GREMLIN Database
Q9HPE4 - GTP-binding protein homolog
UniProt: Q9HPE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 540 (442)
Sequences: 4373 (2581)
Seq/√Len: 122.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_L347_L5.4471.00
413_M416_H4.6381.00
522_F531_G4.0171.00
452_P456_R3.7691.00
218_R349_A3.6581.00
153_S338_G3.6071.00
484_I490_F3.4211.00
388_E420_S3.4171.00
455_V459_D3.3501.00
294_E332_R3.0701.00
153_S341_L2.8161.00
398_F437_E2.7571.00
329_P346_E2.6361.00
30_R34_L2.6261.00
458_F462_V2.6041.00
92_G95_I2.6011.00
305_E308_P2.5311.00
421_A427_V2.5091.00
456_R459_D2.4771.00
254_D284_L2.4631.00
41_S45_Q2.3791.00
282_T339_D2.3551.00
156_T338_G2.3351.00
262_R266_G2.3151.00
266_G511_F2.3091.00
459_D462_V2.2591.00
243_K364_Y2.2431.00
380_G445_L2.2081.00
279_V332_R2.1881.00
463_M466_N2.1501.00
279_V330_I2.1471.00
359_G384_S2.1431.00
280_T335_A2.1221.00
125_G356_A2.1011.00
249_L277_V2.0991.00
268_L275_T2.0921.00
34_L38_R2.0621.00
292_A296_E2.0571.00
304_T308_P2.0501.00
302_R309_L2.0261.00
455_V458_F2.0171.00
25_K33_H2.0131.00
56_E108_D2.0061.00
302_R306_R1.9921.00
132_D218_R1.9921.00
462_V465_L1.9891.00
184_D486_E1.9541.00
300_L306_R1.9481.00
38_R42_L1.9401.00
27_R31_D1.9261.00
332_R339_D1.9241.00
306_R309_L1.9201.00
452_P459_D1.9201.00
304_T307_A1.8871.00
154_L341_L1.8761.00
517_E533_G1.8071.00
47_R51_L1.7761.00
189_V219_V1.7601.00
66_D70_A1.7331.00
306_R328_V1.7291.00
42_L46_L1.7261.00
452_P455_V1.6991.00
189_V425_R1.6961.00
131_G357_A1.6761.00
40_E44_A1.6761.00
422_Q425_R1.6701.00
288_D291_A1.6631.00
37_G41_S1.6581.00
25_K28_F1.6501.00
41_S44_A1.6261.00
35_A39_L1.6051.00
300_L304_T1.5951.00
100_T107_G1.5951.00
458_F461_E1.5841.00
26_E30_R1.5821.00
461_E465_L1.5791.00
126_D129_A1.5751.00
36_E40_E1.5711.00
476_E480_H1.5711.00
389_D419_D1.5681.00
468_P471_I1.5671.00
215_A218_R1.5591.00
39_L43_T1.5421.00
293_V297_V1.5361.00
70_A105_S1.5211.00
454_P457_A1.5201.00
459_D465_L1.5141.00
300_L308_P1.5101.00
129_A358_S1.5071.00
131_G358_S1.5051.00
455_V462_V1.5021.00
214_E219_V1.4981.00
80_T83_V1.4911.00
31_D35_A1.4841.00
43_T47_R1.4821.00
304_T309_L1.4781.00
459_D464_V1.4741.00
457_A461_E1.4711.00
300_L307_A1.4671.00
91_A96_A1.4531.00
308_P328_V1.4491.00
471_I474_G1.4431.00
453_T457_A1.4361.00
460_A464_V1.4351.00
84_L98_V1.4261.00
250_T333_T1.4241.00
46_L50_I1.4201.00
28_F32_I1.4181.00
35_A38_R1.4181.00
462_V466_N1.4171.00
302_R308_P1.4081.00
40_E43_T1.4071.00
288_D295_R1.4071.00
453_T459_D1.4011.00
101_W106_V1.3931.00
477_P480_H1.3851.00
39_L42_L1.3841.00
456_R462_V1.3831.00
287_D291_A1.3821.00
82_D87_L1.3801.00
297_V300_L1.3621.00
337_T340_G1.3621.00
80_T103_I1.3551.00
300_L305_E1.3361.00
44_A48_H1.3341.00
276_I347_L1.3321.00
33_H37_G1.3191.00
117_V120_A1.3181.00
294_E303_R1.3171.00
266_G269_L1.3071.00
78_A82_D1.2951.00
64_T68_G1.2911.00
393_L432_K1.2861.00
360_P449_D1.2841.00
410_S430_A1.2831.00
32_I36_E1.2751.00
458_F466_N1.2671.00
301_L304_T1.2511.00
393_L408_V1.2450.99
44_A47_R1.2450.99
453_T462_V1.2430.99
362_R384_S1.2410.99
49_R52_S1.2400.99
31_D39_L1.2350.99
49_R53_G1.2320.99
455_V461_E1.2300.99
28_F31_D1.2280.99
43_T46_L1.2270.99
125_G129_A1.2270.99
300_L303_R1.2260.99
309_L329_P1.2240.99
376_A438_A1.2110.99
45_Q48_H1.2050.99
494_D498_L1.2040.99
301_L308_P1.1980.99
459_D463_M1.1940.99
454_P460_A1.1870.99
494_D512_R1.1760.99
287_D290_V1.1750.99
452_P458_F1.1710.99
301_L330_I1.1680.99
37_G40_E1.1670.99
476_E479_V1.1660.99
475_Y479_V1.1590.99
116_I119_V1.1550.99
77_F99_Q1.1500.99
76_T79_E1.1500.99
453_T458_F1.1490.99
475_Y480_H1.1380.99
296_E299_A1.1380.99
30_R33_H1.1320.99
338_G341_L1.1230.99
302_R307_A1.1140.99
452_P457_A1.1130.99
290_V293_V1.1070.99
456_R465_L1.1050.99
331_V346_E1.1050.99
523_V526_E1.1040.99
366_D379_S1.1030.99
28_F42_L1.1030.99
411_I421_A1.1010.99
369_Y428_G1.0980.99
458_F464_V1.0920.99
282_T332_R1.0820.99
453_T461_E1.0810.99
25_K30_R1.0770.98
50_I54_D1.0750.98
256_G296_E1.0700.98
153_S337_T1.0690.98
456_R460_A1.0660.98
98_V102_G1.0630.98
26_E34_L1.0620.98
50_I53_G1.0610.98
458_F463_M1.0580.98
305_E309_L1.0570.98
383_K424_G1.0520.98
74_Q78_A1.0500.98
93_A109_A1.0490.98
80_T102_G1.0470.98
300_L309_L1.0470.98
455_V465_L1.0420.98
454_P462_V1.0390.98
47_R52_S1.0380.98
48_H52_S1.0370.98
95_I98_V1.0330.98
37_G45_Q1.0310.98
46_L49_R1.0290.98
73_S76_T1.0260.98
39_L44_A1.0260.98
189_V221_S1.0230.98
94_H98_V1.0230.98
332_R342_A1.0220.98
459_D466_N1.0220.98
32_I35_A1.0180.98
27_R32_I1.0170.98
32_I39_L1.0160.98
291_A332_R1.0150.98
282_T290_V1.0150.98
282_T340_G1.0140.98
461_E464_V1.0100.98
62_G65_D1.0090.98
125_G359_G1.0080.98
149_T153_S1.0010.98
33_H41_S0.9950.97
47_R50_I0.9930.97
290_V332_R0.9890.97
257_P330_I0.9880.97
36_E44_A0.9810.97
455_V464_V0.9740.97
68_G71_G0.9670.97
304_T328_V0.9670.97
80_T84_L0.9650.97
482_E490_F0.9650.97
303_R307_A0.9640.97
139_T347_L0.9630.97
138_G247_G0.9600.97
458_F465_L0.9590.97
453_T456_R0.9590.97
48_H54_D0.9570.97
26_E32_I0.9550.97
28_F36_E0.9540.97
370_S376_A0.9540.97
72_V77_F0.9530.97
294_E330_I0.9520.97
233_S495_G0.9520.97
454_P458_F0.9490.97
456_R464_V0.9470.97
303_R306_R0.9460.97
158_D161_D0.9430.97
303_R308_P0.9430.97
137_V220_V0.9420.96
370_S438_A0.9410.96
36_E39_L0.9390.96
31_D41_S0.9380.96
93_A97_D0.9340.96
454_P466_N0.9320.96
415_Y419_D0.9300.96
393_L429_I0.9300.96
41_S52_S0.9280.96
45_Q49_R0.9280.96
27_R30_R0.9280.96
154_L344_L0.9280.96
25_K35_A0.9270.96
469_T473_A0.9270.96
38_R41_S0.9260.96
291_A295_R0.9250.96
34_L42_L0.9240.96
70_A73_S0.9230.96
247_G264_H0.9210.96
33_H42_L0.9210.96
364_Y383_K0.9210.96
395_L432_K0.9140.96
336_V339_D0.9110.96
302_R305_E0.9100.96
31_D43_T0.9090.96
33_H40_E0.9090.96
42_L45_Q0.9090.96
42_L49_R0.9090.96
35_A42_L0.9080.96
418_V427_V0.9070.96
138_G273_L0.9040.96
457_A462_V0.9030.96
278_A333_T0.9030.96
455_V460_A0.9020.96
129_A356_A0.9020.96
452_P462_V0.9020.96
389_D417_R0.9010.95
139_T341_L0.9000.95
494_D509_F0.9000.95
43_T51_L0.8960.95
293_V300_L0.8920.95
393_L406_V0.8920.95
411_I429_I0.8910.95
356_A359_G0.8860.95
223_V233_S0.8860.95
41_S46_L0.8820.95
31_D38_R0.8820.95
79_E83_V0.8820.95
457_A466_N0.8810.95
72_V76_T0.8720.95
247_G268_L0.8710.95
298_E304_T0.8710.95
101_W104_D0.8700.95
46_L54_D0.8680.94
34_L37_G0.8650.94
421_A425_R0.8650.94
28_F35_A0.8650.94
455_V466_N0.8640.94
59_Y93_A0.8620.94
109_A113_T0.8620.94
363_M445_L0.8590.94
34_L41_S0.8570.94
460_A463_M0.8570.94
39_L45_Q0.8530.94
264_H267_V0.8520.94
287_D293_V0.8480.94
467_H471_I0.8470.94
27_R36_E0.8430.94
123_Q126_D0.8380.93
229_E499_P0.8370.93
456_R466_N0.8320.93
27_R35_A0.8310.93
124_D127_G0.8280.93
136_I381_T0.8270.93
27_R33_H0.8210.93
30_R38_R0.8210.93
232_L527_G0.8180.93
457_A464_V0.8180.93
97_D107_G0.8180.93
476_E506_R0.8150.92
32_I37_G0.8150.92
453_T464_V0.8140.92
32_I41_S0.8140.92
498_L501_D0.8140.92
32_I44_A0.8130.92
301_L306_R0.8130.92
415_Y418_V0.8110.92
115_G118_G0.8090.92
25_K31_D0.8070.92
30_R37_G0.8060.92
332_R340_G0.8030.92
48_H51_L0.8020.92
61_L96_A0.8020.92
36_E46_L0.8010.92
288_D292_A0.7990.92
357_A386_T0.7990.92
412_E417_R0.7960.91
31_D34_L0.7930.91
452_P461_E0.7930.91
100_T105_S0.7930.91
393_L445_L0.7920.91
43_T48_H0.7910.91
440_E443_M0.7900.91
38_R46_L0.7890.91
63_V84_L0.7870.91
418_V421_A0.7850.91
31_D37_G0.7830.91
49_R54_D0.7820.91
262_R300_L0.7760.90
31_D42_L0.7750.90
26_E31_D0.7730.90
361_F387_V0.7720.90
81_M86_L0.7690.90
150_L333_T0.7690.90
305_E328_V0.7630.90
32_I38_R0.7630.90
31_D36_E0.7610.90
97_D101_W0.7600.90
42_L47_R0.7590.89
42_L48_H0.7570.89
93_A96_A0.7570.89
416_H419_D0.7560.89
300_L328_V0.7520.89
461_E466_N0.7510.89
33_H38_R0.7510.89
28_F33_H0.7510.89
31_D45_Q0.7480.89
60_V93_A0.7470.89
30_R43_T0.7470.89
39_L50_I0.7460.89
118_G121_T0.7460.89
361_F447_P0.7460.89
453_T465_L0.7430.88
103_I107_G0.7390.88
25_K37_G0.7350.88
47_R53_G0.7350.88
26_E42_L0.7340.88
339_D342_A0.7330.88
214_E217_D0.7330.88
61_L69_L0.7330.88
460_A465_L0.7310.88
298_E301_L0.7300.88
293_V296_E0.7290.87
44_A52_S0.7270.87
33_H36_E0.7260.87
78_A88_A0.7260.87
62_G66_D0.7260.87
35_A44_A0.7250.87
331_V342_A0.7220.87
44_A49_R0.7210.87
67_G70_A0.7210.87
28_F34_L0.7170.87
398_F436_E0.7160.87
41_S48_H0.7140.86
359_G386_T0.7130.86
482_E494_D0.7110.86
395_L398_F0.7100.86
495_G498_L0.7100.86
35_A43_T0.7080.86
58_E61_L0.7070.86
475_Y478_V0.7070.86
293_V302_R0.7040.86
478_V508_R0.6980.85
70_A103_I0.6980.85
58_E69_L0.6960.85
26_E36_E0.6950.85
290_V300_L0.6950.85
125_G128_L0.6940.85
27_R34_L0.6930.85
70_A74_Q0.6930.85
28_F37_G0.6870.84
34_L47_R0.6870.84
292_A297_V0.6860.84
266_G270_A0.6860.84
34_L53_G0.6840.84
363_M381_T0.6830.84
42_L54_D0.6830.84
65_D68_G0.6820.84
139_T276_I0.6800.84
39_L46_L0.6790.84
253_A287_D0.6790.84
482_E493_A0.6780.83
42_L50_I0.6780.83
34_L48_H0.6770.83
112_G115_G0.6770.83
38_R50_I0.6760.83
266_G513_P0.6750.83
34_L39_L0.6750.83
265_M297_V0.6740.83
37_G42_L0.6730.83
27_R37_G0.6730.83
342_A346_E0.6730.83
115_G119_V0.6720.83
382_V427_V0.6710.83
30_R39_L0.6710.83
97_D109_A0.6700.83
33_H46_L0.6690.83
26_E35_A0.6680.83
40_E45_Q0.6670.82
301_L309_L0.6670.82
134_H219_V0.6670.82
57_A69_L0.6650.82
57_A61_L0.6640.82
453_T460_A0.6630.82
38_R43_T0.6620.82
32_I48_H0.6620.82
34_L44_A0.6600.82
490_F494_D0.6590.82
149_T160_D0.6590.82
75_A78_A0.6590.82
31_D47_R0.6580.82
394_L448_G0.6570.81
88_A91_A0.6560.81
27_R40_E0.6550.81
386_T420_S0.6540.81
37_G43_T0.6510.81
490_F512_R0.6470.80
456_R461_E0.6460.80
309_L346_E0.6450.80
469_T472_D0.6440.80
392_T448_G0.6440.80
39_L47_R0.6390.80
41_S47_R0.6390.80
61_L65_D0.6390.80
468_P475_Y0.6380.80
257_P261_T0.6380.80
34_L46_L0.6370.79
27_R43_T0.6370.79
32_I40_E0.6360.79
99_Q103_I0.6350.79
45_Q53_G0.6350.79
64_T69_L0.6340.79
25_K38_R0.6320.79
162_G178_E0.6320.79
28_F43_T0.6310.79
56_E110_P0.6310.79
365_V395_L0.6280.78
517_E534_T0.6280.78
44_A50_I0.6270.78
303_R309_L0.6240.78
61_L351_L0.6230.78
51_L54_D0.6210.78
144_D228_H0.6210.78
412_E430_A0.6210.78
36_E48_H0.6190.78
452_P464_V0.6190.78
31_D40_E0.6180.77
48_H53_G0.6180.77
251_V257_P0.6150.77
46_L53_G0.6140.77
40_E47_R0.6130.77
136_I243_K0.6120.77
28_F40_E0.6120.77
26_E44_A0.6110.77
220_V347_L0.6110.77
151_V222_F0.6100.76
28_F51_L0.6100.76
140_A268_L0.6100.76
64_T67_G0.6090.76
112_G116_I0.6080.76
484_I493_A0.6080.76
290_V297_V0.6070.76
113_T116_I0.6060.76
454_P459_D0.6060.76
182_S185_L0.6060.76
37_G46_L0.6050.76
27_R39_L0.6040.76
116_I120_A0.6030.76
115_G121_T0.6030.76
249_L297_V0.6010.75
32_I42_L0.6010.75
290_V294_E0.6010.75
297_V305_E0.6000.75
454_P461_E0.5990.75
38_R48_H0.5990.75
362_R444_V0.5980.75
46_L52_S0.5980.75
36_E41_S0.5970.75
110_P113_T0.5970.75
25_K47_R0.5970.75
25_K45_Q0.5960.75
480_H508_R0.5960.75
90_E94_H0.5950.75
36_E43_T0.5950.75
26_E50_I0.5950.75
25_K42_L0.5940.75
30_R41_S0.5940.75
40_E48_H0.5920.74
301_L307_A0.5920.74
31_D46_L0.5910.74
294_E298_E0.5900.74
38_R52_S0.5890.74
394_L451_D0.5890.74
60_V68_G0.5890.74
79_E82_D0.5880.74
66_D96_A0.5870.74
42_L53_G0.5870.74
55_G105_S0.5860.74
26_E45_Q0.5860.74
45_Q51_L0.5840.73
342_A345_D0.5830.73
452_P466_N0.5830.73
500_G504_H0.5830.73
457_A460_A0.5820.73
72_V105_S0.5820.73
34_L43_T0.5810.73
418_V429_I0.5800.73
153_S156_T0.5780.73
122_V126_D0.5780.73
498_L509_F0.5750.72
76_T80_T0.5740.72
130_A356_A0.5740.72
40_E54_D0.5740.72
75_A82_D0.5720.72
120_A446_L0.5710.72
37_G44_A0.5710.72
32_I45_Q0.5710.72
248_L276_I0.5690.71
297_V301_L0.5690.71
28_F39_L0.5680.71
460_A466_N0.5640.71
410_S417_R0.5630.71
98_V101_W0.5620.70
295_R299_A0.5620.70
38_R65_D0.5620.70
43_T49_R0.5610.70
457_A508_R0.5600.70
71_G105_S0.5590.70
494_D530_K0.5590.70
406_V432_K0.5550.70
60_V90_E0.5550.70
365_V445_L0.5550.70
28_F50_I0.5550.70
125_G130_A0.5530.69
62_G90_E0.5530.69
25_K40_E0.5520.69
35_A53_G0.5520.69
262_R269_L0.5520.69
291_A294_E0.5520.69
33_H49_R0.5510.69
38_R45_Q0.5500.69
26_E38_R0.5500.69
387_V429_I0.5500.69
437_E440_E0.5490.69
414_H418_V0.5490.69
238_G263_E0.5480.69
41_S53_G0.5480.69
456_R463_M0.5470.68
36_E42_L0.5470.68
219_V425_R0.5460.68
145_H255_D0.5460.68
34_L45_Q0.5450.68
414_H425_R0.5450.68
188_G221_S0.5440.68
40_E46_L0.5430.68
374_V430_A0.5430.68
308_P330_I0.5420.68
468_P474_G0.5410.68
294_E297_V0.5410.68
40_E52_S0.5410.68
61_L66_D0.5410.68
356_A384_S0.5400.67
221_S425_R0.5390.67
378_A431_L0.5380.67
407_E432_K0.5380.67
27_R42_L0.5370.67
350_R355_T0.5350.67
27_R45_Q0.5340.67
349_A352_P0.5330.66
471_I480_H0.5320.66
292_A301_L0.5300.66
26_E41_S0.5290.66
80_T86_L0.5280.66
97_D100_T0.5270.66
220_V348_F0.5260.65
41_S51_L0.5260.65
478_V481_L0.5250.65
143_V228_H0.5250.65
46_L51_L0.5240.65
76_T84_L0.5240.65
57_A107_G0.5240.65
27_R41_S0.5230.65
43_T50_I0.5230.65
333_T336_V0.5220.65
26_E47_R0.5210.65
25_K53_G0.5200.65
398_F443_M0.5200.65
405_T436_E0.5200.65
114_D118_G0.5200.65
293_V301_L0.5190.64
153_S157_G0.5180.64
117_V121_T0.5170.64
307_A328_V0.5170.64
262_R298_E0.5150.64
296_E300_L0.5150.64
33_H39_L0.5130.64
161_D336_V0.5120.63
28_F53_G0.5100.63
35_A45_Q0.5100.63
92_G101_W0.5070.63
501_D504_H0.5070.63
28_F41_S0.5070.63
453_T463_M0.5070.63
293_V298_E0.5060.62
58_E71_G0.5050.62
345_D497_L0.5050.62
438_A442_G0.5040.62
479_V488_A0.5040.62
44_A53_G0.5020.62
520_Q523_V0.5010.62
55_G67_G0.5000.62
43_T52_S0.5000.62
35_A48_H0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcaA 1 0.6222 100 0.474 Contact Map
4crnP 1 0.7037 100 0.48 Contact Map
1f60A 1 0.7074 100 0.485 Contact Map
3wy9A 1 0.6889 100 0.488 Contact Map
1jnyA 1 0.6815 100 0.491 Contact Map
1r5bA 1 0.6648 100 0.491 Contact Map
4d61i 1 0.7 100 0.492 Contact Map
3avxA 1 0.8444 100 0.501 Contact Map
1d2eA 3 0.6759 100 0.502 Contact Map
3p26A 1 0.7056 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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