GREMLIN Database
Q9HPG1 - Cell division cycle protein
UniProt: Q9HPG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (321)
Sequences: 9809 (5715)
Seq/√Len: 319.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
328_M347_Q5.3751.00
324_Q351_E5.1971.00
332_E346_L4.5801.00
348_L352_S4.0601.00
144_S147_D3.1461.00
85_V89_E3.0061.00
240_I252_I2.9871.00
331_I361_L2.9111.00
148_S151_D2.9091.00
146_V150_Y2.8751.00
94_E98_E2.7751.00
323_T326_E2.7521.00
110_T114_S2.7461.00
342_E345_D2.7271.00
151_D211_K2.7121.00
332_E343_S2.6551.00
263_D271_Q2.6361.00
152_D211_K2.6171.00
295_G313_F2.4481.00
329_E333_K2.4471.00
328_M332_E2.3861.00
150_Y157_T2.3771.00
329_E332_E2.3541.00
355_G358_G2.2271.00
253_F296_A2.2111.00
362_S366_S2.1921.00
136_Y246_K2.1831.00
299_A302_E2.1421.00
104_I107_G2.0471.00
100_A104_I1.9441.00
260_I278_L1.9291.00
109_V114_S1.9051.00
194_F319_F1.8781.00
277_Q281_E1.8771.00
49_K53_V1.8441.00
74_G78_L1.8121.00
135_A290_D1.7741.00
238_R286_E1.7651.00
102_V106_G1.7511.00
193_L313_F1.7421.00
67_V71_A1.7221.00
84_R87_V1.7211.00
84_R88_C1.7161.00
111_A114_S1.6801.00
89_E94_E1.6651.00
336_K339_D1.6621.00
99_G103_K1.6291.00
93_A96_P1.6231.00
97_E101_T1.6211.00
85_V88_C1.6151.00
150_Y160_I1.6021.00
95_N98_E1.5851.00
218_Y252_I1.5841.00
102_V105_Y1.5831.00
324_Q347_Q1.5761.00
39_V43_V1.5631.00
209_V294_I1.5601.00
54_A58_V1.5291.00
85_V93_A1.5151.00
37_R41_D1.5121.00
94_E97_E1.5061.00
365_I369_V1.5061.00
64_S67_V1.5051.00
68_I72_I1.5041.00
360_D363_G1.4801.00
328_M343_S1.4781.00
39_V42_L1.4731.00
370_T374_R1.4721.00
368_A372_S1.4531.00
83_G86_E1.4511.00
191_G282_L1.4401.00
348_L351_E1.4361.00
218_Y244_A1.4201.00
135_A247_K1.4101.00
96_P100_A1.4061.00
76_E88_C1.3911.00
87_V92_D1.3911.00
98_E105_Y1.3901.00
103_K106_G1.3771.00
110_T115_D1.3621.00
206_A294_I1.3561.00
364_V368_A1.3481.00
87_V93_A1.3371.00
347_Q351_E1.3211.00
241_F286_E1.3121.00
160_I205_L1.3091.00
68_I92_D1.2951.00
103_K107_G1.2911.00
353_T361_L1.2681.00
334_I337_D1.2651.00
87_V91_L1.2611.00
305_S308_I1.2601.00
109_V112_T1.2581.00
79_V82_N1.2561.00
281_E293_V1.2471.00
193_L257_V1.2371.00
91_L94_E1.2371.00
76_E79_V1.2371.00
56_E59_G1.2311.00
57_E61_A1.2231.00
110_T113_I1.2191.00
65_V72_I1.2151.00
61_A64_S1.2121.00
61_A65_V1.2031.00
328_M346_L1.2001.00
111_A115_D1.1851.00
101_T105_Y1.1751.00
63_P67_V1.1721.00
324_Q350_A1.1691.00
154_G333_K1.1681.00
99_G106_G1.1681.00
257_V295_G1.1661.00
48_D52_R1.1661.00
66_G70_E1.1651.00
338_V365_I1.1641.00
366_S370_T1.1641.00
331_I346_L1.1631.00
222_G254_I1.1551.00
89_E93_A1.1541.00
100_A107_G1.1521.00
148_S211_K1.1491.00
247_K286_E1.1491.00
93_A97_E1.1461.00
80_E83_G1.1451.00
145_E212_E1.1391.00
299_A308_I1.1341.00
65_V69_R1.1171.00
206_A253_F1.1151.00
309_R359_A1.1101.00
86_E89_E1.1091.00
56_E60_R1.1081.00
92_D99_G1.1081.00
136_Y216_S1.1061.00
146_V161_E1.1061.00
331_I349_F1.0911.00
68_I71_A1.0901.00
96_P104_I1.0861.00
64_S91_L1.0821.00
82_N86_E1.0811.00
101_T104_I1.0801.00
89_E106_G1.0801.00
369_V373_I1.0721.00
217_I253_F1.0691.00
70_E74_G1.0681.00
52_R55_V1.0681.00
38_S42_L1.0661.00
256_E298_N1.0631.00
98_E106_G1.0561.00
144_S148_S1.0551.00
37_R40_G1.0521.00
328_M350_A1.0481.00
92_D95_N1.0421.00
344_V347_Q1.0411.00
130_Q286_E1.0291.00
71_A74_G1.0261.00
98_E102_V1.0191.00
256_E312_R1.0181.00
360_D364_V1.0111.00
96_P102_V1.0101.00
101_T106_G1.0101.00
154_G329_E1.0091.00
108_K114_S1.0031.00
64_S68_I1.0031.00
152_D204_L1.0021.00
75_N80_E0.9951.00
146_V374_R0.9931.00
67_V70_E0.9921.00
55_V59_G0.9871.00
358_G362_S0.9871.00
60_R63_P0.9841.00
60_R64_S0.9771.00
40_G43_V0.9751.00
88_C92_D0.9721.00
84_R89_E0.9711.00
218_Y250_A0.9711.00
85_V94_E0.9711.00
146_V168_E0.9691.00
40_G44_E0.9611.00
48_D51_G0.9551.00
65_V68_I0.9551.00
92_D96_P0.9541.00
256_E279_L0.9391.00
41_D44_E0.9361.00
57_E98_E0.9341.00
308_I315_R0.9311.00
362_S365_I0.9281.00
148_S212_E0.9261.00
58_V62_S0.9241.00
96_P106_G0.9201.00
216_S247_K0.9181.00
300_L308_I0.9171.00
327_R350_A0.9151.00
158_D161_E0.9091.00
81_R84_R0.9071.00
194_F209_V0.8961.00
95_N103_K0.8951.00
173_E182_N0.8951.00
261_A307_I0.8941.00
87_V95_N0.8921.00
205_L319_F0.8921.00
195_H297_T0.8921.00
90_S96_P0.8911.00
98_E103_K0.8901.00
242_S246_K0.8881.00
255_D312_R0.8871.00
69_R72_I0.8861.00
152_D208_A0.8811.00
97_E107_G0.8781.00
71_A83_G0.8781.00
356_W364_V0.8781.00
89_E102_V0.8731.00
357_T362_S0.8711.00
308_I316_K0.8711.00
96_P103_K0.8681.00
37_R43_V0.8671.00
78_L82_N0.8611.00
109_V115_D0.8561.00
320_S326_E0.8501.00
220_V240_I0.8481.00
86_E91_L0.8471.00
84_R93_A0.8451.00
345_D348_L0.8411.00
90_S94_E0.8401.00
343_S347_Q0.8361.00
161_E367_R0.8341.00
361_L365_I0.8311.00
88_C94_E0.8281.00
102_V107_G0.8271.00
39_V44_E0.8261.00
335_T365_I0.8251.00
275_V304_D0.8251.00
89_E92_D0.8231.00
78_L81_R0.8221.00
157_T161_E0.8211.00
68_I95_N0.8181.00
136_Y144_S0.8161.00
228_K263_D0.8161.00
87_V94_E0.8161.00
53_V57_E0.8071.00
98_E104_I0.8061.00
66_G69_R0.8041.00
50_G54_A0.8041.00
53_V56_E0.8041.00
349_F364_V0.8021.00
85_V90_S0.8021.00
359_A370_T0.8001.00
72_I88_C0.7991.00
122_G126_R0.7981.00
93_A102_V0.7951.00
63_P66_G0.7921.00
68_I91_L0.7901.00
49_K52_R0.7901.00
157_T326_E0.7891.00
47_I51_G0.7861.00
88_C93_A0.7821.00
87_V104_I0.7821.00
124_E128_G0.7811.00
48_D55_V0.7791.00
91_L105_Y0.7741.00
93_A107_G0.7741.00
84_R92_D0.7741.00
218_Y247_K0.7721.00
77_Y80_E0.7711.00
100_A105_Y0.7711.00
44_E49_K0.7670.99
47_I54_A0.7620.99
218_Y240_I0.7610.99
361_L366_S0.7580.99
87_V90_S0.7530.99
225_I239_E0.7530.99
324_Q328_M0.7530.99
195_H299_A0.7450.99
133_S137_L0.7430.99
38_S41_D0.7410.99
47_I70_E0.7400.99
89_E96_P0.7320.99
84_R91_L0.7320.99
220_V252_I0.7300.99
76_E83_G0.7290.99
101_T107_G0.7280.99
99_G105_Y0.7280.99
325_T328_M0.7270.99
93_A98_E0.7270.99
140_P144_S0.7270.99
95_N106_G0.7250.99
47_I50_G0.7240.99
41_D49_K0.7200.99
300_L315_R0.7190.99
88_C95_N0.7180.99
91_L95_N0.7150.99
69_R75_N0.7150.99
278_L281_E0.7130.99
112_T115_D0.7120.99
99_G104_I0.7100.99
134_K137_L0.7100.99
121_K125_D0.7090.99
100_A103_K0.7090.99
86_E90_S0.7060.99
52_R59_G0.7050.99
321_K357_T0.7040.99
325_T347_Q0.7040.99
247_K290_D0.7040.99
352_S364_V0.7020.99
75_N79_V0.7020.99
121_K132_R0.7010.99
123_I127_F0.7010.99
254_I278_L0.6990.99
73_G77_Y0.6970.99
97_E105_Y0.6960.99
336_K361_L0.6940.99
356_W360_D0.6940.99
78_L83_G0.6860.99
55_V58_V0.6840.99
88_C91_L0.6820.99
226_I276_A0.6810.99
158_D320_S0.6790.99
208_A211_K0.6750.99
85_V91_L0.6750.99
61_A68_I0.6750.99
95_N99_G0.6740.99
89_E95_N0.6730.99
364_V370_T0.6730.99
93_A104_I0.6730.99
193_L299_A0.6720.99
213_T292_V0.6700.99
331_I350_A0.6700.99
51_G55_V0.6700.99
65_V92_D0.6690.99
357_T366_S0.6680.99
217_I251_I0.6670.99
94_E102_V0.6650.99
175_D180_R0.6650.99
332_E336_K0.6640.99
298_N312_R0.6590.98
369_V374_R0.6540.98
89_E98_E0.6520.98
91_L99_G0.6500.98
92_D97_E0.6480.98
85_V95_N0.6450.98
238_R241_F0.6450.98
143_I374_R0.6440.98
130_Q133_S0.6430.98
76_E81_R0.6420.98
99_G102_V0.6420.98
161_E165_D0.6410.98
54_A57_E0.6410.98
81_R85_V0.6400.98
118_I123_I0.6390.98
363_G369_V0.6370.98
255_D298_N0.6330.98
159_T317_I0.6330.98
216_S250_A0.6320.98
126_R242_S0.6320.98
358_G361_L0.6310.98
42_L47_I0.6290.98
69_R73_G0.6260.98
283_D312_R0.6250.98
55_V62_S0.6250.98
47_I55_V0.6250.98
92_D100_A0.6240.98
153_V204_L0.6220.98
98_E101_T0.6200.98
217_I221_N0.6190.98
96_P105_Y0.6190.98
358_G364_V0.6190.98
52_R60_R0.6180.98
251_I294_I0.6180.98
87_V102_V0.6170.98
54_A59_G0.6160.98
68_I87_V0.6150.98
120_P123_I0.6120.98
133_S138_K0.6090.97
108_K115_D0.6080.97
359_A369_V0.6060.97
59_G62_S0.6040.97
77_Y81_R0.6020.97
216_S246_K0.6010.97
361_L364_V0.5980.97
279_L298_N0.5960.97
82_N85_V0.5960.97
108_K111_A0.5960.97
91_L98_E0.5960.97
62_S65_V0.5950.97
198_P256_E0.5950.97
366_S374_R0.5940.97
81_R88_C0.5930.97
85_V92_D0.5880.97
86_E92_D0.5880.97
72_I92_D0.5880.97
37_R44_E0.5840.97
42_L67_V0.5830.97
51_G54_A0.5820.97
40_G60_R0.5810.97
100_A106_G0.5800.97
366_S369_V0.5770.96
51_G62_S0.5770.96
37_R42_L0.5770.96
87_V97_E0.5750.96
159_T194_F0.5750.96
51_G70_E0.5740.96
50_G53_V0.5740.96
68_I73_G0.5730.96
359_A365_I0.5720.96
96_P107_G0.5700.96
90_S93_A0.5660.96
105_Y108_K0.5650.96
279_L312_R0.5650.96
125_D129_E0.5640.96
173_E180_R0.5620.96
48_D67_V0.5620.96
334_I362_S0.5600.96
207_K217_I0.5580.96
129_E134_K0.5570.96
136_Y139_D0.5560.96
81_R95_N0.5560.96
123_I131_N0.5560.96
157_T329_E0.5560.96
76_E80_E0.5550.96
63_P70_E0.5550.96
164_K168_E0.5540.96
182_N189_D0.5540.96
44_E47_I0.5530.96
195_H316_K0.5530.96
349_F354_D0.5520.95
146_V164_K0.5520.95
118_I122_G0.5490.95
207_K285_F0.5480.95
58_V61_A0.5480.95
366_S371_I0.5470.95
226_I263_D0.5470.95
139_D144_S0.5470.95
350_A353_T0.5450.95
95_N107_G0.5450.95
94_E106_G0.5430.95
186_V215_S0.5430.95
363_G367_R0.5420.95
203_T255_D0.5410.95
75_N83_G0.5410.95
142_E146_V0.5410.95
58_V72_I0.5400.95
279_L306_A0.5390.95
50_G57_E0.5380.95
108_K113_I0.5370.95
328_M351_E0.5360.95
48_D54_A0.5360.95
198_P312_R0.5360.95
180_R183_K0.5350.95
59_G67_V0.5350.95
47_I60_R0.5320.95
370_T373_I0.5320.95
347_Q350_A0.5310.94
97_E102_V0.5300.94
357_T360_D0.5280.94
278_L307_I0.5280.94
275_V303_V0.5270.94
239_E243_N0.5260.94
41_D50_G0.5250.94
43_V49_K0.5240.94
366_S373_I0.5220.94
95_N104_I0.5200.94
87_V107_G0.5190.94
117_V120_P0.5190.94
61_A73_G0.5190.94
124_E134_K0.5170.94
83_G91_L0.5160.94
72_I75_N0.5140.93
335_T346_L0.5130.93
97_E100_A0.5130.93
91_L96_P0.5120.93
61_A99_G0.5120.93
325_T329_E0.5120.93
100_A127_F0.5110.93
74_G79_V0.5100.93
85_V101_T0.5080.93
203_T312_R0.5070.93
104_I114_S0.5050.93
104_I108_K0.5050.93
368_A375_R0.5040.93
133_S247_K0.5030.93
87_V99_G0.5030.93
91_L104_I0.5010.93
278_L282_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2J 1 0.8985 100 0.343 Contact Map
4cr2L 1 0.8985 100 0.371 Contact Map
2ce7A 3 0.6218 100 0.375 Contact Map
3cf2A 3 0.8173 100 0.384 Contact Map
4ww0A 4 0.6294 100 0.394 Contact Map
4cr2M 1 0.8579 100 0.394 Contact Map
4cr2I 1 0.8274 100 0.408 Contact Map
2x8aA 1 0.5838 100 0.411 Contact Map
4cr2H 1 0.8452 100 0.411 Contact Map
4ko8A 3 0.8249 100 0.419 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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