GREMLIN Database
Q9HPF1 - Uncharacterized protein
UniProt: Q9HPF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (239)
Sequences: 56260 (37782)
Seq/√Len: 2443.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_R177_D2.7601.00
178_A193_A2.6841.00
191_F243_L2.6141.00
64_P68_D2.5671.00
85_A179_I2.5391.00
49_T183_A2.4771.00
8_D29_T2.3541.00
19_R180_T2.3181.00
52_V84_Y2.2311.00
238_P242_E2.1891.00
134_V179_I2.1541.00
19_R23_T2.1221.00
51_I183_A2.1141.00
241_T247_T2.0681.00
201_Y205_E2.0671.00
99_R102_D2.0581.00
31_F37_D2.0031.00
71_S120_H1.9921.00
199_S202_E1.9751.00
121_V129_G1.9501.00
6_V52_V1.9501.00
132_L182_L1.9101.00
23_T180_T1.8611.00
115_Q119_D1.8291.00
177_D181_E1.8131.00
196_P241_T1.7651.00
68_D71_S1.7391.00
16_L176_A1.7361.00
180_T184_E1.7341.00
23_T184_E1.7161.00
39_A76_A1.6751.00
70_V117_F1.6741.00
5_V17_A1.6721.00
206_R209_S1.6661.00
71_S75_D1.6541.00
152_D156_G1.6331.00
16_L51_I1.6291.00
206_R210_A1.6121.00
16_L53_T1.6081.00
100_P239_R1.5861.00
12_L137_C1.5621.00
53_T85_A1.5361.00
19_R22_V1.5231.00
86_S90_V1.5221.00
237_G241_T1.5131.00
181_E185_T1.5081.00
81_R130_V1.5021.00
110_T114_I1.4981.00
34_F64_P1.4961.00
50_V77_C1.4951.00
19_R176_A1.4871.00
104_R115_Q1.4591.00
135_S235_L1.4551.00
166_Y197_R1.4551.00
85_A134_V1.4511.00
28_P45_H1.4311.00
170_V175_V1.4281.00
48_D80_R1.4271.00
134_V175_V1.4231.00
74_V124_H1.4221.00
125_D129_G1.4171.00
37_D40_A1.4031.00
40_A44_A1.4001.00
119_D122_D1.3841.00
8_D17_A1.3841.00
122_D131_V1.3791.00
78_A128_N1.3791.00
168_S196_P1.3711.00
132_L179_I1.3281.00
51_I179_I1.3221.00
112_R116_V1.3201.00
172_V176_A1.3031.00
24_A27_H1.2991.00
239_R243_L1.2951.00
84_Y117_F1.2941.00
202_E205_E1.2901.00
18_A141_D1.2761.00
19_R173_T1.2711.00
98_Y102_D1.2671.00
20_A180_T1.2671.00
15_A172_V1.2551.00
15_A173_T1.2531.00
4_L45_H1.2371.00
237_G248_V1.2311.00
138_Y171_H1.2261.00
56_V65_A1.2221.00
52_V70_V1.2191.00
84_Y131_V1.2151.00
99_R236_A1.2131.00
66_Y113_R1.2131.00
75_D78_A1.2121.00
3_A25_T1.2101.00
120_H123_R1.2081.00
194_P235_L1.2061.00
122_D190_V1.1761.00
25_T29_T1.1751.00
83_V132_L1.1671.00
77_C82_L1.1661.00
149_A153_A1.1651.00
33_V69_A1.1631.00
25_T184_E1.1591.00
74_V82_L1.1521.00
40_A43_A1.1501.00
91_F192_H1.1401.00
208_L214_D1.1341.00
84_Y121_V1.1201.00
73_L82_L1.1201.00
149_A152_D1.1141.00
171_H174_D1.1131.00
75_D124_H1.1081.00
133_R190_V1.1041.00
122_D129_G1.1001.00
67_V116_V1.0961.00
158_A219_T1.0891.00
65_A69_A1.0891.00
68_D72_A1.0891.00
118_E133_R1.0871.00
14_A141_D1.0811.00
101_D239_R1.0751.00
197_R234_S1.0721.00
208_L215_T1.0691.00
130_V182_L1.0681.00
205_E208_L1.0611.00
174_D195_G1.0601.00
3_A20_A1.0551.00
82_L121_V1.0521.00
166_Y199_S1.0511.00
198_L202_E1.0501.00
24_A28_P1.0501.00
25_T28_P1.0451.00
181_E184_E1.0381.00
3_A49_T1.0341.00
42_I76_A1.0331.00
137_C175_V1.0251.00
15_A18_A1.0211.00
53_T179_I1.0201.00
38_P76_A1.0141.00
11_P172_V1.0061.00
191_F239_R1.0031.00
72_A75_D1.0021.00
18_A22_V1.0011.00
194_P237_G0.9901.00
197_R232_D0.9901.00
238_P241_T0.9831.00
6_V73_L0.9801.00
49_T81_R0.9791.00
133_R192_H0.9771.00
177_D180_T0.9761.00
131_V190_V0.9751.00
116_V119_D0.9601.00
74_V121_V0.9591.00
193_A240_F0.9571.00
33_V54_A0.9561.00
36_D40_A0.9541.00
70_V121_V0.9521.00
11_P139_A0.9401.00
37_D41_H0.9381.00
132_L193_A0.9341.00
41_H45_H0.9291.00
42_I50_V0.9271.00
42_I45_H0.9261.00
166_Y232_D0.9221.00
137_C170_V0.9201.00
78_A124_H0.9201.00
16_L20_A0.9201.00
78_A127_D0.9201.00
239_R242_E0.9191.00
88_G135_S0.9101.00
72_A76_A0.9101.00
182_L240_F0.8971.00
70_V74_V0.8941.00
178_A240_F0.8941.00
86_S118_E0.8871.00
160_Q221_A0.8851.00
81_R186_D0.8841.00
124_H128_N0.8791.00
140_T171_H0.8791.00
208_L213_V0.8701.00
39_A43_A0.8701.00
154_L208_L0.8661.00
50_V73_L0.8661.00
152_D155_D0.8611.00
34_F65_A0.8541.00
3_A51_I0.8531.00
122_D126_T0.8521.00
6_V54_A0.8501.00
187_H243_L0.8481.00
116_V120_H0.8381.00
148_A152_D0.8361.00
202_E206_R0.8351.00
52_V73_L0.8281.00
15_A19_R0.8261.00
3_A183_A0.8261.00
119_D123_R0.8241.00
88_G235_L0.8191.00
92_D105_T0.8181.00
96_G102_D0.8171.00
24_A29_T0.8101.00
17_A29_T0.8071.00
181_E245_D0.8001.00
177_D246_A0.8001.00
36_D39_A0.7991.00
32_D35_A0.7981.00
196_P237_G0.7981.00
74_V120_H0.7941.00
42_I77_C0.7931.00
221_A224_P0.7921.00
135_S194_P0.7861.00
160_Q163_D0.7841.00
212_G215_T0.7781.00
112_R119_D0.7651.00
109_D112_R0.7641.00
112_R123_R0.7621.00
69_A72_A0.7611.00
241_T248_V0.7591.00
90_V118_E0.7551.00
15_A176_A0.7551.00
97_D236_A0.7521.00
108_D111_G0.7481.00
198_L203_L0.7471.00
100_P240_F0.7421.00
95_D102_D0.7421.00
151_R155_D0.7401.00
123_R127_D0.7391.00
12_L175_V0.7381.00
96_G232_D0.7381.00
94_T98_Y0.7361.00
176_A180_T0.7321.00
14_A18_A0.7321.00
161_R164_D0.7281.00
132_L178_A0.7271.00
16_L179_I0.7261.00
26_S29_T0.7211.00
122_D125_D0.7181.00
134_V137_C0.7151.00
136_S167_R0.7141.00
63_I109_D0.7131.00
38_P72_A0.7101.00
71_S124_H0.7081.00
205_E209_S0.7061.00
15_A141_D0.7041.00
158_A221_A0.6961.00
160_Q219_T0.6951.00
4_L50_V0.6921.00
120_H124_H0.6911.00
83_V179_I0.6891.00
83_V183_A0.6771.00
117_F121_V0.6761.00
31_F38_P0.6761.00
49_T80_R0.6731.00
204_H208_L0.6721.00
165_V200_V0.6711.00
125_D188_T0.6711.00
23_T181_E0.6711.00
174_D177_D0.6701.00
23_T177_D0.6701.00
113_R117_F0.6681.00
50_V82_L0.6681.00
106_P111_G0.6661.00
20_A183_A0.6661.00
157_G213_V0.6641.00
230_A233_R0.6641.00
150_A154_L0.6641.00
178_A246_A0.6631.00
198_L206_R0.6631.00
168_S195_G0.6631.00
147_L150_A0.6621.00
15_A140_T0.6621.00
31_F41_H0.6541.00
240_F248_V0.6541.00
142_P146_Q0.6481.00
77_C80_R0.6481.00
160_Q164_D0.6461.00
4_L41_H0.6451.00
25_T48_D0.6451.00
31_F35_A0.6431.00
4_L42_I0.6431.00
89_A111_G0.6411.00
97_D234_S0.6401.00
153_A157_G0.6371.00
56_V66_Y0.6361.00
90_V104_R0.6351.00
41_H44_A0.6331.00
70_V73_L0.6321.00
67_V71_S0.6311.00
106_P115_Q0.6311.00
100_P192_H0.6311.00
153_A156_G0.6301.00
121_V131_V0.6281.00
21_G27_H0.6261.00
52_V82_L0.6261.00
151_R207_V0.6241.00
142_P145_P0.6231.00
49_T83_V0.6231.00
21_G24_A0.6231.00
130_V191_F0.6221.00
17_A21_G0.6211.00
38_P42_I0.6181.00
123_R126_T0.6141.00
83_V182_L0.6131.00
16_L180_T0.6111.00
148_A153_A0.6071.00
181_E246_A0.6041.00
150_A153_A0.5991.00
99_R238_P0.5981.00
191_F240_F0.5971.00
5_V20_A0.5941.00
20_A25_T0.5901.00
166_Y234_S0.5891.00
18_A173_T0.5881.00
187_H191_F0.5851.00
189_G239_R0.5811.00
135_S168_S0.5811.00
175_V193_A0.5791.00
168_S197_R0.5791.00
237_G246_A0.5771.00
125_D128_N0.5771.00
93_G107_C0.5731.00
58_T61_V0.5691.00
55_P66_Y0.5681.00
180_T183_A0.5651.00
35_A38_P0.5631.00
151_R211_L0.5631.00
67_V120_H0.5601.00
90_V133_R0.5571.00
186_D189_G0.5561.00
104_R119_D0.5551.00
25_T49_T0.5501.00
67_V113_R0.5491.00
42_I73_L0.5471.00
208_L211_L0.5461.00
59_A62_P0.5451.00
28_P44_A0.5441.00
87_T114_I0.5441.00
81_R188_T0.5391.00
11_P15_A0.5361.00
140_T173_T0.5351.00
167_R200_V0.5301.00
130_V188_T0.5281.00
130_V186_D0.5281.00
53_T134_V0.5261.00
226_D229_I0.5261.00
17_A27_H0.5201.00
70_V84_Y0.5191.00
93_G231_R0.5191.00
138_Y195_G0.5171.00
181_E243_L0.5161.00
74_V78_A0.5161.00
237_G240_F0.5151.00
109_D113_R0.5151.00
38_P41_H0.5131.00
159_C162_H0.5131.00
240_F243_L0.5121.00
73_L77_C0.5121.00
4_L31_F0.5021.00
153_A160_Q0.5021.00
86_S133_R0.5011.00
136_S169_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i24A 4 0.9922 100 0.292 Contact Map
2pzmA 2 0.9843 100 0.302 Contact Map
1rpnA 4 1 100 0.303 Contact Map
1n7hA 4 1 100 0.303 Contact Map
1rkxA 3 0.9725 100 0.303 Contact Map
2z1mA 4 1 100 0.307 Contact Map
1vl0A 3 0.9843 100 0.308 Contact Map
2yy7A 2 0.9922 100 0.309 Contact Map
3wmwA 2 0.9451 100 0.311 Contact Map
2pk3A 2 0.9882 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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