Q9HPF7 - HALSA - GREMLIN Contacts

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Q9HPF7 - Uncharacterized protein

UniProt:	Q9HPF7	Sequences: MYDRVLVPTDGSEGTNEAVTHAIDIAEQYGATLHTLYVVESTRSNETPDDDPLHRVQEAGQKAVDRIVKRAQDAGVTSVEATVTRGVPATEILTYVTEMEIDIAVMATAGRSGESRDLLGSISESVVRESPVPVLLVNVGEAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	143 (132)
Sequences:	21248 (17060)
Seq/√Len:	1484.8

ECOLI - USPF USPG USPE USPC USPD USPA
BACSU - YXIE NHAX
HALSA - Q9HPF7 Q9HRP5 Q9HPQ8 Q9HPP5 Q9HP90 Q9HMJ0 Q9HRD8 Q9HNX9 Q9HMI9 Q9HHX5 Q9HHV8 Q9HHY0 Q9HMU1
SULSO - Q97X90 Q97V57 Q7LXW4 Q97U40

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_H	82_T	3.121	1.00
6_L	101_I	2.878	1.00
4_R	34_H	2.750	1.00
89_A	125_S	2.711	1.00
32_T	80_E	2.608	1.00
4_R	32_T	2.513	1.00
21_H	135_L	2.492	1.00
82_T	95_Y	2.408	1.00
103_I	135_L	2.337	1.00
34_H	101_I	2.022	1.00
106_M	126_V	2.019	1.00
104_A	132_V	2.008	1.00
34_H	80_E	1.867	1.00
124_E	128_R	1.831	1.00
68_V	81_A	1.815	1.00
84_T	91_E	1.808	1.00
96_V	104_A	1.798	1.00
32_T	78_S	1.787	1.00
86_G	91_E	1.751	1.00
34_H	95_Y	1.749	1.00
108_T	138_N	1.742	1.00
36_L	95_Y	1.716	1.00
7_V	22_A	1.694	1.00
38_V	91_E	1.661	1.00
8_P	106_M	1.634	1.00
20_T	70_R	1.617	1.00
8_P	92_I	1.616	1.00
68_V	72_Q	1.529	1.00
91_E	94_T	1.498	1.00
25_I	29_Y	1.465	1.00
93_L	129_E	1.407	1.00
16_N	70_R	1.384	1.00
104_A	130_S	1.379	1.00
37_Y	60_G	1.376	1.00
125_S	129_E	1.371	1.00
97_T	131_P	1.355	1.00
31_A	102_D	1.307	1.00
84_T	95_Y	1.286	1.00
7_V	19_V	1.285	1.00
22_A	26_A	1.242	1.00
96_V	131_P	1.240	1.00
61_Q	65_D	1.238	1.00
57_Q	61_Q	1.232	1.00
65_D	68_V	1.214	1.00
96_V	132_V	1.202	1.00
88_P	122_I	1.199	1.00
70_R	74_A	1.195	1.00
104_A	126_V	1.167	1.00
4_R	102_D	1.166	1.00
36_L	84_T	1.141	1.00
95_Y	101_I	1.110	1.00
38_V	88_P	1.095	1.00
130_S	134_V	1.074	1.00
60_G	63_A	1.055	1.00
11_G	37_Y	1.031	1.00
4_R	101_I	1.022	1.00
5_V	103_I	1.022	1.00
114_E	118_L	1.020	1.00
39_V	85_R	1.018	1.00
63_A	67_I	1.017	1.00
96_V	101_I	1.006	1.00
108_T	136_L	1.001	1.00
21_H	137_V	1.000	1.00
106_M	123_S	0.992	1.00
93_L	96_V	0.986	1.00
70_R	73_D	0.962	1.00
56_V	59_A	0.959	1.00
116_R	124_E	0.942	1.00
53_L	57_Q	0.935	1.00
21_H	25_I	0.933	1.00
64_V	81_A	0.920	1.00
22_A	105_V	0.915	1.00
60_G	64_V	0.914	1.00
19_V	67_I	0.914	1.00
65_D	69_K	0.911	1.00
65_D	81_A	0.908	1.00
54_H	58_E	0.908	1.00
9_T	67_I	0.908	1.00
24_D	28_Q	0.906	1.00
37_Y	63_A	0.906	1.00
48_P	51_D	0.895	1.00
63_A	66_R	0.894	1.00
127_V	136_L	0.884	1.00
67_I	70_R	0.882	1.00
29_Y	102_D	0.880	1.00
19_V	35_T	0.879	1.00
113_G	116_R	0.866	1.00
58_E	62_K	0.865	1.00
26_A	33_L	0.860	1.00
6_L	95_Y	0.851	1.00
123_S	136_L	0.850	1.00
15_T	18_A	0.842	1.00
12_S	15_T	0.842	1.00
6_L	36_L	0.841	1.00
67_I	71_A	0.837	1.00
16_N	66_R	0.837	1.00
36_L	92_I	0.836	1.00
108_T	123_S	0.835	1.00
22_A	33_L	0.831	1.00
87_V	90_T	0.828	1.00
23_I	76_V	0.823	1.00
9_T	18_A	0.820	1.00
23_I	74_A	0.816	1.00
49_D	52_P	0.816	1.00
39_V	83_V	0.814	1.00
16_N	20_T	0.813	1.00
21_H	133_P	0.813	1.00
35_T	79_V	0.812	1.00
21_H	24_D	0.812	1.00
17_E	20_T	0.809	1.00
35_T	67_I	0.805	1.00
111_R	115_S	0.796	1.00
20_T	74_A	0.795	1.00
66_R	70_R	0.795	1.00
93_L	130_S	0.789	1.00
64_V	68_V	0.781	1.00
105_V	135_L	0.777	1.00
71_A	74_A	0.774	1.00
6_L	104_A	0.774	1.00
26_A	31_A	0.771	1.00
9_T	35_T	0.769	1.00
69_K	72_Q	0.754	1.00
62_K	66_R	0.753	1.00
26_A	29_Y	0.751	1.00
27_E	75_G	0.750	1.00
60_G	83_V	0.750	1.00
66_R	69_K	0.748	1.00
93_L	126_V	0.740	1.00
9_T	16_N	0.736	1.00
9_T	19_V	0.729	1.00
23_I	71_A	0.729	1.00
50_D	54_H	0.725	1.00
69_K	73_D	0.718	1.00
7_V	33_L	0.717	1.00
58_E	61_Q	0.716	1.00
55_R	58_E	0.714	1.00
59_A	63_A	0.712	1.00
56_V	60_G	0.709	1.00
19_V	23_I	0.705	1.00
8_P	107_A	0.701	1.00
16_N	67_I	0.698	1.00
59_A	62_K	0.698	1.00
113_G	117_D	0.692	1.00
92_I	126_V	0.687	1.00
57_Q	85_R	0.682	1.00
55_R	59_A	0.681	1.00
25_I	28_Q	0.679	1.00
89_A	122_I	0.673	1.00
24_D	27_E	0.668	1.00
51_D	55_R	0.666	1.00
71_A	79_V	0.661	1.00
110_G	119_L	0.660	1.00
52_P	55_R	0.657	1.00
91_E	95_Y	0.654	1.00
89_A	93_L	0.638	1.00
100_E	132_V	0.633	1.00
23_I	27_E	0.630	1.00
82_T	85_R	0.629	1.00
105_V	137_V	0.626	1.00
24_D	74_A	0.621	1.00
53_L	85_R	0.619	1.00
36_L	91_E	0.617	1.00
114_E	117_D	0.615	1.00
12_S	110_G	0.615	1.00
11_G	67_I	0.613	1.00
50_D	53_L	0.606	1.00
126_V	134_V	0.605	1.00
39_V	60_G	0.604	1.00
35_T	71_A	0.602	1.00
14_G	17_E	0.600	1.00
9_T	15_T	0.596	1.00
49_D	53_L	0.596	1.00
61_Q	81_A	0.596	1.00
64_V	70_R	0.592	1.00
107_A	137_V	0.590	1.00
54_H	57_Q	0.586	1.00
106_M	136_L	0.585	1.00
64_V	67_I	0.584	1.00
27_E	74_A	0.581	1.00
62_K	65_D	0.581	1.00
11_G	63_A	0.580	1.00
5_V	105_V	0.579	1.00
51_D	54_H	0.575	1.00
7_V	18_A	0.574	1.00
22_A	31_A	0.567	1.00
25_I	31_A	0.555	1.00
97_T	132_V	0.554	1.00
109_A	123_S	0.550	1.00
119_L	123_S	0.549	1.00
90_T	94_T	0.548	1.00
43_R	46_E	0.546	1.00
89_A	126_V	0.543	1.00
89_A	129_E	0.542	1.00
93_L	125_S	0.538	1.00
5_V	26_A	0.533	1.00
68_V	79_V	0.529	1.00
42_T	45_N	0.528	1.00
108_T	118_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mjhA	2	0.958	99.9	0.133	Contact Map
5ahwA	4	0.979	99.9	0.136	Contact Map
3hgmA	2	0.951	99.9	0.142	Contact Map
4wnyA	2	0.8601	99.9	0.143	Contact Map
2gm3A	2	0.8811	99.9	0.143	Contact Map
2dumA	2	0.965	99.9	0.143	Contact Map
3s3tA	4	0.965	99.9	0.144	Contact Map
3fg9A	3	0.958	99.9	0.176	Contact Map
1tq8A	4	0.8671	99.9	0.177	Contact Map
3loqA	1	0.972	99.9	0.18	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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