GREMLIN Database
TRPG - Anthranilate synthase component 2
UniProt: Q9HPG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (179)
Sequences: 12288 (7092)
Seq/√Len: 530.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_V140_C3.1551.00
93_A169_L2.8191.00
23_Q189_G2.3691.00
127_Q183_V2.3431.00
20_L53_V2.3351.00
148_A165_R2.3271.00
150_T163_R2.3191.00
4_V35_L2.2901.00
94_V162_I2.2761.00
148_A163_R2.2751.00
164_H167_H2.2741.00
22_A185_H2.2511.00
40_S43_A2.2361.00
183_V186_D1.9661.00
151_A161_A1.9201.00
100_T142_S1.9151.00
5_V17_V1.8941.00
19_Y185_H1.8651.00
131_P182_G1.8621.00
120_T163_R1.8471.00
71_T96_E1.8191.00
90_M171_C1.8061.00
130_F183_V1.7871.00
164_H168_P1.7811.00
74_L92_A1.7411.00
65_R95_H1.7381.00
8_N54_I1.7161.00
35_L39_A1.6731.00
102_G139_V1.6201.00
186_D189_G1.6171.00
189_G193_D1.6031.00
71_T95_H1.5881.00
146_C166_D1.5621.00
162_I171_C1.5321.00
149_V152_T1.5001.00
72_D76_A1.4941.00
126_I130_F1.4831.00
33_T47_A1.4631.00
60_H65_R1.4551.00
72_D75_R1.4441.00
43_A46_A1.4291.00
109_H137_S1.4201.00
163_R170_A1.4171.00
140_C162_I1.4121.00
3_V51_A1.3871.00
71_T75_R1.3801.00
5_V53_V1.3651.00
114_P129_D1.3541.00
93_A171_C1.3441.00
30_P192_L1.3401.00
45_R80_R1.3391.00
16_L86_V1.3381.00
45_R76_A1.3321.00
54_I70_T1.3111.00
146_C165_R1.3011.00
113_T129_D1.2981.00
39_A43_A1.2931.00
97_Y169_L1.2851.00
51_A191_F1.2791.00
67_V92_A1.2621.00
90_M140_C1.2591.00
123_F161_A1.2591.00
114_P131_P1.2581.00
102_G141_T1.2371.00
124_A194_A1.2361.00
94_V99_G1.2311.00
75_R96_E1.2301.00
53_V84_L1.2241.00
120_T150_T1.2161.00
9_Y38_T1.2081.00
147_F162_I1.1711.00
130_F187_V1.1691.00
23_Q188_I1.1421.00
147_F164_H1.1391.00
143_I149_V1.1381.00
16_L188_I1.1361.00
118_D152_T1.1351.00
73_V76_A1.1301.00
33_T49_P1.1271.00
170_A194_A1.1031.00
101_V140_C1.0941.00
19_Y22_A1.0741.00
118_D148_A1.0591.00
78_S167_H1.0431.00
112_T131_P1.0351.00
90_M162_I1.0331.00
3_V30_P1.0301.00
104_A139_V1.0121.00
116_S152_T1.0051.00
84_L172_V1.0031.00
42_A46_A0.9961.00
41_L45_R0.9951.00
99_G144_P0.9931.00
80_R167_H0.9921.00
17_V21_S0.9871.00
4_V44_V0.9821.00
94_V144_P0.9751.00
121_G163_R0.9751.00
146_C164_H0.9721.00
78_S169_L0.9721.00
23_Q185_H0.9711.00
105_A157_S0.9701.00
165_R168_P0.9691.00
115_V132_A0.9681.00
97_Y147_F0.9641.00
37_N68_G0.9641.00
39_A47_A0.9611.00
87_C175_H0.9611.00
45_R77_V0.9601.00
70_T92_A0.9601.00
15_N18_E0.9571.00
116_S154_R0.9571.00
54_I83_T0.9541.00
8_N70_T0.9501.00
115_V129_D0.9441.00
59_G66_D0.9401.00
52_V81_V0.9201.00
149_V158_L0.9131.00
143_I158_L0.9111.00
18_E21_S0.9081.00
67_V70_T0.8941.00
51_A192_L0.8941.00
86_V172_V0.8921.00
117_H152_T0.8861.00
174_F187_V0.8831.00
6_V73_V0.8821.00
5_V12_F0.8761.00
52_V73_V0.8681.00
39_A44_V0.8671.00
42_A45_R0.8651.00
4_V47_A0.8651.00
79_P167_H0.8641.00
45_R81_V0.8621.00
132_A181_T0.8571.00
4_V49_P0.8521.00
77_V83_T0.8461.00
127_Q182_G0.8451.00
6_V35_L0.8431.00
41_L76_A0.8421.00
21_S32_V0.8391.00
103_R107_P0.8351.00
123_F174_F0.8331.00
60_H66_D0.8321.00
150_T161_A0.8281.00
23_Q192_L0.8251.00
126_I183_V0.8221.00
67_V71_T0.8121.00
190_N194_A0.8091.00
117_H129_D0.8091.00
8_N37_N0.8061.00
44_V49_P0.8031.00
121_G170_A0.8031.00
35_L43_A0.7981.00
172_V176_P0.7931.00
113_T131_P0.7891.00
116_S129_D0.7891.00
151_A174_F0.7871.00
9_Y36_K0.7821.00
127_Q130_F0.7781.00
78_S97_Y0.7721.00
71_T92_A0.7701.00
42_A76_A0.7611.00
99_G142_S0.7601.00
134_R160_M0.7591.00
20_L30_P0.7591.00
60_H138_L0.7581.00
120_T148_A0.7561.00
87_C91_E0.7561.00
118_D150_T0.7551.00
75_R78_S0.7551.00
150_T170_A0.7501.00
20_L188_I0.7481.00
69_V72_D0.7461.00
153_T157_S0.7461.00
163_R190_N0.7421.00
73_V77_V0.7411.00
3_V20_L0.7351.00
30_P51_A0.7331.00
74_L83_T0.7311.00
14_Y17_V0.7221.00
23_Q29_A0.7201.00
20_L192_L0.7201.00
12_F17_V0.7111.00
5_V20_L0.7101.00
57_G88_L0.7071.00
65_R100_T0.7021.00
124_A186_D0.6921.00
139_V157_S0.6911.00
6_V44_V0.6901.00
120_T170_A0.6881.00
106_E155_D0.6821.00
13_T34_V0.6791.00
122_I170_A0.6781.00
49_P81_V0.6781.00
170_A191_F0.6771.00
185_H189_G0.6771.00
60_H103_R0.6761.00
70_T75_R0.6721.00
29_A32_V0.6711.00
53_V191_F0.6711.00
124_A184_G0.6701.00
107_P137_S0.6701.00
99_G140_C0.6661.00
35_L47_A0.6511.00
152_T156_G0.6491.00
97_Y167_H0.6461.00
115_V152_T0.6451.00
15_N19_Y0.6401.00
7_D13_T0.6401.00
97_Y164_H0.6371.00
101_V138_L0.6341.00
70_T73_V0.6341.00
126_I186_D0.6291.00
17_V34_V0.6281.00
77_V81_V0.6231.00
6_V39_A0.6201.00
52_V83_T0.6201.00
48_D81_V0.6201.00
125_D190_N0.6071.00
130_F182_G0.6041.00
125_D186_D0.6041.00
66_D70_T0.6021.00
41_L77_V0.5981.00
95_H100_T0.5981.00
13_T55_S0.5961.00
164_H169_L0.5951.00
152_T157_S0.5920.99
60_H95_H0.5860.99
4_V33_T0.5820.99
5_V13_T0.5810.99
65_R71_T0.5780.99
142_S145_S0.5760.99
18_E22_A0.5760.99
83_T93_A0.5750.99
172_V187_V0.5640.99
153_T156_G0.5620.99
126_I187_V0.5590.99
135_Y138_L0.5560.99
76_A79_P0.5520.99
41_L73_V0.5500.99
109_H135_Y0.5470.99
69_V73_V0.5450.99
145_S165_R0.5430.99
91_E173_Q0.5420.99
108_M153_T0.5390.99
79_P83_T0.5390.99
60_H101_V0.5370.99
147_F169_L0.5350.99
5_V32_V0.5340.99
139_V156_G0.5330.99
174_F184_G0.5270.99
119_E190_N0.5270.99
39_A42_A0.5230.99
108_M111_K0.5220.99
190_N193_D0.5220.99
189_G192_L0.5210.99
5_V55_S0.5190.99
8_N92_A0.5150.99
4_V39_A0.5130.99
84_L187_V0.5130.99
19_Y188_I0.5120.99
118_D163_R0.5120.99
66_D69_V0.5120.99
124_A193_D0.5080.98
59_G65_R0.5070.98
44_V52_V0.5040.98
51_A84_L0.5020.98
67_V73_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.8838 100 0.209 Contact Map
2ywbA 4 0.9293 100 0.221 Contact Map
1gpmA 3 0.9545 100 0.224 Contact Map
2vxoA 2 0.9343 100 0.232 Contact Map
3uowA 2 0.9646 100 0.255 Contact Map
1qdlB 2 0.9545 100 0.282 Contact Map
1i1qB 1 0.9192 100 0.292 Contact Map
3r75A 2 0.9394 100 0.303 Contact Map
1a9xB 1 0.9141 100 0.304 Contact Map
2vpiA 1 0.904 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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