TRPF - HALSA - GREMLIN Contacts

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TRPF - N-(5'-phosphoribosyl)anthranilate isomerase

UniProt:	Q9HPG4	Sequences: MTRVKVCGLTTERDHAAAVAAGADAVGIIADVPVETPREVSVETATALRAATPPFVTSVLVTMPATPEHAVDLVRTVAPDAVQLHGDLPVGDAAYVAANTPCPVIKAVTAGDQSAARYADVVDALLVDSPPTDDAGAGGGTGRTHDWAATRAFADRVDTPVVLAGGLTPANVADAVDTVDPFAVDVASGVEARPGEKDHAAVSAFVARATATPDPTLT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (199)
Sequences:	3782 (3031)
Seq/√Len:	214.8

ECOLI - TRPC
BACSU - TRPF
HALSA - TRPF
SULSO - TRPF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_L	79_P	3.788	1.00
65_A	69_H	2.947	1.00
11_T	14_D	2.925	1.00
6_V	190_V	2.916	1.00
15_H	48_L	2.876	1.00
192_A	198_D	2.833	1.00
31_D	39_E	2.662	1.00
64_P	87_D	2.199	1.00
29_I	187_A	2.185	1.00
162_V	183_A	2.135	1.00
4_V	206_V	2.099	1.00
16_A	51_A	2.038	1.00
21_A	202_V	2.020	1.00
81_A	105_I	1.999	1.00
9_L	15_H	1.983	1.00
70_A	92_D	1.959	1.00
97_A	123_D	1.931	1.00
186_V	205_F	1.914	1.00
41_S	44_T	1.908	1.00
49_R	58_S	1.859	1.00
66_T	69_H	1.836	1.00
147_W	175_A	1.818	1.00
29_I	61_V	1.817	1.00
64_P	88_L	1.774	1.00
59_V	81_A	1.769	1.00
186_V	190_V	1.748	1.00
168_T	189_G	1.724	1.00
109_T	130_P	1.706	1.00
31_D	63_M	1.668	1.00
44_T	47_A	1.641	1.00
88_L	106_K	1.638	1.00
6_V	202_V	1.617	1.00
131_P	136_G	1.602	1.00
28_I	58_S	1.592	1.00
105_I	124_A	1.563	1.00
30_A	45_A	1.560	1.00
18_A	202_V	1.554	1.00
110_A	149_A	1.549	1.00
203_S	207_A	1.532	1.00
30_A	60_L	1.521	1.00
57_T	80_D	1.505	1.00
89_P	92_D	1.498	1.00
118_Y	121_V	1.471	1.00
190_V	202_V	1.470	1.00
173_A	208_R	1.458	1.00
74_V	82_V	1.442	1.00
17_A	199_H	1.439	1.00
163_L	175_A	1.404	1.00
46_T	76_T	1.394	1.00
74_V	102_C	1.392	1.00
3_R	25_A	1.384	1.00
62_T	70_A	1.381	1.00
19_V	56_V	1.378	1.00
82_V	100_T	1.365	1.00
172_V	184_V	1.364	1.00
62_T	73_L	1.338	1.00
105_I	162_V	1.337	1.00
31_D	35_E	1.335	1.00
46_T	50_A	1.327	1.00
173_A	177_D	1.317	1.00
63_M	138_G	1.311	1.00
65_A	70_A	1.297	1.00
58_S	80_D	1.290	1.00
200_A	203_S	1.287	1.00
127_V	161_V	1.279	1.00
37_P	194_P	1.266	1.00
108_V	125_L	1.264	1.00
124_A	162_V	1.263	1.00
62_T	79_P	1.262	1.00
67_P	92_D	1.253	1.00
25_A	162_V	1.252	1.00
4_V	210_T	1.251	1.00
184_V	205_F	1.242	1.00
11_T	196_E	1.232	1.00
25_A	57_T	1.232	1.00
12_E	51_A	1.228	1.00
174_D	177_D	1.226	1.00
174_D	178_T	1.207	1.00
200_A	204_A	1.207	1.00
167_L	184_V	1.199	1.00
30_A	62_T	1.197	1.00
163_L	179_V	1.196	1.00
204_A	208_R	1.187	1.00
23_A	206_V	1.186	1.00
172_V	205_F	1.169	1.00
14_D	199_H	1.168	1.00
110_A	127_V	1.161	1.00
18_A	23_A	1.159	1.00
42_V	73_L	1.147	1.00
72_D	76_T	1.133	1.00
49_R	77_V	1.123	1.00
111_G	130_P	1.121	1.00
84_L	104_V	1.109	1.00
64_P	138_G	1.102	1.00
109_T	138_G	1.097	1.00
17_A	21_A	1.096	1.00
144_T	171_N	1.083	1.00
167_L	205_F	1.081	1.00
21_A	203_S	1.078	1.00
84_L	88_L	1.074	1.00
43_E	76_T	1.063	1.00
17_A	202_V	1.052	1.00
172_V	176_V	1.051	1.00
87_D	138_G	1.048	1.00
129_S	141_T	1.043	1.00
62_T	65_A	1.038	1.00
81_A	103_P	1.019	1.00
207_A	211_A	1.018	1.00
137_A	141_T	1.017	1.00
71_V	99_N	1.014	1.00
206_V	209_A	1.014	1.00
18_A	26_V	1.012	1.00
176_V	209_A	1.011	1.00
122_V	125_L	0.994	1.00
71_V	100_T	0.988	1.00
12_E	16_A	0.987	1.00
131_P	141_T	0.972	1.00
105_I	126_L	0.970	1.00
3_R	183_A	0.967	1.00
3_R	182_F	0.962	1.00
31_D	37_P	0.959	1.00
72_D	75_R	0.959	1.00
6_V	206_V	0.950	1.00
21_A	206_V	0.942	1.00
24_D	210_T	0.934	0.99
10_T	196_E	0.930	0.99
65_A	92_D	0.929	0.99
192_A	201_A	0.929	0.99
35_E	39_E	0.919	0.99
19_V	52_T	0.911	0.99
69_H	72_D	0.908	0.99
10_T	44_T	0.898	0.99
15_H	26_V	0.894	0.99
74_V	78_A	0.891	0.99
52_T	58_S	0.884	0.99
127_V	150_T	0.880	0.99
70_A	82_V	0.880	0.99
17_A	203_S	0.861	0.99
115_A	118_Y	0.855	0.99
116_A	119_A	0.853	0.99
169_P	204_A	0.852	0.99
176_V	184_V	0.849	0.99
119_A	158_D	0.846	0.99
45_A	77_V	0.842	0.99
40_V	44_T	0.840	0.99
20_A	199_H	0.837	0.99
146_D	149_A	0.837	0.99
86_G	106_K	0.836	0.99
138_G	141_T	0.835	0.99
87_D	109_T	0.834	0.99
10_T	14_D	0.831	0.99
12_E	44_T	0.821	0.99
19_V	53_P	0.821	0.99
204_A	207_A	0.816	0.99
208_R	211_A	0.813	0.99
47_A	50_A	0.804	0.98
64_P	106_K	0.802	0.98
30_A	79_P	0.800	0.98
67_P	71_V	0.797	0.98
186_V	209_A	0.797	0.98
42_V	72_D	0.796	0.98
198_D	201_A	0.796	0.98
16_A	20_A	0.794	0.98
171_N	175_A	0.782	0.98
13_R	16_A	0.780	0.98
64_P	86_G	0.780	0.98
42_V	46_T	0.780	0.98
52_T	56_V	0.779	0.98
175_A	179_V	0.778	0.98
53_P	56_V	0.777	0.98
66_T	92_D	0.776	0.98
20_A	203_S	0.774	0.98
17_A	20_A	0.769	0.98
25_A	81_A	0.768	0.98
144_T	147_W	0.767	0.98
199_H	203_S	0.766	0.98
5_K	8_G	0.766	0.98
12_E	48_L	0.764	0.98
172_V	208_R	0.757	0.98
49_R	78_A	0.754	0.98
131_P	137_A	0.743	0.97
202_V	206_V	0.738	0.97
164_A	188_S	0.733	0.97
26_V	56_V	0.731	0.97
190_V	205_F	0.729	0.97
117_R	120_D	0.728	0.97
186_V	189_G	0.726	0.97
167_L	186_V	0.725	0.97
39_E	42_V	0.722	0.97
3_R	57_T	0.720	0.97
25_A	105_I	0.712	0.97
120_D	159_T	0.709	0.97
12_E	47_A	0.708	0.97
129_S	145_H	0.705	0.96
97_A	104_V	0.704	0.96
67_P	99_N	0.701	0.96
161_V	179_V	0.700	0.96
136_G	141_T	0.698	0.96
24_D	206_V	0.692	0.96
42_V	76_T	0.691	0.96
14_D	196_E	0.689	0.96
28_I	45_A	0.684	0.96
3_R	24_D	0.682	0.96
4_V	209_A	0.681	0.96
73_L	77_V	0.678	0.96
9_L	26_V	0.678	0.96
148_A	178_T	0.675	0.95
93_A	104_V	0.667	0.95
62_T	82_V	0.666	0.95
170_A	204_A	0.663	0.95
84_L	96_V	0.655	0.95
150_T	161_V	0.652	0.95
81_A	124_A	0.648	0.94
15_H	28_I	0.648	0.94
18_A	22_G	0.648	0.94
68_E	71_V	0.648	0.94
28_I	49_R	0.648	0.94
110_A	145_H	0.643	0.94
68_E	72_D	0.640	0.94
191_E	197_K	0.637	0.94
71_V	101_P	0.635	0.94
15_H	19_V	0.631	0.94
95_Y	99_N	0.630	0.93
15_H	52_T	0.628	0.93
167_L	175_A	0.628	0.93
30_A	39_E	0.625	0.93
154_A	161_V	0.622	0.93
65_A	73_L	0.620	0.93
205_F	209_A	0.619	0.93
57_T	103_P	0.617	0.93
60_L	73_L	0.613	0.93
14_D	202_V	0.613	0.93
150_T	154_A	0.609	0.92
88_L	92_D	0.608	0.92
14_D	18_A	0.606	0.92
94_A	98_A	0.606	0.92
130_P	141_T	0.605	0.92
25_A	59_V	0.604	0.92
57_T	81_A	0.601	0.92
64_P	84_L	0.592	0.91
192_A	196_E	0.591	0.91
161_V	181_P	0.587	0.91
74_V	100_T	0.586	0.91
22_G	53_P	0.586	0.91
35_E	63_M	0.585	0.91
31_D	138_G	0.584	0.91
109_T	131_P	0.582	0.90
148_A	151_R	0.581	0.90
92_D	100_T	0.580	0.90
184_V	206_V	0.579	0.90
9_L	18_A	0.579	0.90
140_G	188_S	0.576	0.90
84_L	93_A	0.572	0.90
201_A	204_A	0.571	0.90
144_T	174_D	0.570	0.90
96_V	104_V	0.570	0.90
82_V	102_C	0.566	0.89
11_T	202_V	0.562	0.89
38_R	191_E	0.562	0.89
130_P	136_G	0.559	0.89
16_A	19_V	0.558	0.89
131_P	143_R	0.558	0.89
169_P	208_R	0.552	0.88
9_L	29_I	0.547	0.88
145_H	150_T	0.546	0.88
21_A	199_H	0.545	0.87
128_D	145_H	0.544	0.87
193_R	196_E	0.542	0.87
172_V	186_V	0.542	0.87
187_A	205_F	0.542	0.87
48_L	51_A	0.540	0.87
10_T	194_P	0.537	0.87
71_V	75_R	0.537	0.87
107_A	126_L	0.537	0.87
115_A	125_L	0.534	0.86
43_E	47_A	0.534	0.86
126_L	162_V	0.533	0.86
108_V	127_V	0.531	0.86
161_V	182_F	0.531	0.86
70_A	96_V	0.529	0.86
125_L	159_T	0.528	0.86
92_D	96_V	0.527	0.86
75_R	101_P	0.526	0.86
91_G	95_Y	0.522	0.85
10_T	195_G	0.522	0.85
93_A	122_V	0.521	0.85
176_V	181_P	0.520	0.85
15_H	51_A	0.519	0.85
206_V	210_T	0.514	0.84
167_L	189_G	0.514	0.84
30_A	77_V	0.513	0.84
58_S	79_P	0.510	0.84
25_A	56_V	0.509	0.84
30_A	73_L	0.505	0.83
67_P	95_Y	0.505	0.83
36_T	107_A	0.502	0.83
128_D	142_G	0.501	0.83
129_S	139_G	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v5xA	2	0.9128	100	0.119	Contact Map
4aajA	1	0.8578	100	0.138	Contact Map
1nsjA	2	0.9266	100	0.216	Contact Map
1piiA	1	0.9037	100	0.239	Contact Map
4wuiA	1	0.922	100	0.28	Contact Map
3ctlA	4	0.8945	99.9	0.678	Contact Map
2tpsA	1	0.9174	99.8	0.695	Contact Map
2fliA	5	0.8807	99.8	0.697	Contact Map
3ovpA	2	0.9037	99.8	0.702	Contact Map
3bo9A	2	0.9083	99.8	0.711	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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