GREMLIN Database
TRPF - N-(5'-phosphoribosyl)anthranilate isomerase
UniProt: Q9HPG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (199)
Sequences: 3782 (3031)
Seq/√Len: 214.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_L79_P3.7881.00
65_A69_H2.9471.00
11_T14_D2.9251.00
6_V190_V2.9161.00
15_H48_L2.8761.00
192_A198_D2.8331.00
31_D39_E2.6621.00
64_P87_D2.1991.00
29_I187_A2.1851.00
162_V183_A2.1351.00
4_V206_V2.0991.00
16_A51_A2.0381.00
21_A202_V2.0201.00
81_A105_I1.9991.00
9_L15_H1.9831.00
70_A92_D1.9591.00
97_A123_D1.9311.00
186_V205_F1.9141.00
41_S44_T1.9081.00
49_R58_S1.8591.00
66_T69_H1.8361.00
147_W175_A1.8181.00
29_I61_V1.8171.00
64_P88_L1.7741.00
59_V81_A1.7691.00
186_V190_V1.7481.00
168_T189_G1.7241.00
109_T130_P1.7061.00
31_D63_M1.6681.00
44_T47_A1.6411.00
88_L106_K1.6381.00
6_V202_V1.6171.00
131_P136_G1.6021.00
28_I58_S1.5921.00
105_I124_A1.5631.00
30_A45_A1.5601.00
18_A202_V1.5541.00
110_A149_A1.5491.00
203_S207_A1.5321.00
30_A60_L1.5211.00
57_T80_D1.5051.00
89_P92_D1.4981.00
118_Y121_V1.4711.00
190_V202_V1.4701.00
173_A208_R1.4581.00
74_V82_V1.4421.00
17_A199_H1.4391.00
163_L175_A1.4041.00
46_T76_T1.3941.00
74_V102_C1.3921.00
3_R25_A1.3841.00
62_T70_A1.3811.00
19_V56_V1.3781.00
82_V100_T1.3651.00
172_V184_V1.3641.00
62_T73_L1.3381.00
105_I162_V1.3371.00
31_D35_E1.3351.00
46_T50_A1.3271.00
173_A177_D1.3171.00
63_M138_G1.3111.00
65_A70_A1.2971.00
58_S80_D1.2901.00
200_A203_S1.2871.00
127_V161_V1.2791.00
37_P194_P1.2661.00
108_V125_L1.2641.00
124_A162_V1.2631.00
62_T79_P1.2621.00
67_P92_D1.2531.00
25_A162_V1.2521.00
4_V210_T1.2511.00
184_V205_F1.2421.00
11_T196_E1.2321.00
25_A57_T1.2321.00
12_E51_A1.2281.00
174_D177_D1.2261.00
174_D178_T1.2071.00
200_A204_A1.2071.00
167_L184_V1.1991.00
30_A62_T1.1971.00
163_L179_V1.1961.00
204_A208_R1.1871.00
23_A206_V1.1861.00
172_V205_F1.1691.00
14_D199_H1.1681.00
110_A127_V1.1611.00
18_A23_A1.1591.00
42_V73_L1.1471.00
72_D76_T1.1331.00
49_R77_V1.1231.00
111_G130_P1.1211.00
84_L104_V1.1091.00
64_P138_G1.1021.00
109_T138_G1.0971.00
17_A21_A1.0961.00
144_T171_N1.0831.00
167_L205_F1.0811.00
21_A203_S1.0781.00
84_L88_L1.0741.00
43_E76_T1.0631.00
17_A202_V1.0521.00
172_V176_V1.0511.00
87_D138_G1.0481.00
129_S141_T1.0431.00
62_T65_A1.0381.00
81_A103_P1.0191.00
207_A211_A1.0181.00
137_A141_T1.0171.00
71_V99_N1.0141.00
206_V209_A1.0141.00
18_A26_V1.0121.00
176_V209_A1.0111.00
122_V125_L0.9941.00
71_V100_T0.9881.00
12_E16_A0.9871.00
131_P141_T0.9721.00
105_I126_L0.9701.00
3_R183_A0.9671.00
3_R182_F0.9621.00
31_D37_P0.9591.00
72_D75_R0.9591.00
6_V206_V0.9501.00
21_A206_V0.9421.00
24_D210_T0.9340.99
10_T196_E0.9300.99
65_A92_D0.9290.99
192_A201_A0.9290.99
35_E39_E0.9190.99
19_V52_T0.9110.99
69_H72_D0.9080.99
10_T44_T0.8980.99
15_H26_V0.8940.99
74_V78_A0.8910.99
52_T58_S0.8840.99
127_V150_T0.8800.99
70_A82_V0.8800.99
17_A203_S0.8610.99
115_A118_Y0.8550.99
116_A119_A0.8530.99
169_P204_A0.8520.99
176_V184_V0.8490.99
119_A158_D0.8460.99
45_A77_V0.8420.99
40_V44_T0.8400.99
20_A199_H0.8370.99
146_D149_A0.8370.99
86_G106_K0.8360.99
138_G141_T0.8350.99
87_D109_T0.8340.99
10_T14_D0.8310.99
12_E44_T0.8210.99
19_V53_P0.8210.99
204_A207_A0.8160.99
208_R211_A0.8130.99
47_A50_A0.8040.98
64_P106_K0.8020.98
30_A79_P0.8000.98
67_P71_V0.7970.98
186_V209_A0.7970.98
42_V72_D0.7960.98
198_D201_A0.7960.98
16_A20_A0.7940.98
171_N175_A0.7820.98
13_R16_A0.7800.98
64_P86_G0.7800.98
42_V46_T0.7800.98
52_T56_V0.7790.98
175_A179_V0.7780.98
53_P56_V0.7770.98
66_T92_D0.7760.98
20_A203_S0.7740.98
17_A20_A0.7690.98
25_A81_A0.7680.98
144_T147_W0.7670.98
199_H203_S0.7660.98
5_K8_G0.7660.98
12_E48_L0.7640.98
172_V208_R0.7570.98
49_R78_A0.7540.98
131_P137_A0.7430.97
202_V206_V0.7380.97
164_A188_S0.7330.97
26_V56_V0.7310.97
190_V205_F0.7290.97
117_R120_D0.7280.97
186_V189_G0.7260.97
167_L186_V0.7250.97
39_E42_V0.7220.97
3_R57_T0.7200.97
25_A105_I0.7120.97
120_D159_T0.7090.97
12_E47_A0.7080.97
129_S145_H0.7050.96
97_A104_V0.7040.96
67_P99_N0.7010.96
161_V179_V0.7000.96
136_G141_T0.6980.96
24_D206_V0.6920.96
42_V76_T0.6910.96
14_D196_E0.6890.96
28_I45_A0.6840.96
3_R24_D0.6820.96
4_V209_A0.6810.96
73_L77_V0.6780.96
9_L26_V0.6780.96
148_A178_T0.6750.95
93_A104_V0.6670.95
62_T82_V0.6660.95
170_A204_A0.6630.95
84_L96_V0.6550.95
150_T161_V0.6520.95
81_A124_A0.6480.94
15_H28_I0.6480.94
18_A22_G0.6480.94
68_E71_V0.6480.94
28_I49_R0.6480.94
110_A145_H0.6430.94
68_E72_D0.6400.94
191_E197_K0.6370.94
71_V101_P0.6350.94
15_H19_V0.6310.94
95_Y99_N0.6300.93
15_H52_T0.6280.93
167_L175_A0.6280.93
30_A39_E0.6250.93
154_A161_V0.6220.93
65_A73_L0.6200.93
205_F209_A0.6190.93
57_T103_P0.6170.93
60_L73_L0.6130.93
14_D202_V0.6130.93
150_T154_A0.6090.92
88_L92_D0.6080.92
14_D18_A0.6060.92
94_A98_A0.6060.92
130_P141_T0.6050.92
25_A59_V0.6040.92
57_T81_A0.6010.92
64_P84_L0.5920.91
192_A196_E0.5910.91
161_V181_P0.5870.91
74_V100_T0.5860.91
22_G53_P0.5860.91
35_E63_M0.5850.91
31_D138_G0.5840.91
109_T131_P0.5820.90
148_A151_R0.5810.90
92_D100_T0.5800.90
184_V206_V0.5790.90
9_L18_A0.5790.90
140_G188_S0.5760.90
84_L93_A0.5720.90
201_A204_A0.5710.90
144_T174_D0.5700.90
96_V104_V0.5700.90
82_V102_C0.5660.89
11_T202_V0.5620.89
38_R191_E0.5620.89
130_P136_G0.5590.89
16_A19_V0.5580.89
131_P143_R0.5580.89
169_P208_R0.5520.88
9_L29_I0.5470.88
145_H150_T0.5460.88
21_A199_H0.5450.87
128_D145_H0.5440.87
193_R196_E0.5420.87
172_V186_V0.5420.87
187_A205_F0.5420.87
48_L51_A0.5400.87
10_T194_P0.5370.87
71_V75_R0.5370.87
107_A126_L0.5370.87
115_A125_L0.5340.86
43_E47_A0.5340.86
126_L162_V0.5330.86
108_V127_V0.5310.86
161_V182_F0.5310.86
70_A96_V0.5290.86
125_L159_T0.5280.86
92_D96_V0.5270.86
75_R101_P0.5260.86
91_G95_Y0.5220.85
10_T195_G0.5220.85
93_A122_V0.5210.85
176_V181_P0.5200.85
15_H51_A0.5190.85
206_V210_T0.5140.84
167_L189_G0.5140.84
30_A77_V0.5130.84
58_S79_P0.5100.84
25_A56_V0.5090.84
30_A73_L0.5050.83
67_P95_Y0.5050.83
36_T107_A0.5020.83
128_D142_G0.5010.83
129_S139_G0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v5xA 2 0.9128 100 0.119 Contact Map
4aajA 1 0.8578 100 0.138 Contact Map
1nsjA 2 0.9266 100 0.216 Contact Map
1piiA 1 0.9037 100 0.239 Contact Map
4wuiA 1 0.922 100 0.28 Contact Map
3ctlA 4 0.8945 99.9 0.678 Contact Map
2tpsA 1 0.9174 99.8 0.695 Contact Map
2fliA 5 0.8807 99.8 0.697 Contact Map
3ovpA 2 0.9037 99.8 0.702 Contact Map
3bo9A 2 0.9083 99.8 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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