Q9HPE0 - HALSA - GREMLIN Contacts

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Q9HPE0 - Uncharacterized protein

UniProt:	Q9HPE0	Sequences: MADRARVEARLHELVAAYRFEIAVVFPVVGAVTLLASAWGWLPPALSFNPYFILFGTVVMRLPLVAGLAPLVDRRAAVAVAVLTAYAFGIELLGVTAGWPYGEFAYRIELGPMLAGKVPLGLPVFFFPLVVNSYLLVVLLLGPRARNRLLRLAAVAATVVWMDVVLDPAAVGLGFWRYFAGGPYYGVPLSNYAGWVLSAVVSVSLLDWGFSRAGIQARVADCEYLLDDLVSFVILWGTVNLAFGNLLPAAAAAALGVGLLQTDRFDFAVLRDRGPGTRQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	279 (240)
Sequences:	414 (340)
Seq/√Len:	22.0

HALSA - Q9HPE0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_I	101_Y	3.554	1.00
165_V	187_V	3.245	1.00
87_A	198_S	3.090	1.00
94_G	126_F	2.926	0.99
106_Y	176_W	2.843	0.99
162_M	170_A	2.711	0.99
167_D	194_G	2.652	0.99
101_Y	104_F	2.603	0.99
153_A	257_V	2.603	0.99
67_G	76_A	2.412	0.98
246_L	249_A	2.405	0.97
25_V	28_V	2.388	0.97
225_L	229_L	2.275	0.96
159_V	199_A	2.228	0.96
155_V	203_V	2.162	0.95
66_A	131_V	2.125	0.95
49_N	230_V	2.109	0.95
193_A	197_L	2.056	0.94
136_L	199_A	2.020	0.93
184_Y	192_Y	2.015	0.93
105_A	179_F	2.008	0.93
111_G	121_G	1.996	0.93
134_Y	203_V	1.950	0.92
130_V	203_V	1.948	0.92
103_E	179_F	1.944	0.92
104_F	126_F	1.859	0.90
90_I	198_S	1.840	0.89
26_F	30_G	1.839	0.89
77_A	81_A	1.775	0.87
241_L	249_A	1.772	0.87
160_V	198_S	1.755	0.87
237_G	252_A	1.747	0.87
105_A	177_R	1.724	0.86
138_V	151_R	1.718	0.86
166_L	170_A	1.717	0.86
104_F	236_W	1.683	0.84
163_D	191_N	1.646	0.83
64_L	80_V	1.579	0.80
167_D	187_V	1.556	0.79
171_V	198_S	1.549	0.79
43_P	54_L	1.546	0.79
249_A	253_A	1.509	0.77
156_A	200_V	1.493	0.76
104_F	128_P	1.492	0.76
86_Y	252_A	1.490	0.76
129_L	162_M	1.485	0.76
188_P	191_N	1.483	0.76
143_P	220_A	1.462	0.75
81_A	216_Q	1.457	0.75
32_V	36_A	1.457	0.75
187_V	199_A	1.448	0.74
178_Y	236_W	1.447	0.74
221_D	252_A	1.445	0.74
114_L	197_L	1.442	0.74
115_A	133_S	1.436	0.73
171_V	187_V	1.432	0.73
114_L	205_L	1.413	0.72
246_L	250_A	1.402	0.72
128_P	236_W	1.398	0.71
254_A	258_G	1.384	0.71
247_L	255_L	1.369	0.70
91_E	163_D	1.362	0.69
55_F	165_V	1.357	0.69
127_F	162_M	1.353	0.69
23_A	30_G	1.347	0.68
251_A	255_L	1.332	0.68
76_A	80_V	1.323	0.67
80_V	90_I	1.315	0.67
201_V	205_L	1.313	0.66
85_A	227_D	1.308	0.66
215_I	218_R	1.307	0.66
194_G	198_S	1.284	0.65
152_L	156_A	1.280	0.64
178_Y	188_P	1.279	0.64
165_V	199_A	1.270	0.64
119_P	195_W	1.268	0.64
59_V	97_A	1.265	0.63
101_Y	236_W	1.260	0.63
164_V	189_L	1.251	0.63
144_R	216_Q	1.248	0.62
83_L	130_V	1.236	0.62
27_P	31_A	1.230	0.61
162_M	169_A	1.211	0.60
23_A	28_V	1.211	0.60
226_L	252_A	1.211	0.60
156_A	160_V	1.209	0.60
77_A	124_V	1.196	0.59
93_L	99_W	1.171	0.57
95_V	199_A	1.166	0.57
91_E	191_N	1.165	0.57
156_A	196_V	1.162	0.57
208_W	250_A	1.154	0.56
115_A	200_V	1.152	0.56
33_T	58_V	1.150	0.56
86_Y	139_L	1.146	0.56
24_V	199_A	1.137	0.55
151_R	207_D	1.134	0.55
167_D	245_N	1.132	0.55
192_Y	236_W	1.127	0.54
83_L	128_P	1.125	0.54
56_G	178_Y	1.123	0.54
104_F	202_S	1.119	0.54
253_A	258_G	1.117	0.54
223_E	227_D	1.117	0.54
178_Y	190_S	1.113	0.53
85_A	253_A	1.108	0.53
57_T	156_A	1.103	0.53
182_G	262_T	1.097	0.52
40_G	48_F	1.091	0.52
220_A	260_L	1.089	0.52
149_L	250_A	1.085	0.52
82_V	205_L	1.080	0.51
159_V	192_Y	1.074	0.51
166_L	200_V	1.074	0.51
106_Y	178_Y	1.072	0.51
29_V	53_I	1.072	0.51
91_E	106_Y	1.059	0.50
104_F	122_L	1.054	0.49
34_L	235_L	1.051	0.49
83_L	159_V	1.051	0.49
137_V	156_A	1.050	0.49
41_W	45_A	1.049	0.49
23_A	205_L	1.045	0.49
143_P	217_A	1.044	0.49
91_E	195_W	1.036	0.48
203_V	207_D	1.032	0.48
231_S	244_G	1.029	0.48
101_Y	122_L	1.022	0.47
160_V	196_V	1.018	0.47
101_Y	196_V	1.017	0.47
85_A	89_G	1.015	0.47
155_V	199_A	1.012	0.47
143_P	154_A	1.012	0.47
130_V	202_S	1.006	0.46
205_L	219_V	0.995	0.45
158_T	255_L	0.989	0.45
165_V	169_A	0.982	0.45
115_A	181_G	0.974	0.44
135_L	218_R	0.974	0.44
42_L	45_A	0.973	0.44
81_A	247_L	0.972	0.44
91_E	119_P	0.967	0.44
163_D	194_G	0.967	0.44
95_V	111_G	0.965	0.43
54_L	197_L	0.965	0.43
77_A	204_S	0.964	0.43
152_L	204_S	0.962	0.43
104_F	163_D	0.958	0.43
154_A	158_T	0.956	0.43
46_L	50_P	0.955	0.43
29_V	33_T	0.949	0.42
87_A	122_L	0.949	0.42
177_R	241_L	0.944	0.42
96_T	114_L	0.942	0.42
64_L	192_Y	0.941	0.42
125_F	129_L	0.939	0.42
93_L	210_F	0.939	0.42
155_V	161_W	0.934	0.41
25_V	29_V	0.930	0.41
25_V	157_A	0.926	0.41
79_A	131_V	0.914	0.40
25_V	193_A	0.913	0.40
87_A	202_S	0.912	0.40
160_V	181_G	0.912	0.40
125_F	128_P	0.905	0.40
186_G	251_A	0.892	0.39
160_V	185_Y	0.890	0.39
216_Q	250_A	0.887	0.38
254_A	261_Q	0.885	0.38
129_L	170_A	0.881	0.38
41_W	87_A	0.879	0.38
75_R	213_A	0.875	0.38
94_G	102_G	0.874	0.38
125_F	187_V	0.872	0.37
53_I	123_P	0.870	0.37
35_L	256_G	0.869	0.37
110_L	123_P	0.868	0.37
33_T	43_P	0.866	0.37
65_V	108_I	0.865	0.37
178_Y	192_Y	0.862	0.37
90_I	187_V	0.858	0.36
163_D	176_W	0.849	0.36
87_A	121_G	0.848	0.36
33_T	67_G	0.848	0.36
163_D	167_D	0.842	0.35
97_A	162_M	0.841	0.35
175_F	202_S	0.840	0.35
113_M	122_L	0.838	0.35
103_E	133_S	0.834	0.35
91_E	104_F	0.829	0.35
182_G	186_G	0.829	0.35
129_L	236_W	0.828	0.35
190_S	237_G	0.822	0.34
84_T	90_I	0.815	0.34
60_M	63_P	0.814	0.34
31_A	115_A	0.806	0.33
59_V	128_P	0.805	0.33
55_F	76_A	0.799	0.33
97_A	100_P	0.797	0.33
33_T	36_A	0.796	0.33
94_G	123_P	0.795	0.33
77_A	214_G	0.795	0.33
178_Y	242_A	0.786	0.32
33_T	50_P	0.782	0.32
136_L	262_T	0.782	0.32
161_W	164_V	0.776	0.32
137_V	155_V	0.776	0.32
104_F	198_S	0.771	0.31
162_M	199_A	0.768	0.31
200_V	257_V	0.765	0.31
151_R	155_V	0.765	0.31
75_R	105_A	0.765	0.31
115_A	182_G	0.764	0.31
196_V	199_A	0.763	0.31
204_S	251_A	0.761	0.31
83_L	104_F	0.758	0.30
107_R	181_G	0.752	0.30
232_F	235_L	0.752	0.30
187_V	191_N	0.751	0.30
235_L	248_P	0.750	0.30
65_V	193_A	0.748	0.30
62_L	85_A	0.747	0.30
60_M	129_L	0.741	0.29
93_L	208_W	0.740	0.29
77_A	143_P	0.740	0.29
167_D	192_Y	0.737	0.29
99_W	216_Q	0.737	0.29
25_V	144_R	0.734	0.29
178_Y	240_N	0.719	0.28
102_G	118_V	0.718	0.28
252_A	258_G	0.716	0.28
86_Y	235_L	0.716	0.28
144_R	147_N	0.715	0.28
187_V	236_W	0.710	0.28
59_V	160_V	0.709	0.28
94_G	110_L	0.707	0.28
31_A	85_A	0.705	0.27
152_L	203_V	0.703	0.27
58_V	206_L	0.696	0.27
178_Y	191_N	0.692	0.27
51_Y	96_T	0.691	0.27
45_A	56_G	0.689	0.27
62_L	244_G	0.685	0.26
82_V	148_R	0.685	0.26
153_A	234_I	0.681	0.26
89_G	93_L	0.677	0.26
187_V	212_R	0.676	0.26
48_F	137_V	0.675	0.26
89_G	220_A	0.674	0.26
68_L	184_Y	0.674	0.26
61_R	193_A	0.669	0.26
31_A	73_D	0.668	0.26
66_A	79_A	0.665	0.25
123_P	170_A	0.662	0.25
51_Y	229_L	0.661	0.25
115_A	220_A	0.661	0.25
225_L	228_D	0.660	0.25
129_L	161_W	0.656	0.25
250_A	254_A	0.655	0.25
126_F	170_A	0.653	0.25
244_G	250_A	0.653	0.25
177_R	213_A	0.653	0.25
90_I	94_G	0.649	0.25
88_F	159_V	0.647	0.24
178_Y	244_G	0.644	0.24
123_P	171_V	0.642	0.24
72_V	123_P	0.642	0.24
231_S	241_L	0.641	0.24
81_A	85_A	0.640	0.24
109_E	175_F	0.639	0.24
92_L	115_A	0.633	0.24
88_F	92_L	0.632	0.24
76_A	127_F	0.628	0.24
31_A	99_W	0.627	0.23
115_A	189_L	0.626	0.23
188_P	195_W	0.619	0.23
125_F	236_W	0.618	0.23
133_S	233_V	0.618	0.23
133_S	159_V	0.616	0.23
94_G	166_L	0.616	0.23
65_V	208_W	0.616	0.23
164_V	251_A	0.615	0.23
101_Y	252_A	0.612	0.23
81_A	190_S	0.611	0.23
181_G	239_V	0.611	0.23
83_L	101_Y	0.603	0.22
163_D	195_W	0.602	0.22
125_F	178_Y	0.601	0.22
147_N	150_L	0.595	0.22
38_A	48_F	0.593	0.22
34_L	204_S	0.592	0.22
134_Y	137_V	0.591	0.22
77_A	149_L	0.590	0.22
126_F	166_L	0.586	0.22
100_P	191_N	0.585	0.21
154_A	160_V	0.584	0.21
80_V	255_L	0.582	0.21
165_V	245_N	0.579	0.21
125_F	169_A	0.578	0.21
190_S	249_A	0.577	0.21
57_T	215_I	0.577	0.21
96_T	206_L	0.576	0.21
137_V	264_R	0.576	0.21
170_A	240_N	0.574	0.21
114_L	200_V	0.573	0.21
124_V	171_V	0.572	0.21
67_G	155_V	0.570	0.21
106_Y	163_D	0.567	0.21
104_F	191_N	0.567	0.21
101_Y	126_F	0.566	0.21
43_P	83_L	0.566	0.21
112_P	120_L	0.566	0.21
35_L	38_A	0.565	0.21
208_W	217_A	0.565	0.21
149_L	260_L	0.563	0.20
122_L	125_F	0.562	0.20
168_P	189_L	0.560	0.20
151_R	166_L	0.560	0.20
63_P	101_Y	0.558	0.20
158_T	166_L	0.555	0.20
258_G	262_T	0.555	0.20
31_A	109_E	0.550	0.20
71_L	205_L	0.544	0.20
71_L	134_Y	0.543	0.20
75_R	133_S	0.543	0.20
99_W	154_A	0.540	0.19
64_L	76_A	0.539	0.19
133_S	154_A	0.538	0.19
152_L	200_V	0.538	0.19
32_V	93_L	0.535	0.19
42_L	204_S	0.534	0.19
59_V	173_L	0.533	0.19
158_T	161_W	0.531	0.19
55_F	124_V	0.530	0.19
180_A	251_A	0.530	0.19
67_G	74_R	0.529	0.19
93_L	120_L	0.529	0.19
78_V	218_R	0.528	0.19
87_A	160_V	0.526	0.19
31_A	76_A	0.525	0.19
255_L	265_F	0.520	0.19
119_P	163_D	0.520	0.19
96_T	116_G	0.517	0.19
104_F	162_M	0.517	0.19
197_L	245_N	0.517	0.19
240_N	245_N	0.515	0.18
85_A	197_L	0.513	0.18
119_P	188_P	0.513	0.18
134_Y	138_V	0.510	0.18
23_A	29_V	0.510	0.18
102_G	163_D	0.508	0.18
61_R	157_A	0.508	0.18
138_V	155_V	0.507	0.18
61_R	70_P	0.506	0.18
234_I	241_L	0.504	0.18
80_V	180_A	0.504	0.18
88_F	122_L	0.503	0.18
167_D	196_V	0.501	0.18
188_P	244_G	0.500	0.18
172_G	192_Y	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2xq2A	2	0.7921	51	0.95	Contact Map
4x5mA	2	0.3226	30.2	0.956	Contact Map
4rngA	2	0.2867	14.9	0.962	Contact Map
2kluA	1	0.1649	14.6	0.962	Contact Map
4qncA	2	0.2796	14.5	0.962	Contact Map
1xioA	2	0.5269	14.4	0.962	Contact Map
3qapA	1	0.5269	14.3	0.962	Contact Map
1m56C	2	0.2545	7.5	0.966	Contact Map
2m20A	2	0.1362	7.5	0.966	Contact Map
5bnxC	1	0.0645	6.7	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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