Q9HPG1 - HALSA - GREMLIN Contacts

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Q9HPG1 - Cell division cycle protein

UniProt:	Q9HPG1	Sequences: MDVHFATVRSTNSSEGTLDVLIDGQAVTIEDNTEGDRSVGDLVEVWIDKGGRVAVEEVGRASPSVGVIREAIGGNEYLVERNGRVEVCESLDAENPEEGATVKIYGGKVTATISDEVIAPKGIEDRFGEQNRSKAYLKDPEEISEVDSGYDDVGGLTDTIEEVKDVVEIPLRESDKETNRFNKHGVEPDTGILFHGPPGTGKTLLAKAVAKETGSSIYLVNGPEIISKWYGETEDIIREIFSNAKKKKRAIIFIDEVDSIAPDRGDTKQFQRKIVAQLLTELDGFEPLNDVVVIGATNALNEVDSAIIRPGRFDRKIKFSKPTQTERMEIIEKITKDVDFGESVDLQLFAESTDGWTGADLSGVISRAVTISIRREGDLVTQDDLFRAIKGAGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (321)
Sequences:	9809 (5715)
Seq/√Len:	319.0

ECOLI - FTSH
BACSU - FTSH YJOB SP5K
HALSA - Q9HPG1 CDCH Q9HHW2 Q9HPU1 PAN1 PAN2 Q9HPV0 Q9HNK6
SULSO - Q980U9 Q97ZZ9 PAN Q97W25 Q97ZJ7 Q97V06

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
328_M	347_Q	5.375	1.00
324_Q	351_E	5.197	1.00
332_E	346_L	4.580	1.00
348_L	352_S	4.060	1.00
144_S	147_D	3.146	1.00
85_V	89_E	3.006	1.00
240_I	252_I	2.987	1.00
331_I	361_L	2.911	1.00
148_S	151_D	2.909	1.00
146_V	150_Y	2.875	1.00
94_E	98_E	2.775	1.00
323_T	326_E	2.752	1.00
110_T	114_S	2.746	1.00
342_E	345_D	2.727	1.00
151_D	211_K	2.712	1.00
332_E	343_S	2.655	1.00
263_D	271_Q	2.636	1.00
152_D	211_K	2.617	1.00
295_G	313_F	2.448	1.00
329_E	333_K	2.447	1.00
328_M	332_E	2.386	1.00
150_Y	157_T	2.377	1.00
329_E	332_E	2.354	1.00
355_G	358_G	2.227	1.00
253_F	296_A	2.211	1.00
362_S	366_S	2.192	1.00
136_Y	246_K	2.183	1.00
299_A	302_E	2.142	1.00
104_I	107_G	2.047	1.00
100_A	104_I	1.944	1.00
260_I	278_L	1.929	1.00
109_V	114_S	1.905	1.00
194_F	319_F	1.878	1.00
277_Q	281_E	1.877	1.00
49_K	53_V	1.844	1.00
74_G	78_L	1.812	1.00
135_A	290_D	1.774	1.00
238_R	286_E	1.765	1.00
102_V	106_G	1.751	1.00
193_L	313_F	1.742	1.00
67_V	71_A	1.722	1.00
84_R	87_V	1.721	1.00
84_R	88_C	1.716	1.00
111_A	114_S	1.680	1.00
89_E	94_E	1.665	1.00
336_K	339_D	1.662	1.00
99_G	103_K	1.629	1.00
93_A	96_P	1.623	1.00
97_E	101_T	1.621	1.00
85_V	88_C	1.615	1.00
150_Y	160_I	1.602	1.00
95_N	98_E	1.585	1.00
218_Y	252_I	1.584	1.00
102_V	105_Y	1.583	1.00
324_Q	347_Q	1.576	1.00
39_V	43_V	1.563	1.00
209_V	294_I	1.560	1.00
54_A	58_V	1.529	1.00
85_V	93_A	1.515	1.00
37_R	41_D	1.512	1.00
94_E	97_E	1.506	1.00
365_I	369_V	1.506	1.00
64_S	67_V	1.505	1.00
68_I	72_I	1.504	1.00
360_D	363_G	1.480	1.00
328_M	343_S	1.478	1.00
39_V	42_L	1.473	1.00
370_T	374_R	1.472	1.00
368_A	372_S	1.453	1.00
83_G	86_E	1.451	1.00
191_G	282_L	1.440	1.00
348_L	351_E	1.436	1.00
218_Y	244_A	1.420	1.00
135_A	247_K	1.410	1.00
96_P	100_A	1.406	1.00
76_E	88_C	1.391	1.00
87_V	92_D	1.391	1.00
98_E	105_Y	1.390	1.00
103_K	106_G	1.377	1.00
110_T	115_D	1.362	1.00
206_A	294_I	1.356	1.00
364_V	368_A	1.348	1.00
87_V	93_A	1.337	1.00
347_Q	351_E	1.321	1.00
241_F	286_E	1.312	1.00
160_I	205_L	1.309	1.00
68_I	92_D	1.295	1.00
103_K	107_G	1.291	1.00
353_T	361_L	1.268	1.00
334_I	337_D	1.265	1.00
87_V	91_L	1.261	1.00
305_S	308_I	1.260	1.00
109_V	112_T	1.258	1.00
79_V	82_N	1.256	1.00
281_E	293_V	1.247	1.00
193_L	257_V	1.237	1.00
91_L	94_E	1.237	1.00
76_E	79_V	1.237	1.00
56_E	59_G	1.231	1.00
57_E	61_A	1.223	1.00
110_T	113_I	1.219	1.00
65_V	72_I	1.215	1.00
61_A	64_S	1.212	1.00
61_A	65_V	1.203	1.00
328_M	346_L	1.200	1.00
111_A	115_D	1.185	1.00
101_T	105_Y	1.175	1.00
63_P	67_V	1.172	1.00
324_Q	350_A	1.169	1.00
154_G	333_K	1.168	1.00
99_G	106_G	1.168	1.00
257_V	295_G	1.166	1.00
48_D	52_R	1.166	1.00
66_G	70_E	1.165	1.00
338_V	365_I	1.164	1.00
366_S	370_T	1.164	1.00
331_I	346_L	1.163	1.00
222_G	254_I	1.155	1.00
89_E	93_A	1.154	1.00
100_A	107_G	1.152	1.00
148_S	211_K	1.149	1.00
247_K	286_E	1.149	1.00
93_A	97_E	1.146	1.00
80_E	83_G	1.145	1.00
145_E	212_E	1.139	1.00
299_A	308_I	1.134	1.00
65_V	69_R	1.117	1.00
206_A	253_F	1.115	1.00
309_R	359_A	1.110	1.00
86_E	89_E	1.109	1.00
56_E	60_R	1.108	1.00
92_D	99_G	1.108	1.00
136_Y	216_S	1.106	1.00
146_V	161_E	1.106	1.00
331_I	349_F	1.091	1.00
68_I	71_A	1.090	1.00
96_P	104_I	1.086	1.00
64_S	91_L	1.082	1.00
82_N	86_E	1.081	1.00
101_T	104_I	1.080	1.00
89_E	106_G	1.080	1.00
369_V	373_I	1.072	1.00
217_I	253_F	1.069	1.00
70_E	74_G	1.068	1.00
52_R	55_V	1.068	1.00
38_S	42_L	1.066	1.00
256_E	298_N	1.063	1.00
98_E	106_G	1.056	1.00
144_S	148_S	1.055	1.00
37_R	40_G	1.052	1.00
328_M	350_A	1.048	1.00
92_D	95_N	1.042	1.00
344_V	347_Q	1.041	1.00
130_Q	286_E	1.029	1.00
71_A	74_G	1.026	1.00
98_E	102_V	1.019	1.00
256_E	312_R	1.018	1.00
360_D	364_V	1.011	1.00
96_P	102_V	1.010	1.00
101_T	106_G	1.010	1.00
154_G	329_E	1.009	1.00
108_K	114_S	1.003	1.00
64_S	68_I	1.003	1.00
152_D	204_L	1.002	1.00
75_N	80_E	0.995	1.00
146_V	374_R	0.993	1.00
67_V	70_E	0.992	1.00
55_V	59_G	0.987	1.00
358_G	362_S	0.987	1.00
60_R	63_P	0.984	1.00
60_R	64_S	0.977	1.00
40_G	43_V	0.975	1.00
88_C	92_D	0.972	1.00
84_R	89_E	0.971	1.00
218_Y	250_A	0.971	1.00
85_V	94_E	0.971	1.00
146_V	168_E	0.969	1.00
40_G	44_E	0.961	1.00
48_D	51_G	0.955	1.00
65_V	68_I	0.955	1.00
92_D	96_P	0.954	1.00
256_E	279_L	0.939	1.00
41_D	44_E	0.936	1.00
57_E	98_E	0.934	1.00
308_I	315_R	0.931	1.00
362_S	365_I	0.928	1.00
148_S	212_E	0.926	1.00
58_V	62_S	0.924	1.00
96_P	106_G	0.920	1.00
216_S	247_K	0.918	1.00
300_L	308_I	0.917	1.00
327_R	350_A	0.915	1.00
158_D	161_E	0.909	1.00
81_R	84_R	0.907	1.00
194_F	209_V	0.896	1.00
95_N	103_K	0.895	1.00
173_E	182_N	0.895	1.00
261_A	307_I	0.894	1.00
87_V	95_N	0.892	1.00
205_L	319_F	0.892	1.00
195_H	297_T	0.892	1.00
90_S	96_P	0.891	1.00
98_E	103_K	0.890	1.00
242_S	246_K	0.888	1.00
255_D	312_R	0.887	1.00
69_R	72_I	0.886	1.00
152_D	208_A	0.881	1.00
97_E	107_G	0.878	1.00
71_A	83_G	0.878	1.00
356_W	364_V	0.878	1.00
89_E	102_V	0.873	1.00
357_T	362_S	0.871	1.00
308_I	316_K	0.871	1.00
96_P	103_K	0.868	1.00
37_R	43_V	0.867	1.00
78_L	82_N	0.861	1.00
109_V	115_D	0.856	1.00
320_S	326_E	0.850	1.00
220_V	240_I	0.848	1.00
86_E	91_L	0.847	1.00
84_R	93_A	0.845	1.00
345_D	348_L	0.841	1.00
90_S	94_E	0.840	1.00
343_S	347_Q	0.836	1.00
161_E	367_R	0.834	1.00
361_L	365_I	0.831	1.00
88_C	94_E	0.828	1.00
102_V	107_G	0.827	1.00
39_V	44_E	0.826	1.00
335_T	365_I	0.825	1.00
275_V	304_D	0.825	1.00
89_E	92_D	0.823	1.00
78_L	81_R	0.822	1.00
157_T	161_E	0.821	1.00
68_I	95_N	0.818	1.00
136_Y	144_S	0.816	1.00
228_K	263_D	0.816	1.00
87_V	94_E	0.816	1.00
53_V	57_E	0.807	1.00
98_E	104_I	0.806	1.00
66_G	69_R	0.804	1.00
50_G	54_A	0.804	1.00
53_V	56_E	0.804	1.00
349_F	364_V	0.802	1.00
85_V	90_S	0.802	1.00
359_A	370_T	0.800	1.00
72_I	88_C	0.799	1.00
122_G	126_R	0.798	1.00
93_A	102_V	0.795	1.00
63_P	66_G	0.792	1.00
68_I	91_L	0.790	1.00
49_K	52_R	0.790	1.00
157_T	326_E	0.789	1.00
47_I	51_G	0.786	1.00
88_C	93_A	0.782	1.00
87_V	104_I	0.782	1.00
124_E	128_G	0.781	1.00
48_D	55_V	0.779	1.00
91_L	105_Y	0.774	1.00
93_A	107_G	0.774	1.00
84_R	92_D	0.774	1.00
218_Y	247_K	0.772	1.00
77_Y	80_E	0.771	1.00
100_A	105_Y	0.771	1.00
44_E	49_K	0.767	0.99
47_I	54_A	0.762	0.99
218_Y	240_I	0.761	0.99
361_L	366_S	0.758	0.99
87_V	90_S	0.753	0.99
225_I	239_E	0.753	0.99
324_Q	328_M	0.753	0.99
195_H	299_A	0.745	0.99
133_S	137_L	0.743	0.99
38_S	41_D	0.741	0.99
47_I	70_E	0.740	0.99
89_E	96_P	0.732	0.99
84_R	91_L	0.732	0.99
220_V	252_I	0.730	0.99
76_E	83_G	0.729	0.99
101_T	107_G	0.728	0.99
99_G	105_Y	0.728	0.99
325_T	328_M	0.727	0.99
93_A	98_E	0.727	0.99
140_P	144_S	0.727	0.99
95_N	106_G	0.725	0.99
47_I	50_G	0.724	0.99
41_D	49_K	0.720	0.99
300_L	315_R	0.719	0.99
88_C	95_N	0.718	0.99
91_L	95_N	0.715	0.99
69_R	75_N	0.715	0.99
278_L	281_E	0.713	0.99
112_T	115_D	0.712	0.99
99_G	104_I	0.710	0.99
134_K	137_L	0.710	0.99
121_K	125_D	0.709	0.99
100_A	103_K	0.709	0.99
86_E	90_S	0.706	0.99
52_R	59_G	0.705	0.99
321_K	357_T	0.704	0.99
325_T	347_Q	0.704	0.99
247_K	290_D	0.704	0.99
352_S	364_V	0.702	0.99
75_N	79_V	0.702	0.99
121_K	132_R	0.701	0.99
123_I	127_F	0.701	0.99
254_I	278_L	0.699	0.99
73_G	77_Y	0.697	0.99
97_E	105_Y	0.696	0.99
336_K	361_L	0.694	0.99
356_W	360_D	0.694	0.99
78_L	83_G	0.686	0.99
55_V	58_V	0.684	0.99
88_C	91_L	0.682	0.99
226_I	276_A	0.681	0.99
158_D	320_S	0.679	0.99
208_A	211_K	0.675	0.99
85_V	91_L	0.675	0.99
61_A	68_I	0.675	0.99
95_N	99_G	0.674	0.99
89_E	95_N	0.673	0.99
364_V	370_T	0.673	0.99
93_A	104_I	0.673	0.99
193_L	299_A	0.672	0.99
213_T	292_V	0.670	0.99
331_I	350_A	0.670	0.99
51_G	55_V	0.670	0.99
65_V	92_D	0.669	0.99
357_T	366_S	0.668	0.99
217_I	251_I	0.667	0.99
94_E	102_V	0.665	0.99
175_D	180_R	0.665	0.99
332_E	336_K	0.664	0.99
298_N	312_R	0.659	0.98
369_V	374_R	0.654	0.98
89_E	98_E	0.652	0.98
91_L	99_G	0.650	0.98
92_D	97_E	0.648	0.98
85_V	95_N	0.645	0.98
238_R	241_F	0.645	0.98
143_I	374_R	0.644	0.98
130_Q	133_S	0.643	0.98
76_E	81_R	0.642	0.98
99_G	102_V	0.642	0.98
161_E	165_D	0.641	0.98
54_A	57_E	0.641	0.98
81_R	85_V	0.640	0.98
118_I	123_I	0.639	0.98
363_G	369_V	0.637	0.98
255_D	298_N	0.633	0.98
159_T	317_I	0.633	0.98
216_S	250_A	0.632	0.98
126_R	242_S	0.632	0.98
358_G	361_L	0.631	0.98
42_L	47_I	0.629	0.98
69_R	73_G	0.626	0.98
283_D	312_R	0.625	0.98
55_V	62_S	0.625	0.98
47_I	55_V	0.625	0.98
92_D	100_A	0.624	0.98
153_V	204_L	0.622	0.98
98_E	101_T	0.620	0.98
217_I	221_N	0.619	0.98
96_P	105_Y	0.619	0.98
358_G	364_V	0.619	0.98
52_R	60_R	0.618	0.98
251_I	294_I	0.618	0.98
87_V	102_V	0.617	0.98
54_A	59_G	0.616	0.98
68_I	87_V	0.615	0.98
120_P	123_I	0.612	0.98
133_S	138_K	0.609	0.97
108_K	115_D	0.608	0.97
359_A	369_V	0.606	0.97
59_G	62_S	0.604	0.97
77_Y	81_R	0.602	0.97
216_S	246_K	0.601	0.97
361_L	364_V	0.598	0.97
279_L	298_N	0.596	0.97
82_N	85_V	0.596	0.97
108_K	111_A	0.596	0.97
91_L	98_E	0.596	0.97
62_S	65_V	0.595	0.97
198_P	256_E	0.595	0.97
366_S	374_R	0.594	0.97
81_R	88_C	0.593	0.97
85_V	92_D	0.588	0.97
86_E	92_D	0.588	0.97
72_I	92_D	0.588	0.97
37_R	44_E	0.584	0.97
42_L	67_V	0.583	0.97
51_G	54_A	0.582	0.97
40_G	60_R	0.581	0.97
100_A	106_G	0.580	0.97
366_S	369_V	0.577	0.96
51_G	62_S	0.577	0.96
37_R	42_L	0.577	0.96
87_V	97_E	0.575	0.96
159_T	194_F	0.575	0.96
51_G	70_E	0.574	0.96
50_G	53_V	0.574	0.96
68_I	73_G	0.573	0.96
359_A	365_I	0.572	0.96
96_P	107_G	0.570	0.96
90_S	93_A	0.566	0.96
105_Y	108_K	0.565	0.96
279_L	312_R	0.565	0.96
125_D	129_E	0.564	0.96
173_E	180_R	0.562	0.96
48_D	67_V	0.562	0.96
334_I	362_S	0.560	0.96
207_K	217_I	0.558	0.96
129_E	134_K	0.557	0.96
136_Y	139_D	0.556	0.96
81_R	95_N	0.556	0.96
123_I	131_N	0.556	0.96
157_T	329_E	0.556	0.96
76_E	80_E	0.555	0.96
63_P	70_E	0.555	0.96
164_K	168_E	0.554	0.96
182_N	189_D	0.554	0.96
44_E	47_I	0.553	0.96
195_H	316_K	0.553	0.96
349_F	354_D	0.552	0.95
146_V	164_K	0.552	0.95
118_I	122_G	0.549	0.95
207_K	285_F	0.548	0.95
58_V	61_A	0.548	0.95
366_S	371_I	0.547	0.95
226_I	263_D	0.547	0.95
139_D	144_S	0.547	0.95
350_A	353_T	0.545	0.95
95_N	107_G	0.545	0.95
94_E	106_G	0.543	0.95
186_V	215_S	0.543	0.95
363_G	367_R	0.542	0.95
203_T	255_D	0.541	0.95
75_N	83_G	0.541	0.95
142_E	146_V	0.541	0.95
58_V	72_I	0.540	0.95
279_L	306_A	0.539	0.95
50_G	57_E	0.538	0.95
108_K	113_I	0.537	0.95
328_M	351_E	0.536	0.95
48_D	54_A	0.536	0.95
198_P	312_R	0.536	0.95
180_R	183_K	0.535	0.95
59_G	67_V	0.535	0.95
47_I	60_R	0.532	0.95
370_T	373_I	0.532	0.95
347_Q	350_A	0.531	0.94
97_E	102_V	0.530	0.94
357_T	360_D	0.528	0.94
278_L	307_I	0.528	0.94
275_V	303_V	0.527	0.94
239_E	243_N	0.526	0.94
41_D	50_G	0.525	0.94
43_V	49_K	0.524	0.94
366_S	373_I	0.522	0.94
95_N	104_I	0.520	0.94
87_V	107_G	0.519	0.94
117_V	120_P	0.519	0.94
61_A	73_G	0.519	0.94
124_E	134_K	0.517	0.94
83_G	91_L	0.516	0.94
72_I	75_N	0.514	0.93
335_T	346_L	0.513	0.93
97_E	100_A	0.513	0.93
91_L	96_P	0.512	0.93
61_A	99_G	0.512	0.93
325_T	329_E	0.512	0.93
100_A	127_F	0.511	0.93
74_G	79_V	0.510	0.93
85_V	101_T	0.508	0.93
203_T	312_R	0.507	0.93
104_I	114_S	0.505	0.93
104_I	108_K	0.505	0.93
368_A	375_R	0.504	0.93
133_S	247_K	0.503	0.93
87_V	99_G	0.503	0.93
91_L	104_I	0.501	0.93
278_L	282_L	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cr2J	1	0.8985	100	0.343	Contact Map
4cr2L	1	0.8985	100	0.371	Contact Map
2ce7A	3	0.6218	100	0.375	Contact Map
3cf2A	3	0.8173	100	0.384	Contact Map
4ww0A	4	0.6294	100	0.394	Contact Map
4cr2M	1	0.8579	100	0.394	Contact Map
4cr2I	1	0.8274	100	0.408	Contact Map
2x8aA	1	0.5838	100	0.411	Contact Map
4cr2H	1	0.8452	100	0.411	Contact Map
4ko8A	3	0.8249	100	0.419	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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