1.0260.87
95_Y99_L1.0130.87
185_I189_P1.0120.87
59_K183_F1.0010.86
137_Q140_T0.9660.84
62_S190_I0.9640.84
182_V190_I0.9630.84
117_V158_Q0.9600.84
141_F203_G0.9590.84
78_V143_A0.9560.83
14_L66_S0.9510.83
62_S68_S0.9440.83
155_T158_Q0.9350.82
116_G177_V0.9350.82
21_I25_S0.9300.82
20_A192_I0.9290.82
46_A166_G0.9280.82
30_K33_R0.9220.81
29_L32_A0.9210.81
74_G123_G0.9200.81
17_F26_Y0.9170.81
147_A188_I0.9150.81
46_A85_T0.9060.80
143_A147_A0.9000.79
56_S102_H0.9000.79
76_A184_S0.8950.79
130_L142_A0.8910.79
188_I192_I0.8860.78
12_W15_V0.8820.78
34_L41_N0.8820.78
157_I176_I0.8790.78
84_V121_V0.8520.76
152_Y155_T0.8510.76
77_V125_V0.8460.75
28_A32_A0.8420.75
62_S100_L0.8380.74
71_T147_A0.8360.74
159_L183_F0.8340.74
114_S155_T0.8260.73
114_S160_G0.8210.73
27_G160_G0.8200.73
119_G151_T0.8190.73
183_F187_Q0.8180.73
23_V27_G0.8150.72
118_V158_Q0.8110.72
15_V18_V0.8040.71
4_M179_F0.7990.71
126_V146_I0.7950.70
1_M18_V0.7940.70
205_I214_T0.7910.70
25_S157_I0.7850.70
134_L138_K0.7810.69
10_G13_A0.7790.69
127_F202_I0.7790.69
19_V28_A0.7760.69
24_I87_F0.7710.68
156_S183_F0.7690.68
187_Q191_G0.7670.68
27_G87_F0.7660.68
28_A86_A0.7570.67
43_S47_V0.7570.67
94_L98_L0.7490.66
155_T186_T0.7480.66
59_K155_T0.7460.66
102_H107_T0.7410.65
16_W106_T0.7390.65
25_S37_N0.7380.65
150_T154_V0.7370.65
34_L128_R0.7220.63
204_Y207_M0.7170.62
55_L186_T0.7150.62
36_R105_L0.7140.62
35_A38_D0.7140.62
156_S163_F0.7130.62
12_W47_V0.7120.62
157_I173_V0.7100.62
5_E27_G0.7090.62
149_W188_I0.7070.61
36_R91_I0.7050.61
58_L89_S0.7020.61
43_S212_I0.6970.60
56_S59_K0.6960.60
45_I159_L0.6930.60
46_A57_A0.6920.60
58_L70_P0.6920.60
68_S155_T0.6910.60
24_I108_L0.6900.60
21_I26_Y0.6890.59
37_N47_V0.6870.59
120_P125_V0.6860.59
138_K145_V0.6850.59
2_H6_G0.6840.59
17_F112_V0.6840.59
5_E43_S0.6820.59
206_A213_K0.6810.59
48_A88_L0.6810.59
124_W127_F0.6800.58
141_F144_A0.6760.58
133_Y139_A0.6750.58
185_I188_I0.6750.58
158_Q162_A0.6750.58
131_N139_A0.6740.58
28_A47_V0.6740.58
86_A90_A0.6730.58
26_Y30_K0.6680.57
163_F166_G0.6590.56
78_V208_S0.6590.56
157_I161_V0.6590.56
132_P135_D0.6580.56
159_L163_F0.6560.56
5_E63_V0.6540.55
18_V21_I0.6500.55
59_K73_T0.6500.55
165_S168_G0.6490.55
27_G86_A0.6470.55
51_F184_S0.6410.54
131_N196_A0.6360.53
129_A146_I0.6350.53
25_S29_L0.6330.53
108_L195_G0.6290.53
1_M93_L0.6280.52
149_W191_G0.6240.52
14_L17_F0.6240.52
68_S102_H0.6220.52
97_A178_R0.6210.52
8_L174_D0.6200.52
68_S189_P0.6180.51
70_P148_D0.6180.51
11_I14_L0.6150.51
9_P160_G0.6140.51
195_G199_A0.6140.51
118_V176_I0.6100.50
17_F20_A0.6040.50
32_A36_R0.6020.49
50_A196_A0.6010.49
68_S186_T0.6010.49
95_Y184_S0.6010.49
86_A121_V0.6010.49
199_A204_Y0.5980.49
99_L115_M0.5960.49
118_V150_T0.5960.49
121_V165_S0.5960.49
121_V125_V0.5920.48
5_E101_G0.5900.48
122_A161_V0.5850.48
159_L166_G0.5840.47
85_T151_T0.5820.47
129_A132_P0.5780.47
129_A199_A0.5750.46
136_L139_A0.5710.46
52_I56_S0.5700.46
7_F66_S0.5700.46
186_T189_P0.5680.46
17_F116_G0.5640.45
143_A156_S0.5620.45
80_F126_V0.5620.45
85_T119_G0.5620.45
55_L80_F0.5610.45
3_I182_V0.5610.45
155_T187_Q0.5600.45
99_L159_L0.5590.45
73_T152_Y0.5580.44
83_A205_I0.5570.44
74_G144_A0.5570.44
4_M174_D0.5550.44
80_F84_V0.5550.44
24_I79_L0.5540.44
7_F57_A0.5530.44
24_I83_A0.5520.44
41_N46_A0.5520.44
33_R128_R0.5510.44
124_W129_A0.5490.43
30_K83_A0.5480.43
11_I30_K0.5460.43
4_M101_G0.5450.43
101_G152_Y0.5450.43
62_S186_T0.5440.43
155_T159_L0.5410.43
15_V21_I0.5410.43
41_N49_A0.5400.42
72_G92_V0.5390.42
95_Y102_H0.5330.42
110_A153_L0.5320.42
57_A102_H0.5300.41
23_V86_A0.5290.41
38_D41_N0.5280.41
159_L162_A0.5260.41
14_L58_L0.5260.41
60_I91_I0.5250.41
191_G201_L0.5230.41
68_S107_T0.5220.40
14_L29_L0.5220.40
113_V158_Q0.5200.40
97_A107_T0.5190.40
30_K34_L0.5190.40
4_M46_A0.5180.40
9_P166_G0.5180.40
137_Q203_G0.5170.40
153_L157_I0.5140.40
197_L204_Y0.5130.39
10_G15_V0.5130.39
127_F131_N0.5090.39
7_F163_F0.5090.39
64_T181_S0.5080.39
93_L119_G0.5070.39
19_V76_A0.5060.39
125_V142_A0.5050.39
168_G173_V0.5050.39
128_R133_Y0.5040.38
140_T206_A0.5000.38
93_L96_Q0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m5bA 1 0.9273 100 0.27 Contact Map
3p5nA 2 0.7318 98.9 0.82 Contact Map
4huqS 1 0.7318 98.5 0.847 Contact Map
3rlbA 1 0.7773 98.4 0.852 Contact Map
4rfsS 1 0.7818 98.2 0.86 Contact Map
4tkrA 2 0.7864 98.1 0.862 Contact Map
4z7fA 2 0.7455 98 0.865 Contact Map
4hzuS 1 0.7273 97.9 0.87 Contact Map
4dveA 3 0.7909 97.4 0.882 Contact Map
4r1iA 2 0.2682 21.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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