TRPD - HALSA - GREMLIN Contacts

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TRPD - Anthranilate phosphoribosyltransferase

UniProt:	Q9HPG3	Sequences: MQEYIERVAAGEDLSLDAARDAVTTLFEDATDAEIGALLGALRAKGETEAEIAGFAQGMRDAAITVAPDCTPLVDTCGTGGDDYDTINVSTTAALVAAGAGIPTAKHGNYSVSSASGSSDVLDALGVELATDPAAVEARIETDGIGYMHAPAFHPGMEAVIGPRRDLGVRTIFNLLGPLTNPARADAQVVGVYDPALVPVLARALSRMAVDRALVVHGAGLDEFALHGDSTVAEVDGDTVTTTTVSPSTFGLAEAPIDAVAGGGPEANAADLRGIVTGELTGPKRDIVVANAGAAIYVGGGADSLAAGADRAAAAIDSGAAADTLAALTDAHAVQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (326)
Sequences:	4306 (2839)
Seq/√Len:	157.2

ECOLI - TRPGD YBIB
BACSU - TRPD
HALSA - TRPD Q9HNW7
SULSO - TRPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
274_G	279_E	3.855	1.00
16_L	57_Q	3.339	1.00
7_R	18_A	3.248	1.00
99_G	315_A	3.223	1.00
324_T	327_A	3.113	1.00
224_F	230_S	3.047	1.00
285_R	317_D	2.950	1.00
13_D	45_K	2.859	1.00
277_T	322_A	2.787	1.00
20_R	57_Q	2.571	1.00
248_S	254_E	2.547	1.00
224_F	294_A	2.519	1.00
270_A	274_G	2.508	1.00
199_P	242_T	2.493	1.00
264_G	267_A	2.405	1.00
92_T	272_L	2.330	1.00
31_T	166_D	2.327	1.00
289_V	313_A	2.324	1.00
198_V	233_A	2.313	1.00
138_A	142_T	2.311	1.00
20_R	61_D	2.305	1.00
140_I	146_G	2.243	1.00
24_T	62_A	2.235	1.00
37_A	40_G	2.203	1.00
53_A	207_R	2.150	1.00
100_A	315_A	2.115	1.00
314_A	318_S	2.067	1.00
256_P	259_A	2.052	1.00
15_S	18_A	2.015	1.00
22_A	38_L	1.992	1.00
304_S	307_A	1.992	1.00
136_V	146_G	1.959	1.00
96_V	288_V	1.892	1.00
195_P	231_T	1.873	1.00
31_T	34_E	1.849	1.00
219_A	231_T	1.842	1.00
234_E	243_T	1.825	1.00
214_L	298_V	1.825	1.00
262_G	268_N	1.815	1.00
100_A	296_I	1.811	1.00
102_I	296_I	1.811	1.00
7_R	12_E	1.800	1.00
206_S	235_V	1.794	1.00
124_A	266_E	1.772	1.00
19_A	55_F	1.771	1.00
226_L	255_A	1.760	1.00
246_S	249_T	1.751	1.00
24_T	61_D	1.748	1.00
310_D	313_A	1.745	1.00
199_P	203_R	1.742	1.00
232_V	243_T	1.722	1.00
132_D	135_A	1.720	1.00
246_S	254_E	1.714	1.00
28_E	62_A	1.708	1.00
97_A	102_I	1.700	1.00
214_L	294_A	1.695	1.00
233_A	240_V	1.650	1.00
54_G	58_G	1.641	1.00
143_D	324_T	1.630	1.00
26_L	35_I	1.614	1.00
89_V	287_I	1.595	1.00
25_T	29_D	1.590	1.00
323_D	326_A	1.588	1.00
229_D	244_T	1.578	1.00
137_E	141_E	1.568	1.00
127_V	328_L	1.567	1.00
59_M	180_T	1.552	1.00
97_A	295_A	1.545	1.00
99_G	324_T	1.544	1.00
212_R	236_D	1.533	1.00
24_T	58_G	1.530	1.00
16_L	54_G	1.528	1.00
273_R	329_T	1.491	1.00
213_A	235_V	1.483	1.00
322_A	326_A	1.481	1.00
55_F	172_I	1.477	1.00
186_D	211_D	1.471	1.00
40_G	169_V	1.470	1.00
131_T	135_A	1.467	1.00
320_A	323_D	1.459	1.00
175_L	197_L	1.449	1.00
219_A	228_G	1.441	1.00
77_C	188_Q	1.440	1.00
302_A	308_G	1.426	1.00
98_A	324_T	1.414	1.00
293_G	308_G	1.407	1.00
65_T	184_R	1.403	1.00
93_A	292_A	1.400	1.00
37_A	167_L	1.395	1.00
326_A	329_T	1.384	1.00
84_Y	221_L	1.376	1.00
67_A	137_E	1.373	1.00
9_A	169_V	1.366	1.00
293_G	297_Y	1.364	1.00
145_I	328_L	1.358	1.00
43_R	47_E	1.354	1.00
23_V	55_F	1.349	1.00
301_G	311_R	1.336	1.00
258_D	261_A	1.334	1.00
273_R	277_T	1.331	1.00
74_V	295_A	1.321	1.00
278_G	317_D	1.316	1.00
16_L	207_R	1.312	1.00
231_T	242_T	1.312	1.00
135_A	138_A	1.303	1.00
121_V	272_L	1.299	1.00
210_V	213_A	1.296	1.00
127_V	329_T	1.294	1.00
131_T	139_R	1.286	1.00
285_R	313_A	1.281	1.00
205_L	213_A	1.268	1.00
125_L	269_A	1.265	1.00
263_G	268_N	1.265	1.00
303_D	307_A	1.264	1.00
313_A	317_D	1.262	1.00
32_D	166_D	1.254	1.00
9_A	40_G	1.240	1.00
40_G	44_A	1.240	1.00
121_V	269_A	1.233	1.00
229_D	246_S	1.231	1.00
33_A	166_D	1.222	1.00
289_V	309_A	1.219	1.00
22_A	30_A	1.218	1.00
323_D	327_A	1.215	1.00
4_Y	22_A	1.213	1.00
255_A	283_P	1.210	1.00
49_E	53_A	1.209	1.00
35_I	163_P	1.199	1.00
110_Y	120_D	1.195	1.00
50_A	207_R	1.195	1.00
49_E	204_A	1.188	1.00
263_G	267_A	1.177	1.00
273_R	326_A	1.172	1.00
218_G	228_G	1.149	1.00
276_V	321_A	1.148	1.00
30_A	35_I	1.131	1.00
326_A	330_D	1.120	1.00
233_A	242_T	1.117	1.00
33_A	36_G	1.116	1.00
73_L	185_A	1.114	1.00
293_G	309_A	1.108	1.00
308_G	312_A	1.103	1.00
157_M	160_V	1.096	0.99
206_S	240_V	1.093	0.99
58_G	62_A	1.091	0.99
119_S	149_H	1.088	0.99
212_R	234_E	1.083	0.99
203_R	206_S	1.078	0.99
224_F	245_V	1.078	0.99
20_R	58_G	1.078	0.99
102_I	299_G	1.076	0.99
275_I	284_K	1.074	0.99
231_T	244_T	1.073	0.99
160_V	163_P	1.067	0.99
19_A	54_G	1.062	0.99
282_G	286_D	1.050	0.99
224_F	290_A	1.045	0.99
245_V	250_F	1.042	0.99
73_L	105_A	1.038	0.99
38_L	55_F	1.031	0.99
230_S	247_P	1.027	0.99
219_A	229_D	1.021	0.99
93_A	97_A	1.020	0.99
8_V	41_A	1.016	0.99
24_T	28_E	1.015	0.99
306_A	310_D	1.008	0.99
59_M	157_M	1.006	0.99
72_P	186_D	1.005	0.99
110_Y	123_D	1.000	0.99
226_L	287_I	0.998	0.99
97_A	104_T	0.980	0.99
250_F	309_A	0.974	0.99
188_Q	210_V	0.973	0.99
252_L	290_A	0.967	0.99
34_E	166_D	0.963	0.99
33_A	163_P	0.963	0.99
311_R	314_A	0.961	0.99
234_E	297_Y	0.961	0.99
27_F	59_M	0.959	0.99
226_L	260_V	0.958	0.99
17_D	20_R	0.957	0.99
9_A	43_R	0.957	0.99
246_S	250_F	0.952	0.99
127_V	145_I	0.952	0.99
327_A	330_D	0.951	0.99
265_P	269_A	0.945	0.98
136_V	153_F	0.938	0.98
270_A	273_R	0.936	0.98
87_I	271_D	0.936	0.98
102_I	301_G	0.920	0.98
314_A	320_A	0.919	0.98
302_A	311_R	0.918	0.98
45_K	51_E	0.916	0.98
112_V	151_P	0.916	0.98
50_A	54_G	0.911	0.98
76_T	93_A	0.911	0.98
273_R	322_A	0.910	0.98
275_I	288_V	0.910	0.98
187_A	211_D	0.907	0.98
225_A	228_G	0.900	0.98
162_G	166_D	0.897	0.98
47_E	170_R	0.894	0.98
259_A	283_P	0.893	0.98
49_E	203_R	0.893	0.98
286_D	313_A	0.893	0.98
6_E	10_A	0.892	0.98
56_A	208_M	0.888	0.98
235_V	240_V	0.880	0.98
310_D	314_A	0.877	0.97
97_A	103_P	0.876	0.97
13_D	50_A	0.870	0.97
47_E	52_I	0.870	0.97
115_A	264_G	0.868	0.97
30_A	34_E	0.865	0.97
255_A	286_D	0.862	0.97
142_T	327_A	0.861	0.97
189_V	216_V	0.860	0.97
8_V	38_L	0.860	0.97
187_A	298_V	0.859	0.97
72_P	187_A	0.856	0.97
35_I	160_V	0.855	0.97
53_A	57_Q	0.854	0.97
219_A	244_T	0.853	0.97
214_L	297_Y	0.850	0.97
52_I	204_A	0.850	0.97
53_A	204_A	0.848	0.97
269_A	273_R	0.848	0.97
252_L	309_A	0.845	0.97
311_R	315_A	0.843	0.97
60_R	184_R	0.842	0.97
96_V	316_I	0.837	0.97
187_A	212_R	0.836	0.97
14_L	51_E	0.835	0.97
25_T	30_A	0.833	0.97
77_C	118_S	0.831	0.97
281_T	284_K	0.829	0.96
76_T	94_A	0.828	0.96
103_P	141_E	0.827	0.96
300_G	308_G	0.825	0.96
26_L	160_V	0.822	0.96
192_V	201_L	0.820	0.96
297_Y	302_A	0.814	0.96
77_C	93_A	0.813	0.96
19_A	172_I	0.812	0.96
82_D	86_T	0.810	0.96
289_V	317_D	0.809	0.96
235_V	238_D	0.809	0.96
136_V	140_I	0.809	0.96
59_M	176_L	0.807	0.96
84_Y	257_I	0.805	0.96
217_H	220_G	0.805	0.96
9_A	44_A	0.804	0.96
253_A	286_D	0.802	0.96
143_D	328_L	0.802	0.96
32_D	163_P	0.800	0.96
139_R	146_G	0.797	0.96
201_L	215_V	0.795	0.96
74_V	104_T	0.792	0.95
282_G	317_D	0.790	0.95
11_G	44_A	0.790	0.95
41_A	45_K	0.789	0.95
266_E	270_A	0.788	0.95
49_E	207_R	0.784	0.95
69_D	141_E	0.777	0.95
37_A	169_V	0.776	0.95
249_T	306_A	0.772	0.95
13_D	48_T	0.770	0.95
32_D	162_G	0.770	0.95
76_T	188_Q	0.768	0.95
136_V	148_M	0.768	0.95
97_A	100_A	0.767	0.95
27_F	180_T	0.765	0.94
293_G	305_L	0.760	0.94
218_G	225_A	0.759	0.94
297_Y	304_S	0.758	0.94
139_R	143_D	0.755	0.94
125_L	325_L	0.755	0.94
130_A	152_A	0.754	0.94
91_T	122_L	0.754	0.94
199_P	233_A	0.754	0.94
197_L	200_V	0.751	0.94
276_V	322_A	0.750	0.94
64_I	155_P	0.750	0.94
21_D	25_T	0.748	0.94
20_R	54_G	0.745	0.94
133_P	137_E	0.745	0.94
294_A	305_L	0.741	0.94
16_L	53_A	0.732	0.93
4_Y	21_D	0.732	0.93
95_L	324_T	0.730	0.93
224_F	250_F	0.727	0.93
68_P	140_I	0.722	0.93
300_G	311_R	0.716	0.92
227_H	256_P	0.716	0.92
234_E	241_T	0.716	0.92
36_G	163_P	0.714	0.92
193_Y	197_L	0.714	0.92
92_T	276_V	0.713	0.92
76_T	118_S	0.711	0.92
219_A	225_A	0.709	0.92
87_I	284_K	0.709	0.92
22_A	26_L	0.706	0.92
255_A	260_V	0.701	0.92
86_T	221_L	0.699	0.91
211_D	237_G	0.699	0.91
190_V	201_L	0.699	0.91
157_M	180_T	0.697	0.91
138_A	141_E	0.697	0.91
124_A	265_P	0.695	0.91
49_E	200_V	0.694	0.91
221_L	257_I	0.691	0.91
132_D	152_A	0.690	0.91
283_P	286_D	0.689	0.91
32_D	159_A	0.688	0.91
96_V	292_A	0.687	0.91
325_L	329_T	0.687	0.91
95_L	328_L	0.687	0.91
214_L	232_V	0.685	0.91
17_D	21_D	0.678	0.90
297_Y	305_L	0.678	0.90
97_A	292_A	0.677	0.90
20_R	24_T	0.676	0.90
83_D	113_S	0.675	0.90
127_V	325_L	0.675	0.90
285_R	289_V	0.671	0.90
189_V	298_V	0.668	0.89
42_L	47_E	0.668	0.89
66_V	136_V	0.668	0.89
297_Y	308_G	0.667	0.89
121_V	125_L	0.667	0.89
63_A	180_T	0.667	0.89
60_R	208_M	0.667	0.89
95_L	145_I	0.664	0.89
296_I	312_A	0.664	0.89
27_F	159_A	0.664	0.89
214_L	243_T	0.663	0.89
82_D	85_D	0.662	0.89
39_L	157_M	0.658	0.89
236_D	241_T	0.657	0.89
324_T	328_L	0.656	0.89
136_V	139_R	0.655	0.89
23_V	172_I	0.653	0.88
4_Y	25_T	0.653	0.88
52_I	175_L	0.650	0.88
135_A	139_R	0.649	0.88
82_D	114_S	0.649	0.88
243_T	297_Y	0.649	0.88
99_G	321_A	0.647	0.88
92_T	275_I	0.644	0.88
85_D	261_A	0.642	0.88
116_S	265_P	0.640	0.87
124_A	269_A	0.639	0.87
205_L	210_V	0.636	0.87
203_R	240_V	0.635	0.87
315_A	321_A	0.634	0.87
105_A	148_M	0.634	0.87
51_E	54_G	0.633	0.87
271_D	275_I	0.633	0.87
128_E	135_A	0.631	0.87
7_R	11_G	0.630	0.87
227_H	257_I	0.630	0.87
187_A	299_G	0.629	0.86
94_A	145_I	0.627	0.86
206_S	239_T	0.626	0.86
305_L	308_G	0.621	0.86
48_T	51_E	0.621	0.86
171_T	174_N	0.621	0.86
281_T	317_D	0.616	0.85
64_I	133_P	0.614	0.85
40_G	167_L	0.614	0.85
95_L	325_L	0.614	0.85
229_D	254_E	0.612	0.85
74_V	102_I	0.609	0.85
36_G	40_G	0.608	0.85
246_S	290_A	0.607	0.84
203_R	207_R	0.604	0.84
151_P	165_R	0.604	0.84
56_A	59_M	0.603	0.84
248_S	253_A	0.601	0.84
55_F	176_L	0.599	0.84
97_A	296_I	0.598	0.84
212_R	300_G	0.596	0.83
16_L	50_A	0.595	0.83
7_R	15_S	0.594	0.83
250_F	305_L	0.593	0.83
56_A	176_L	0.593	0.83
226_L	286_D	0.593	0.83
214_L	305_L	0.590	0.83
289_V	316_I	0.590	0.83
58_G	61_D	0.588	0.83
195_P	242_T	0.586	0.82
296_I	308_G	0.582	0.82
41_A	44_A	0.581	0.82
76_T	189_V	0.580	0.82
206_S	238_D	0.580	0.82
270_A	279_E	0.579	0.82
321_A	325_L	0.579	0.82
81_G	177_G	0.579	0.82
250_F	290_A	0.579	0.82
315_A	324_T	0.577	0.81
289_V	293_G	0.576	0.81
56_A	60_R	0.576	0.81
296_I	301_G	0.575	0.81
76_T	295_A	0.575	0.81
119_S	147_Y	0.573	0.81
297_Y	301_G	0.572	0.81
309_A	313_A	0.572	0.81
226_L	252_L	0.572	0.81
190_V	205_L	0.571	0.81
303_D	311_R	0.569	0.80
293_G	304_S	0.568	0.80
195_P	219_A	0.567	0.80
85_D	115_A	0.567	0.80
119_S	123_D	0.567	0.80
74_V	298_V	0.567	0.80
95_L	127_V	0.564	0.80
37_A	44_A	0.562	0.80
8_V	44_A	0.561	0.80
296_I	302_A	0.560	0.79
22_A	25_T	0.560	0.79
37_A	41_A	0.559	0.79
57_Q	61_D	0.559	0.79
198_V	231_T	0.557	0.79
226_L	283_P	0.556	0.79
255_A	259_A	0.555	0.79
84_Y	261_A	0.555	0.79
92_T	288_V	0.555	0.79
212_R	297_Y	0.554	0.79
198_V	242_T	0.552	0.78
272_L	276_V	0.551	0.78
202_A	235_V	0.549	0.78
282_G	285_R	0.549	0.78
300_G	303_D	0.548	0.78
307_A	310_D	0.547	0.78
319_G	322_A	0.542	0.77
105_A	140_I	0.542	0.77
307_A	311_R	0.541	0.77
118_S	121_V	0.541	0.77
19_A	51_E	0.541	0.77
267_A	270_A	0.540	0.77
320_A	324_T	0.540	0.77
74_V	187_A	0.540	0.77
26_L	38_L	0.540	0.77
125_L	273_R	0.539	0.77
134_A	137_E	0.538	0.77
92_T	116_S	0.538	0.77
73_L	103_P	0.535	0.76
68_P	137_E	0.533	0.76
318_S	321_A	0.532	0.76
78_G	222_D	0.532	0.76
80_G	178_P	0.532	0.76
37_A	163_P	0.531	0.76
68_P	71_T	0.531	0.76
74_V	299_G	0.531	0.76
142_T	323_D	0.530	0.76
128_E	131_T	0.530	0.76
227_H	259_A	0.529	0.76
295_A	298_V	0.529	0.76
228_G	257_I	0.529	0.76
281_T	313_A	0.528	0.75
7_R	14_L	0.528	0.75
216_V	224_F	0.528	0.75
190_V	215_V	0.528	0.75
3_E	6_E	0.527	0.75
19_A	23_V	0.527	0.75
88_N	106_K	0.526	0.75
18_A	54_G	0.525	0.75
260_V	287_I	0.525	0.75
144_G	324_T	0.524	0.75
93_A	288_V	0.522	0.75
278_G	281_T	0.522	0.75
139_R	145_I	0.522	0.75
43_R	168_G	0.515	0.74
293_G	312_A	0.515	0.74
112_V	193_Y	0.514	0.73
66_V	183_A	0.513	0.73
95_L	321_A	0.513	0.73
121_V	325_L	0.511	0.73
188_Q	213_A	0.508	0.73
56_A	179_L	0.506	0.72
74_V	185_A	0.504	0.72
77_C	175_L	0.504	0.72
278_G	285_R	0.503	0.72
110_Y	149_H	0.503	0.72
72_P	301_G	0.502	0.72
63_A	154_H	0.502	0.72
53_A	56_A	0.501	0.72
95_L	99_G	0.501	0.72
39_L	160_V	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1khdA	2	0.9792	100	0.067	Contact Map
4giuA	2	0.9881	100	0.067	Contact Map
4gtnA	2	0.9643	100	0.067	Contact Map
1vquA	2	0.9792	100	0.073	Contact Map
2elcA	4	0.9762	100	0.083	Contact Map
4hkmA	2	0.9673	100	0.087	Contact Map
1o17A	2	0.9821	100	0.096	Contact Map
4muoA	2	0.8869	100	0.165	Contact Map
3h5qA	2	0.8839	100	0.303	Contact Map
1brwA	2	0.8839	100	0.312	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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