Q9HPH4 - HALSA - GREMLIN Contacts

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Q9HPH4 - Putative cobalt transport protein CbiM

UniProt:	Q9HPH4	Sequences: MHIMEGFLPGIWALVWFVVAIPVISYGALKTARLARNDELNKSHIAVAAAFIFVLSALKIPSVTGSTSHPTGTGIAVVLFGPAVTAFLSAIVLLYQALLLGHGGLTTLGANVVSMGVVGPVAGWVVFRALNPYLDLQKATFAAAVIADWTTYLVTSIQLGVAFPSGPGVAGVVDSIVRFASVFSITQIPIGIVEGALAAGLIGYIAMSRQSIKTRLGVTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	220 (207)
Sequences:	1305 (910)
Seq/√Len:	63.2

HALSA - Q9HPH4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_S	162_A	4.713	1.00
90_A	112_V	4.466	1.00
20_A	113_V	4.137	1.00
24_I	90_A	3.760	1.00
89_S	116_G	3.580	1.00
176_I	180_A	3.254	1.00
145_V	195_G	3.035	1.00
118_V	154_V	3.035	1.00
75_I	201_L	2.746	1.00
76_A	85_T	2.599	1.00
128_R	132_P	2.590	1.00
49_A	88_L	2.550	1.00
16_W	113_V	2.505	1.00
20_A	24_I	2.452	1.00
16_W	110_A	2.411	1.00
122_A	150_T	2.379	1.00
144_A	198_A	2.242	1.00
13_A	17_F	2.223	1.00
10_G	14_L	2.155	1.00
20_A	112_V	2.147	1.00
141_F	195_G	2.001	1.00
123_G	147_A	1.905	1.00
26_Y	83_A	1.879	1.00
24_I	112_V	1.796	1.00
145_V	149_W	1.758	1.00
144_A	199_A	1.746	0.99
209_R	212_I	1.725	0.99
108_L	112_V	1.718	0.99
71_T	119_G	1.697	0.99
31_T	87_F	1.675	0.99
118_V	122_A	1.669	0.99
193_V	197_L	1.669	0.99
114_S	158_Q	1.647	0.99
125_V	129_A	1.628	0.99
130_L	134_L	1.618	0.99
26_Y	29_L	1.591	0.99
52_I	76_A	1.565	0.99
83_A	121_V	1.525	0.99
23_V	117_V	1.523	0.99
186_T	190_I	1.497	0.98
48_A	79_L	1.489	0.98
153_L	184_S	1.489	0.98
75_I	198_A	1.442	0.98
14_L	18_V	1.424	0.98
68_S	190_I	1.419	0.98
94_L	108_L	1.404	0.98
128_R	131_N	1.397	0.97
131_N	136_L	1.395	0.97
29_L	33_R	1.390	0.97
204_Y	208_S	1.370	0.97
20_A	117_V	1.359	0.97
73_T	123_G	1.353	0.97
78_V	127_F	1.350	0.97
68_S	187_Q	1.342	0.97
8_L	110_A	1.339	0.97
52_I	73_T	1.332	0.97
41_N	44_H	1.331	0.97
48_A	76_A	1.328	0.97
74_G	145_V	1.321	0.96
113_V	117_V	1.303	0.96
19_V	113_V	1.302	0.96
140_T	144_A	1.298	0.96
17_F	21_I	1.290	0.96
136_L	206_A	1.289	0.96
90_A	94_L	1.274	0.96
130_L	133_Y	1.265	0.95
120_P	127_F	1.247	0.95
66_S	179_F	1.243	0.95
192_I	196_A	1.243	0.95
9_P	12_W	1.239	0.95
52_I	85_T	1.216	0.94
59_K	102_H	1.215	0.94
64_T	178_R	1.213	0.94
21_I	24_I	1.212	0.94
55_L	70_P	1.206	0.94
17_F	105_L	1.193	0.94
151_T	155_T	1.188	0.94
66_S	182_V	1.170	0.93
148_D	152_Y	1.168	0.93
22_P	25_S	1.161	0.93
130_L	139_A	1.161	0.93
92_V	184_S	1.152	0.93
177_V	181_S	1.134	0.92
135_D	138_K	1.129	0.92
138_K	142_A	1.108	0.91
4_M	7_F	1.100	0.91
113_V	118_V	1.090	0.90
119_G	122_A	1.088	0.90
57_A	100_L	1.087	0.90
28_A	87_F	1.086	0.90
160_G	176_I	1.083	0.90
178_R	181_S	1.068	0.89
198_A	202_I	1.068	0.89
168_G	174_D	1.065	0.89
59_K	187_Q	1.050	0.89
3_I	7_F	1.043	0.88
196_A	200_G	1.030	0.88
115_M	155_T	1.028	0.87
82_P	124_W	1.026	0.87
25_S	28_A	1.026	0.87
95_Y	99_L	1.013	0.87
185_I	189_P	1.012	0.87
59_K	183_F	1.001	0.86
137_Q	140_T	0.966	0.84
62_S	190_I	0.964	0.84
182_V	190_I	0.963	0.84
117_V	158_Q	0.960	0.84
141_F	203_G	0.959	0.84
78_V	143_A	0.956	0.83
14_L	66_S	0.951	0.83
62_S	68_S	0.944	0.83
155_T	158_Q	0.935	0.82
116_G	177_V	0.935	0.82
21_I	25_S	0.930	0.82
20_A	192_I	0.929	0.82
46_A	166_G	0.928	0.82
30_K	33_R	0.922	0.81
29_L	32_A	0.921	0.81
74_G	123_G	0.920	0.81
17_F	26_Y	0.917	0.81
147_A	188_I	0.915	0.81
46_A	85_T	0.906	0.80
143_A	147_A	0.900	0.79
56_S	102_H	0.900	0.79
76_A	184_S	0.895	0.79
130_L	142_A	0.891	0.79
188_I	192_I	0.886	0.78
12_W	15_V	0.882	0.78
34_L	41_N	0.882	0.78
157_I	176_I	0.879	0.78
84_V	121_V	0.852	0.76
152_Y	155_T	0.851	0.76
77_V	125_V	0.846	0.75
28_A	32_A	0.842	0.75
62_S	100_L	0.838	0.74
71_T	147_A	0.836	0.74
159_L	183_F	0.834	0.74
114_S	155_T	0.826	0.73
114_S	160_G	0.821	0.73
27_G	160_G	0.820	0.73
119_G	151_T	0.819	0.73
183_F	187_Q	0.818	0.73
23_V	27_G	0.815	0.72
118_V	158_Q	0.811	0.72
15_V	18_V	0.804	0.71
4_M	179_F	0.799	0.71
126_V	146_I	0.795	0.70
1_M	18_V	0.794	0.70
205_I	214_T	0.791	0.70
25_S	157_I	0.785	0.70
134_L	138_K	0.781	0.69
10_G	13_A	0.779	0.69
127_F	202_I	0.779	0.69
19_V	28_A	0.776	0.69
24_I	87_F	0.771	0.68
156_S	183_F	0.769	0.68
187_Q	191_G	0.767	0.68
27_G	87_F	0.766	0.68
28_A	86_A	0.757	0.67
43_S	47_V	0.757	0.67
94_L	98_L	0.749	0.66
155_T	186_T	0.748	0.66
59_K	155_T	0.746	0.66
102_H	107_T	0.741	0.65
16_W	106_T	0.739	0.65
25_S	37_N	0.738	0.65
150_T	154_V	0.737	0.65
34_L	128_R	0.722	0.63
204_Y	207_M	0.717	0.62
55_L	186_T	0.715	0.62
36_R	105_L	0.714	0.62
35_A	38_D	0.714	0.62
156_S	163_F	0.713	0.62
12_W	47_V	0.712	0.62
157_I	173_V	0.710	0.62
5_E	27_G	0.709	0.62
149_W	188_I	0.707	0.61
36_R	91_I	0.705	0.61
58_L	89_S	0.702	0.61
43_S	212_I	0.697	0.60
56_S	59_K	0.696	0.60
45_I	159_L	0.693	0.60
46_A	57_A	0.692	0.60
58_L	70_P	0.692	0.60
68_S	155_T	0.691	0.60
24_I	108_L	0.690	0.60
21_I	26_Y	0.689	0.59
37_N	47_V	0.687	0.59
120_P	125_V	0.686	0.59
138_K	145_V	0.685	0.59
2_H	6_G	0.684	0.59
17_F	112_V	0.684	0.59
5_E	43_S	0.682	0.59
206_A	213_K	0.681	0.59
48_A	88_L	0.681	0.59
124_W	127_F	0.680	0.58
141_F	144_A	0.676	0.58
133_Y	139_A	0.675	0.58
185_I	188_I	0.675	0.58
158_Q	162_A	0.675	0.58
131_N	139_A	0.674	0.58
28_A	47_V	0.674	0.58
86_A	90_A	0.673	0.58
26_Y	30_K	0.668	0.57
163_F	166_G	0.659	0.56
78_V	208_S	0.659	0.56
157_I	161_V	0.659	0.56
132_P	135_D	0.658	0.56
159_L	163_F	0.656	0.56
5_E	63_V	0.654	0.55
18_V	21_I	0.650	0.55
59_K	73_T	0.650	0.55
165_S	168_G	0.649	0.55
27_G	86_A	0.647	0.55
51_F	184_S	0.641	0.54
131_N	196_A	0.636	0.53
129_A	146_I	0.635	0.53
25_S	29_L	0.633	0.53
108_L	195_G	0.629	0.53
1_M	93_L	0.628	0.52
149_W	191_G	0.624	0.52
14_L	17_F	0.624	0.52
68_S	102_H	0.622	0.52
97_A	178_R	0.621	0.52
8_L	174_D	0.620	0.52
68_S	189_P	0.618	0.51
70_P	148_D	0.618	0.51
11_I	14_L	0.615	0.51
9_P	160_G	0.614	0.51
195_G	199_A	0.614	0.51
118_V	176_I	0.610	0.50
17_F	20_A	0.604	0.50
32_A	36_R	0.602	0.49
50_A	196_A	0.601	0.49
68_S	186_T	0.601	0.49
95_Y	184_S	0.601	0.49
86_A	121_V	0.601	0.49
199_A	204_Y	0.598	0.49
99_L	115_M	0.596	0.49
118_V	150_T	0.596	0.49
121_V	165_S	0.596	0.49
121_V	125_V	0.592	0.48
5_E	101_G	0.590	0.48
122_A	161_V	0.585	0.48
159_L	166_G	0.584	0.47
85_T	151_T	0.582	0.47
129_A	132_P	0.578	0.47
129_A	199_A	0.575	0.46
136_L	139_A	0.571	0.46
52_I	56_S	0.570	0.46
7_F	66_S	0.570	0.46
186_T	189_P	0.568	0.46
17_F	116_G	0.564	0.45
143_A	156_S	0.562	0.45
80_F	126_V	0.562	0.45
85_T	119_G	0.562	0.45
55_L	80_F	0.561	0.45
3_I	182_V	0.561	0.45
155_T	187_Q	0.560	0.45
99_L	159_L	0.559	0.45
73_T	152_Y	0.558	0.44
83_A	205_I	0.557	0.44
74_G	144_A	0.557	0.44
4_M	174_D	0.555	0.44
80_F	84_V	0.555	0.44
24_I	79_L	0.554	0.44
7_F	57_A	0.553	0.44
24_I	83_A	0.552	0.44
41_N	46_A	0.552	0.44
33_R	128_R	0.551	0.44
124_W	129_A	0.549	0.43
30_K	83_A	0.548	0.43
11_I	30_K	0.546	0.43
4_M	101_G	0.545	0.43
101_G	152_Y	0.545	0.43
62_S	186_T	0.544	0.43
155_T	159_L	0.541	0.43
15_V	21_I	0.541	0.43
41_N	49_A	0.540	0.42
72_G	92_V	0.539	0.42
95_Y	102_H	0.533	0.42
110_A	153_L	0.532	0.42
57_A	102_H	0.530	0.41
23_V	86_A	0.529	0.41
38_D	41_N	0.528	0.41
159_L	162_A	0.526	0.41
14_L	58_L	0.526	0.41
60_I	91_I	0.525	0.41
191_G	201_L	0.523	0.41
68_S	107_T	0.522	0.40
14_L	29_L	0.522	0.40
113_V	158_Q	0.520	0.40
97_A	107_T	0.519	0.40
30_K	34_L	0.519	0.40
4_M	46_A	0.518	0.40
9_P	166_G	0.518	0.40
137_Q	203_G	0.517	0.40
153_L	157_I	0.514	0.40
197_L	204_Y	0.513	0.39
10_G	15_V	0.513	0.39
127_F	131_N	0.509	0.39
7_F	163_F	0.509	0.39
64_T	181_S	0.508	0.39
93_L	119_G	0.507	0.39
19_V	76_A	0.506	0.39
125_V	142_A	0.505	0.39
168_G	173_V	0.505	0.39
128_R	133_Y	0.504	0.38
140_T	206_A	0.500	0.38
93_L	96_Q	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m5bA	1	0.9273	100	0.27	Contact Map
3p5nA	2	0.7318	98.9	0.82	Contact Map
4huqS	1	0.7318	98.5	0.847	Contact Map
3rlbA	1	0.7773	98.4	0.852	Contact Map
4rfsS	1	0.7818	98.2	0.86	Contact Map
4tkrA	2	0.7864	98.1	0.862	Contact Map
4z7fA	2	0.7455	98	0.865	Contact Map
4hzuS	1	0.7273	97.9	0.87	Contact Map
4dveA	3	0.7909	97.4	0.882	Contact Map
4r1iA	2	0.2682	21.5	0.954	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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