GREMLIN Database
Q9HPE0 - Uncharacterized protein
UniProt: Q9HPE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (240)
Sequences: 414 (340)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_I101_Y3.5541.00
165_V187_V3.2451.00
87_A198_S3.0901.00
94_G126_F2.9260.99
106_Y176_W2.8430.99
162_M170_A2.7110.99
167_D194_G2.6520.99
101_Y104_F2.6030.99
153_A257_V2.6030.99
67_G76_A2.4120.98
246_L249_A2.4050.97
25_V28_V2.3880.97
225_L229_L2.2750.96
159_V199_A2.2280.96
155_V203_V2.1620.95
66_A131_V2.1250.95
49_N230_V2.1090.95
193_A197_L2.0560.94
136_L199_A2.0200.93
184_Y192_Y2.0150.93
105_A179_F2.0080.93
111_G121_G1.9960.93
134_Y203_V1.9500.92
130_V203_V1.9480.92
103_E179_F1.9440.92
104_F126_F1.8590.90
90_I198_S1.8400.89
26_F30_G1.8390.89
77_A81_A1.7750.87
241_L249_A1.7720.87
160_V198_S1.7550.87
237_G252_A1.7470.87
105_A177_R1.7240.86
138_V151_R1.7180.86
166_L170_A1.7170.86
104_F236_W1.6830.84
163_D191_N1.6460.83
64_L80_V1.5790.80
167_D187_V1.5560.79
171_V198_S1.5490.79
43_P54_L1.5460.79
249_A253_A1.5090.77
156_A200_V1.4930.76
104_F128_P1.4920.76
86_Y252_A1.4900.76
129_L162_M1.4850.76
188_P191_N1.4830.76
143_P220_A1.4620.75
81_A216_Q1.4570.75
32_V36_A1.4570.75
187_V199_A1.4480.74
178_Y236_W1.4470.74
221_D252_A1.4450.74
114_L197_L1.4420.74
115_A133_S1.4360.73
171_V187_V1.4320.73
114_L205_L1.4130.72
246_L250_A1.4020.72
128_P236_W1.3980.71
254_A258_G1.3840.71
247_L255_L1.3690.70
91_E163_D1.3620.69
55_F165_V1.3570.69
127_F162_M1.3530.69
23_A30_G1.3470.68
251_A255_L1.3320.68
76_A80_V1.3230.67
80_V90_I1.3150.67
201_V205_L1.3130.66
85_A227_D1.3080.66
215_I218_R1.3070.66
194_G198_S1.2840.65
152_L156_A1.2800.64
178_Y188_P1.2790.64
165_V199_A1.2700.64
119_P195_W1.2680.64
59_V97_A1.2650.63
101_Y236_W1.2600.63
164_V189_L1.2510.63
144_R216_Q1.2480.62
83_L130_V1.2360.62
27_P31_A1.2300.61
162_M169_A1.2110.60
23_A28_V1.2110.60
226_L252_A1.2110.60
156_A160_V1.2090.60
77_A124_V1.1960.59
93_L99_W1.1710.57
95_V199_A1.1660.57
91_E191_N1.1650.57
156_A196_V1.1620.57
208_W250_A1.1540.56
115_A200_V1.1520.56
33_T58_V1.1500.56
86_Y139_L1.1460.56
24_V199_A1.1370.55
151_R207_D1.1340.55
167_D245_N1.1320.55
192_Y236_W1.1270.54
83_L128_P1.1250.54
56_G178_Y1.1230.54
104_F202_S1.1190.54
253_A258_G1.1170.54
223_E227_D1.1170.54
178_Y190_S1.1130.53
85_A253_A1.1080.53
57_T156_A1.1030.53
182_G262_T1.0970.52
40_G48_F1.0910.52
220_A260_L1.0890.52
149_L250_A1.0850.52
82_V205_L1.0800.51
159_V192_Y1.0740.51
166_L200_V1.0740.51
106_Y178_Y1.0720.51
29_V53_I1.0720.51
91_E106_Y1.0590.50
104_F122_L1.0540.49
34_L235_L1.0510.49
83_L159_V1.0510.49
137_V156_A1.0500.49
41_W45_A1.0490.49
23_A205_L1.0450.49
143_P217_A1.0440.49
91_E195_W1.0360.48
203_V207_D1.0320.48
231_S244_G1.0290.48
101_Y122_L1.0220.47
160_V196_V1.0180.47
101_Y196_V1.0170.47
85_A89_G1.0150.47
155_V199_A1.0120.47
143_P154_A1.0120.47
130_V202_S1.0060.46
205_L219_V0.9950.45
158_T255_L0.9890.45
165_V169_A0.9820.45
115_A181_G0.9740.44
135_L218_R0.9740.44
42_L45_A0.9730.44
81_A247_L0.9720.44
91_E119_P0.9670.44
163_D194_G0.9670.44
95_V111_G0.9650.43
54_L197_L0.9650.43
77_A204_S0.9640.43
152_L204_S0.9620.43
104_F163_D0.9580.43
154_A158_T0.9560.43
46_L50_P0.9550.43
29_V33_T0.9490.42
87_A122_L0.9490.42
177_R241_L0.9440.42
96_T114_L0.9420.42
64_L192_Y0.9410.42
125_F129_L0.9390.42
93_L210_F0.9390.42
155_V161_W0.9340.41
25_V29_V0.9300.41
25_V157_A0.9260.41
79_A131_V0.9140.40
25_V193_A0.9130.40
87_A202_S0.9120.40
160_V181_G0.9120.40
125_F128_P0.9050.40
186_G251_A0.8920.39
160_V185_Y0.8900.39
216_Q250_A0.8870.38
254_A261_Q0.8850.38
129_L170_A0.8810.38
41_W87_A0.8790.38
75_R213_A0.8750.38
94_G102_G0.8740.38
125_F187_V0.8720.37
53_I123_P0.8700.37
35_L256_G0.8690.37
110_L123_P0.8680.37
33_T43_P0.8660.37
65_V108_I0.8650.37
178_Y192_Y0.8620.37
90_I187_V0.8580.36
163_D176_W0.8490.36
87_A121_G0.8480.36
33_T67_G0.8480.36
163_D167_D0.8420.35
97_A162_M0.8410.35
175_F202_S0.8400.35
113_M122_L0.8380.35
103_E133_S0.8340.35
91_E104_F0.8290.35
182_G186_G0.8290.35
129_L236_W0.8280.35
190_S237_G0.8220.34
84_T90_I0.8150.34
60_M63_P0.8140.34
31_A115_A0.8060.33
59_V128_P0.8050.33
55_F76_A0.7990.33
97_A100_P0.7970.33
33_T36_A0.7960.33
94_G123_P0.7950.33
77_A214_G0.7950.33
178_Y242_A0.7860.32
33_T50_P0.7820.32
136_L262_T0.7820.32
161_W164_V0.7760.32
137_V155_V0.7760.32
104_F198_S0.7710.31
162_M199_A0.7680.31
200_V257_V0.7650.31
151_R155_V0.7650.31
75_R105_A0.7650.31
115_A182_G0.7640.31
196_V199_A0.7630.31
204_S251_A0.7610.31
83_L104_F0.7580.30
107_R181_G0.7520.30
232_F235_L0.7520.30
187_V191_N0.7510.30
235_L248_P0.7500.30
65_V193_A0.7480.30
62_L85_A0.7470.30
60_M129_L0.7410.29
93_L208_W0.7400.29
77_A143_P0.7400.29
167_D192_Y0.7370.29
99_W216_Q0.7370.29
25_V144_R0.7340.29
178_Y240_N0.7190.28
102_G118_V0.7180.28
252_A258_G0.7160.28
86_Y235_L0.7160.28
144_R147_N0.7150.28
187_V236_W0.7100.28
59_V160_V0.7090.28
94_G110_L0.7070.28
31_A85_A0.7050.27
152_L203_V0.7030.27
58_V206_L0.6960.27
178_Y191_N0.6920.27
51_Y96_T0.6910.27
45_A56_G0.6890.27
62_L244_G0.6850.26
82_V148_R0.6850.26
153_A234_I0.6810.26
89_G93_L0.6770.26
187_V212_R0.6760.26
48_F137_V0.6750.26
89_G220_A0.6740.26
68_L184_Y0.6740.26
61_R193_A0.6690.26
31_A73_D0.6680.26
66_A79_A0.6650.25
123_P170_A0.6620.25
51_Y229_L0.6610.25
115_A220_A0.6610.25
225_L228_D0.6600.25
129_L161_W0.6560.25
250_A254_A0.6550.25
126_F170_A0.6530.25
244_G250_A0.6530.25
177_R213_A0.6530.25
90_I94_G0.6490.25
88_F159_V0.6470.24
178_Y244_G0.6440.24
123_P171_V0.6420.24
72_V123_P0.6420.24
231_S241_L0.6410.24
81_A85_A0.6400.24
109_E175_F0.6390.24
92_L115_A0.6330.24
88_F92_L0.6320.24
76_A127_F0.6280.24
31_A99_W0.6270.23
115_A189_L0.6260.23
188_P195_W0.6190.23
125_F236_W0.6180.23
133_S233_V0.6180.23
133_S159_V0.6160.23
94_G166_L0.6160.23
65_V208_W0.6160.23
164_V251_A0.6150.23
101_Y252_A0.6120.23
81_A190_S0.6110.23
181_G239_V0.6110.23
83_L101_Y0.6030.22
163_D195_W0.6020.22
125_F178_Y0.6010.22
147_N150_L0.5950.22
38_A48_F0.5930.22
34_L204_S0.5920.22
134_Y137_V0.5910.22
77_A149_L0.5900.22
126_F166_L0.5860.22
100_P191_N0.5850.21
154_A160_V0.5840.21
80_V255_L0.5820.21
165_V245_N0.5790.21
125_F169_A0.5780.21
190_S249_A0.5770.21
57_T215_I0.5770.21
96_T206_L0.5760.21
137_V264_R0.5760.21
170_A240_N0.5740.21
114_L200_V0.5730.21
124_V171_V0.5720.21
67_G155_V0.5700.21
106_Y163_D0.5670.21
104_F191_N0.5670.21
101_Y126_F0.5660.21
43_P83_L0.5660.21
112_P120_L0.5660.21
35_L38_A0.5650.21
208_W217_A0.5650.21
149_L260_L0.5630.20
122_L125_F0.5620.20
168_P189_L0.5600.20
151_R166_L0.5600.20
63_P101_Y0.5580.20
158_T166_L0.5550.20
258_G262_T0.5550.20
31_A109_E0.5500.20
71_L205_L0.5440.20
71_L134_Y0.5430.20
75_R133_S0.5430.20
99_W154_A0.5400.19
64_L76_A0.5390.19
133_S154_A0.5380.19
152_L200_V0.5380.19
32_V93_L0.5350.19
42_L204_S0.5340.19
59_V173_L0.5330.19
158_T161_W0.5310.19
55_F124_V0.5300.19
180_A251_A0.5300.19
67_G74_R0.5290.19
93_L120_L0.5290.19
78_V218_R0.5280.19
87_A160_V0.5260.19
31_A76_A0.5250.19
255_L265_F0.5200.19
119_P163_D0.5200.19
96_T116_G0.5170.19
104_F162_M0.5170.19
197_L245_N0.5170.19
240_N245_N0.5150.18
85_A197_L0.5130.18
119_P188_P0.5130.18
134_Y138_V0.5100.18
23_A29_V0.5100.18
102_G163_D0.5080.18
61_R157_A0.5080.18
138_V155_V0.5070.18
61_R70_P0.5060.18
234_I241_L0.5040.18
80_V180_A0.5040.18
88_F122_L0.5030.18
167_D196_V0.5010.18
188_P244_G0.5000.18
172_G192_Y0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.7921 51 0.95 Contact Map
4x5mA 2 0.3226 30.2 0.956 Contact Map
4rngA 2 0.2867 14.9 0.962 Contact Map
2kluA 1 0.1649 14.6 0.962 Contact Map
4qncA 2 0.2796 14.5 0.962 Contact Map
1xioA 2 0.5269 14.4 0.962 Contact Map
3qapA 1 0.5269 14.3 0.962 Contact Map
1m56C 2 0.2545 7.5 0.966 Contact Map
2m20A 2 0.1362 7.5 0.966 Contact Map
5bnxC 1 0.0645 6.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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