GREMLIN Database
TRPD - Anthranilate phosphoribosyltransferase
UniProt: Q9HPG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (326)
Sequences: 4306 (2839)
Seq/√Len: 157.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_G279_E3.8551.00
16_L57_Q3.3391.00
7_R18_A3.2481.00
99_G315_A3.2231.00
324_T327_A3.1131.00
224_F230_S3.0471.00
285_R317_D2.9501.00
13_D45_K2.8591.00
277_T322_A2.7871.00
20_R57_Q2.5711.00
248_S254_E2.5471.00
224_F294_A2.5191.00
270_A274_G2.5081.00
199_P242_T2.4931.00
264_G267_A2.4051.00
92_T272_L2.3301.00
31_T166_D2.3271.00
289_V313_A2.3241.00
198_V233_A2.3131.00
138_A142_T2.3111.00
20_R61_D2.3051.00
140_I146_G2.2431.00
24_T62_A2.2351.00
37_A40_G2.2031.00
53_A207_R2.1501.00
100_A315_A2.1151.00
314_A318_S2.0671.00
256_P259_A2.0521.00
15_S18_A2.0151.00
22_A38_L1.9921.00
304_S307_A1.9921.00
136_V146_G1.9591.00
96_V288_V1.8921.00
195_P231_T1.8731.00
31_T34_E1.8491.00
219_A231_T1.8421.00
234_E243_T1.8251.00
214_L298_V1.8251.00
262_G268_N1.8151.00
100_A296_I1.8111.00
102_I296_I1.8111.00
7_R12_E1.8001.00
206_S235_V1.7941.00
124_A266_E1.7721.00
19_A55_F1.7711.00
226_L255_A1.7601.00
246_S249_T1.7511.00
24_T61_D1.7481.00
310_D313_A1.7451.00
199_P203_R1.7421.00
232_V243_T1.7221.00
132_D135_A1.7201.00
246_S254_E1.7141.00
28_E62_A1.7081.00
97_A102_I1.7001.00
214_L294_A1.6951.00
233_A240_V1.6501.00
54_G58_G1.6411.00
143_D324_T1.6301.00
26_L35_I1.6141.00
89_V287_I1.5951.00
25_T29_D1.5901.00
323_D326_A1.5881.00
229_D244_T1.5781.00
137_E141_E1.5681.00
127_V328_L1.5671.00
59_M180_T1.5521.00
97_A295_A1.5451.00
99_G324_T1.5441.00
212_R236_D1.5331.00
24_T58_G1.5301.00
16_L54_G1.5281.00
273_R329_T1.4911.00
213_A235_V1.4831.00
322_A326_A1.4811.00
55_F172_I1.4771.00
186_D211_D1.4711.00
40_G169_V1.4701.00
131_T135_A1.4671.00
320_A323_D1.4591.00
175_L197_L1.4491.00
219_A228_G1.4411.00
77_C188_Q1.4401.00
302_A308_G1.4261.00
98_A324_T1.4141.00
293_G308_G1.4071.00
65_T184_R1.4031.00
93_A292_A1.4001.00
37_A167_L1.3951.00
326_A329_T1.3841.00
84_Y221_L1.3761.00
67_A137_E1.3731.00
9_A169_V1.3661.00
293_G297_Y1.3641.00
145_I328_L1.3581.00
43_R47_E1.3541.00
23_V55_F1.3491.00
301_G311_R1.3361.00
258_D261_A1.3341.00
273_R277_T1.3311.00
74_V295_A1.3211.00
278_G317_D1.3161.00
16_L207_R1.3121.00
231_T242_T1.3121.00
135_A138_A1.3031.00
121_V272_L1.2991.00
210_V213_A1.2961.00
127_V329_T1.2941.00
131_T139_R1.2861.00
285_R313_A1.2811.00
205_L213_A1.2681.00
125_L269_A1.2651.00
263_G268_N1.2651.00
303_D307_A1.2641.00
313_A317_D1.2621.00
32_D166_D1.2541.00
9_A40_G1.2401.00
40_G44_A1.2401.00
121_V269_A1.2331.00
229_D246_S1.2311.00
33_A166_D1.2221.00
289_V309_A1.2191.00
22_A30_A1.2181.00
323_D327_A1.2151.00
4_Y22_A1.2131.00
255_A283_P1.2101.00
49_E53_A1.2091.00
35_I163_P1.1991.00
110_Y120_D1.1951.00
50_A207_R1.1951.00
49_E204_A1.1881.00
263_G267_A1.1771.00
273_R326_A1.1721.00
218_G228_G1.1491.00
276_V321_A1.1481.00
30_A35_I1.1311.00
326_A330_D1.1201.00
233_A242_T1.1171.00
33_A36_G1.1161.00
73_L185_A1.1141.00
293_G309_A1.1081.00
308_G312_A1.1031.00
157_M160_V1.0960.99
206_S240_V1.0930.99
58_G62_A1.0910.99
119_S149_H1.0880.99
212_R234_E1.0830.99
203_R206_S1.0780.99
224_F245_V1.0780.99
20_R58_G1.0780.99
102_I299_G1.0760.99
275_I284_K1.0740.99
231_T244_T1.0730.99
160_V163_P1.0670.99
19_A54_G1.0620.99
282_G286_D1.0500.99
224_F290_A1.0450.99
245_V250_F1.0420.99
73_L105_A1.0380.99
38_L55_F1.0310.99
230_S247_P1.0270.99
219_A229_D1.0210.99
93_A97_A1.0200.99
8_V41_A1.0160.99
24_T28_E1.0150.99
306_A310_D1.0080.99
59_M157_M1.0060.99
72_P186_D1.0050.99
110_Y123_D1.0000.99
226_L287_I0.9980.99
97_A104_T0.9800.99
250_F309_A0.9740.99
188_Q210_V0.9730.99
252_L290_A0.9670.99
34_E166_D0.9630.99
33_A163_P0.9630.99
311_R314_A0.9610.99
234_E297_Y0.9610.99
27_F59_M0.9590.99
226_L260_V0.9580.99
17_D20_R0.9570.99
9_A43_R0.9570.99
246_S250_F0.9520.99
127_V145_I0.9520.99
327_A330_D0.9510.99
265_P269_A0.9450.98
136_V153_F0.9380.98
270_A273_R0.9360.98
87_I271_D0.9360.98
102_I301_G0.9200.98
314_A320_A0.9190.98
302_A311_R0.9180.98
45_K51_E0.9160.98
112_V151_P0.9160.98
50_A54_G0.9110.98
76_T93_A0.9110.98
273_R322_A0.9100.98
275_I288_V0.9100.98
187_A211_D0.9070.98
225_A228_G0.9000.98
162_G166_D0.8970.98
47_E170_R0.8940.98
259_A283_P0.8930.98
49_E203_R0.8930.98
286_D313_A0.8930.98
6_E10_A0.8920.98
56_A208_M0.8880.98
235_V240_V0.8800.98
310_D314_A0.8770.97
97_A103_P0.8760.97
13_D50_A0.8700.97
47_E52_I0.8700.97
115_A264_G0.8680.97
30_A34_E0.8650.97
255_A286_D0.8620.97
142_T327_A0.8610.97
189_V216_V0.8600.97
8_V38_L0.8600.97
187_A298_V0.8590.97
72_P187_A0.8560.97
35_I160_V0.8550.97
53_A57_Q0.8540.97
219_A244_T0.8530.97
214_L297_Y0.8500.97
52_I204_A0.8500.97
53_A204_A0.8480.97
269_A273_R0.8480.97
252_L309_A0.8450.97
311_R315_A0.8430.97
60_R184_R0.8420.97
96_V316_I0.8370.97
187_A212_R0.8360.97
14_L51_E0.8350.97
25_T30_A0.8330.97
77_C118_S0.8310.97
281_T284_K0.8290.96
76_T94_A0.8280.96
103_P141_E0.8270.96
300_G308_G0.8250.96
26_L160_V0.8220.96
192_V201_L0.8200.96
297_Y302_A0.8140.96
77_C93_A0.8130.96
19_A172_I0.8120.96
82_D86_T0.8100.96
289_V317_D0.8090.96
235_V238_D0.8090.96
136_V140_I0.8090.96
59_M176_L0.8070.96
84_Y257_I0.8050.96
217_H220_G0.8050.96
9_A44_A0.8040.96
253_A286_D0.8020.96
143_D328_L0.8020.96
32_D163_P0.8000.96
139_R146_G0.7970.96
201_L215_V0.7950.96
74_V104_T0.7920.95
282_G317_D0.7900.95
11_G44_A0.7900.95
41_A45_K0.7890.95
266_E270_A0.7880.95
49_E207_R0.7840.95
69_D141_E0.7770.95
37_A169_V0.7760.95
249_T306_A0.7720.95
13_D48_T0.7700.95
32_D162_G0.7700.95
76_T188_Q0.7680.95
136_V148_M0.7680.95
97_A100_A0.7670.95
27_F180_T0.7650.94
293_G305_L0.7600.94
218_G225_A0.7590.94
297_Y304_S0.7580.94
139_R143_D0.7550.94
125_L325_L0.7550.94
130_A152_A0.7540.94
91_T122_L0.7540.94
199_P233_A0.7540.94
197_L200_V0.7510.94
276_V322_A0.7500.94
64_I155_P0.7500.94
21_D25_T0.7480.94
20_R54_G0.7450.94
133_P137_E0.7450.94
294_A305_L0.7410.94
16_L53_A0.7320.93
4_Y21_D0.7320.93
95_L324_T0.7300.93
224_F250_F0.7270.93
68_P140_I0.7220.93
300_G311_R0.7160.92
227_H256_P0.7160.92
234_E241_T0.7160.92
36_G163_P0.7140.92
193_Y197_L0.7140.92
92_T276_V0.7130.92
76_T118_S0.7110.92
219_A225_A0.7090.92
87_I284_K0.7090.92
22_A26_L0.7060.92
255_A260_V0.7010.92
86_T221_L0.6990.91
211_D237_G0.6990.91
190_V201_L0.6990.91
157_M180_T0.6970.91
138_A141_E0.6970.91
124_A265_P0.6950.91
49_E200_V0.6940.91
221_L257_I0.6910.91
132_D152_A0.6900.91
283_P286_D0.6890.91
32_D159_A0.6880.91
96_V292_A0.6870.91
325_L329_T0.6870.91
95_L328_L0.6870.91
214_L232_V0.6850.91
17_D21_D0.6780.90
297_Y305_L0.6780.90
97_A292_A0.6770.90
20_R24_T0.6760.90
83_D113_S0.6750.90
127_V325_L0.6750.90
285_R289_V0.6710.90
189_V298_V0.6680.89
42_L47_E0.6680.89
66_V136_V0.6680.89
297_Y308_G0.6670.89
121_V125_L0.6670.89
63_A180_T0.6670.89
60_R208_M0.6670.89
95_L145_I0.6640.89
296_I312_A0.6640.89
27_F159_A0.6640.89
214_L243_T0.6630.89
82_D85_D0.6620.89
39_L157_M0.6580.89
236_D241_T0.6570.89
324_T328_L0.6560.89
136_V139_R0.6550.89
23_V172_I0.6530.88
4_Y25_T0.6530.88
52_I175_L0.6500.88
135_A139_R0.6490.88
82_D114_S0.6490.88
243_T297_Y0.6490.88
99_G321_A0.6470.88
92_T275_I0.6440.88
85_D261_A0.6420.88
116_S265_P0.6400.87
124_A269_A0.6390.87
205_L210_V0.6360.87
203_R240_V0.6350.87
315_A321_A0.6340.87
105_A148_M0.6340.87
51_E54_G0.6330.87
271_D275_I0.6330.87
128_E135_A0.6310.87
7_R11_G0.6300.87
227_H257_I0.6300.87
187_A299_G0.6290.86
94_A145_I0.6270.86
206_S239_T0.6260.86
305_L308_G0.6210.86
48_T51_E0.6210.86
171_T174_N0.6210.86
281_T317_D0.6160.85
64_I133_P0.6140.85
40_G167_L0.6140.85
95_L325_L0.6140.85
229_D254_E0.6120.85
74_V102_I0.6090.85
36_G40_G0.6080.85
246_S290_A0.6070.84
203_R207_R0.6040.84
151_P165_R0.6040.84
56_A59_M0.6030.84
248_S253_A0.6010.84
55_F176_L0.5990.84
97_A296_I0.5980.84
212_R300_G0.5960.83
16_L50_A0.5950.83
7_R15_S0.5940.83
250_F305_L0.5930.83
56_A176_L0.5930.83
226_L286_D0.5930.83
214_L305_L0.5900.83
289_V316_I0.5900.83
58_G61_D0.5880.83
195_P242_T0.5860.82
296_I308_G0.5820.82
41_A44_A0.5810.82
76_T189_V0.5800.82
206_S238_D0.5800.82
270_A279_E0.5790.82
321_A325_L0.5790.82
81_G177_G0.5790.82
250_F290_A0.5790.82
315_A324_T0.5770.81
289_V293_G0.5760.81
56_A60_R0.5760.81
296_I301_G0.5750.81
76_T295_A0.5750.81
119_S147_Y0.5730.81
297_Y301_G0.5720.81
309_A313_A0.5720.81
226_L252_L0.5720.81
190_V205_L0.5710.81
303_D311_R0.5690.80
293_G304_S0.5680.80
195_P219_A0.5670.80
85_D115_A0.5670.80
119_S123_D0.5670.80
74_V298_V0.5670.80
95_L127_V0.5640.80
37_A44_A0.5620.80
8_V44_A0.5610.80
296_I302_A0.5600.79
22_A25_T0.5600.79
37_A41_A0.5590.79
57_Q61_D0.5590.79
198_V231_T0.5570.79
226_L283_P0.5560.79
255_A259_A0.5550.79
84_Y261_A0.5550.79
92_T288_V0.5550.79
212_R297_Y0.5540.79
198_V242_T0.5520.78
272_L276_V0.5510.78
202_A235_V0.5490.78
282_G285_R0.5490.78
300_G303_D0.5480.78
307_A310_D0.5470.78
319_G322_A0.5420.77
105_A140_I0.5420.77
307_A311_R0.5410.77
118_S121_V0.5410.77
19_A51_E0.5410.77
267_A270_A0.5400.77
320_A324_T0.5400.77
74_V187_A0.5400.77
26_L38_L0.5400.77
125_L273_R0.5390.77
134_A137_E0.5380.77
92_T116_S0.5380.77
73_L103_P0.5350.76
68_P137_E0.5330.76
318_S321_A0.5320.76
78_G222_D0.5320.76
80_G178_P0.5320.76
37_A163_P0.5310.76
68_P71_T0.5310.76
74_V299_G0.5310.76
142_T323_D0.5300.76
128_E131_T0.5300.76
227_H259_A0.5290.76
295_A298_V0.5290.76
228_G257_I0.5290.76
281_T313_A0.5280.75
7_R14_L0.5280.75
216_V224_F0.5280.75
190_V215_V0.5280.75
3_E6_E0.5270.75
19_A23_V0.5270.75
88_N106_K0.5260.75
18_A54_G0.5250.75
260_V287_I0.5250.75
144_G324_T0.5240.75
93_A288_V0.5220.75
278_G281_T0.5220.75
139_R145_I0.5220.75
43_R168_G0.5150.74
293_G312_A0.5150.74
112_V193_Y0.5140.73
66_V183_A0.5130.73
95_L321_A0.5130.73
121_V325_L0.5110.73
188_Q213_A0.5080.73
56_A179_L0.5060.72
74_V185_A0.5040.72
77_C175_L0.5040.72
278_G285_R0.5030.72
110_Y149_H0.5030.72
72_P301_G0.5020.72
63_A154_H0.5020.72
53_A56_A0.5010.72
95_L99_G0.5010.72
39_L160_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1khdA 2 0.9792 100 0.067 Contact Map
4giuA 2 0.9881 100 0.067 Contact Map
4gtnA 2 0.9643 100 0.067 Contact Map
1vquA 2 0.9792 100 0.073 Contact Map
2elcA 4 0.9762 100 0.083 Contact Map
4hkmA 2 0.9673 100 0.087 Contact Map
1o17A 2 0.9821 100 0.096 Contact Map
4muoA 2 0.8869 100 0.165 Contact Map
3h5qA 2 0.8839 100 0.303 Contact Map
1brwA 2 0.8839 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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