GREMLIN Database
Q9HPF7 - Uncharacterized protein
UniProt: Q9HPF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (132)
Sequences: 21248 (17060)
Seq/√Len: 1484.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_H82_T3.1211.00
6_L101_I2.8781.00
4_R34_H2.7501.00
89_A125_S2.7111.00
32_T80_E2.6081.00
4_R32_T2.5131.00
21_H135_L2.4921.00
82_T95_Y2.4081.00
103_I135_L2.3371.00
34_H101_I2.0221.00
106_M126_V2.0191.00
104_A132_V2.0081.00
34_H80_E1.8671.00
124_E128_R1.8311.00
68_V81_A1.8151.00
84_T91_E1.8081.00
96_V104_A1.7981.00
32_T78_S1.7871.00
86_G91_E1.7511.00
34_H95_Y1.7491.00
108_T138_N1.7421.00
36_L95_Y1.7161.00
7_V22_A1.6941.00
38_V91_E1.6611.00
8_P106_M1.6341.00
20_T70_R1.6171.00
8_P92_I1.6161.00
68_V72_Q1.5291.00
91_E94_T1.4981.00
25_I29_Y1.4651.00
93_L129_E1.4071.00
16_N70_R1.3841.00
104_A130_S1.3791.00
37_Y60_G1.3761.00
125_S129_E1.3711.00
97_T131_P1.3551.00
31_A102_D1.3071.00
84_T95_Y1.2861.00
7_V19_V1.2851.00
22_A26_A1.2421.00
96_V131_P1.2401.00
61_Q65_D1.2381.00
57_Q61_Q1.2321.00
65_D68_V1.2141.00
96_V132_V1.2021.00
88_P122_I1.1991.00
70_R74_A1.1951.00
104_A126_V1.1671.00
4_R102_D1.1661.00
36_L84_T1.1411.00
95_Y101_I1.1101.00
38_V88_P1.0951.00
130_S134_V1.0741.00
60_G63_A1.0551.00
11_G37_Y1.0311.00
4_R101_I1.0221.00
5_V103_I1.0221.00
114_E118_L1.0201.00
39_V85_R1.0181.00
63_A67_I1.0171.00
96_V101_I1.0061.00
108_T136_L1.0011.00
21_H137_V1.0001.00
106_M123_S0.9921.00
93_L96_V0.9861.00
70_R73_D0.9621.00
56_V59_A0.9591.00
116_R124_E0.9421.00
53_L57_Q0.9351.00
21_H25_I0.9331.00
64_V81_A0.9201.00
22_A105_V0.9151.00
60_G64_V0.9141.00
19_V67_I0.9141.00
65_D69_K0.9111.00
65_D81_A0.9081.00
54_H58_E0.9081.00
9_T67_I0.9081.00
24_D28_Q0.9061.00
37_Y63_A0.9061.00
48_P51_D0.8951.00
63_A66_R0.8941.00
127_V136_L0.8841.00
67_I70_R0.8821.00
29_Y102_D0.8801.00
19_V35_T0.8791.00
113_G116_R0.8661.00
58_E62_K0.8651.00
26_A33_L0.8601.00
6_L95_Y0.8511.00
123_S136_L0.8501.00
15_T18_A0.8421.00
12_S15_T0.8421.00
6_L36_L0.8411.00
67_I71_A0.8371.00
16_N66_R0.8371.00
36_L92_I0.8361.00
108_T123_S0.8351.00
22_A33_L0.8311.00
87_V90_T0.8281.00
23_I76_V0.8231.00
9_T18_A0.8201.00
23_I74_A0.8161.00
49_D52_P0.8161.00
39_V83_V0.8141.00
16_N20_T0.8131.00
21_H133_P0.8131.00
35_T79_V0.8121.00
21_H24_D0.8121.00
17_E20_T0.8091.00
35_T67_I0.8051.00
111_R115_S0.7961.00
20_T74_A0.7951.00
66_R70_R0.7951.00
93_L130_S0.7891.00
64_V68_V0.7811.00
105_V135_L0.7771.00
71_A74_A0.7741.00
6_L104_A0.7741.00
26_A31_A0.7711.00
9_T35_T0.7691.00
69_K72_Q0.7541.00
62_K66_R0.7531.00
26_A29_Y0.7511.00
27_E75_G0.7501.00
60_G83_V0.7501.00
66_R69_K0.7481.00
93_L126_V0.7401.00
9_T16_N0.7361.00
9_T19_V0.7291.00
23_I71_A0.7291.00
50_D54_H0.7251.00
69_K73_D0.7181.00
7_V33_L0.7171.00
58_E61_Q0.7161.00
55_R58_E0.7141.00
59_A63_A0.7121.00
56_V60_G0.7091.00
19_V23_I0.7051.00
8_P107_A0.7011.00
16_N67_I0.6981.00
59_A62_K0.6981.00
113_G117_D0.6921.00
92_I126_V0.6871.00
57_Q85_R0.6821.00
55_R59_A0.6811.00
25_I28_Q0.6791.00
89_A122_I0.6731.00
24_D27_E0.6681.00
51_D55_R0.6661.00
71_A79_V0.6611.00
110_G119_L0.6601.00
52_P55_R0.6571.00
91_E95_Y0.6541.00
89_A93_L0.6381.00
100_E132_V0.6331.00
23_I27_E0.6301.00
82_T85_R0.6291.00
105_V137_V0.6261.00
24_D74_A0.6211.00
53_L85_R0.6191.00
36_L91_E0.6171.00
114_E117_D0.6151.00
12_S110_G0.6151.00
11_G67_I0.6131.00
50_D53_L0.6061.00
126_V134_V0.6051.00
39_V60_G0.6041.00
35_T71_A0.6021.00
14_G17_E0.6001.00
9_T15_T0.5961.00
49_D53_L0.5961.00
61_Q81_A0.5961.00
64_V70_R0.5921.00
107_A137_V0.5901.00
54_H57_Q0.5861.00
106_M136_L0.5851.00
64_V67_I0.5841.00
27_E74_A0.5811.00
62_K65_D0.5811.00
11_G63_A0.5801.00
5_V105_V0.5791.00
51_D54_H0.5751.00
7_V18_A0.5741.00
22_A31_A0.5671.00
25_I31_A0.5551.00
97_T132_V0.5541.00
109_A123_S0.5501.00
119_L123_S0.5491.00
90_T94_T0.5481.00
43_R46_E0.5461.00
89_A126_V0.5431.00
89_A129_E0.5421.00
93_L125_S0.5381.00
5_V26_A0.5331.00
68_V79_V0.5291.00
42_T45_N0.5281.00
108_T118_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mjhA 2 0.958 99.9 0.133 Contact Map
5ahwA 4 0.979 99.9 0.136 Contact Map
3hgmA 2 0.951 99.9 0.142 Contact Map
4wnyA 2 0.8601 99.9 0.143 Contact Map
2gm3A 2 0.8811 99.9 0.143 Contact Map
2dumA 2 0.965 99.9 0.143 Contact Map
3s3tA 4 0.965 99.9 0.144 Contact Map
3fg9A 3 0.958 99.9 0.176 Contact Map
1tq8A 4 0.8671 99.9 0.177 Contact Map
3loqA 1 0.972 99.9 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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