GREMLIN Database
TRPE1 - Anthranilate synthase component 1 1
UniProt: Q9HPG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 527 (452)
Sequences: 4845 (3174)
Seq/√Len: 149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_R411_D4.5211.00
377_A405_T4.3491.00
376_S404_G4.2291.00
425_L449_G4.1951.00
377_A408_A3.6341.00
248_R252_T3.3591.00
335_C350_E3.1081.00
325_T403_T3.0521.00
261_A266_E2.9571.00
494_D497_A2.9201.00
334_T395_V2.8611.00
277_E480_T2.8351.00
248_R496_D2.8271.00
384_P403_T2.8011.00
261_A439_A2.7761.00
65_F83_G2.7521.00
120_D417_R2.7261.00
120_D123_D2.6461.00
251_Y487_A2.6451.00
385_E388_R2.5921.00
252_T496_D2.5661.00
247_D250_A2.5141.00
277_E482_T2.4451.00
453_G463_L2.4161.00
473_T478_E2.3741.00
260_T264_D2.3581.00
155_Y434_M2.3511.00
382_S403_T2.3231.00
348_A391_K2.3051.00
432_R435_E2.2981.00
345_R349_G2.2751.00
349_G353_A2.2601.00
279_D480_T2.2351.00
246_G254_A2.2071.00
324_D405_T2.1931.00
253_D256_E2.1931.00
410_A414_D2.1841.00
407_A410_A2.1701.00
310_V447_I2.1611.00
258_A270_A2.1431.00
78_R190_D2.1291.00
337_R344_D2.0861.00
267_V270_A2.0691.00
325_T405_T2.0681.00
389_V398_I2.0241.00
372_V376_S1.9961.00
352_L398_I1.9961.00
81_F188_V1.9961.00
284_P309_T1.9821.00
65_F150_V1.9551.00
345_R348_A1.8851.00
341_P345_R1.8631.00
496_D500_E1.7941.00
272_V487_A1.7911.00
269_Q488_G1.7911.00
422_A465_I1.7731.00
436_H440_I1.7711.00
245_A443_T1.7651.00
301_F452_V1.7521.00
283_D286_A1.7411.00
311_V472_I1.7281.00
472_I481_L1.7271.00
391_K396_Q1.7111.00
447_I466_T1.6991.00
301_F312_G1.6951.00
339_A343_A1.6911.00
343_A346_R1.6521.00
55_K289_D1.6471.00
328_T368_A1.6471.00
164_D435_E1.6331.00
256_E259_A1.6331.00
331_I399_E1.6231.00
416_T455_F1.6201.00
500_E504_A1.6141.00
375_V418_A1.6101.00
338_G343_A1.6001.00
149_L182_V1.5971.00
248_R499_Y1.5961.00
256_E495_P1.5871.00
260_T263_R1.5821.00
46_H50_L1.5811.00
50_L54_E1.5641.00
346_R350_E1.5471.00
347_L350_E1.5461.00
258_A272_V1.5401.00
326_V376_S1.5391.00
91_T98_T1.5331.00
213_Y217_E1.5321.00
54_E64_A1.5291.00
487_A502_T1.5041.00
304_A309_T1.5031.00
372_V404_G1.4941.00
373_R379_G1.4891.00
171_P174_P1.4851.00
470_G481_L1.4751.00
242_T278_L1.4721.00
121_V178_A1.4701.00
198_L220_A1.4581.00
156_D438_D1.4571.00
329_N390_L1.4511.00
261_A432_R1.4381.00
377_A407_A1.4281.00
390_L399_E1.4181.00
255_V495_P1.4171.00
326_V372_V1.4121.00
168_V438_D1.4111.00
45_D50_L1.3971.00
317_T462_E1.3931.00
63_G89_V1.3901.00
312_G464_A1.3891.00
250_A442_A1.3771.00
257_T439_A1.3761.00
327_V403_T1.3751.00
416_T463_L1.3741.00
261_A436_H1.3711.00
153_L157_A1.3711.00
340_S343_A1.3611.00
301_F310_V1.3581.00
338_G347_L1.3501.00
280_G472_I1.3471.00
354_D357_E1.3461.00
329_N385_E1.3441.00
243_E279_D1.3391.00
348_A389_V1.3291.00
252_T256_E1.3281.00
188_V199_V1.3241.00
497_A500_E1.3171.00
68_D292_R1.3111.00
322_H460_D1.3091.00
156_D444_P1.3031.00
185_R219_E1.3011.00
454_Y462_E1.2831.00
287_L472_I1.2731.00
248_R500_E1.2691.00
432_R439_A1.2671.00
252_T495_P1.2651.00
499_Y503_E1.2611.00
121_V160_D1.2611.00
274_R502_T1.2601.00
413_F455_F1.2591.00
255_V489_V1.2581.00
302_L309_T1.2551.00
272_V489_V1.2541.00
321_V326_V1.2531.00
384_P401_T1.2481.00
362_T386_F1.2431.00
406_L415_A1.2261.00
80_S191_R1.2241.00
342_V346_R1.2221.00
271_V486_G1.2211.00
321_V415_A1.2121.00
46_H49_L1.2111.00
153_L455_F1.2061.00
365_V386_F1.2061.00
250_A253_D1.2061.00
500_E503_E1.2031.00
362_T387_M1.1911.00
287_L470_G1.1891.00
137_I141_D1.1821.00
447_I471_T1.1811.00
210_T214_D1.1741.00
89_V179_E1.1681.00
253_D257_T1.1681.00
249_D253_D1.1671.00
54_E57_P1.1661.00
284_P472_I1.1641.00
126_R130_P1.1581.00
189_F196_V1.1561.00
257_T260_T1.1531.00
165_E435_E1.1531.00
372_V419_A1.1531.00
126_R414_D1.1481.00
470_G509_V1.1471.00
182_V457_W1.1451.00
250_A254_A1.1431.00
456_S460_D1.1401.00
301_F464_A1.1391.00
246_G442_A1.1391.00
91_T179_E1.1331.00
358_R387_M1.1310.99
270_A437_I1.1270.99
101_R104_D1.1130.99
267_V433_A1.1110.99
263_R491_A1.1040.99
483_V510_L1.1030.99
273_S484_R1.1020.99
120_D160_D1.1000.99
244_R274_R1.0980.99
329_N401_T1.0970.99
485_A506_M1.0970.99
278_L481_L1.0870.99
377_A380_T1.0850.99
257_T261_A1.0820.99
144_L322_H1.0810.99
258_A489_V1.0800.99
52_S55_K1.0740.99
50_L57_P1.0730.99
299_Y317_T1.0710.99
290_A515_R1.0710.99
287_L311_V1.0710.99
171_P444_P1.0700.99
124_R127_S1.0690.99
258_A267_V1.0690.99
295_N313_A1.0640.99
318_L328_T1.0640.99
159_Y438_D1.0630.99
499_Y502_T1.0630.99
198_L224_Q1.0630.99
87_A184_T1.0550.99
161_L420_F1.0550.99
285_R302_L1.0540.99
275_T482_T1.0500.99
125_L180_F1.0470.99
280_G287_L1.0420.99
198_L223_V1.0370.99
88_A128_V1.0370.99
185_R200_C1.0350.99
288_Y292_R1.0350.99
52_S56_T1.0340.99
346_R349_G1.0340.99
312_G452_V1.0300.99
332_A424_T1.0270.99
256_E260_T1.0270.99
172_P443_T1.0270.99
279_D479_D1.0260.99
271_V426_S1.0250.99
274_R499_Y1.0230.99
173_T482_T1.0210.99
93_D96_D1.0190.99
321_V412_A1.0110.99
487_A497_A1.0010.99
126_R417_R1.0010.99
451_G463_L0.9980.99
297_S394_H0.9930.99
452_V466_T0.9930.99
242_T510_L0.9900.99
284_P302_L0.9870.99
180_F463_L0.9860.99
87_A182_V0.9860.99
83_G150_V0.9860.99
483_V506_M0.9850.99
300_M313_A0.9850.99
511_A514_D0.9840.99
274_R503_E0.9780.99
123_D127_S0.9770.99
214_D218_A0.9770.99
86_P183_T0.9740.98
348_A396_Q0.9730.98
158_V434_M0.9680.98
324_D408_A0.9660.98
85_D185_R0.9650.98
266_E432_R0.9640.98
507_D511_A0.9630.98
307_D473_T0.9610.98
243_E277_E0.9600.98
270_A436_H0.9590.98
169_E438_D0.9590.98
438_D444_P0.9580.98
153_L180_F0.9570.98
45_D49_L0.9570.98
332_A364_L0.9510.98
336_Q504_A0.9500.98
157_A178_A0.9490.98
321_V406_L0.9430.98
65_F183_T0.9410.98
332_A361_H0.9410.98
145_L150_V0.9390.98
327_V401_T0.9380.98
187_L196_V0.9380.98
179_E305_H0.9380.98
219_E222_R0.9370.98
220_A224_Q0.9370.98
145_L148_G0.9350.98
276_R503_E0.9330.98
186_T199_V0.9310.98
175_L471_T0.9310.98
252_T494_D0.9310.98
364_L424_T0.9240.98
159_Y167_G0.9220.98
280_G481_L0.9210.98
297_S300_M0.9210.98
271_V425_L0.9200.98
295_N394_H0.9200.98
166_V435_E0.9190.98
93_D177_D0.9190.98
175_L308_H0.9150.98
53_A189_F0.9110.98
54_E302_L0.9070.98
412_A461_A0.9040.98
425_L467_I0.9040.98
317_T327_V0.8990.97
122_L157_A0.8960.97
123_D126_R0.8910.97
259_A491_A0.8900.97
50_L189_F0.8870.97
154_A177_D0.8850.97
361_H364_L0.8820.97
373_R378_P0.8810.97
352_L389_V0.8790.97
336_Q497_A0.8750.97
335_C347_L0.8750.97
81_F186_T0.8750.97
422_A464_A0.8750.97
79_Y188_V0.8730.97
68_D288_Y0.8720.97
61_P85_D0.8690.97
244_R502_T0.8640.97
271_V449_G0.8610.97
213_Y216_L0.8590.97
153_L178_A0.8590.97
90_V124_R0.8580.97
318_L419_A0.8580.97
259_A263_R0.8550.97
156_D159_Y0.8540.97
179_E308_H0.8510.96
349_G352_L0.8500.96
92_V97_T0.8480.96
261_A435_E0.8480.96
256_E263_R0.8460.96
222_R226_V0.8440.96
130_P411_D0.8430.96
335_C357_E0.8420.96
336_Q347_L0.8410.96
416_T461_A0.8400.96
159_Y166_V0.8390.96
290_A516_L0.8380.96
240_V279_D0.8350.96
351_M389_V0.8340.96
288_Y311_V0.8310.96
157_A160_D0.8270.96
343_A347_L0.8220.96
49_L52_S0.8200.96
432_R436_H0.8180.96
153_L463_L0.8170.96
392_Y399_E0.8170.96
323_D460_D0.8160.96
308_H473_T0.8150.95
328_T419_A0.8130.95
50_L53_A0.8130.95
162_W374_R0.8080.95
53_A227_L0.8060.95
53_A57_P0.8060.95
153_L416_T0.8060.95
61_P304_A0.8060.95
78_R192_A0.8060.95
310_V452_V0.8030.95
326_V415_A0.8030.95
212_V216_L0.7980.95
175_L447_I0.7970.95
162_W431_V0.7940.95
276_R510_L0.7930.95
246_G250_A0.7930.95
92_V160_D0.7920.95
84_Y185_R0.7890.95
160_D177_D0.7880.95
252_T255_V0.7860.95
258_A440_I0.7840.94
309_T472_I0.7810.94
152_F447_I0.7790.94
385_E401_T0.7790.94
361_H449_G0.7780.94
224_Q228_R0.7780.94
91_T100_T0.7760.94
310_V466_T0.7750.94
59_S304_A0.7740.94
270_A433_A0.7730.94
470_G483_V0.7710.94
72_E77_A0.7710.94
328_T372_V0.7700.94
383_V386_F0.7700.94
92_V178_A0.7690.94
93_D98_T0.7650.94
354_D497_A0.7650.94
329_N388_R0.7610.94
336_Q339_A0.7610.94
150_V303_L0.7590.93
217_E221_K0.7580.93
317_T329_N0.7580.93
132_V457_W0.7580.93
380_T405_T0.7580.93
394_H508_G0.7580.93
212_V215_A0.7570.93
361_H368_A0.7530.93
368_A422_A0.7520.93
49_L54_E0.7510.93
167_G438_D0.7500.93
245_A274_R0.7490.93
368_A464_A0.7490.93
275_T443_T0.7460.93
216_L227_L0.7410.93
161_L417_R0.7400.93
358_R386_F0.7380.92
174_P473_T0.7370.92
158_V161_L0.7360.92
472_I479_D0.7360.92
214_D217_E0.7350.92
245_A277_E0.7340.92
249_D252_T0.7310.92
321_V461_A0.7310.92
218_A222_R0.7290.92
173_T444_P0.7280.92
254_A258_A0.7270.92
335_C504_A0.7260.92
425_L465_I0.7250.92
361_H424_T0.7240.92
49_L189_F0.7240.92
324_D377_A0.7210.92
420_F465_I0.7210.92
281_D479_D0.7210.92
393_S508_G0.7200.92
276_R485_A0.7160.91
433_A488_G0.7160.91
305_H308_H0.7150.91
128_V131_A0.7150.91
361_H396_Q0.7150.91
275_T484_R0.7120.91
169_E172_P0.7120.91
335_C396_Q0.7120.91
336_Q500_E0.7110.91
85_D219_E0.7100.91
318_L368_A0.7090.91
388_R401_T0.7090.91
127_S130_P0.7080.91
271_V368_A0.7070.91
295_N508_G0.7070.91
167_G444_P0.7070.91
285_R289_D0.7060.91
88_A182_V0.7040.91
358_R398_I0.7030.91
87_A149_L0.7020.90
368_A449_G0.7000.90
350_E353_A0.7000.90
46_H51_E0.6960.90
68_D300_M0.6950.90
357_E497_A0.6950.90
254_A272_V0.6930.90
126_R413_F0.6920.90
101_R115_D0.6910.90
319_V415_A0.6910.90
258_A437_I0.6900.90
340_S346_R0.6900.90
144_L320_A0.6890.90
254_A442_A0.6860.89
173_T275_T0.6860.89
436_H439_A0.6860.89
318_L332_A0.6860.89
45_D51_E0.6840.89
273_S486_G0.6840.89
352_L358_R0.6840.89
87_A457_W0.6820.89
159_Y177_D0.6760.89
255_V487_A0.6760.89
455_F461_A0.6750.89
255_V259_A0.6730.89
326_V406_L0.6710.88
262_V491_A0.6690.88
303_L452_V0.6690.88
294_V394_H0.6680.88
138_P141_D0.6680.88
405_T408_A0.6680.88
225_A229_D0.6660.88
171_P275_T0.6640.88
274_R469_S0.6610.88
96_D118_T0.6600.88
443_T484_R0.6570.87
271_V422_A0.6570.87
267_V436_H0.6570.87
81_F150_V0.6560.87
359_A492_D0.6550.87
472_I478_E0.6550.87
422_A425_L0.6550.87
318_L361_H0.6550.87
215_A218_A0.6540.87
187_L198_L0.6530.87
272_V440_I0.6530.87
145_L462_E0.6500.87
51_E289_D0.6490.87
364_L487_A0.6470.87
176_P308_H0.6470.87
221_K224_Q0.6470.87
216_L220_A0.6470.87
222_R225_A0.6460.86
153_L453_G0.6460.86
321_V324_D0.6460.86
251_Y502_T0.6450.86
512_A516_L0.6430.86
326_V404_G0.6420.86
89_V181_A0.6410.86
92_V121_V0.6400.86
60_D304_A0.6400.86
422_A449_G0.6400.86
324_D406_L0.6390.86
312_G422_A0.6380.86
473_T479_D0.6380.86
116_H119_G0.6370.86
64_A304_A0.6340.85
271_V312_G0.6340.85
266_E370_N0.6320.85
411_D414_D0.6310.85
382_S405_T0.6260.85
310_V469_S0.6230.84
169_E444_P0.6210.84
287_L481_L0.6210.84
294_V511_A0.6200.84
358_R362_T0.6190.84
329_N392_Y0.6180.84
223_V227_L0.6160.84
312_G425_L0.6160.84
318_L364_L0.6160.84
342_V345_R0.6150.84
422_A433_A0.6130.83
373_R376_S0.6130.83
92_V177_D0.6130.83
63_G179_E0.6120.83
57_P82_V0.6120.83
419_A464_A0.6100.83
332_A487_A0.6080.83
301_F422_A0.6080.83
389_V396_Q0.6070.83
271_V464_A0.6070.83
271_V433_A0.6070.83
350_E354_D0.6060.83
431_V435_E0.6050.83
506_M510_L0.6040.83
361_H365_V0.6030.82
284_P304_A0.6020.82
352_L355_E0.6010.82
201_T457_W0.6010.82
128_V149_L0.6000.82
241_T514_D0.5990.82
301_F469_S0.5980.82
306_G309_T0.5960.82
54_E82_V0.5930.81
122_L161_L0.5920.81
100_T103_R0.5920.81
195_S293_A0.5910.81
259_A495_P0.5910.81
148_G457_W0.5910.81
489_V497_A0.5900.81
412_A459_G0.5890.81
328_T402_V0.5890.81
503_E507_D0.5880.81
291_L509_V0.5870.81
471_T482_T0.5870.81
79_Y144_L0.5860.81
202_P216_L0.5840.80
367_L423_G0.5840.80
219_E226_V0.5840.80
357_E424_T0.5830.80
99_I104_D0.5810.80
449_G464_A0.5810.80
420_F449_G0.5810.80
510_L514_D0.5810.80
81_F454_Y0.5800.80
374_R431_V0.5790.80
303_L310_V0.5790.80
96_D116_H0.5780.80
152_F308_H0.5780.80
301_F311_V0.5770.80
361_H400_S0.5770.80
70_T73_E0.5770.80
269_Q433_A0.5750.79
177_D444_P0.5750.79
171_P473_T0.5740.79
244_R485_A0.5730.79
221_K225_A0.5730.79
424_T487_A0.5720.79
258_A436_H0.5710.79
93_D176_P0.5690.79
247_D252_T0.5690.79
431_V434_M0.5680.79
95_D160_D0.5670.78
153_L420_F0.5660.78
186_T456_S0.5660.78
273_S502_T0.5660.78
487_A506_M0.5650.78
259_A490_V0.5640.78
53_A187_L0.5630.78
183_T186_T0.5630.78
155_Y426_S0.5620.78
336_Q343_A0.5610.78
80_S484_R0.5600.78
337_R391_K0.5600.78
244_R247_D0.5590.77
122_L417_R0.5590.77
425_L509_V0.5580.77
335_C354_D0.5570.77
511_A515_R0.5550.77
244_R499_Y0.5540.77
297_S508_G0.5530.77
61_P84_Y0.5530.77
485_A502_T0.5520.77
345_R391_K0.5500.76
169_E442_A0.5500.76
246_G274_R0.5500.76
366_D369_R0.5500.76
290_A514_D0.5490.76
185_R198_L0.5490.76
54_E285_R0.5480.76
55_K285_R0.5480.76
370_N374_R0.5480.76
311_V470_G0.5470.76
312_G449_G0.5470.76
375_V415_A0.5450.76
244_R276_R0.5440.76
271_V397_H0.5440.76
247_D274_R0.5440.76
387_M398_I0.5420.75
397_H488_G0.5410.75
252_T499_Y0.5400.75
269_Q490_V0.5380.75
348_A352_L0.5370.75
470_G512_A0.5370.75
259_A492_D0.5360.75
146_D456_S0.5350.74
312_G368_A0.5350.74
173_T446_G0.5350.74
216_L219_E0.5340.74
366_D371_D0.5340.74
435_E439_A0.5340.74
504_A507_D0.5330.74
152_F420_F0.5330.74
262_V295_N0.5320.74
342_V408_A0.5320.74
158_V438_D0.5300.74
211_D215_A0.5300.74
296_P313_A0.5290.74
357_E487_A0.5280.73
271_V301_F0.5270.73
158_V271_V0.5270.73
364_L368_A0.5270.73
90_V97_T0.5270.73
274_R485_A0.5260.73
319_V419_A0.5260.73
357_E364_L0.5260.73
130_P349_G0.5250.73
97_T124_R0.5240.73
313_A509_V0.5220.73
172_P275_T0.5210.72
508_G512_A0.5210.72
335_C338_G0.5200.72
373_R381_V0.5190.72
51_E66_T0.5190.72
327_V384_P0.5190.72
165_E169_E0.5190.72
158_V424_T0.5170.72
154_A157_A0.5170.72
272_V502_T0.5150.72
119_G123_D0.5150.72
269_Q361_H0.5140.71
262_V267_V0.5140.71
273_S424_T0.5140.71
239_E281_D0.5130.71
175_L446_G0.5130.71
318_L424_T0.5130.71
268_Y378_P0.5120.71
224_Q231_T0.5120.71
370_N492_D0.5110.71
99_I114_P0.5100.71
466_T469_S0.5090.71
326_V375_V0.5090.71
70_T392_Y0.5070.70
79_Y152_F0.5070.70
298_P435_E0.5060.70
344_D396_Q0.5060.70
145_L186_T0.5060.70
130_P133_P0.5060.70
369_R428_A0.5060.70
47_A50_L0.5060.70
368_A433_A0.5050.70
368_A424_T0.5050.70
82_V187_L0.5030.70
211_D214_D0.5020.70
128_V132_V0.5010.70
73_E77_A0.5010.70
282_I287_L0.5010.70
492_D513_V0.5000.69
294_V512_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i1qA 2 0.8937 100 0.254 Contact Map
1k0eA 1 0.8311 100 0.257 Contact Map
4grhA 1 0.8254 100 0.279 Contact Map
1qdlA 1 0.7875 100 0.28 Contact Map
3logA 1 0.8482 100 0.325 Contact Map
3h9mA 1 0.7457 100 0.327 Contact Map
2fn0A 2 0.7799 100 0.363 Contact Map
3gseA 1 0.7837 100 0.42 Contact Map
3bzmA 1 0.8065 100 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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