GREMLIN Database
Q9HPH3 - Halocyanin-like
UniProt: Q9HPH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (249)
Sequences: 3148 (2706)
Seq/√Len: 171.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_R165_E6.0281.00
104_T139_T5.1211.00
257_T260_F3.9511.00
122_A125_S3.9321.00
102_T139_T3.4661.00
256_V260_F3.1281.00
94_L161_I3.0521.00
108_T135_T3.0391.00
106_E137_T3.0371.00
256_V259_T3.0011.00
107_W130_A2.9941.00
70_D81_V2.9151.00
99_P166_E2.4671.00
148_Y160_G2.4191.00
131_T134_H2.4061.00
12_T15_R2.3771.00
72_R81_V2.3691.00
184_D187_G2.3101.00
218_G223_W2.2221.00
251_E254_V2.1451.00
150_S153_D2.1241.00
182_V185_Y2.0681.00
161_I215_V2.0591.00
177_R181_P2.0501.00
78_S82_G2.0001.00
99_P167_Y1.9891.00
175_V179_L1.9051.00
114_H153_D1.9051.00
182_V187_G1.8911.00
174_D179_L1.8591.00
70_D75_A1.7851.00
67_S70_D1.7491.00
113_A131_T1.7471.00
175_V178_W1.7431.00
78_S81_V1.7401.00
257_T261_N1.7331.00
25_I28_C1.7261.00
174_D177_R1.7041.00
114_H150_S1.6931.00
98_A165_E1.6391.00
117_I151_E1.6091.00
90_F159_K1.6051.00
224_K249_R1.6011.00
97_V103_V1.5781.00
177_R182_V1.5771.00
250_S256_V1.5641.00
25_I29_T1.5611.00
84_H156_S1.5601.00
63_N70_D1.5111.00
233_A244_G1.5101.00
69_T72_R1.4931.00
77_V81_V1.4821.00
68_W72_R1.4641.00
224_K247_E1.4511.00
70_D73_G1.4241.00
98_A101_T1.4211.00
21_G24_A1.4051.00
63_N66_E1.4031.00
97_V162_I1.3971.00
97_V164_V1.3881.00
28_C31_R1.3311.00
176_D179_L1.3291.00
27_G31_R1.3251.00
119_V151_E1.2951.00
107_W116_V1.2941.00
64_T70_D1.2911.00
227_G232_G1.2401.00
58_W61_S1.2371.00
70_D74_D1.2301.00
198_V223_W1.2261.00
104_T137_T1.2191.00
192_D195_T1.2111.00
87_P93_A1.2101.00
182_V186_D1.2101.00
169_T172_Y1.2091.00
68_W74_D1.2011.00
13_F17_A1.1961.00
199_G202_S1.1921.00
86_L158_M1.1881.00
65_P70_D1.1841.00
119_V149_V1.1681.00
223_W228_E1.1641.00
67_S72_R1.1591.00
85_D90_F1.1491.00
75_A81_V1.1351.00
225_W248_L1.1271.00
211_L214_K1.1261.00
73_G82_G1.1251.00
72_R82_G1.1251.00
72_R75_A1.1221.00
165_E177_R1.1221.00
66_E72_R1.1211.00
77_V80_A1.1061.00
112_G153_D1.0941.00
67_S71_H1.0931.00
145_T215_V1.0891.00
115_N118_A1.0881.00
50_P53_M1.0871.00
24_A28_C1.0761.00
114_H117_I1.0761.00
166_E169_T1.0751.00
183_H187_G1.0741.00
99_P143_I1.0651.00
45_H48_T1.0641.00
55_L59_V1.0480.99
106_E135_T1.0430.99
226_A247_E1.0360.99
263_T266_Y1.0300.99
204_G207_Q1.0290.99
26_A30_D1.0260.99
159_K183_H1.0260.99
205_S208_F1.0250.99
9_D12_T1.0250.99
74_D81_V1.0250.99
20_G24_A1.0190.99
76_T79_I1.0190.99
227_G234_H1.0170.99
22_L25_I1.0160.99
257_T262_S1.0130.99
177_R180_S1.0120.99
73_G81_V1.0070.99
239_K254_V1.0070.99
72_R80_A0.9970.99
161_I179_L0.9940.99
222_Q251_E0.9870.99
9_D13_F0.9870.99
34_T37_T0.9850.99
26_A29_T0.9820.99
181_P187_G0.9810.99
98_A167_Y0.9720.99
86_L116_V0.9720.99
161_I181_P0.9720.99
27_G30_D0.9630.99
69_T73_G0.9630.99
69_T108_T0.9580.99
74_D77_V0.9500.99
210_P213_L0.9490.99
62_A70_D0.9460.99
28_C32_T0.9460.99
93_A148_Y0.9450.99
69_T106_E0.9410.99
69_T81_V0.9390.99
107_W114_H0.9270.99
182_V189_V0.9180.99
36_T39_Q0.9170.99
25_I31_R0.9170.99
44_T48_T0.9160.99
74_D82_G0.9160.99
70_D76_T0.9160.99
94_L148_Y0.9010.98
77_V82_G0.8990.98
147_R217_E0.8980.98
49_Q52_E0.8950.98
115_N120_D0.8910.98
35_G39_Q0.8900.98
186_D189_V0.8860.98
235_N244_G0.8840.98
204_G208_F0.8840.98
64_T72_R0.8830.98
207_Q210_P0.8800.98
262_S266_Y0.8790.98
94_L165_E0.8710.98
136_F140_F0.8680.98
29_T32_T0.8680.98
62_A65_P0.8670.98
44_T47_E0.8640.98
220_T223_W0.8640.98
107_W118_A0.8620.98
118_A140_F0.8600.98
71_H75_A0.8560.98
68_W81_V0.8540.98
64_T67_S0.8510.98
233_A246_Q0.8490.98
234_H258_H0.8390.97
186_D190_V0.8390.97
72_R78_S0.8380.97
72_R77_V0.8360.97
66_E73_G0.8340.97
66_E71_H0.8270.97
66_E70_D0.8270.97
13_F16_S0.8260.97
68_W71_H0.8240.97
79_I82_G0.8200.97
70_D82_G0.8180.97
210_P214_K0.8160.97
98_A170_S0.8150.97
147_R151_E0.8120.97
93_A160_G0.8080.97
72_R76_T0.8070.97
168_P171_G0.8060.97
66_E101_T0.8040.97
15_R19_A0.7970.97
63_N67_S0.7900.96
120_D123_F0.7880.96
21_G26_A0.7780.96
85_D88_Y0.7750.96
23_A26_A0.7730.96
184_D190_V0.7720.96
124_D128_S0.7710.96
174_D178_W0.7650.96
63_N68_W0.7610.96
33_T36_T0.7520.95
59_V62_A0.7460.95
91_Q159_K0.7410.95
65_P68_W0.7410.95
241_A244_G0.7400.95
111_G132_E0.7380.95
67_S104_T0.7330.95
97_V101_T0.7320.95
208_F213_L0.7320.95
192_D197_T0.7310.94
196_V202_S0.7300.94
71_H110_Y0.7280.94
165_E169_T0.7280.94
92_P148_Y0.7250.94
64_T75_A0.7240.94
195_T200_D0.7230.94
195_T198_V0.7230.94
103_V140_F0.7210.94
68_W82_G0.7190.94
228_E246_Q0.7180.94
183_H189_V0.7170.94
63_N72_R0.7170.94
194_T198_V0.7140.94
49_Q53_M0.7140.94
64_T81_V0.7110.94
12_T17_A0.7100.94
216_P219_T0.7090.94
61_S66_E0.7080.93
115_N152_P0.7060.93
75_A85_D0.7060.93
68_W75_A0.6930.93
226_A246_Q0.6920.93
216_P222_Q0.6920.93
68_W73_G0.6900.93
24_A27_G0.6900.93
99_P141_T0.6890.93
110_Y135_T0.6830.92
96_R177_R0.6830.92
222_Q252_P0.6800.92
72_R79_I0.6790.92
72_R86_L0.6780.92
120_D151_E0.6740.92
198_V221_V0.6730.92
70_D79_I0.6720.92
159_K217_E0.6720.92
26_A32_T0.6690.91
66_E81_V0.6680.91
86_L114_H0.6640.91
75_A79_I0.6590.91
193_T199_G0.6590.91
65_P72_R0.6590.91
187_G190_V0.6530.90
185_Y189_V0.6530.90
96_R163_A0.6510.90
60_T63_N0.6510.90
236_V239_K0.6450.90
28_C33_T0.6440.90
50_P54_S0.6420.90
113_A129_T0.6420.90
168_P172_Y0.6420.90
71_H76_T0.6410.90
66_E78_S0.6400.90
105_W118_A0.6370.89
197_T204_G0.6360.89
95_T105_W0.6330.89
170_S173_P0.6310.89
30_D33_T0.6300.89
58_W62_A0.6290.89
192_D196_V0.6280.89
74_D111_G0.6220.88
178_W181_P0.6210.88
181_P184_D0.6190.88
192_D202_S0.6170.88
193_T196_V0.6130.87
62_A73_G0.6120.87
51_S54_S0.6110.87
12_T16_S0.6070.87
195_T221_V0.6070.87
70_D78_S0.6050.87
222_Q249_R0.6040.87
107_W129_T0.6040.87
183_H186_D0.6040.87
32_T35_G0.6040.87
69_T74_D0.6030.87
55_L63_N0.6030.87
120_D124_D0.6030.87
181_P189_V0.6010.86
22_L26_A0.6010.86
45_H51_S0.5980.86
34_T38_N0.5980.86
192_D199_G0.5940.86
48_T51_S0.5940.86
92_P202_S0.5920.86
19_A22_L0.5920.86
84_H111_G0.5910.86
114_H130_A0.5890.85
16_S23_A0.5870.85
235_N239_K0.5810.85
219_T253_G0.5770.84
88_Y91_Q0.5770.84
55_L60_T0.5760.84
236_V248_L0.5750.84
220_T252_P0.5750.84
107_W138_H0.5740.84
76_T81_V0.5740.84
181_P217_E0.5740.84
61_S65_P0.5730.84
44_T50_P0.5720.84
233_A237_A0.5700.83
193_T198_V0.5690.83
118_A150_S0.5690.83
236_V245_I0.5660.83
44_T49_Q0.5630.83
193_T197_T0.5610.82
101_T167_Y0.5600.82
65_P104_T0.5580.82
74_D78_S0.5550.82
182_V190_V0.5550.82
181_P185_Y0.5540.82
218_G252_P0.5540.82
143_I164_V0.5530.82
73_G110_Y0.5530.82
199_G204_G0.5530.82
48_T52_E0.5520.81
46_T54_S0.5520.81
112_G118_A0.5510.81
47_E52_E0.5490.81
151_E255_H0.5490.81
60_T79_I0.5460.81
70_D80_A0.5440.81
11_R17_A0.5410.80
169_T173_P0.5410.80
226_A234_H0.5380.80
235_N238_F0.5370.80
97_V165_E0.5360.80
75_A82_G0.5350.79
69_T78_S0.5350.79
64_T73_G0.5340.79
191_T195_T0.5340.79
97_V105_W0.5340.79
66_E75_A0.5330.79
259_T263_T0.5320.79
145_T177_R0.5270.78
92_P158_M0.5260.78
179_L185_Y0.5240.78
20_G23_A0.5230.78
195_T199_G0.5230.78
35_G38_N0.5220.78
209_D213_L0.5210.78
248_L256_V0.5200.77
232_G261_N0.5200.77
32_T36_T0.5190.77
64_T78_S0.5180.77
99_P169_T0.5170.77
118_A121_S0.5170.77
74_D80_A0.5160.77
214_K259_T0.5160.77
66_E77_V0.5160.77
48_T54_S0.5140.77
257_T264_G0.5130.77
216_P225_W0.5110.76
66_E69_T0.5110.76
155_E219_T0.5110.76
14_L17_A0.5110.76
199_G203_S0.5100.76
76_T80_A0.5090.76
215_V221_V0.5070.76
195_T202_S0.5070.76
117_I149_V0.5060.76
63_N71_H0.5020.75
59_V66_E0.5020.75
67_S73_G0.5010.75
31_R35_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5akrA 3 0.8351 100 0.41 Contact Map
3zx1A 1 0.8561 100 0.421 Contact Map
2xu9A 1 0.814 100 0.424 Contact Map
2uxtA 1 0.7649 100 0.429 Contact Map
1zpuA 3 0.7614 100 0.431 Contact Map
3g5wA 4 0.7614 100 0.435 Contact Map
1kbvA 3 0.8351 100 0.436 Contact Map
4e9xA 3 0.7614 100 0.44 Contact Map
1v10A 1 0.7754 100 0.44 Contact Map
4e9sA 1 0.807 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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