GREMLIN Database
Q9HPF4 - Uncharacterized protein
UniProt: Q9HPF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (346)
Sequences: 208 (143)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R98_E3.6000.94
135_V158_V3.5770.94
135_V156_L3.3870.92
158_V202_V3.1870.89
213_A236_V3.0830.88
169_V205_E2.9370.85
135_V249_L2.7870.82
160_D163_G2.5230.74
34_G37_V2.4470.72
217_D225_D2.3810.70
96_V210_V2.3170.68
245_V256_R2.3000.67
135_V202_V2.2800.66
211_K231_Y2.2720.66
104_G167_G2.2650.66
132_V170_T2.2560.66
82_T292_V2.2470.65
105_V111_I2.2200.64
14_V26_L2.2190.64
74_S106_I2.1850.63
36_I249_L2.1770.63
135_V139_D2.1400.61
28_E31_N2.1200.60
338_E355_R2.1200.60
93_I193_E2.0720.59
17_E29_R2.0520.58
14_V37_V2.0510.58
73_V81_E2.0500.58
337_G355_R2.0370.57
15_D26_L2.0150.56
167_G206_M2.0110.56
124_V222_A2.0090.56
135_V254_V1.9830.55
99_A289_E1.9770.55
126_D289_E1.9720.55
141_M221_D1.9710.55
117_A224_D1.9650.54
20_L30_E1.9560.54
50_R156_L1.9480.54
338_E341_G1.9390.53
140_S216_D1.9030.52
144_V168_I1.8980.52
96_V255_L1.8860.51
139_D143_R1.8680.50
127_I245_V1.8440.50
34_G39_E1.8310.49
32_P43_Y1.8060.48
337_G341_G1.8020.48
64_A141_M1.7850.47
258_L305_V1.7520.46
10_D24_R1.7440.46
63_V67_V1.7420.45
105_V131_H1.6850.43
188_G192_G1.6740.43
167_G173_D1.6740.43
158_V265_H1.6670.42
141_M246_G1.6580.42
304_H357_V1.6570.42
26_L35_V1.6270.41
110_A248_I1.6090.40
294_K298_M1.6060.40
76_T123_D1.5930.40
140_S324_I1.5920.40
15_D139_D1.5810.39
145_I174_I1.5800.39
82_T128_Y1.5630.38
32_P36_I1.5510.38
73_V288_I1.5490.38
156_L247_G1.5460.38
326_L353_L1.5400.38
10_D14_V1.5380.38
42_A147_L1.5330.37
10_D40_A1.5310.37
217_D297_D1.5300.37
26_L39_E1.5150.37
353_L357_V1.5060.36
141_M152_G1.5040.36
168_I231_Y1.5010.36
184_K189_D1.5010.36
316_G319_L1.4900.36
75_R94_A1.4670.35
146_N150_E1.4580.35
42_A240_D1.4460.34
92_K335_G1.4450.34
22_K29_R1.4330.34
77_E82_T1.4220.33
24_R32_P1.4120.33
138_D255_L1.4110.33
155_R233_G1.3930.32
168_I193_E1.3920.32
64_A73_V1.3910.32
122_L213_A1.3880.32
81_E257_A1.3870.32
315_R319_L1.3840.32
119_L268_V1.3700.31
170_T174_I1.3610.31
36_I218_S1.3420.30
101_S280_S1.3280.30
97_F103_W1.3230.30
233_G245_V1.3200.30
39_E67_V1.3110.29
35_V40_A1.3070.29
316_G328_T1.3040.29
319_L338_E1.3010.29
213_A217_D1.3000.29
73_V128_Y1.2940.29
34_G38_T1.2900.29
129_T313_K1.2860.29
69_D135_V1.2810.28
182_T299_D1.2770.28
81_E86_L1.2710.28
300_V303_A1.2510.27
20_L26_L1.2480.27
325_R331_G1.2330.27
170_T219_V1.2320.27
280_S283_E1.2280.27
286_E290_N1.2230.27
16_A38_T1.2230.27
33_K41_G1.2150.26
19_R29_R1.2140.26
53_I139_D1.2140.26
108_E232_S1.2120.26
12_V34_G1.2080.26
51_Q307_L1.2040.26
48_T186_T1.2020.26
15_D105_V1.2000.26
12_V26_L1.1960.26
60_D77_E1.1930.26
131_H156_L1.1900.26
239_D330_K1.1880.26
208_S288_I1.1870.25
319_L331_G1.1810.25
73_V101_S1.1680.25
61_T165_L1.1590.25
83_A113_D1.1580.25
15_D38_T1.1510.24
113_D244_A1.1500.24
315_R341_G1.1490.24
86_L111_I1.1430.24
24_R38_T1.1410.24
162_A218_S1.1390.24
215_F321_Q1.1350.24
310_H318_P1.1320.24
201_P256_R1.1300.24
119_L209_P1.1230.24
306_R323_Q1.1150.23
184_K187_V1.1100.23
161_D333_I1.1080.23
344_N347_H1.1070.23
29_R40_A1.1020.23
163_G213_A1.0950.23
14_V148_L1.0940.23
37_V106_I1.0940.23
341_G345_S1.0930.23
141_M224_D1.0930.23
21_G232_S1.0870.23
64_A162_A1.0830.22
26_L34_G1.0710.22
270_I335_G1.0690.22
74_S77_E1.0660.22
38_T41_G1.0640.22
68_T240_D1.0630.22
144_V156_L1.0600.22
302_H305_V1.0520.22
168_I232_S1.0520.22
159_V184_K1.0500.22
334_A357_V1.0490.21
46_V98_E1.0440.21
32_P38_T1.0430.21
10_D38_T1.0420.21
79_V237_T1.0400.21
61_T66_M1.0380.21
232_S333_I1.0380.21
337_G342_A1.0340.21
73_V133_V1.0340.21
16_A39_E1.0280.21
266_L276_L1.0260.21
215_F248_I1.0190.21
312_E326_L1.0080.20
195_E296_G1.0070.20
94_A132_V1.0060.20
14_V19_R1.0000.20
24_R28_E0.9970.20
343_D346_F0.9920.20
346_F357_V0.9910.20
76_T205_E0.9900.20
141_M158_V0.9890.20
52_L209_P0.9830.20
186_T231_Y0.9810.20
16_A20_L0.9770.20
25_S31_N0.9760.20
341_G349_A0.9720.19
14_V36_I0.9620.19
300_V304_H0.9570.19
17_E52_L0.9530.19
10_D33_K0.9520.19
144_V282_Q0.9510.19
148_L258_L0.9510.19
15_D98_E0.9510.19
39_E42_A0.9510.19
143_R181_D0.9470.19
128_Y138_D0.9430.19
16_A25_S0.9400.19
31_N60_D0.9400.19
194_I347_H0.9390.19
175_V178_V0.9320.18
74_S101_S0.9300.18
15_D40_A0.9280.18
11_Y18_Q0.9240.18
18_Q29_R0.9230.18
26_L30_E0.9200.18
157_P165_L0.9190.18
315_R318_P0.9180.18
35_V213_A0.9170.18
78_D255_L0.9150.18
138_D160_D0.9110.18
73_V238_P0.9080.18
16_A40_A0.9070.18
117_A165_L0.9060.18
147_L160_D0.9050.18
300_V324_I0.9040.18
233_G349_A0.9020.18
210_V245_V0.9000.18
165_L234_V0.9000.18
25_S29_R0.8980.18
178_V212_T0.8920.18
339_G353_L0.8910.18
96_V319_L0.8890.17
125_R164_L0.8830.17
150_E199_D0.8830.17
167_G213_A0.8820.17
177_F347_H0.8820.17
74_S224_D0.8810.17
160_D213_A0.8810.17
48_T74_S0.8800.17
73_V215_F0.8790.17
19_R59_D0.8720.17
31_N37_V0.8710.17
353_L356_N0.8640.17
73_V77_E0.8600.17
29_R38_T0.8600.17
189_D192_G0.8560.17
19_R31_N0.8540.17
249_L255_L0.8530.17
311_K315_R0.8530.17
245_V254_V0.8500.17
24_R30_E0.8430.16
47_I228_A0.8420.16
15_D25_S0.8380.16
54_Q57_I0.8380.16
71_P83_A0.8380.16
141_M159_V0.8370.16
64_A248_I0.8340.16
124_V305_V0.8300.16
228_A342_A0.8280.16
113_D135_V0.8280.16
40_A131_H0.8270.16
141_M197_L0.8270.16
15_D28_E0.8250.16
276_L294_K0.8210.16
341_G355_R0.8200.16
249_L259_S0.8180.16
111_I247_G0.8170.16
77_E246_G0.8150.16
79_V346_F0.8140.16
123_D126_D0.8100.16
134_T197_L0.8070.16
249_L273_I0.8030.16
236_V262_E0.8020.16
71_P236_V0.8000.16
282_Q289_E0.7980.15
86_L105_V0.7960.15
125_R239_D0.7960.15
150_E163_G0.7950.15
326_L339_G0.7940.15
199_D267_D0.7940.15
160_D166_S0.7920.15
232_S283_E0.7920.15
169_V214_S0.7920.15
28_E33_K0.7910.15
140_S161_D0.7910.15
24_R36_I0.7900.15
128_Y231_Y0.7890.15
95_P247_G0.7890.15
22_K38_T0.7880.15
124_V236_V0.7860.15
326_L334_A0.7840.15
108_E339_G0.7820.15
23_V47_I0.7790.15
63_V132_V0.7780.15
16_A28_E0.7760.15
162_A187_V0.7710.15
28_E35_V0.7710.15
43_Y95_P0.7680.15
15_D23_V0.7670.15
138_D184_K0.7670.15
54_Q211_K0.7660.15
88_E337_G0.7630.15
51_Q160_D0.7610.15
17_E30_E0.7610.15
23_V31_N0.7570.15
94_A230_D0.7570.15
155_R170_T0.7540.15
310_H319_L0.7540.15
215_F255_L0.7530.15
30_E34_G0.7510.15
235_I245_V0.7480.14
119_L201_P0.7460.14
222_A324_I0.7450.14
315_R320_I0.7450.14
315_R331_G0.7430.14
319_L349_A0.7400.14
13_E35_V0.7390.14
83_A158_V0.7360.14
75_R103_W0.7360.14
270_I274_D0.7350.14
22_K33_K0.7340.14
88_E281_R0.7340.14
222_A249_L0.7340.14
14_V152_G0.7320.14
248_I287_R0.7320.14
135_V147_L0.7300.14
188_G191_S0.7280.14
12_V107_T0.7280.14
40_A73_V0.7280.14
15_D42_A0.7270.14
20_L44_D0.7220.14
240_D297_D0.7220.14
63_V217_D0.7210.14
19_R39_E0.7210.14
100_G274_D0.7190.14
52_L104_G0.7180.14
174_I251_K0.7170.14
63_V158_V0.7170.14
28_E32_P0.7140.14
145_I160_D0.7140.14
76_T101_S0.7130.14
24_R34_G0.7130.14
26_L29_R0.7120.14
174_I236_V0.7110.14
35_V38_T0.7100.14
194_I205_E0.7090.14
22_K34_G0.7070.14
29_R59_D0.7070.14
287_R346_F0.7060.14
138_D164_L0.7040.14
78_D156_L0.7020.14
15_D73_V0.7020.14
193_E333_I0.7020.14
104_G169_V0.7010.14
26_L50_R0.7000.14
168_I202_V0.6990.14
18_Q39_E0.6980.13
162_A280_S0.6970.13
161_D324_I0.6960.13
10_D36_I0.6920.13
124_V128_Y0.6900.13
20_L28_E0.6880.13
338_E344_N0.6880.13
15_D54_Q0.6870.13
65_A208_S0.6840.13
113_D161_D0.6830.13
12_V36_I0.6820.13
249_L321_Q0.6760.13
110_A249_L0.6760.13
105_V228_A0.6730.13
18_Q40_A0.6730.13
209_P268_V0.6720.13
117_A132_V0.6700.13
170_T350_L0.6680.13
219_V332_Q0.6660.13
271_T276_L0.6650.13
12_V22_K0.6640.13
63_V117_A0.6610.13
144_V231_Y0.6610.13
162_A240_D0.6600.13
131_H162_A0.6580.13
83_A226_M0.6580.13
78_D111_I0.6570.13
26_L38_T0.6550.13
328_T331_G0.6530.13
17_E140_S0.6530.13
53_I56_H0.6520.13
172_Y182_T0.6510.13
310_H326_L0.6490.13
12_V30_E0.6440.13
18_Q21_G0.6440.13
153_I240_D0.6420.12
213_A244_A0.6400.12
126_D247_G0.6380.12
62_R345_S0.6360.12
316_G338_E0.6350.12
169_V329_N0.6350.12
84_R126_D0.6340.12
319_L341_G0.6340.12
12_V44_D0.6340.12
15_D64_A0.6310.12
186_T344_N0.6300.12
312_E337_G0.6290.12
26_L40_A0.6290.12
158_V169_V0.6260.12
33_K111_I0.6250.12
195_E237_T0.6250.12
120_D169_V0.6240.12
214_S217_D0.6220.12
185_T191_S0.6220.12
144_V158_V0.6210.12
319_L337_G0.6200.12
312_E355_R0.6190.12
30_E38_T0.6170.12
254_V308_S0.6150.12
175_V218_S0.6140.12
325_R329_N0.6140.12
137_E203_S0.6110.12
20_L23_V0.6100.12
205_E288_I0.6100.12
243_R255_L0.6090.12
273_I334_A0.6080.12
63_V75_R0.6070.12
36_I113_D0.6070.12
222_A325_R0.6060.12
83_A149_R0.6050.12
92_K320_I0.6050.12
166_S177_F0.6040.12
192_G355_R0.6040.12
152_G178_V0.6030.12
79_V224_D0.6010.12
152_G198_L0.5980.12
316_G326_L0.5960.12
10_D284_V0.5950.12
194_I356_N0.5940.12
266_L272_N0.5930.12
323_Q352_K0.5890.12
54_Q61_T0.5890.12
88_E338_E0.5880.12
67_V130_E0.5860.12
165_L210_V0.5860.12
23_V29_R0.5850.12
10_D143_R0.5850.12
173_D209_P0.5830.11
135_V143_R0.5820.11
103_W213_A0.5810.11
34_G174_I0.5810.11
73_V79_V0.5800.11
145_I205_E0.5790.11
18_Q30_E0.5780.11
18_Q33_K0.5760.11
218_S330_K0.5750.11
166_S333_I0.5730.11
28_E38_T0.5720.11
249_L308_S0.5710.11
345_S354_E0.5710.11
27_F55_S0.5690.11
95_P112_L0.5690.11
233_G256_R0.5690.11
23_V205_E0.5690.11
48_T231_Y0.5690.11
94_A245_V0.5680.11
36_I41_G0.5680.11
95_P111_I0.5660.11
73_V255_L0.5650.11
337_G354_E0.5640.11
348_V351_D0.5640.11
19_R25_S0.5620.11
239_D293_A0.5620.11
24_R58_G0.5620.11
223_V284_V0.5590.11
134_T263_E0.5580.11
138_D221_D0.5570.11
267_D271_T0.5560.11
62_R66_M0.5550.11
124_V325_R0.5550.11
25_S41_G0.5540.11
17_E40_A0.5500.11
98_E137_E0.5470.11
23_V249_L0.5460.11
201_P252_T0.5450.11
140_S152_G0.5450.11
20_L35_V0.5420.11
12_V274_D0.5410.11
140_S243_R0.5400.11
324_I329_N0.5380.11
231_Y336_T0.5380.11
144_V169_V0.5350.11
153_I247_G0.5300.11
53_I169_V0.5290.11
86_L317_T0.5290.11
37_V77_E0.5290.11
90_G347_H0.5280.11
77_E250_T0.5270.11
332_Q335_G0.5250.11
10_D19_R0.5250.11
264_E348_V0.5250.11
11_Y36_I0.5250.11
119_L255_L0.5240.11
73_V143_R0.5210.11
119_L294_K0.5200.10
82_T329_N0.5200.10
149_R202_V0.5190.10
211_K225_D0.5170.10
45_G154_S0.5150.10
63_V76_T0.5150.10
170_T173_D0.5150.10
10_D279_L0.5140.10
134_T137_E0.5140.10
20_L27_F0.5140.10
105_V236_V0.5140.10
218_S270_I0.5130.10
219_V233_G0.5130.10
105_V278_T0.5080.10
352_K356_N0.5080.10
111_I333_I0.5060.10
22_K41_G0.5060.10
66_M156_L0.5050.10
194_I344_N0.5020.10
140_S187_V0.5020.10
231_Y347_H0.5010.10
176_D305_V0.5000.10
130_E135_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzqA 2 0.5737 100 0.616 Contact Map
2qrdG 1 0.6737 100 0.622 Contact Map
3t4nC 1 0.6474 100 0.625 Contact Map
3kh5A 1 0.6684 100 0.63 Contact Map
3ddjA 1 0.6842 100 0.632 Contact Map
2v8qE 1 0.6553 100 0.635 Contact Map
4af0A 3 0.6211 100 0.739 Contact Map
3l2bA 2 0.3474 99.9 0.76 Contact Map
5ahnA 3 0.4921 99.9 0.764 Contact Map
1vrdA 3 0.5395 99.9 0.77 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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